TLR2 – an innate immune checkpoint in multiple sclerosis

Longistatin in tick-saliva targets RAGE

RBP-J and ITAM crosstalk

EPI-X4, a novel endogenous antagonist of CXCR4

AMPK potentiation by LKB1 isoforms

Metabolic plasticity of cancer stem cells

Lysosomal mTORC2/PHLPP1/Akt axis: a new point of control of chaperone-mediated autophagy

The PHD2 oxygen sensor paves the way to metastasis

Prmt5 differentiates developmental vs regenerative myogenesis

Coping with cancer genes altered by copy number

PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP

Epigenetic silencing of miR-145-5p contributes to brain metastasis

MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma

Chromosome transplantation as a novel approach for correcting complex genomic disorders

The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma

Rapamycin preserves gut homeostasis during Drosophila aging

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity

Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

Age-dependent uncoupling of mitochondria from Ca²⁺ release units in skeletal muscle

MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications

Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts

Association between serum uric acid and bone health in general population: a large and multicentre study

c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells

Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development

Dendritic and Langerhans cells respond to Aβ peptides differently: implication for AD immunotherapy

The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders

The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia

Cordycepin prevents oxidative stress-induced inhibition of osteogenesis

Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma

Free intraperitoneal tumor cells and outcome in gastric cancer patients: a systematic review and meta-analysis

Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis

What links BRAF to the heart function? new insights from the cardiotoxicity of BRAF inhibitors in cancer treatment

First description of a sporadic breast cancer in a woman with BRCA1 germline mutation

A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region

Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity

The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells

Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer

Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers

The tissue dependent interactions between p53 and Bcl-2 in vivo

MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators

Detection of canonical A-to-G editing events at 3’ UTRs and microRNA target sites in human lungs using next-generation sequencing

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

Bone marrow macrophages support prostate cancer growth in bone

Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design

High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis

Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling

Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis

MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells

Mechanisms of dihydrotestosterone action on resveratrol-induced anti-proliferation in breast cancer cells with different ERα status

Loss of p27^Kip1 promotes metaplasia in the pancreas via the regulation of Sox9 expression

The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L

Blockade of telomerase reverse transcriptase enhances chemosensitivity in head and neck cancers through inhibition of AKT/ERK signaling pathways

Frequent DPH3 promoter mutations in skin cancers

Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling

Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression

Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler’s kidney

miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition

Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acrylamide in human colorectal cancer cells in vitro and in vivo

The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

CD4⁺ T cells play a crucial role for lenalidomide in vivo anti-tumor activity in murine multiple myeloma

Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway

Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer

Septin cooperation with tubulin polyglutamylation contributes to cancer cell adaptation to taxanes

Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies

Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn Ptch1^+/− mice after paternal irradiation

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin

The effective bioengineering method of implantation decellularized renal extracellular matrix scaffolds

Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo

Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells

High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial β-F1-ATPase subunit in head and neck squamous cell carcinoma

Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors

Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1

HER2 as a novel therapeutic target for cervical cancer

miR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells

Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model

Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia

GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment

On representing the prognostic value of continuous gene expression biomarkers with the restricted mean survival curve

Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms

Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1

Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth

Regulation of SOX10 stability via ubiquitination-mediated degradation by Fbxw7α modulates melanoma cell migration

SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma

Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression

Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages

TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo

Mitotic entry: Non-genetic heterogeneity exposes the requirement for Plk1

URGCP promotes non-small cell lung cancer invasiveness by activating the NF-κB-MMP-9 pathway

Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes

Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9

Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3γ

Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia

Novel RNA variants in colorectal cancers

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment

Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma

Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer

Identification of high risk anaplastic gliomas by a diagnostic and prognostic signature derived from mRNA expression profiling

Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development

microRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical carcinoma

PRIMA-1^met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms

INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma

Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway

The axon guidance molecule semaphorin 3F is a negative regulator of tumor progression and proliferation in ileal neuroendocrine tumors

Adiponectin promotes VEGF-A-dependent angiogenesis in human chondrosarcoma through PI3K, Akt, mTOR, and HIF-α pathway

CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices

DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells

Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome

The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model

Hepatic resection alone versus in combination with pre- and post-operative transarterial chemoembolization for the treatment of hepatocellular carcinoma: A systematic review and meta-analysis

Isolated locoregional recurrence patterns of breast cancer after mastectomy and adjuvant systemic therapies in the contemporary era

Clinicopathological and prognostic factors for long-term survival in Chinese patients with metastatic renal cell carcinoma treated with sorafenib: a single-center retrospective study

Risk factors, short and long term outcome of anastomotic leaks in rectal cancer

Alterations of biomarker profiles after neoadjuvant chemotherapy in breast cancer: tumor heterogeneity should be taken into consideration

Resected pancreatic ductal adenocarcinomas with recurrence limited in lung have a significantly better prognosis than those with other recurrence patterns

Prognosis of patients with esophageal squamous cell carcinoma after esophagectomy using the log odds of positive lymph nodes