Specificity and diversity of the mouse Peyer’s patch mononuclear phagocyte system

Rejuvenation by inhibiting TGF-β1/pSmad signaling

The APC/C and CK1 in the developing brain

Aging phenomics enabled by quantitative imaging analysis

The higher-order molecular organization of p62/SQSTM1

Infectious origins of childhood leukemia

Mitochondriolus: assembling mitoribosomes

IRX1 hypomethylation in osteosarcoma metastasis

LKB1 in transmembrane receptor signaling

The MIOREX complex - lean management of mitochondrial gene expression

Genetically-encoded sensors of protein hydrodynamics

mTORtuous effect on the elastic heart

Redefining protein moonlighting

Sirtuin 3 in acute kidney injury

miR-24 in diabetes

Protein quality and quantity control at the yeast ER

Plant immune receptors mimic pathogen virulence targets

Antimicrobial peptides target ribosomes

DNA repair: Location, location, location

Reactive oxygen species a double-edged sword for mesothelioma

Circadian disruption and breast cancer: An epigenetic link?

ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs)

Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics

Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells

SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications

Age-related changes in monocytes exacerbate neointimal hyperplasia after vascular injury

Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor

Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells

MicroRNA analysis suggests an additional level of feedback regulation in the NF-κB signaling cascade

Inhibition of histamine receptor 3 suppresses glioblastoma tumor growth, invasion, and epithelial-to-mesenchymal transition

SNAI2/Slug gene is silenced in prostate cancer and regulates neuroendocrine differentiation, metastasis-suppressor and pluripotency gene expression

Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma

The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells

3’-Phosphoadenosine 5’-phosphosulfate synthase 1 (PAPSS1) knockdown sensitizes non-small cell lung cancer cells to DNA damaging agents

Radiosensitization and downregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K) upon inhibition of mitogen/extracellular signal-regulated kinase (MEK) in malignant melanoma cells

Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death

YAP is a critical oncogene in human cholangiocarcinoma

TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells

Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme – phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis

Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues

Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome

Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis

FGF23 promotes prostate cancer progression

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes

Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies

MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the hippo signaling pathway

Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma

Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer

MiR-361-5p inhibits colorectal and gastric cancer growth and metastasis by targeting staphylococcal nuclease domain containing-1

TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy

C/D-box snoRNA-derived RNA production is associated with malignant transformation and metastatic progression in prostate cancer

HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses

CD4⁺ and CD8⁺ T cells have opposing roles in breast cancer progression and outcome

RhoE is required for contact inhibition and negatively regulates tumor initiation and progression

EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy

Endothelial Rac1 is essential for hematogenous metastasis to the lung

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma

The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5

Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns

By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth

Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells

UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity

NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells

Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status

Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms

AKAP4 is a circulating biomarker for non-small cell lung cancer

Attenuated mutant strain of Salmonella Typhimurium lacking the ZnuABC transporter contrasts tumor growth promoting anti-cancer immune response

Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit

CEMTDD: The database for elucidating the relationships among herbs, compounds, targets and related diseases for Chinese ethnic minority traditional drugs

The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27^Kip1

BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells

Identification and evaluation of network modules for the prognosis of basal-like breast cancer

Regulation of VCP/p97 demonstrates the critical balance between cell death and epithelial-mesenchymal transition (EMT) downstream of ER stress

Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes

miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma

Genetic alterations of JAK/STAT cascade and histone modification in extranodal NK/T-cell lymphoma nasal type

Purification and identification of a polysaccharide from medicinal mushroom Amauroderma rude with immunomodulatory activity and inhibitory effect on tumor growth

Thioredoxin reductase: A novel, independent prognostic marker in patients with hepatocellular carcinoma

Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma

CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage

Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors