PinX1: structure, regulation and its functions in cancer

Hai-Long Li; Jun Song; Hong-Mei Yong; Ping-Fu Hou; Yan-Su Chen; Wen-Bo Song; Jin Bai; Jun-Nian Zheng

doi:10.18632/oncotarget.11411

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PinX1: structure, regulation and its functions in cancer

Hai-Long Li, Jun Song, Hong-Mei Yong, Ping-Fu Hou, Yan-Su Chen, Wen-Bo Song, Jin Bai and Jun-Nian Zheng _

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Oncotarget. 2016; 7:66267-66275. https://doi.org/10.18632/oncotarget.11411

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Abstract

Hai-Long Li1,2,*, Jun Song3,4,*, Hong-Mei Yong5,*, Ping-Fu Hou1,3, Yan-Su Chen1,3, Wen-Bo Song1, Jin Bai1 and Jun-Nian Zheng1,3

1 Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu, China

2 Department of Urology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China

3 Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, Jiangsu, China

4 Department of General Surgery, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China

5 Department of Medical Oncology, Huai’an Hospital to Xuzhou Medical College, Huai’an, Jiangsu, China

* These authors have contributed equally to this study

Correspondence to:

Jun-Nian Zheng, email:

Jin Bai, email:

Keywords: PinX1; cancer; structure; regulation; function

Received: March 14, 2016 Accepted: August 09, 2016 Published: August 19, 2016

Abstract

PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) is a novel cloned gene located at human chromosome 8p23, playing a vital role in maintaining telomeres length and chromosome stability. It has been demonstrated to be involved in tumor genesis and progression in most malignancies. However, some researches showed opposing molecular status of PinX1 gene and its expression patterns in several other types of tumors. The pathogenic mechanism of PinX1 expression in human malignancy is not yet clear. Moreover, emerging evidence suggest that PinX1 (especially its TID domain) might be a potential new target cancer treatment. Therefore, PinX1 may be a new potential diagnostic biomarker and therapeutic target for human cancers, and may play different roles in different human cancers. The functions and the mechanisms of PinX1 in various human cancers remain unclear, suggesting the necessity of further extensive works of its role in tumor genesis and progression.

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PinX1: structure, regulation and its functions in cancer

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