In The News - Breakthroughs

Undergraduate researcher discovers genes linked to glioblastoma

January 2018 publication in the journal Oncotarget, Dunwoodie's study is the first to describe glioblastoma-specific gene co-expression relationships between a group of 22 specific genes. Heard in the news as the disease afflicting Senator John McCain and Beau Biden, the late son of U.S. Vice President Joe Biden, glioblastoma is highly malignant and is characterized by its lethality. Patients with glioblastoma have a median survival time of only 14.6 months after diagnosis.

Orbit Genomics Aims to Develop Cancer Tests Based on Microsatellite Sequences

Startup Orbit Genomics plans to develop next-generation sequencing-based assays that analyze microsatellite sequences to diagnose cancer and other diseases.

Virginia Tech Carilion Research Institute teams converge on strategies to defeat McCain's form of brain cancer

Research teams at the Virginia Tech Carilion Research Institute from three colleges -- Engineering, Science, and Veterinary Medicine -- are developing new approaches to treat glioblastoma, the aggressive form of brain cancer recently diagnosed in U.S. Sen. John McCain.

First molecules discovered by next-generation artificial intelligence to be developed into drugs

Platforms incorporate new AI techniques such as Generative Adversarial Networks in order to generate novel compounds with desired pharmacokinetic and pharmacodynamic properties.

Shooting the Achilles Heel of Nervous System Cancers

The multidisciplinary team expects that by following up on these discoveries they will identify new targets and therapeutic leads for the treatment of aggressive nervous system cancers driven by NF1 loss, including GBM

Low-cost nutrient halts growth of cancer stem cells

An exciting medical breakthrough published in the science journal Oncotarget has discovered the astonishing ability of concentrated vitamin C to halt the growth of cancer tumor stem cells.

Scientists stumble across new method of making antibiotics

Cancer researchers in the UK may have stumbled across a solution to reverse antibiotic drug resistance and stop infections like MRSA.

The accident that could save the world from deadly antibiotic resistance: Scientists stumble across a solution by CHANCE

Study author Professor Michael Lisanti told MailOnline they were looking into ways of inhibiting mitochondria, the 'powerhouse' of cells which fuel fatal tumours, when they made the discovery.

Morphotek Announces Publication Uncovering One Of The Mechanisms By Which The Tumor-Produced CA125 Protein Suppresses Immune-Mediated Killing Via Farletuzumab

Morphotek®, Inc., a subsidiary of Eisai Inc., announced today that a publication entitled "Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc receptor engagement" was published in the journal Oncotarget as a priority paper.

Time since chemotherapy may predict response to olaparib in ovarian cancer

Women with advanced ovarian cancer who begin treatment with olaparib are more likely to respond to the drug if it has been more than a year since their last round of chemotherapy, according to new research.

Heart attack shown to be 'systemic condition'

An acute heart attack should not be viewed in isolation - myocardial infarction is a "systemic" condition with an impact upon the whole body and engenders responses in other organs, such as liver and spleen. That is the main finding of a study conducted by PhD student Matthias Zimmermann under the supervision of Hendrik Jan Ankersmit and Michael Mildner at the Division of Thoracic Surgery at the Departments of Surgery and Dermatology of MedUni Vienna. This study has now been published in the...

A radical solution

Understanding reactive oxygen species is vital for tackling many diseases - but you need to catch them first. Here Dr Kalina Ranguelova talks us through this challenge and a possible solution in the shape of electron paramagnetic resonance

Cells that make blood vessels can also make tumors and enable their spread

Dr. Lan Ko, cancer biologist in the Department of Pathology at MCG at Augusta University and Dr. Ali S. Arbab, a tumor angiogenesis expert at the Georgia Cancer Center and the MCG Department of Biochemistry and Molecular Biology, was a major collaborator

Combining vitamin C with antibiotics destroys cancer stem cells

"Researchers found that a therapy involving the antibiotic Doxycycline and ascorbic acid, or vitamin C, was up to 100 times more effective for killing cancer stem cells (CSCs) than 2-DG, a molecule currently being tested as an anti-cancer agent in clinical trials. Study co-author Prof. Michael Lisanti, of the Biomedical Research Centre at the University of Salford in the United Kingdom, and colleagues recently reported their findings in the journal Oncotarget."

Immune profiling leads to implications for immunotherapy for NF1-associated tumors

Recently a team in the Center for Childhood Cancer and Blood Diseases in The Research Institute at Nationwide Children's Hospital led a study published in Oncotarget that further seeks to define the immunogenic profiles of these NF1-associated tumors in the hopes of identifying targeted immunotherapy options. The collaborative study included researchers from the Center for Childhood Cancer and Blood Diseases, the Division of Hematology, Oncology and Blood and Marrow Transplant and the... continue reading >>

AI-Based Personalized Drug Discovery Platform Launched

Insilico Medicine, Inc., a company applying the latest advances in deep learning to biomarker development, drug discovery and aging research, launched ALS.AI, a personalized drug discovery and biomarker development platform utilizing the latest advances in deep learning.

Oncoceutics Publishes Positive Efficacy Results for Recurrent Glioblastoma Trial

Researchers, reporting in Oncotarget, described efficacy results from the first 17 patients in a Phase 2 trial for the treatment of adult recurrent glioblastoma.

Brain cancer researcher, Dr. Raffaella Spina, explains cancer recurrence in glioblastomas and her approaches to fighting it in the laboratory

The glioblastomas are the most stubborn and aggressive of brain cancers. Referred to as glioblastoma multiforme, this form of grade IV brain tumor is considered malignant. Once diagnosed, doctors surgically remove the tumor from the brain, and prescribe concurrent radiation and oral chemotherapy for the weeks that follow.

Fat Oxidation Inhibitor, Anti-Androgen Therapy Combination Increases Prostate Cancer Sensitivity

A combination treatment was found to increase the sensitivity of castration resistant prostate cancer (CRPC) to anti-androgen therapy, and may provide a new option for patients with this aggressive form of cancer, according to a recent study.

Genetic test for anal cancer could identify those at high risk

A new test, based on a patient's epigenetics, could be an accurate and inexpensive way to find and treat those at highest risk of anal cancer - a disease with growing incidence in women, men who have sex with men (MSM) and people with HIV.

A new molecular target to improve neuroblastoma treatment

The annual mortality rate in childhood cancer of the sympathetic nervous system, or neuroblastoma, is 10 per million between the ages of zero and four. A collaborative work between Basque and Valencian researchers has identified some genetic mutations that could improve the treatment of this disease

Breakthrough study stops fat-eating prostate cancer cells

Patients with castration resistant prostate cancer (CRPC) usually have a poor prognosis. In part, this is due to the cancer's ability to resist anti-androgen therapy. A study shows that combining a CPT1A inhibitors with anti-androgen therapy increases the cancer's sensitivity to the anti-androgen drug enzalutamide.

The BGRF is helping develop AI to accelerate drug discovery for aging and age-associated diseases

Biogerontology Research Foundation scientists to help develop AI for accelerated drug discovery for aging and age-related disease

Scrib protein identified as a natural suppressor of liver cancer

A protein that typically helps keep cells organized and on task becomes a tumor suppressor in the face of liver cancer, scientists say.

8 New Biomarkers Discovered to Aid Earlier Cancer Diagnosis

A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan. Shimadzu Corporation, the Kobe University Graduate School of Medicine, and the National Cancer Center in Japan have collaborated to develop a new screening method that comprehensively analyzes the metabolites in our blood. The results of this research were published in the online edition of Oncotarget, a U.S. scientific publication, on February 4, 2017.

New method for early screening of colorectal cancer

A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan. Shimadzu Corporation, the Kobe University Graduate School of Medicine, and the National Cancer Center in Japan have collaborated to develop a new screening method that comprehensively analyzes the metabolites in our blood. The results of this research were published in the online edition of Oncotarget, a U.S. scientific publication, on February 4, 2017.

Scientists Have Found a New Way to Get Cancer Cells to Self-Destruct

A newly discovered mechanism causes cancerous cells to kill themselves off, and researchers say it could be particularly effective for aggressive forms of the disease, such as pancreatic cancer.

A Gene that's Driving Cancer Drug Resistance

In a paper published this week in the journal Oncotarget, biochemists tested a hypothesis that the mechanism of tamoxifen resistance is related to energy-generating mitochondria in cancer cells.

New gene discovered driving drug resistance

In a paper published this week in the journal Oncotarget, biochemists tested a hypothesis that the mechanism of tamoxifen resistance is related to energy-generating mitochondria in cancer cells.

Can the Siberian fir cure cancer and slow down aging?

Groundbreaking research into the healing properties of conifer trees will give cancer patients yet another weapon in the arsenal against the dread disease.

Experimental MERS Treatments Target Host Cell Receptor

A virus component called spike glycoprotein (S) and a host cell receptor called dipeptidyl peptidase 4 (DPP-4) are targets in researchers' efforts to stop the spread of MERS, the Middle East respiratory syndrome, and possibly treat it. MERS is caused by a coronavirus implicated in 684 deaths since September 2012, according to the World Health Organization.

Georgetown University, 10x Genomics, Jackson Laboratory, And More: News From March 2017

Researchers from Georgetown University used an Oxford Nanopore MK1B MinION device to sequence environmental DNA in Antarctica. They reported their findings in the April issue of The Journal of Biomolecular Techniques.

Breast Cancer Cure: Future Treatment May Destroy 'Incurable' Triple Negative, Pancreatic Cancer Cells

While chemotherapy remains one of the most widely used cancer treatments, it also harms and kills healthy cells in the process. However, a new study from Tel Aviv University in Israel shows that cancer treatment does not always have to be toxic for the body. The study instead reveals how three natural proteins can be modified to kill cancer cells while they are quickly dividing, all while leaving healthy cells alone.

Study identifies how BPA may encourage inflammatory breast cancer growth

The chemical bisphenol A, or BPA, appears to aid the survival of inflammatory breast cancer cells, revealing a potential mechanism for how the disease grows, according to a study led by researchers in the Department of Surgery at Duke University School of Medicine and the Duke Cancer Institute.

Phenanthridine PJ34 Causes Fast Cell Death During Cancer Cell Mitosis

Proteins that can be specifically modified during mitosis, the division process, to unleash an inherent death mechanism that self-eradicates duplicating cancer cells have been identified by researchers at Tel Aviv University.

Israeli medical breakthrough: Healthy cells eliminating aggressive cancer cells?

Researchers at Tel Aviv University have discovered that the "cell death mechanism" found in every healthy cell can also be modulated to kill infected cells. Experiments carried out on mice have given hope for beginning experimentation on humans.

Research results in AI for drug discovery to be presented at the BioDataWorld West in San Francisco

Insilico Medicine, a Baltimore-based Big Data analytics company applying deep learning techniques to drug discovery, biomarker development and human longevity research will present and chair a panel at the BioDataWorld West, San Francisco, April 26-27. The CEO of Insilico Medicine, Alex Zhavoronkov, PhD will present new research applying generative adversarial networks (GANs) to developing new molecular structures for leads in oncology and other diseases.

This young Alabama scientist led breakthrough work in breast cancer

Breast cancer researcher Dr. Joy McDaniel in the laboratory at Huntsville's HudsonAlpha Institute for Biotechnology. McDaniel's work may lead to a new targeted therapy for deadly triple negative breast cancer.

Scientists develop scoring system to calculate prognosis for breast cancer patients

Berkeley Lab researchers have developed a genetic score reflecting the prognosis for specific types of breast cancer. The score is based upon a 12-gene signature identified through analysis of large genomic datasets and clinical patient data.

Electric hum' technology opening window on cancer treatment

Sound waves similar to the hum of an electric shaver could show which cancer treatments work. 'Wave sound digital representation splitted channels.

Deep learning transforms the drug discovery process in collaboration between Insilico Medicine and Life Extension

Insilico Medicine was the first company to apply deep generative adversarial networks (GANs) to generating anti-cancer drugs with given parameters and published a seminal paper in Oncotarget. The paper published in Molecular Pharmaceutics, demonstrating the applications of deep neural networks for predicting the therapeutic class of the molecule using the transcriptional response data, received the American Chemical Society Editors' Choice Award.

Exosome Surface Markers May Enable Cancer-Specific Dx Tests

Though researchers and diagnostic development firms have for some time been exploring using exosomes -- persistent, circulating vesicles that carry cellular nucleic acids and proteins -- for cancer and other disease testing, the field has yet to see many tests translated into clinical use.

Can we hit the snooze button on aging?

Researchers take aim at the biological machinery that causes our bodies to decline

Precision targeting provides new insights into therapy-resistant cancers

Filipp has already mapped the genetic landscape of melanoma and found a drug that could be effective in battling the deadly skin cancer, and has now identified epigenetic master regulators that control cancer published today in Oncotarget, Cancer Metastasis Review, and Oxford Academic Press.

Artificial intelligence enters the nutraceutical industry

Life Extension and Insilico Medicine to launch the first natural geroprotector combination and start a new research collaboration

Fir extract could have anti-cancer and anti-aging properties

Scientists from the Engelhardt Institute of Molecular Biology and MIPT have studied the effects of Siberian fir terpenoids on senescent and human cancer cell lines at the genetic level. Research into terpenoids, including their effect on cancers, was initiated by scientists at Initium-Pharm Ltd. The study was published in the biomedical journal Oncotarget, and the results have attracted the interest of geneticists.

New culture method boosts T cells' ability to recognize multiple cancers

The method has its challenges, including "achieving robust expansion" of tumor-specific T cells from blood, the researchers wrote in their study, which was published in Oncotarget. The researchers' new culture method could improve the ability of engineered T cells to recognize cancer cells.

Researchers identify new process to raise natural armies of cancer-targeting T lymphocytes

Mayo Clinic and University of Washington researchers have discovered a new culture method that unlocks the natural fighter function of immune T cells when they are passing through the bloodstream. This allows T cell armies to be raised directly from blood that naturally recognize and target proteins that are present on most human cancers. The results are published in the Feb. 14 issue of Oncotarget.

Neural network learns to select potential anticancer drugs

Scientists from Mail.Ru group Insilico Medicine and MIPT have for the first time applied a generative neural network to create new pharmaceutical medicines with the desired characteristics. Generative adversarial networks (GANs) developed and trained to "invent" new molecular structures may produce a dramatic reduction in the time and cost of searching for substances with potential medicinal properties. The researchers intend to use these technologies in the search for new medications within... continue reading >>

Two investigational antitumor agents work better together against MPNST and neuroblastoma

Two investigational agents, Aurora A kinase inhibitor (alisertib) and HSV1716, a virus derived from HSV-1 and attenuated by the deletion of RL1, have shown some antitumor efficacy in early clinical trials as monotherapies. A new study published last week in Oncotarget, however, demonstrates that the combined usage of the agents results in significantly increased antitumor efficacy in models of malignant peripheral nerve sheath tumor (MPNST) and neuroblastoma.

Peregrine Pharma (PPHM) Says Recent Publication Highlights Proof-of-Concept Data for Exosome-Based Cancer Detection Platform

Results of the study, conducted at University of Texas (UT) Southwestern Medical Center, showed researchers were able to distinguish between healthy subjects and patients with ovarian tumors based on the levels of exosomes containing phosphatidylserine (PS) found in their plasma. Furthermore, analysis of the PS-positive exosome levels allowed researchers to distinguish between malignant and benign tumors. These data were recently published online by the peer-reviewed journal, Oncotarget, in a... continue reading >>

Melanoma research breakthrough gives hope for treatment

A QUT-driven project has identified the way in which melanoma cells spread, opening up new pathways to treatment via drugs to 'turn off' the invasive gene.

Pancreatic Cancer Liquid Biopsy Test to Be First Product of Harvard Spinout Biomarx Therapeutics

Biomarx Therapeutics is preparing a blood-based test for early-stage pancreatic cancer that it hopes to have on the market by the first quarter of 2019.

Propranolol in Angiosarcoma: First Major Advance in Decades

Early clinical trial results using the β-blocker propranolol for the treatment of advanced angiosarcoma are so positive that an international group of researchers is urging clinicians worldwide to "embrace this new therapeutic option."

Scientists describe lab technique with potential to change medicine and research

The Georgetown University Medical Center (GUMC) researchers hope that by doing so, scientists around the world can realize the many of possibilities of "conditional reprogramming," which includes living biobanks, personalized and regenerative medicine, and novel cancer research.

Molecular Subgroups of Non-Small Cell Lung Cancer Predict Tumor Behavior, Reveal Treatment Targets

A recent study, published in the journal Oncotarget, describes further scientific insight into the metastatic patters of Epidermal Growth Factor Receptor (EGFR) mutated NSCLCs. The authors determined that bio-molecular characteristics and genotype may influence the metastatic process in NSCLC tumors, and might help the development of enrichment strategies for tumor genotyping in these tumors, especially in the presence of limited tissue availability. Furthermore, the understanding that... continue reading >>

Irish researchers make stem-cell cancer breakthrough

Irish-led researchers have found a way to make it potentially easier to kill off tumour cells and make radiotherapy more effective for people with oesophageal cancer.

Stem cell 'marking' study offers alterative hypothesis of cancer metastasis

In research published in the journal Oncotarget, the Salford team conclude that stem cell characteristics and behaviour are instrumental in metastasis and believe the key to their reactivation is an enzyme called Telomerase, or hTERT.

Researchers find cancer-fighting drugs help morbidly obese mice lose weight

Scientific investigations sometimes result in serendipitous discoveries which shift the investigations from one focus to another. In the case of researchers recent research, studies addressing obesity's impact on cancer treatment resulted in an unexpected discovery that shifted the focus from cancer to obesity. The investigators observed that two common cancer-fighting drugs sparked significant weight loss in the obese mice, even though the mice continued their excessive consumption of a...

Prostate cancer researchers find genetic fingerprint identifying how, when disease spreads

Canadian prostate cancer researchers have discovered the genetic fingerprint that explains why up to 30 per cent of men with potentially curable localized prostate cancer develop aggressive disease that spreads following radiotherapy or surgery.

Enzyme could protect against type of colorectal cancer by suppressing tumors, study finds

Researchers at Georgia State University and Stony Brook University have identified the tumor suppressor role of matrix-metalloproteinase (MMP9), which belongs to a family of enzymes called proteinases and serves as an essential regulator of extracellular matrix components via a novel mechanistic pathway. The findings are reported in the journal Oncotarget.

Pancreatic Cancer Study Finds NGS-Based Liquid, Tissue Biopsies Provide Discordant Results

A team led by researchers from molecular profiling firm Perthera has published a study comparing results from liquid and tissue biopsies in pancreatic cancer patients.

How Chinese medicine kills cancer cells

Researchers at the University of Adelaide have shown how a complex mix of plant compounds derived from ancient clinical practice in China -- a Traditional Chinese Medicine -- works to kill cancer cells.

Scientists Have Isolated 6 Natural Compounds That Could Help Us Slow Down Ageing

As the authors report in Oncotarget, one of these compounds - a specific extract of willow bark (Salix alba) - is the most potent longevity-extending pharmacological intervention ever described in scientific literature. In testing, the willow bark extract increased the average chronological lifespan of yeast by 475 percent and the maximum chronological lifespan by 369 percent.

Common vitamin hailed for cancer healing properties

New research has shown that a combination of vitamin C and the antibiotic Doxycycline could be key to killing cancer stem cells.

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