Oncotarget

Recently on Gerotarget (Aging)

2018

Editorials: Gerotarget (Focus on Aging)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly

https://doi.org/10.18632/oncotarget.26417

Stefanie Lerche,  and Kathrin Brockmann
36732-36733
PDF

Research Papers: Gerotarget (Focus on Aging)

Active lifestyles in older adults: an integrated predictive model of physical activity and exercise

https://doi.org/10.18632/oncotarget.25352

Federica Galli, Andrea Chirico, Luca Mallia, Laura Girelli, Michelino De Laurentiis, Fabio Lucidi, Antonio Giordano,  and Gerardo Botti
25402-25413
Abstract  |  PDF  |  HTML
Genome-wide significant risk factors on chromosome 19 and the APOE locus

https://doi.org/10.18632/oncotarget.25083

Sonia Moreno-Grau Moreno-Grau, Isabel Hernández, Stefanie Heilmann-Heimbach, Susana Ruiz, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Octavio Rodríguez- Gómez, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Nuria Aguilera, Carla Abdelnour, Alzheimer’s Disease Neuroimaging Initiative, Silvia Gil, Wolfgang Maier, Oscar Sotolongo-Grau, Lluís Tárraga, Alfredo Ramirez, Jesús López-Arrrieta, Carmen Antúnez, Manuel Serrano- Ríos, Mercè Boada,  and Agustín Ruiz
24590-24600
Abstract  |  PDF  |  HTML  |  Supplementary Information
Inhibition of aldose-reductase-2 by a benzofuroxane derivative bf-5m increases the expression of kcne1, kcnq1 in high glucose cultured H9c2 cardiac cells and sudden cardiac death

https://doi.org/10.18632/oncotarget.23270

Maria Consiglia Trotta, Monica Salerno, Anna Lisa Brigida, Vincenzo Monda, Antonietta Messina, Carmela Fiore, Roberto Avola, Renato Bernardini, Francesco Sessa, Gabriella Marsala, Guido N. Zanghì, Giovanni Messina, Michele D’Amico,  and Clara Di Filippo
17257-17269
Abstract  |  PDF  |  HTML
Associations of the polymorphisms in long non-coding RNA H19 with hepatocellular carcinoma risk in a Southern Chinese population

https://doi.org/10.18632/oncotarget.23854

Zhifeng Lin, Junguo Zhang, Xiaohui Ji, Lucheng Pi, Nana Tian, Xinqi Lin, Li Liu, Sidong Chen, Xinfa Yu,  and Yanhui Gao
s16-s24
Abstract  |  PDF  |  HTML  |  Supplementary Information
Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model

https://doi.org/10.18632/oncotarget.24449

Yuko Iwata, Yoshimi Katayama, Yasushi Okuno,  and Shigeo Wakabayashi
14042-14057
Abstract  |  PDF  |  HTML
Identification of prefrontal cortex protein alterations in Alzheimer’s Disease

https://doi.org/10.18632/oncotarget.24303

Maria Garranzo-Asensio, Pablo San Segundo-Acosta, Javier Martínez-Useros, Ana Montero-Calle, María Jesús Fernández-Aceñero, Anna Häggmark-Månberg, Alberto Pelaez-Garcia, Mayte Villalba, Alberto Rabano, Peter Nilsson,  and Rodrigo Barderas
10847-10867
Abstract  |  PDF  |  HTML  |  Supplementary Information
CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans

https://doi.org/10.18632/oncotarget.24039

Yujie Li, Sandra Finkbeiner, Athina Ganner, Julia Gerber, Marinella Klein, Manuel Grafe, Jakob Kandzia, Antje Thien, Kathrin Thedieck, Gerhard Breves, Thomas Jank, Ralf Baumeister, Gerd Walz,  and Elke Neumann- Haefelin
9581-9595
Abstract  |  PDF  |  HTML  |  Supplementary Information
Effect of the diet type and temperature on the C. elegans transcriptome

https://doi.org/10.18632/oncotarget.23563

Eva Gomez-Orte, Eric Cornes, Angelina Zheleva, Beatriz Sáenz-Narciso, María de Toro, María Iñiguez, Rosario Lopez, Juan-Félix San-Juan, Begoña Ezcurra, Begoña Sacristán, Adolfo Sánchez-Blanco, Julián Cerón,  and Juan Cabello
9556-9571
Abstract  |  PDF  |  HTML  |  Supplementary Information
Octogenarians with EGFR-mutated non-small cell lung cancer treated by tyrosine-kinase inhibitor: a multicentric real-world study assessing tolerance and efficacy (OCTOMUT study)

https://doi.org/10.18632/oncotarget.23836

Romain Corre, Radj Gervais, Florian Guisier, Louis Tassy, Florent Vinas, Régine Lamy, Gislaine Fraboulet, Laurent Greillier, Helene Doubre, Renaud Descourt, Christos Chouaid,  and Jean-Bernard Auliac
8253-8262
Abstract  |  PDF  |  HTML
Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

https://doi.org/10.18632/oncotarget.23660

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri,  and Takahiro Maeda
7749-7757
Abstract  |  PDF  |  HTML
Anticoagulants inhibit proteolytic clearance of plasma amyloid beta

https://doi.org/10.18632/oncotarget.23718

Lu Yang, Arup Bhattacharya, Yun Li,  and Yuesheng Zhang
5614-5626
Abstract  |  PDF  |  HTML
MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction

https://doi.org/10.18632/oncotarget.23652

Kyung Mok Kim, Ki Wung Chung, Hyeong Oh Jeong, Bonggi Lee, Dae Hyun Kim, June Whoun Park, Seong Min Kim, Byung Pal Yu,  and Hae Young Chung
5588-5599
Abstract  |  PDF  |  HTML  |  Supplementary Information
Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFα

https://doi.org/10.18632/oncotarget.23726

Norihiko Sasaki, Yoko Itakura,  and Masashi Toyoda
5562-5577
Abstract  |  PDF  |  HTML  |  Supplementary Information
Developmental and light regulation of tumor suppressor protein PP2A in the retina

https://doi.org/10.18632/oncotarget.23351

Ammaji Rajala, Yuhong Wang, Steven F. Abcouwer, Thomas W. Gardner,  and Raju V.S. Rajala
1505-1523
Abstract  |  PDF  |  HTML  |  Supplementary Information
PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation

https://doi.org/10.18632/oncotarget.21554

Weiwei Yang, Xue Wang, Jia Liu, Chunli Duan, Ge Gao, Lingling Lu, Shun Yu,  and Hui Yang
37-53
Abstract  |  PDF  |  HTML
Genetic polymorphisms in ataxin-3 and liver cirrhosis risk related to aflatoxin B1

https://doi.org/10.18632/oncotarget.24535

Xing-Zhizi Wang, Xiao-Ying Huang, Jin-Guang Yao, Chao Wang, Qiang Xia,  and Xi-Dai Long
27321-27332
Abstract  |  PDF  |  HTML
Genetic variations in chromodomain helicase DNA-binding protein 5, gene-environment interactions and risk of sporadic Alzheimer’s disease in Chinese population

https://doi.org/10.18632/oncotarget.23791

Xiao Zhu, Haibing Yu, Qin Xiao, Jianhao Ke, Hongmei Li, Zhihong Chen, Hongrong Ding, Shuilong Leng, Yongmei Huang, Jingting Zhan, Jinli Lei, Wenguo Fan,  and Hui Luo
24872-24881
Abstract  |  PDF  |  HTML  |  Supplementary Information
Drosophila PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway

https://doi.org/10.18632/oncotarget.24834

Jung-Hoon Pyo, Ho-Jun Jeon, Joung-Sun Park, Jae-Sun Lee, Hae-Young Chung,  and Mi-Ae Yoo
17980-17993
Abstract  |  PDF  |  HTML  |  Supplementary Information
Outcome after neoadjuvant chemotherapy in elderly breast cancer patients – a pooled analysis of individual patient data from eight prospectively randomized controlled trials

https://doi.org/10.18632/oncotarget.24586

Gabriel von Waldenfels, Sibylle Loibl, Jenny Furlanetto, Anna Machleidt, Bianca Lederer, Carsten Denkert, Claus Hanusch, Sherko Kümmel, Gunter von Minckwitz, Andreas Schneeweiss, Michael Untch, Kerstin Rhiem, Peter A. Fasching,  and Jens-Uwe Blohmer
15168-15179
Abstract  |  PDF  |  HTML
Human umbilical cord-derived mesenchymal stromal cells ameliorated motor defects of 6-OHDA-induced rat model of Parkinson's disease

https://doi.org/10.18632/oncotarget.24103

Fabin Han, Chao Chen, Wei Wang, Hao Song, Sen Li, Jing Duan, Xianjie Lu, Shichao Wu, Nan Zhang, Qingfa Chen, Yan Wang, Shuwei Liu, Chongluo Fu, Chengbiao Lu,  and Paul Lu
s1-s15
Abstract  |  PDF  |  HTML
Epigenetic modifications in hyperhomocysteinemia; potential role in diabetic retinopathy and age-related macular degeneration

https://doi.org/10.18632/oncotarget.24333

Khaled Elmasry, Riyaz Mohamed, Isha Sharma, Nehal M. Elsherbiny, Yutao Liu, Mohamed Al-Shabrawey,  and Amany Tawfik
12562-12590
Abstract  |  PDF  |  HTML  |  Supplementary Information
Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly

https://doi.org/10.18632/oncotarget.24330

Pablo Garrido-Gil, Antonio Dominguez-Meijide, Rosario Moratalla, Maria J. Guerra,  and Jose L. Labandeira-Garcia
10834-10846
Abstract  |  PDF  |  HTML
Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes

https://doi.org/10.18632/oncotarget.23851

Xiaomei Wang, Anna Malawista, Feng Qian, Christine Ramsey, Heather G. Allore,  and Ruth R. Montgomery
9572-9580
Abstract  |  PDF  |  HTML  |  Supplementary Information
Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack

https://doi.org/10.18632/oncotarget.23653

Yoichi Yoshida, Hao Wang, Takaki Hiwasa, Toshio Machida, Eiichi Kobayashi, Seiichiro Mine, Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Hideyuki Kuroda, Hirotaka Takizawa, Koichi Kashiwado, Ikuo Kamitsukasa, Hideo Shin, Takeshi Wada, Akiyo Aotsuka, Eiichiro Nishi, Mikiko Ohno, Minoru Takemoto, Koutaro Yokote, Sho Takahashi, Jun Matsushima, Xiao-Meng Zhang, Masaki Takiguchi,  and Yasuo Iwadate
8836-8848
Abstract  |  PDF  |  HTML  |  Supplementary Information
Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis

https://doi.org/10.18632/oncotarget.23246

Luying Huang, Yi Wang, Hua Liu,  and Jianhua Huang
8241-8252
Abstract  |  PDF  |  HTML
Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila

https://doi.org/10.18632/oncotarget.23292

Deng-Tai Wen, Lan Zheng, Fan Yang, Han-Zhe Li,  and Wen-Qi Hou
7298-7311
Abstract  |  PDF  |  HTML
Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction

https://doi.org/10.18632/oncotarget.23789

Hao Wang, Xiao-Meng Zhang, Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Hideyuki Kuroda, Risa Kimura, Seiichiro Mine, Ikuo Kamitsukasa, Takeshi Wada, Akiyo Aotsuka, Yoichi Yoshida, Eiichi Kobayashi, Tomoo Matsutani, Yasuo Iwadate, Kazuo Sugimoto, Masahiro Mori, Akiyuki Uzawa, Mayumi Muto, Satoshi Kuwabara, Minoru Takemoto, Kazuki Kobayashi, Harukiyo Kawamura, Ryoichi Ishibashi, Koutaro Yokote, Mikiko Ohno, Po-Min Chen, Eiichiro Nishi, Koh Ono, Takeshi Kimura, Toshio Machida, Hirotaka Takizawa, Koichi Kashiwado, Hideaki Shimada, Masaaki Ito, Ken-Ichiro Goto, Katsuro Iwase, Hiromi Ashino, Akiko Taira, Emiko Arita, Masaki Takiguchi,  and Takaki Hiwasa
5600-5613
Abstract  |  PDF  |  HTML  |  Supplementary Information
The involvement of serum exosomal miR-500-3p and miR-770-3p in aging: modulation by calorie restriction

https://doi.org/10.18632/oncotarget.23651

Eun Kyeong Lee, Hyoung Oh Jeong, Eun Jin Bang, Chul Hong Kim, Ji Young Mun, Seulgi Noh, Jeong-An Gim, Dae Hyun Kim, Ki Wung Chung, Byung Pal Yu,  and Hae Young Chung
5578-5587
Abstract  |  PDF  |  HTML  |  Supplementary Information
Comprehensive transcriptional landscape of porcine cardiac and skeletal muscles reveals differences of aging

https://doi.org/10.18632/oncotarget.23290

Jianning Chen, Qin Zou, Daojun Lv, Yingying Wei, Muhammad Ali Raza, Yan Chen, Peilin Li, Xiaoyu Xi, Huaming Xu, Anxiang Wen, Li Zhu, Guoqing Tang, Mingzhou Li, Anan Jiang, Yihui Liu, Yuhua Fu, Yanzhi Jiang,  and Xuewei Li
1524-1541
Abstract  |  PDF  |  HTML  |  Supplementary Information
RCAN1 in the inverse association between Alzheimer’s disease and cancer

https://doi.org/10.18632/oncotarget.23094

Qiang Fu,  and Yili Wu
54-66
Abstract  |  PDF  |  HTML

2017

Priority Research Papers: Gerotarget

Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

DOI: 10.18632/oncotarget.13919

Preety Bajwa, Sarah Nielsen, Janine M. Lombard, Loui Rassam, Pravin Nahar, Bo R. Rueda, J. Erby Wilkinson, Richard A. Miller,  and Pradeep S. Tanwar
7265-7275
Abstract  |   PDF  |  HTML  |  Supplementary Information
Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility

https://doi.org/10.18632/oncotarget.21818

Marc Núnez-Ollé, Carole Jung, Berta Terré, Norman A. Balsiger, Cristina Plata, Ramon Roset, Carlos Pardo-Pastor, Marta Garrido, Santiago Rojas, Francesc Alameda, Josep Lloreta, Juan Martín-Caballero, Juana M. Flores, Travis H. Stracker, Miguel A. Valverde, Francisco J. Muñoz,  and Gabriel Gil-Gómez
99261-99273
Abstract  |  PDF  |  HTML  |  Supplementary Information

Research Papers: Gerotarget (Focus on Aging)

High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines

https://doi.org/10.18632/oncotarget.22937

Jie Gao, Gao-Ju Wang, Zhao Wang, Na Gao, Jing Li, Yun-Fei Zhang, Jun Zhou, Hong-Xin Zhang, Qiang Wen, Han Jin,  and Hai-Ling Qiao
112199-112210
Abstract  |  PDF  |  HTML
End stage renal disease is associated with development of dementia

https://doi.org/10.18632/oncotarget.22458

Peir-Haur Hung, Chih-Ching Yeh, Chih-Yen Hsiao, Pi-Shan Sung, Chih-Hsin Muo, Fung-Chang Sung, Kuan-Yu Hung,  and Kuen-Jer Tsai
107348-107355
Abstract  |  PDF  |  HTML
Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer’s disease

https://doi.org/10.18632/oncotarget.22218

Amanda Jimenez, Jordi Pegueroles, María Carmona-Iragui, Eduard Vilaplana, Victor Montal, Daniel Alcolea, Laura Videla, Ignacio Illán-Gala, Adriana Pané, Anna Casajoana, Olivia Belbin, Jordi Clarimón, Violeta Moizé, Josep Vidal, Alberto Lleó, Juan Fortea, Rafael Blesa,  and The Alzheimer’s Disease Neuroimaging Initiative
104706-104716
Abstract  |  PDF  |  HTML  |  Supplementary Information
Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing

https://doi.org/10.18632/oncotarget.21849

Tao Hu, Zhangang Xiao, Rui Mao, Bo Chen, Min-Nan Lu, Jun Tong, Rong Mei, Shan-Shan Li, Zhi-Cheng Xiao, Lian-Feng Zhang,  and Yan-Bin Xiyang
99284-99295
Abstract  |  PDF  |  HTML  |  Supplementary Information
Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro

https://doi.org/10.18632/oncotarget.21852

Han Wang, Lin Du, Tong Wu, Gangyi Yang, Wenjing Hu, Hansheng Wang, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Zhiming Zhu, Hongting Zheng,  and Ling Li
96604-96614
Abstract  |  PDF  |  HTML  |  Supplementary Information
Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells

https://doi.org/10.18632/oncotarget.19951

Kumar K.J. Senthil, Vani M. M. Gokila,  and Sheng-Yang Wang
96568-96587
Abstract  |  PDF  |  HTML
Age-related modulation of plasmatic beta-Galactosidase activity in healthy subjects and in patients affected by T2DM

https://doi.org/10.18632/oncotarget.21848

Liana Spazzafumo, Emanuela Mensà, Giulia Matacchione, Tiziana Galeazzi, Lucia Zampini, Rina Recchioni, Fiorella Marcheselli, Francesco Prattichizzo, Roberto Testa, Roberto Antonicelli, Paolo Garagnani, Massimo Boemi, Massimiliano Bonafè, Anna Rita Bonfigli, Antonio Domenico Procopio,  and Fabiola Olivieri
93338-93348
Abstract  |  PDF  |  HTML
TSH-independent release of thyroid hormones through cold exposure in aging rats

https://doi.org/10.18632/oncotarget.19851

Gi Cheol Park, Ji Min Kim, Hee-Young Park, Ji Min Han, Sung-Chan Shin, Jeon Yeob Jang, Dawoon Jung, In Joo Kim, Jin-Choon Lee,  and Byung-Joo Lee
89431-89438
Abstract  |  PDF  |  HTML
Regulation of S-formylglutathione hydrolase by the anti-aging gene klotho

https://doi.org/10.18632/oncotarget.19111

Yuechi Xu,  and Zhongjie Sun
88259-88275
Abstract  |  PDF  |  HTML  |  Supplementary Information
Therapeutic management and one-year outcomes in elderly patients with acute coronary syndrome

https://doi.org/10.18632/oncotarget.21260

Esteban Orenes-Piñero, Juan M. Ruiz-Nodar, María Asunción Esteve-Pastor, Miriam Quintana-Giner, José Miguel Rivera-Caravaca, Andrea Veliz, Mariano Valdés, Manuel Macías, Vicente Pernias-Escrig, Nuria Vicente-Ibarra, Luna Carrillo, Miriam Sandín-Rollán, Elena Candela, Teresa Lozano,  and Francisco Marín
80182-80191
Abstract  |  PDF  |  HTML
Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7

https://doi.org/10.18632/oncotarget.20962

Young Jin Jang, Hyo Jeong Son, Yong Min Choi, Jiyun Ahn, Chang Hwa Jung,  and Tae Youl Ha
78300-78311
Abstract  |  PDF  |  HTML  |  Supplementary Information
An extract from the Atlantic brown algae Saccorhiza polyschides counteracts diet-induced obesity in mice via a gut related multi-factorial mechanisms

https://doi.org/10.18632/oncotarget.18113

Patricia Huebbe, Sibylle Nikolai, Anke Schloesser, Diran Herebian, Graeme Campbell, Claus-Christian Glüer, Annette Zeyner, Tobias Demetrowitsch, Karin Schwarz, Cornelia C. Metges, Thomas Roeder, Gerhard Schultheiss, Ignacio R. Ipharraguerre,  and Gerald Rimbach
73501-73515
Abstract  |  PDF  |  HTML  |  Supplementary Information
Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells

https://doi.org/10.18632/oncotarget.20628

Xiaojun Wen, Lijiao Xiao, Zhuoyan Zhong, Limin Wang, Ze Li, Xiaoping Pan,  and Zhonglin Liu
69370-69385
Abstract  |  PDF  |  HTML
HIF-1α:CRAT:miR-144-3p axis dysregulation promotes osteoarthritis chondrocyte apoptosis and VLCFA accumulation

https://doi.org/10.18632/oncotarget.20615

Jinsoo Song, Yeon-Ho Kang, Sik Yoon, Churl-Hong Chun,  and Eun-Jung Jin
69351-69361
Abstract  |  PDF  |  HTML
Wnt/β-catenin signaling promotes aging-associated hair graying in mice

https://doi.org/10.18632/oncotarget.20613

Zhihui Zhang, Mingxing Lei, Haoran Xin, Chunyan Hu, Tian Yang, Yizhan Xing, Yuhong Li, Haiying Guo, Xiaohua Lian,  and Fang Deng
69316-69327
Abstract  |  PDF  |  HTML
Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

https://doi.org/10.18632/oncotarget.19363

Diana Gabriel, Dinah Dorith Shafry, Leslie B. Gordon,  and Karima Djabali
64809-64826
Abstract  |  PDF  |  HTML  |  Supplementary Information
Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression

https://doi.org/10.18632/oncotarget.17616

Yanfei Peng, Ran Zhang, Lingfei Kong, Yongmei Shen, Da Xu, Fang Zheng, Jianwei Liu, Qian Wu, Bona Jia,  and Ju Zhang
64779-64792
Abstract  |  PDF  |  HTML  |  Supplementary Information
Changes of peripheral lymphocyte subsets and cytokine environment during aging and deteriorating gastrointestinal tract health status

https://doi.org/10.18632/oncotarget.18485

Jing Wang, Guodong Yang, Dongfang Wang, Kuiliang Liu, Yongchao Ma, Hong Liu, Jing Wu,  and Min Fang
60764-60777
Abstract  |  PDF  |  HTML
Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation

https://doi.org/10.18632/oncotarget.19853

Jun Xie, Yuhan Chen, Chuanxian Hu, Quanhua Pan, Bingjian Wang, Xueling Li, Jin Geng,  and Biao Xu
57981-57990
Abstract  |  PDF  |  HTML
Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction

https://doi.org/10.18632/oncotarget.18362

Changwei Wei, Ting Luo, Shanshan Zou, Xiaobin Zhou, Wenzhen Shen, Xiaolin Ji, Qi Li,  and Anshi Wu
55901-55914
Abstract  |  PDF  |  HTML
Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains

https://doi.org/10.18632/oncotarget.19431

Xiangzhu Xiao, Pingping Shen, Zerui Wang, Johnny Dang, Alise Adornato, Lewis S. Zou, Zhiqian Dong, Jue Yuan, Jiachun Feng, Li Cui,  and Wen-Quan Zou
53888-53898
Abstract  |  PDF  |  HTML
Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection

https://doi.org/10.18632/oncotarget.18122

Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee,  and Joo-Ho Shin
48603-48618
Abstract  |  PDF  |  HTML  |  Supplementary Information
Soluble antigens from the neurotropic pathogen Angiostrongylus cantonensis directly induce thymus atrophy in a mouse model

https://doi.org/10.18632/oncotarget.17836

Zhen Liu, Dong-Ming Su, Zi-Long Yu, Feng Wu, Rui-Feng Liu, Shi-Qi Luo, Zhi-Yue Lv, Xin Zeng, Xi Sun,  and Zhong-Dao Wu
48575-48590
Abstract  |  PDF  |  HTML  |  Supplementary Information
Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis

DOI: 10.18632/oncotarget.16967

Sung Wook Park, Sora Im, Hyoung Oh Jun, Kihwang Lee, Young-Jun Park, Jin Hyoung Kim, Woo Jin Park, Young-Hoon Lee,  and Jeong Hun Kim
40006-40018
Abstract  |   PDF  |  HTML  |  Supplementary Information
Downregulation of protein kinase CK2 activity induces age-related biomarkers in C. elegans

DOI: 10.18632/oncotarget.16939

Jeong-Hwan Park, Joo-Hyun Lee, Jeong-Woo Park, Dong-Yun Kim, Jeong-Hoon Hahm, Hong Gil Nam,  and Young-Seuk Bae
36950-36963
Abstract  |   PDF  |  HTML  |  Supplementary Information
Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway

DOI: 10.18632/oncotarget.15973

Daisuke Kinoshita, Ayako Nagasawa, Ippei Shimizu, Takashi K. Ito, Yohko Yoshida, Masanori Tsuchida, Atsushi Iwama, Toshiya Hayano,  and Tohru Minamino
34045-34056
Abstract  |   PDF  |  HTML  |  Supplementary Information
Senoptosis: non-lethal DNA cleavage as a route to deep senescence

DOI: 10.18632/oncotarget.15693

Maja Studencka,  and Jörg Schaber
30656-30671
Abstract  |   PDF  |  HTML  |  Supplementary Information
Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

DOI: 10.18632/oncotarget.15906

Michela Ferrucci, Francesca Biagioni, Paola Lenzi, Stefano Gambardella, Rosangela Ferese, Maria Teresa Calierno, Alessandra Falleni, Alfonso Grimaldi, Alessandro Frati, Vincenzo Esposito, Cristina Limatola,  and Francesco Fornai
29574-29599
Abstract  |   PDF  |  HTML  |  Supplementary Information
Serum uric acid level as a cardio-cerebrovascular event risk factor in middle-aged and non-obese Chinese men

DOI: 10.18632/oncotarget.15902

Zhi-Jun Li, Chen-Ju Yi, Jing Li,  and Na Tang
24110-24118
Abstract  |   PDF  |  HTML  |  Supplementary Information
Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population

DOI: 10.18632/oncotarget.15493

Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C. Yang, Chung-Feng Kao,  and Shih-Jen Tsai
24088-24098
Abstract  |   PDF  |  HTML  |  Supplementary Information
Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old

DOI: 10.18632/oncotarget.15296

Lauren C. Tindale, Stephen Leach, John J. Spinelli,  and Angela R. Brooks-Wilson
20612-20621
Abstract  |   PDF  |  HTML  |  Supplementary Information
Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells

DOI: 10.18632/oncotarget.15246

Kuo-Yun Tseng, Yi-Hsuan Chen,  and Shankung Lin
20588-20601
Abstract  |   PDF  |  HTML  |  Supplementary Information
Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

DOI: 10.18632/oncotarget.15728

Jingjing Fan, Xiaoqi Yang, Jie Li, Ziyang Shu, Jun Dai, Xingran Liu, Biao Li, Shaohui Jia, Xianjuan Kou, Yi Yang,  and Ning Chen
17475-17490
Abstract  |   PDF  |  HTML
Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling

DOI: 10.18632/oncotarget.14884

Dan Dong, Guang-yan Cai, Yi-chun Ning, Jing-chao Wang, Yang Lv, Quan Hong, Shao-yuan Cui, Bo Fu, Ya-nan Guo,  and Xiang-mei Chen
16109-16121
Abstract  |   PDF  |  HTML
Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

DOI: 10.18632/oncotarget.14721

Jie Cheng, Meng-Yun Cai, Yu-Ning Chen, Zhi-Cheng Li, Sai-Sai Tang, Xi-Li Yang, Can Chen, Xinguang Liu,  and Xing-dong Xiong
12607-12619
Abstract  |   PDF  |  HTML  |  Supplementary Information
Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis

DOI: 10.18632/oncotarget.14614

Ki Wung Chung, Hyeong Oh Jeong, Bonggi Lee, Daeui Park, Dae Hyun Kim, Yeun Ja Choi, Eun Kyeong Lee, Kyung Mok Kim, June Whoun Park, Byung Pal Yu,  and Hae Young Chung
7315-7327
Abstract  |   PDF  |  HTML  |  Supplementary Information
Variation of lifespan in multiple strains, and effects of dietary restriction and BmFoxO on lifespan in silkworm, Bombyx mori

DOI: 10.18632/oncotarget.14235

Jiangbo Song, Dongmei Tang, Zhiquan Li, Xiaoling Tong, Jianfei Zhang, Minjin Han, Hai Hu, Cheng Lu,  and Fangyin Dai
7294-7300
Abstract  |   PDF  |  HTML  |  Supplementary Information
SS31 Ameliorates age-related activation of NF-κB signaling in senile mice model, SAMP8

DOI: 10.18632/oncotarget.14077

Zhi-Hua Hao, Yue Huang, Mei-Rong Wang, Tian-Tian Huo, Qian Jia, Rong-Fang Feng, Ping Fan,  and Jian-Hua Wang
1983-1992
Abstract  |   PDF  |  HTML
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian

DOI: 10.18632/oncotarget.13905

Mingshu Mo, Yousheng Xiao, Shuxuan Huang, Luan Cen, Xiang Chen, Limin Zhang, Qin Luo, Shaomin Li, Xinling Yang, Xian Lin,  and Pingyi Xu
15-28
Abstract  |   PDF  |  HTML  |  Supplementary Information
Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling

https://doi.org/10.18632/oncotarget.22826

Huidan Deng, Ping Kuang, Hengmin Cui, Qin Luo, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang,  and Ling Zhao
114428-114441
Abstract  |  PDF  |  HTML
Lysophosphatidylcholine induces cytotoxicity/apoptosis and IL-8 production of human endothelial cells: Related mechanisms

https://doi.org/10.18632/oncotarget.22425

Mei-Chi Chang, Jang-Jaer Lee, Yi-Jane Chen, Szu-I Lin, Li-Deh Lin, Eric Jein-Wen Liou, Wei-Ling Huang, Chiu-Po Chan, Chi-Chia Huang,  and Jiiang-Huei Jeng
106177-106189
Abstract  |  PDF  |  HTML
Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor α in a β-amyloid protein -dependent mechanism

https://doi.org/10.18632/oncotarget.18462

Shao-Qin Zheng, Zi-Yi Gong, Chen-Di Lu,  and Pu Wang
102801-102819
Abstract  |  PDF  |  HTML  |  Supplementary Information
COX-2 metabolic products, the prostaglandin I2 and F, mediate the effects of TNF-α and Zn2+ in stimulating the phosphorylation of Tau

https://doi.org/10.18632/oncotarget.21853

Yue Wang, Pei-Pei Guan, Xin Yu, Yan-Su Guo, Ying-Jie Zhang, Zhan-You Wang,  and Pu Wang
99296-99311
Abstract  |  PDF  |  HTML
GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

https://doi.org/10.18632/oncotarget.20062

Wai Yin Vivien Chiu, Alex Chun Koon, Jacky Chi Ki Ngo, Ho Yin Edwin Chan,  and Kwok-Fai Lau
99274-99283
Abstract  |  PDF  |  HTML
Systemic analysis of gene expression profiles in porcine granulosa cells during aging

https://doi.org/10.18632/oncotarget.21731

Li Hui, Guo Shuangshuang, Yu Jianning,  and Shi Zhendan
96588-96603
Abstract  |  PDF  |  HTML  |  Supplementary Information
Social-demographics, health behaviors, and telomere length in the Mexican American Mano a Mano Cohort

https://doi.org/10.18632/oncotarget.19903

Hua Zhao, Lixia Han, David Chang, Yuanqing Ye, Jie Shen, Carrie R. Daniel, Jian Gu, Wong-Ho Chow,  and Xifeng Wu
96553-96567
Abstract  |  PDF  |  HTML
E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion

https://doi.org/10.18632/oncotarget.20143

Stefano Benvegnù, Tina Wahle,  and Carlos G. Dotti
89439-89450
Abstract  |  PDF  |  HTML  |  Supplementary Information
Growth of malignant extracranial tumors alters microRNAome in the prefrontal cortex of TumorGraft mice

https://doi.org/10.18632/oncotarget.19835

Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Amanda Katz, David Sidransky, Bryan Kolb,  and Olga Kovalchuk
88276-88293
Abstract  |  PDF  |  HTML  |  Supplementary Information
Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice

https://doi.org/10.18632/oncotarget.19948

Daniele Lettieri-Barbato, Fabiana D’Angelo, Francesca Sciarretta, Giuseppe Tatulli, Flavia Tortolici, Maria Rosa Ciriolo,  and Katia Aquilano
83407-83418
Abstract  |  PDF  |  HTML
Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States

https://doi.org/10.18632/oncotarget.20706

Moshen Mazidi, Peyman Rezaie, Adriac Covic, Jolanta Malyszko, Jacek Rysz, Andre Pascal Kengne,  and Maciej Banach
80175-80181
Abstract  |  PDF  |  HTML
MeCP2 mediated dysfunction in senescent EPCs

https://doi.org/10.18632/oncotarget.20961

Chunli Wang, Fei Wang, Zhen Li, Liya Huang, Qing Cao,  and Shuyan Chen
78289-78299
Abstract  |  PDF  |  HTML
Dysfunctional transcripts are formed by alternative polyadenylation in OPMD

https://doi.org/10.18632/oncotarget.20640

Vered Raz, George Dickson,  and Peter A.C. ’t Hoen
73516-73528
Abstract  |  PDF  |  HTML  |  Supplementary Information
Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese

https://doi.org/10.18632/oncotarget.20618

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri, Keita Inoue, Yasuhiro Nagata,  and Takahiro Maeda
69362-69369
Abstract  |  PDF  |  HTML
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state

https://doi.org/10.18632/oncotarget.20614

Anna Leonov, Rachel Feldman, Amanda Piano, Anthony Arlia-Ciommo, Vicky Lutchman, Masoumeh Ahmadi, Sarah Elsaser, Hana Fakim, Mahdi Heshmati-Moghaddam, Asimah Hussain, Sandra Orfali, Harshvardhan Rajen, Negar Roofigari-Esfahani, Leana Rosanelli,  and Vladimir I. Titorenko
69328-69350
Abstract  |  PDF  |  HTML  |  Supplementary Information
Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats

https://doi.org/10.18632/oncotarget.17951

Zhiming Xia, Fengfei Wang, Shuang Zhou, Rui Zhang, Fushun Wang, Jason H. Huang, Erxi Wu, Yongfang Zhang,  and Yaer Hu
69303-69315
Abstract  |  PDF  |  HTML  |  Supplementary Information
Spermine and spermidine reversed age-related cardiac deterioration in rats

https://doi.org/10.18632/oncotarget.18334

Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian,  and Yajun Zhao
64793-64808
Abstract  |  PDF  |  HTML  |  Supplementary Information
Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies

https://doi.org/10.18632/oncotarget.17371

Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano,  and Giuseppina Amadoro
64745-64778
Abstract  |  PDF  |  HTML  |  Supplementary Information
Modulation of GDF11 expression and synaptic plasticity by age and training

https://doi.org/10.18632/oncotarget.19854

Emanuela De Domenico, Giovanna D’Arcangelo, Isabella Faraoni, Mattia Palmieri, Virginia Tancredi, Grazia Graziani, Paola Grimaldi,  and Lucio Tentori
57991-58002
Abstract  |  PDF  |  HTML  |  Supplementary Information
Detecting the genetic link between Alzheimer’s disease and obesity using bioinformatics analysis of GWAS data

https://doi.org/10.18632/oncotarget.19115

Qi-Shuai Zhuang, Hao Zheng, Xiao-Dan Gu, Liang Shen,  and Hong-Fang Ji
55915-55919
Abstract  |  PDF  |  HTML
Pharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during aging

https://doi.org/10.18632/oncotarget.18600

Pilar Alvarez-Illera, Paloma García-Casas, Jessica Arias-del-Val, Rosalba I. Fonteriz, Javier Alvarez,  and Mayte Montero
55889-55900
Abstract  |  PDF  |  HTML
Diagnostic performance of gait speed, G8 and G8 modified indices to screen for vulnerability in older cancer patients: the prospective PF-EC cohort study

https://doi.org/10.18632/oncotarget.17361

Frederic Pamoukdjian, Florence Canoui-Poitrine, Coralie Longelin-Lombard, Thomas Aparicio, Nathalie Ganne, Philippe Wind, Claudia Martinez-Tapia, Etienne Audureau, Georges Sebbane, Laurent Zelek,  and Elena Paillaud
50393-50402
Abstract  |  PDF  |  HTML
Aging-dependent DNA hypermethylation and gene expression of GSTM1 involved in T cell differentiation

https://doi.org/10.18632/oncotarget.18109

Shu-Hui Yeh, Cheng-Ling Liu, Ren-Chieh Chang, Chih-Chiang Wu, Chia-Hsueh Lin,  and Kuender D. Yang
48591-48602
Abstract  |  PDF  |  HTML
The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer’s Disease by the inhibitions of NF-κB/MAPK pathway and NLRP3 inflammasome

DOI: 10.18632/oncotarget.12574

Zhou Lan, Guangjing Xie, Meng Wei, Ping Wang,  and Lvyi Chen
43709-43720
Abstract  |  PDF  |  HTML
Estrogen receptors involvement in intervertebral discogenic pain of the elderly women: colocalization and correlation with the expression of Substance P in nucleus pulposus

DOI: 10.18632/oncotarget.15421

Xiao-Xing Song, Sheng Shi, Zhen Guo, Xin-Feng Li,  and Bu-Wei Yu
38136-38144
Abstract  |   PDF  |  HTML
Examining the association between anthropometric parameters and telomere length and mortality risk

DOI: 10.18632/oncotarget.15976

Chen-Jung Wu, Tung-Wei Kao, Yuan-Yung Lin, Fang-Yih Liaw, Li-Wei Wu, Yaw-Wen Chang, Tao-Chun Peng,  and Wei-Liang Chen
34057-34069
Abstract  |   PDF  |  HTML
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast

DOI: 10.18632/oncotarget.16766

Anna Leonov, Anthony Arlia-Ciommo, Simon D. Bourque, Olivia Koupaki, Pavlo Kyryakov, Paméla Dakik, Mélissa McAuley, Younes Medkour, Karamat Mohammad, Tamara Di Maulo,  and Vladimir I. Titorenko
30672-30691
Abstract  |   PDF  |  HTML  |  Supplementary Information
Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity

DOI: 10.18632/oncotarget.16768

Kun-Ling Tsai, Chung-Lan Kao, Ching-Hsia Hung, Yung-Hsin Cheng, Huei-Chen Lin,  and Pei-Ming Chu
29600-29612
Abstract  |   PDF  |  HTML
Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer’s disease mice

DOI: 10.18632/oncotarget.15398

Jing Ma, Yuan Gao, Lin Jiang, Feng-lei Chao, Wei Huang, Chun-ni Zhou, Wei Tang, Lei Zhang, Chun-xia Huang, Yi Zhang, Yan-min Luo, Qian Xiao, Hua-rong Yu, Rong Jiang,  and Yong Tang
27676-27692
Abstract  |   PDF  |  HTML
Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson’s disease

DOI: 10.18632/oncotarget.15732

Qing Gao, Zhou Ou, Teng Jiang, You-Yong Tian, Jun-Shan Zhou, Liang Wu, Jian-Quan Shi,  and Ying-Dong Zhang
24099-24109
Abstract  |   PDF  |  HTML
Association and interaction effects of Alzheimer’s disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population

DOI: 10.18632/oncotarget.15269

Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C. Yang,  and Chung-Feng Kao
24077-24087
Abstract  |   PDF  |  HTML  |  Supplementary Information
Caffeine delays oocyte aging and maintains the quality of aged oocytes safely in mouse

DOI: 10.18632/oncotarget.15292

Xia Zhang, Xiaoyan Liu, Li Chen, Dan-Ya Wu, Zheng-Wen Nie, Ying-Ying Gao,  and Yi-Liang Miao
20602-20611
Abstract  |   PDF  |  HTML
The effects of graded levels of calorie restriction: VIII. Impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

DOI: 10.18632/oncotarget.15294

Sharon E. Mitchell, ZhanHui Tang, Celine Kerbois, Camille Delville, Davina Derous, Cara L. Green, Yingchun Wang, Jackie J.D. Han, Luonan Chen, Alex Douglas, David Lusseau, Daniel E.L. Promislow,  and John R. Speakman
17453-17474
Abstract  |   PDF  |  HTML  |  Supplementary Information
Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid

DOI: 10.18632/oncotarget.15245

Nikolai Gobshtis, Matanel Tfilin, Marina Wolfson, Vadim E. Fraifeld,  and Gadi Turgeman
17443-17452
Abstract  |   PDF  |  HTML
Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects

DOI: 10.18632/oncotarget.15109

Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J. Dębski, Joanna Wojsiat, Michał Dąbrowski, Tomasz Gabryelewicz, Jacek Kuźnicki,  and Urszula Wojda
16122-16143
Abstract  |   PDF  |  HTML  |  Supplementary Information
Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis

DOI: 10.18632/oncotarget.14236

Jingnan Chen, Yan Wei, Xinyu Chen, Jingjing Jiao,  and Yu Zhang
7301-7314
Abstract  |   PDF  |  HTML  |  Supplementary Information
Drug-induced premature senescence model in human dental follicle stem cells

DOI: 10.18632/oncotarget.14085

Yuanfen Zhai, Rongbin Wei, Junjun Liu, Huihui Wang, Wenping Cai, Mengmeng Zhao, Yongguang Hu, Shuwei Wang, Tianshu Yang, Xiaodong Liu, Jianhua Yang,  and Shangfeng Liu
7276-7293
Abstract  |   PDF  |  HTML
How does white matter microstructure differ between the vascular and amnestic mild cognitive impairment?

DOI: 10.18632/oncotarget.13960

Yang Yu, Xinyu Liang, Haikuo Yu, Weina Zhao, Yan Lu, Yue Huang, Changhao Yin, Gaolang Gong,  and Ying Han
42-50
Abstract  |   PDF  |  HTML  |  Supplementary Information
Influence of aging on the activity of mice Sca-1+CD31 cardiac stem cells

DOI: 10.18632/oncotarget.13930

Qiong Wu, Jinxi Zhan, Shiming Pu, Liu Qin, Yun Li,  and Zuping Zhou
29-41
Abstract  |   PDF  |  HTML

2016

Editorial: Gerotarget (Focus on Aging)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
Guihua Li, Xing-hua Gao,  and Qing-Sheng Mi
15290-15291
PDF

Research Papers: Gerotarget (Focus on Aging)

Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs

DOI: 10.18632/oncotarget.13920

Manish Kumar, Joshua Atkins, Murray Cairns, Ayesha Ali,  and Pradeep S. Tanwar
85709-85727
Abstract  |   PDF  |  HTML  |  Supplementary Information
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities

DOI: 10.18632/oncotarget.13341

Jean-Philippe Gagné, Sophie Lachapelle, Chantal Garand, Serges P. Tsofack, Yan Coulombe, Marie-Christine Caron, Guy G. Poirier, Jean-Yves Masson,  and Michel Lebel
85680-85696
Abstract  |   PDF  |  HTML  |  Supplementary Information
CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population

DOI: 10.18632/oncotarget.12575

Qingbin Zhao, Shudan Liao, Huiyi Wei, Dandan Liu, Jingjie Li, Xiyang Zhang, Mengdan Yan,  and Tianbo Jin
82046-82054
Abstract  |   PDF  |  HTML
Mitochondria-targeted antioxidant SkQ1 reduces age-related alterations in the ultrastructure of the lacrimal gland

DOI: 10.18632/oncotarget.13303

Lora E. Bakeeva, Chupalav M. Eldarov, Irina M. Vangely, Nataliya G. Kolosova,  and Valeriya B. Vays
80208-80222
Abstract  |   PDF  |  HTML
Presence of lacunar infarctions is associated with the spatial navigation impairment in patients with mild cognitive impairment: a DTI study

DOI: 10.18632/oncotarget.13409

Yan-Feng Wu, Wen-Bo Wu, Qing-Ping Liu, Wen-Wen He, Hong Ding, Zuzana Nedelska, Jakub Hort, Bing Zhang,  and Yun Xu
78310-78319
Abstract  |   PDF  |  HTML
Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1

DOI: 10.18632/oncotarget.12930

Vinod K. Nelson, Asif Ali, Naibedya Dutta, Suvranil Ghosh, Manas Jana, Arnab Ganguli, Andrei Komarov, Soumyadip Paul, Vibha Dwivedi, Subhrangsu Chatterjee, Nihar R. Jana, Subhash C. Lakhotia, Gopal Chakrabarti, Anup K. Misra, Subhash C. Mandal,  and Mahadeb Pal
78281-78296
Abstract  |   PDF  |  HTML  |  Supplementary Information
Age-related decline in cardiac autonomic function is not attenuated with increased physical activity

DOI: 10.18632/oncotarget.12403

Hugo Njemanze, Charlotte Warren, Christopher Eggett, Guy A. MacGowan, Matthew G D Bates, Mario Siervo, Srdjan Ivkovic, Michael I. Trenell,  and Djordje G. Jakovljevic
76390-76397
Abstract  |   PDF  |  HTML
Long-term exposure to air pollution is associated with biological aging

DOI: 10.18632/oncotarget.12903

Cavin K. Ward-Caviness, Jamaji C. Nwanaji-Enwerem, Kathrin Wolf, Simone Wahl, Elena Colicino, Letizia Trevisi, Itai Kloog, Allan C. Just, Pantel Vokonas, Josef Cyrys, Christian Gieger, Joel Schwartz, Andrea A. Baccarelli, Alexandra Schneider,  and Annette Peters
74510-74525
Abstract  |   PDF  |  HTML  |  Supplementary Information
Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

DOI: 10.18632/oncotarget.12811

Xianjuan Kou, Xingran Liu, Xianbing Chen, Jie Li, Xiaoqi Yang, Jingjing Fan, Yi Yang,  and Ning Chen
74484-74495
Abstract  |   PDF  |  HTML
Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

DOI: 10.18632/oncotarget.11952

Christin Kretzschmar, Catrin Roolf, Katrin Timmer, Anett Sekora, Gudrun Knübel, Hugo Murua Escobar, Georg Fuellen, Saleh M. Ibrahim, Markus Tiedge, Simone Baltrusch, Robert Jaster, Rüdiger Köhling,  and Christian Junghanss
74460-74472
Abstract  |   PDF  |  HTML  |  Supplementary Information
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status

DOI: 10.18632/oncotarget.11957

Kenney R. Roodakker, Tamador Elsir, Per-Henrik D. Edqvist, Daniel Hägerstrand, Joseph Carlson, Malgorzata Lysiak, Roger Henriksson, Fredrik Pontén, Johan Rosell, Peter Söderkvist, Roger Stupp, Elena Tchougounova, Monica Nistér, Annika Malmström,  and Anja Smits
72431-72442
Abstract  |   PDF  |  HTML  |  Supplementary Information
Baicalein protects against oxLDL-caused oxidative stress and inflammation by modulation of AMPK- alpha

DOI: 10.18632/oncotarget.12788

Kun-Ling Tsai, Ching-Hsia Hung, Shih-Hung Chan, Jhih-Yuan Shih, Yung-Hsin Cheng, Yi-Ju Tsai, Huei-Chen Lin,  and Pei-Ming Chu
72458-72468
Abstract  |   PDF  |  HTML
Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice

DOI: 10.18632/oncotarget.12125

Xi Chen, Lihui Li, Jianmin Guo, Lingli Zhang, Yu Yuan, Binglin Chen, Zhongguang Sun, Jiake Xu,  and Jun Zou
71072-71086
Abstract  |   PDF  |  HTML
The effect of the severity of obstructive sleep apnea syndrome on telomere length

DOI: 10.18632/oncotarget.12293

Priscila Farias Tempaku, Diego Robles Mazzotti, Camila Hirotsu, Monica Levy Andersen, Gabriela Xavier, Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Elisa Brietzke, Sintia Iole Belangero, Lia Bittencourt,  and Sergio Tufik
69216-69224
Abstract PDF HTML
Mutational load and mutational patterns in relation to age in head and neck cancer

DOI: 10.18632/oncotarget.11312

Stefano Meucci, Ulrich Keilholz, Ingeborg Tinhofer,  and Oliva A. Ebner
69188-69199
Abstract PDF HTML Supplementary Information
Long-term monitoring of Ca2+ dynamics in C. elegans pharynx: an in vivo energy balance sensor

DOI: 10.18632/oncotarget.12177

Pilar Alvarez-Illera, Adolfo Sanchez-Blanco, Silvia Lopez-Burillo, Rosalba I. Fonteriz, Javier Alvarez,  and Mayte Montero
67732-67747
Abstract PDF HTML Supplementary Information
ATF6α regulates morphological changes associated with senescence in human fibroblasts

DOI: 10.18632/oncotarget.11505

Clémentine Druelle, Claire Drullion, Julie Deslé, Nathalie Martin, Laure Saas, Johanna Cormenier, Nicolas Malaquin, Ludovic Huot, Christian Slomianny, Fatima Bouali, Chantal Vercamer, David Hot, Albin Pourtier, Eric Chevet, Corinne Abbadie,  and Olivier Pluquet
67699-67715
Abstract PDF HTML Supplementary Information
β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation

DOI: 10.18632/oncotarget.12119

Ha Ram Bae, Dae Hyun Kim, Min Hi Park, Bonggi Lee, Min Jo Kim, Eun Kyeong Lee, Ki Wung Chung, Seong Min Kim, Dong Soon Im,  and Hae Young Chung
66444-66454
Abstract PDF HTML
Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female

DOI: 10.18632/oncotarget.12013

Olivier Camuzard, Sabine Santucci-Darmanin, Véronique Breuil, Chantal Cros, Tatiana Gritsaenko, Sophie Pagnotta, Laurence Cailleteau, Séverine Battaglia, Patricia Panaïa-Ferrari, Dominique Heymann, Georges F. Carle,  and Valérie Pierrefite-Carle
66416-66428
Abstract PDF HTML Supplementary Information
Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer’s disease

DOI: 10.18632/oncotarget.10905

Nady Braidy, Musthafa Mohamed Essa, Anne Poljak, Subash Selvaraju, Samir Al-Adawi, Thamilarasan Manivasagm, Arokiasamy Justin Thenmozhi, Lezanne Ooi, Perminder Sachdev,  and Gilles J. Guillemin
64589-64604
Abstract PDF HTML
Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging

DOI: 10.18632/oncotarget.11871

Peng-Cheng Liu, Kuan Liu, Jun-Feng Liu, Kuo Xia, Li-Yang Chen,  and Xing Wu
62873-62885
Abstract PDF HTML
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1

DOI: 10.18632/oncotarget.11229

Kumar K.J. Senthil, Vani M. Gokila, Jeng-Leun Mau, Chin-Chung Lin, Fang-Hua Chu, Chia-Cheng Wei, Vivian Hsiu-Chuan Liao,  and Sheng-Yang Wang
62836-62861
Abstract PDF HTML
Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson’s disease model

DOI: 10.18632/oncotarget.11661

Jia Liu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang,  and Hui Yang
60823-60843
Abstract PDF HTML
Repetitive transcranial magnetic stimulation (rTMS) improves behavioral and biochemical deficits in levodopa-induced dyskinetic rats model

DOI: 10.18632/oncotarget.11587

Maowen Ba, Min Kong, Lina Guan, Maoli Yi,  and Hongli Zhang
58802-58812
Abstract PDF HTML
MS4A6A genotypes are associated with the atrophy rates of Alzheimer’s disease related brain structures

DOI: 10.18632/oncotarget.9563

Jing Ma, Wei Zhang, Lin Tan, Hui-Fu Wang, Yu Wan, Fu-Rong Sun, Chen-Chen Tan, Jin-Tai Yu, Lan Tan,  and Alzheimer’s Disease Neuroimaging Initiative
58779-58788
Abstract PDF HTML Supplementary Information
Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging

DOI: 10.18632/oncotarget.11190

Sin Man Lam, Gek Huey Chua, Xiao-Jiang Li, Bing Su,  and Guanghou Shui
55970-55989
Abstract PDF HTML Supplementary Information
GDF11 administration does not extend lifespan in a mouse model of premature aging

DOI: 10.18632/oncotarget.11096

Sandra Freitas-Rodríguez, Francisco Rodríguez,  and Alicia R. Folgueras
55951-55956
Abstract PDF HTML Supplementary Information
Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer’s disease

DOI: 10.18632/oncotarget.11027

Pin-Hsuan Lin, Shih-Jen Tsai, Chi-Wei Huang, Liu Mu-En, Shih-Wei Hsu, Chen-Chang Lee, Nai-Ching Chen, Ya-Ting Chang, Min-Yu Lan,  and Chiung-Chih Chang
54200-54214
Abstract PDF HTML Supplementary Information
Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer’s disease

DOI: 10.18632/oncotarget.10857

Xiaoxia Wang, Min Cao,  and Yuqing Dong
54183-54193
Abstract PDF HTML
Identification of the lncRNA, AK156230, as a novel regulator of cellular senescence in mouse embryonic fibroblasts

DOI: 10.18632/oncotarget.10170

Yu-ning Chen, Meng-yun Cai, Shun Xu, Mei Meng, ingcong Ren, Jay W. Yang, Yu-qi Dong, Xinguang Liu, Jin-Ming Yang,  and Xing-dong Xiong
52673-52684
Abstract PDF HTML Supplementary Information
Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle

DOI: 10.18632/oncotarget.10685

Nicholas R. Wawrzyniak, Anna-Maria Joseph, David G. Levin, David M. Gundermann, Christiaan Leeuwenburgh, Bhanuprasad Sandesara, Todd M. Manini,  and Peter J. Adhihetty
52695-52709
Abstract PDF HTML
Six plant extracts delay yeast chronological aging through different signaling pathways

DOI: 10.18632/oncotarget.10689

Vicky Lutchman, Pamela Dakik, Mélissa McAuley, Berly Cortes, George Ferraye, Leonid Gontmacher, David Graziano, Fatima-Zohra Moukhariq, Éric Simard,  and Vladimir I. Titorenko
50845-50863
Abstract PDF HTML Supplementary Information
Virtual screening, optimization, and identification of a novel specific PTP-MEG2 Inhibitor with potential therapy for T2DM

DOI: 10.18632/oncotarget.10341

Meiyan Wang, Xiaobo Li, Lei Dong, Xiubo Chen, Weiren Xu,  and Runling Wang
50828-50834
Abstract PDF HTML Supplementary Information
Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

DOI: 10.18632/oncotarget.10346

Jian Kang, Eric P. Kusnadi, Allison J. Ogden, Rodney J. Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D. Hannan, Katherine M. Hannan,  and Richard B. Pearson
48887-48904
Abstract PDF HTML Supplementary Information
Platelets as an indicator of vascular repair in elderly Japanese men

DOI: 10.18632/oncotarget.10229

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota,  and Takahiro Maeda
44919-44926
Abstract PDF HTML
Mitochondrial dysfunction and oxidative stress in aging and cancer

DOI: 10.18632/oncotarget.9821

Anna V. Kudryavtseva, George S. Krasnov, Alexey A. Dmitriev, Boris Y. Alekseev, Olga L. Kardymon, Asiya F. Sadritdinova, Maria S. Fedorova, Anatoly V. Pokrovsky, Nataliya V. Melnikova, Andrey D. Kaprin, Alexey A. Moskalev,  and Anastasiya V. Snezhkina
44879-44905
Abstract PDF HTML
Do human B-lymphocytes avoid aging until 60 years?

DOI: 10.18632/oncotarget.10146

Andrea Knight, Pavel Nemec, Sona Bretzova, Lucie Valkova, Marketa Kolmanova, Renata Vytopilova, Marek Havelka, Pavla Vsianska, Lucie Rihova, Marta Krejci,  and Martin Piskacek
42873-42880
Abstract PDF HTML
Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors

DOI: 10.18632/oncotarget.8801

Ana Lustig, Ivo Shterev, Susan Geyer, Alvin Shi, Yiqun Hu, Yukari Morishita, Hiroko Nagamura, Keiko Sasaki, Mayumi Maki, Ikue Hayashi, Kyoji Furukawa, Kengo Yoshida, Junko Kajimura, Seishi Kyoizumi, Yoichiro Kusunoki, Waka Ohishi, Kei Nakachi, Nan-ping Weng,  and Tomonori Hayashi
38988-38998
Abstract PDF HTML Supplementary Information
Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

DOI: 10.18632/oncotarget.9175

Francesca Pistollato, Elan L. Ohayon, Ann Lam, Gillian R. Langley, Thomas J. Novak, David Pamies, George Perry, Eugenia Trushina, Robin S. B. Williams, Alex E. Roher, Thomas Hartung, Stevan Harnad, Neal Barnard, Martha Clare Morris, Mei-Chun Lai, Ryan Merkley,  and P. Charukeshi Chandrasekera
38999-39016
Abstract PDF HTML
Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts

DOI: 10.18632/oncotarget.9176

Wei-Jen Ting, Jaw-Ji Yang, Chia-Hua Kuo, Zi-Jun Xiao, Xin-Ze Lu, Yu-Lan Yeh, Cecilia-Hsuan Day, Su-Ying Wen, Vijaya PadmaViswanadha, Chong-He Jiang, Wei-Wen Kuo,  and Chih-Yang Huang
39017-39025
Abstract PDF HTML
De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

DOI: 10.18632/oncotarget.9346

Sihem Mebarki, Romain Désert, Laurent Sulpice, Marie Sicard, Mireille Desille, Frédéric Canal, Hélène Dubois-Pot Schneider, Damien Bergeat, Bruno Turlin, Pascale Bellaud, Elise Lavergne, Rémy Le Guével, Anne Corlu, Christine Perret, Cédric Coulouarn, Bruno Clément,  and Orlando Musso
39026-39043
Abstract PDF HTML Supplementary Information
FERMT2 rs17125944 polymorphism with Alzheimer’s disease risk: a replication and meta-analysis

DOI: 10.18632/oncotarget.9679

Qiu-Yue Zhang, Hui-Fu Wang, Zhan-Jie Zheng, Ling-Li Kong, Meng-Shan Tan, Chen-Chen Tan, Wei Zhang, Zi-Xuan Wang, Lin Tan, Jin-Tai Yu,  and Lan Tan
39044-39050
Abstract PDF HTML
Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence

DOI: 10.18632/oncotarget.9694

Clara Di Germanio, Michel Bernier, Michael Petr, Mauro Mattioli, Barbara Barboni,  and Rafael de Cabo
39051-39064
Abstract PDF HTML Supplementary Information
Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

DOI: 10.18632/oncotarget.9687

Bo Bai, Andy W. C. Man, Kangmin Yang, Yumeng Guo, Cheng Xu, Hung-Fat Tse, Weiping Han, Maria Bloksgaard, Jo G. R. De Mey, Paul M. Vanhoutte, Aimin Xu,  and Yu Wang
39065-39081
Abstract PDF HTML Supplementary Information
Run-on of germline apoptosis promotes gonad senescence in C. elegans

DOI: 10.18632/oncotarget.9681

Yila de la Guardia, Ann F. Gilliat, Josephine Hellberg, Peter Rennert, Filipe Cabreiro,  and David Gems
39082-39096
Abstract PDF HTML Supplementary Information
MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence

DOI: 10.18632/oncotarget.9357

Jia-an Zhang, Bing-rong Zhou, Yang Xu, Xu Chen, Juan Liu, Maya Gozali, Di Wu, Zhi-qiang Yin,  and Dan Luo
37420-37435
Abstract PDF HTML Supplementary Information
VPO1 mediates oxidation of LDL and formation of foam cells

DOI: 10.18632/oncotarget.9193

Youfeng Yang, Ruizheng Shi, Zehong Cao, Guogang Zhang,  and Guangjie Cheng
35500-35511
Abstract PDF HTML
The potential role of epigenetic modulations in BPPV maneuver exercises

DOI: 10.18632/oncotarget.9446

Kun-Ling Tsai, Chia-To Wang, Chia-Hua Kuo, Yuan-Yang Cheng, Hsin-I Ma, Ching-Hsia Hung, Yi-Ju Tsai,  and Chung-Lan Kao
35522-35534
Abstract PDF HTML
Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner

DOI: 10.18632/oncotarget.9652

Peter Thériault, Audrey Le Béhot, Ayman ElAli,  and Serge Rivest
35552-35561
Abstract PDF HTML Supplementary Information
Vaccine efficacy and T helper cell differentiation change with aging

DOI: 10.18632/oncotarget.9254

Julie S. Lefebvre, Erica C. Lorenzo, April R. Masters, Jacob W. Hopkins, Sheri M. Eaton, Stephen T. Smiley,  and Laura Haynes
33581-33594
Abstract PDF HTML Supplementary Information
Impact of SORL1 genetic variations on MRI markers in non-demented elders
Rui-Hua Yin, Jun Li, Lin Tan, Hui-Fu Wang, Meng-Shan Tan, Wan-Jiang Yu, Chen-Chen Tan, Jin-Tai Yu, Lan Tan,  and Alzheimer's Disease Neuroimaging Initiative
31689-31698
Abstract PDF HTML Supplementary Information
Inflammaging increases susceptibility to cigarette smoke-induced COPD
Gerrit John-Schuster, Stefanie Günter, Katrin Hager, Thomas M. Conlon, Oliver Eickelberg,  and Ali önder Yildirim
30068-30083
Abstract PDF HTML
Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: Role in neuroinflammation and aging
Ana I. Rodriguez-Perez, Ana Borrajo, Carmen Diaz-Ruiz, Pablo Garrido-Gil,  and Jose L. Labandeira-Garcia
30049-30067
Abstract PDF HTML
RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney
Daeui Park, Byoung-Chul Kim, Chul-Hong Kim, Yeon Ja Choi, Hyoung Oh Jeong, Mi Eun Kim, Jun Sik Lee, Min Hi Park, Ki Wung Chung, Dae Hyun Kim, Jaewon Lee, Dong-Soon Im, Seokjoo Yoon, Sunghoon Lee, Byung Pal Yu, Jong Bhak,  and Hae Young Chung
30037-30048
Abstract PDF HTML Supplementary Information
Effects of aging on the effectiveness of smoking cessation medication
Jaqueline Scholz, Paulo Caleb Junior Lima Santos, Carolina Giusti Buzo, Neuza Helena Moreira Lopes, Tania Marie Ogawa Abe, Patricia Viviane Gaya, Humberto Pierri, Clarice Amorim,  and Alexandre Costa Pereira
30032-30036
Abstract PDF HTML
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes
Ray Kreienkamp, Monica Croke, Martin A. Neumann, Gonzalo Bedia-Diaz, Simona Graziano, Adriana Dusso, Dale Dorsett, Carsten Carlberg,  and Susana Gonzalo
30018-30031
Abstract PDF HTML Supplementary Information
Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice
Junjun Sun, Hong Zhou, Feng Bai, Qingguo Ren,  and Zhijun Zhang
30003-30017
Abstract PDF HTML
Human prion protein-induced autophagy flux governs neuron cell damage in primary neuron cells
Ji-Hong Moon, Ju-Hee Lee, Uddin MD. Nazim, You-Jin Lee, Jae-Won Seol, Seong-Kug Eo, John-hwa Lee,  and Sang-Youel Park
29989-30002
Abstract PDF HTML
The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters
Barbara Brouwers, Sigrid Hatse, Lissandra Dal Lago, Patrick Neven, Peter Vuylsteke, Bruna Dalmasso, Guy Debrock, Heidi Van Den Bulck, Ann Smeets, Oliver Bechter, Jithendra Kini Bailur, Cindy Kenis, Annouschka Laenen, Patrick Schöffski, Graham Pawelec, Fabrice Journe, Ghanem-Elias Ghanem,  and Hans Wildiers
29977-29988
Abstract PDF HTML Supplementary Information
Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts
Jagoda Adamczyk, Anna Deregowska, Marek Skoneczny, Adrianna Skoneczna, Aleksandra Kwiatkowska, Leszek Potocki, Ewa Rawska, Sylwia Pabian, Jakub Kaplan, Anna Lewinska,  and Maciej Wnuk
29958-29976
Abstract PDF HTML Supplementary Information
Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1
Ji-Hong Moon, Ju-Hee Lee, You-Jin Lee,  and Sang-Youel Park
29944-29957
Abstract PDF HTML
Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice
Colin Selman, Amy Sinclair, Silvia M. A. Pedroni, Elaine E. Irvine, Alison M. Michie,  and Dominic J. Withers
29937-29943
Abstract PDF HTML Supplementary Information
Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies
Yanxia Lu, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Esther Wing Hei Mok, Xavier Camous, Hassen Kared, Tamas Fulop, Liang Feng, Tze Pin Ng,  and Anis Larbi
28783-28795
Abstract PDF HTML Supplementary Information
Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes
Junjie Gao, Tak Sum Cheng, An Qin, Nathan J. Pavlos, Tao Wang, Kai Song, Yan Wang, Lianzhi Chen, Lin Zhou, Qing Jiang, Hiroshi Takayanagi, Sheng Yan,  and Minghao Zheng
26966-26978
Abstract PDF HTML Supplementary Information
The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
Jianhui Wang, Xiaorui Cheng, Xiaorui Zhang, Junping Cheng, Yiran Xu, Ju Zeng, Wenxia Zhou,  and Yongxiang Zhang
26949-26965
Abstract PDF HTML Supplementary Information
Gadd45b deficiency promotes premature senescence and skin aging
Andrew Magimaidas, Priyanka Madireddi, Silvia Maifrede, Kaushiki Mukherjee, Barbara Hoffman,  and Dan A. Liebermann
26935-26948
Abstract PDF HTML
CLEC4C p.K210del variant causes impaired cell surface transport in plasmacytoid dendritic cells of amyotrophic lateral sclerosis
Su Min Lim, Young-Eun Kim, Won Jun Choi, Ki-Wook Oh, Min-Young Noh, Min-Soo Kwon, Minyeop Nahm, Namshin Kim, Chang-Seok Ki,  and Seung Hyun Kim
24942-24949
Abstract PDF HTML
Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism
Bram C. J. van der Eerden, W. Nadia H. Koek, Paul Roschger, M. Carola Zillikens, Jan H. Waarsing, Annemiete van der Kemp, Marijke Schreuders-Koedam, Nadja Fratzl-Zelman, Pieter J. M. Leenen, Joost G. J. Hoenderop, Klaus Klaushofer, René J. M. Bindels,  and Johannes P. T. M. van Leeuwen
24928-24941
Abstract PDF HTML Supplementary Information
Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression
Charles Saby, Emilie Buache, Sylvie Brassart-Pasco, Hassan El Btaouri, Marie-Pierre Courageot, Laurence Van Gulick, Roselyne Garnotel, Pierre Jeannesson,  and Hamid Morjani
24908-24927
Abstract PDF HTML Supplementary Information
Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae
Júlia Santos, Fernanda Leitão-Correia, Maria João Sousa,  and Cecília Leão
23033-23042
Abstract PDF HTML
Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response
Katia Aquilano, Sara Baldelli, Livia La Barbera, Daniele Lettieri Barbato, Giuseppe Tatulli,  and Maria Rosa Ciriolo
23019-23032
Abstract PDF HTML
Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis
Philipp Seidel, Martina Remus, Michael Delacher, Paulius Grigaravicius, David E. Reuss, Lucien Frappart, Andreas von Deimling, Markus Feueuer, Amir Abdollahi,  and Pierre-Olivier Frappart
23006-23018
Abstract PDF HTML Supplementary Information
Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment
Jian-hui Wang, Xiao-rui Cheng, Xiao-rui Zhang, Tong-xing Wang, Wen-jian Xu, Fei Li, Feng Liu, Jun-ping Cheng, Xiao-chen Bo, Sheng-qi Wang, Wen-xia Zhou,  and Yong-xiang Zhang
22988-23005
Abstract PDF HTML Supplementary Information
Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms
Kui Zhai, Zhiguang Yang, Xiaofei Zhu, Eric Nyirimigabo, Yue Mi, Yan Wang, Qinghua Liu, Libo Man, Shiliang Wu, Jie Jin,  and Guangju Ji
21156-21167
Abstract PDF HTML
Tissue repair genes: the TiRe database and its implication for skin wound healing
Hagai Yanai, Arie Budovsky, Robi Tacutu, Thomer Barzilay, Amir Abramovich, Rolf Ziesche,  and Vadim E. Fraifeld
21145-21155
Abstract PDF HTML Supplementary Information
Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function
Jae Kyo Yi, Ruijuan Xu, Eunmi Jeong, Izolda Mileva, Jean-Philip Truman, Chih-li Lin, Kai Wang, Justin Snider, Sally Wen, Lina M. Obeid, Yusuf A. Hannun,  and Cungui Mao
21124-21144
Abstract PDF HTML Supplementary Information
Methylomic predictors demonstrate the role of NF-𝛋B in old-age mortality and are unrelated to the aging-associated epigenetic drift
Juulia Jylhävä, Laura Kananen, Jani Raitanen, Saara Marttila, Tapio Nevalainen, Antti Hervonen, Marja Jylhä,  and Mikko Hurme
19228-19241
Abstract PDF HTML Supplementary Information
Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium
Preety Bajwa, Prathima B. Nagendra, Sarah Nielsen, Subhransu S. Sahoo, Amanda Bielanowicz, Janine M. Lombard, J. Erby Wilkinson, Richard A. Miller,  and Pradeep S. Tanwar
19214-19227
Abstract PDF HTML Supplementary Information
Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
Wioleta Grabowska, MaÅ�gorzata Suszek, Maciej Wnuk, Anna Lewinska, Emilia Wasiak, Ewa Sikora,  and Anna Bielak-Zmijewska
19201-19213
Abstract PDF HTML
Olfactory phenotypic expression unveils human aging
Andrea Mazzatenta, Alessandro Cellerino, Nicola Origlia, Davide Barloscio, Ferdinando Sartucci, Camillo Di Giulio,  and Luciano Domenici
19193-19200
Abstract PDF HTML
MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD
Catherine Ménard, Flavio A. Rezende, Khalil Miloudi, Ariel Wilson, Nicolas Tétreault, Pierre Hardy, John Paul SanGiovanni, Vincent De Guire,  and Przemyslaw Sapieha
19171-19184
Abstract PDF HTML Supplementary Information
BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21
Hyemin Lee, Fangyan Dai, Li Zhuang, Zhen-Dong Xiao, Jongchan Kim, Yilei Zhang, Li Ma, M. James You, Zhong Wang,  and Boyi Gan
19134-19146
Abstract PDF HTML Supplementary Information
Safety of two-year caloric restriction in non-obese healthy individuals
Sergei V. Romashkan, Sai Krupa Das, Dennis T. Villareal, Eric Ravussin, Leanne M. Redman, James Rochon, Manjushri Bhapkar,  and William E. Kraus
19124-19133
Abstract PDF HTML
C-phycocyanin protects against low fertility by inhibiting reactive oxygen species in aging mice
Yan-Jiao Li, Zhe Han, Lei Ge, Cheng-Jie Zhou, Yue-Fang Zhao, Dong-Hui Wang, Jing Ren, Xin-Xin Niu,  and Cheng-Guang Liang
17393-17409
Abstract PDF HTML Supplementary Information
The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling
Gang Wang, Ling Chen, Xiaoyu Pan, Jiechun Chen, Liqun Wang, Weijie Wang, Ruochuan Cheng, Fan Wu, Xiaoqing Feng, Yingcong Yu, Han-Ting Zhang, James M. O'Donnell,  and Ying Xu
17380-17392
Abstract PDF HTML
Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials
Jie Liu, Feixiang Yuan, Jian Gao, Boer Shan, Yulan Ren, Huaying Wang,  and Ying Gao
17369-17379
Abstract PDF HTML
Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
Yu Hu, Xia-Chun Li, Zhi-hao Wang, Yu Luo, Xiangnan Zhang, Xiu-Ping Liu, Qiong Feng, Qun Wang, Zhenyu Yue, Zhong Chen, Keqiang Ye, Jian-Zhi Wang,  and Gong-Ping Liu
17356-17368
Abstract PDF HTML Supplementary Information
Age-related reduction of antibody response against the human endogenous retrovirus K envelope in women
Hyoung Jin Kim, Byung-In Moon, Jun Woo Lee, Seung Cheol Kim,  and Hong-Jin Kim
17327-17337
Abstract PDF HTML Supplementary Information
Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction

DOI: 10.18632/oncotarget.13730

Ji-Hong Moon, Ju-Hee Lee, You-Jin Lee,  and Sang-Youel Park
85697-85708
Abstract  |   PDF  |  HTML
Abdominal adipose tissue thickness measured using magnetic resonance imaging is associated with lumbar disc degeneration in a Chinese patient population

DOI: 10.18632/oncotarget.13255

Lili Yang, Liangshan Mu, Kaiyu Huang, Tianyi Zhang, Zihan Mei, Wenrong Zeng, Jiawei He, Wei Chen, Xiaozheng Liu, Xinjian Ye,  and Zhihan Yan
82055-82062
Abstract  |   PDF  |  HTML
Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress

DOI: 10.18632/oncotarget.13049

Erez Eitan, Admoni Tamar, Grin Yossi, Refael Peleg, Alex Braiman,  and Esther Priel
78297-78309
Abstract  |   PDF  |  HTML  |  Supplementary Information
G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers

DOI: 10.18632/oncotarget.12931

Yan Zeng, Yehui Lv, Li Tao, Jianlong Ma, Heng Zhang, Hongmei Xu, Bi Xiao, Qun Shi, Kaijun Ma,  and Long Chen
74526-74536
Abstract  |   PDF  |  HTML
Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease

DOI: 10.18632/oncotarget.12812

Su Min Lim, Byung-Ok Choi, Seong-il Oh, Won Jun Choi, Ki-Wook Oh, Minyeop Nahm, Yuanchao Xue, Jae Hyeok Choi, Ji Young Choi, Young-Eun Kim, Ki Wha Chung, Xiang-Dong Fu, Chang-Seok Ki,  and Seung Hyun Kim
74496-74509
Abstract  |   PDF  |  HTML  |  Supplementary Information
7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells

DOI: 10.18632/oncotarget.12578

Mei-Chi Chang, Yi-Jane Chen, Eric Jein-Wein Liou, Wan-Yu Tseng, Chiu-Po Chan, Hseuh-Jen Lin, Wan-Chuen Liao, Ya-Ching Chang, Po-Yuan Jeng,  and Jiiang-Huei Jeng
74473-74483
Abstract  |   PDF  |  HTML
A small molecule inhibitor of PAI-1 protects against Doxorubicin-induced cellular senescence: molecular basis

DOI: 10.18632/oncotarget.12494

Asish K. Ghosh, Rahul Rai, Kitae E. Park, Mesut Eren, Toshio Miyata, Lisa D. Wilsbacher,  and Douglas E. Vaughan
72443-72457
Abstract  |   PDF  |  HTML  |  Supplementary Information
INPP5D rs35349669 polymorphism with late-onset Alzheimer’s disease: A replication study and meta-analysis

DOI: 10.18632/oncotarget.12648

Hua Jing, Jun-Xia Zhu, Hui-Fu Wang, Wei Zhang, Zhan-Jie Zheng, Ling-Li Kong, Chen-Chen Tan, Zi-Xuan Wang, Lin Tan,  and Lan Tan
69225-69230
Abstract PDF HTML
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial

DOI: 10.18632/oncotarget.10171

Ingvild Eide Graff, Jannike Øyen, Marian Kjellevold, Livar Frøyland, Clara Gram Gjesdal, Bjørg Almås, Grethe Rosenlund,  and Øyvind Lie
69200-69215
Abstract PDF HTML
Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression

DOI: 10.18632/oncotarget.11963

Yan Kong, Ke Li, Tingting Fu, Chao Wan, Dongdong Zhang, Hang Song, Yao Zhang, Na Liu, Zhenji Gan,  and Liudi Yuan
67716-67731
Abstract PDF HTML Supplementary Information
NOX4 downregulation leads to senescence of human vascular smooth muscle cells

DOI: 10.18632/oncotarget.12079

Dorota Przybylska, Dorota Janiszewska, Aleksandra Goździk, Anna Bielak-Zmijewska, Piotr Sunderland, Ewa Sikora,  and Grażyna Mosieniak
66429-66443
Abstract PDF HTML Supplementary Information
Interferon-gamma deficiency protects against aging-related goblet cell loss

DOI: 10.18632/oncotarget.11872

Eugene A. Volpe, Johanna Tukler Henriksson, Changjun Wang, Flavia L. Barbosa, Mahira Zaheer, Xiaobo Zhang, Stephen C. Pflugfelder,  and Cintia S. de Paiva
64605-64614
Abstract PDF HTML
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly

DOI: 10.18632/oncotarget.11760

Lisa Rodrigues, Isabel M. Miranda, Geanne M. Andrade, Marta Mota, Luísa Cortes, Acácio G. Rodrigues, Rodrigo A. Cunha,  and Teresa Gonçalves
62862-62872
Abstract PDF HTML
The rate of change in declining steroid hormones: a new parameter of healthy aging in men?

DOI: 10.18632/oncotarget.11752

Andreas Walther, Michel Philipp, Niclà Lozza,  and Ulrike Ehlert
60844-60857
Abstract PDF HTML Supplementary Information
Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease

DOI: 10.18632/oncotarget.11289

Jiu Chen, Hao Shu, Zan Wang, Duan Liu, Yongmei Shi, Lin Xu,  and Zhijun Zhang
58789-58801
Abstract PDF HTML Supplementary Information
BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration

DOI: 10.18632/oncotarget.11182

Kalonji Ntumba, Naoufal Akla, S. Paul Oh, Anne Eichmann,  and Bruno Larrivée
55957-55969
Abstract PDF HTML Supplementary Information
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson’s disease

DOI: 10.18632/oncotarget.11090

Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yi-Hsin Weng, Yin-Cheng Huang, Yi-Chuan Cheng, Rou-Shayn Chen, Ying-Zu Huang, June Hung, Chiung-Chu Chen, Wey-Yil Lin, Hsiu-Chen Chang, Yu-Jie Chen, Chao-Lang Chen, Hsin-Yi Chen, Yan-Wei Lin, Yah-Huei Wu-Chou, Hung-Li Wang,  and Chin-Song Lu
54215-54227
Abstract PDF HTML Supplementary Information
Age is associated with time in therapeutic range for warfarin therapy in patients with atrial fibrillation

DOI: 10.18632/oncotarget.10944

Leiliane Rodrigues Marcatto, Luciana Sacilotto, Francisco Carlos da Costa Darrieux, Denise Tessariol Hachul, Maurício Ibrahim Scanavacca, Jose Eduardo Krieger, Alexandre Costa Pereira,  and Paulo Caleb Junior Lima Santos
54194-54199
Abstract PDF HTML Supplementary Information
The underlying mechanism of proinflammatory NF-?B activation by the mTORC2/Akt/IKK? pathway during skin aging

DOI: 10.18632/oncotarget.10943

Yeon Ja Choi, Kyoung Mi Moon, Ki Wung Chung, Ji Won Jeong, Daeui Park, Dae Hyun Kim, Byung Pal Yu,  and Hae Young Chung
52685-52694
Abstract PDF HTML Supplementary Information
Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys

DOI: 10.18632/oncotarget.10854

Eun Ji Jang, Dae Hyun Kim, Bonggi Lee, Eun Kyeong Lee, Ki Wung Chung, Kyoung Mi Moon, Min Jo Kim, Hye Jin An, Ji Won Jeong, Ye Ra Kim, Byung Pal Yu,  and Hae Young Chung
50864-50874
Abstract PDF HTML
Leukocyte telomere length and mortality risk in patients with type 2 diabetes

DOI: 10.18632/oncotarget.10615

Anna Rita Bonfigli, Liana Spazzafumo, Francesco Prattichizzo, Massimiliano Bonafè, Emanuela Mensà, Luigina Micolucci, Angelica Giuliani, Paolo Fabbietti, Roberto Testa, Massimo Boemi, Fabrizia Lattanzio,  and Fabiola Olivieri
50835-50844
Abstract PDF HTML
Vδ2+ and α/ß T cells show divergent trajectories during human aging

DOI: 10.18632/oncotarget.10096

Crystal Tze Ying Tan, Kilian Wistuba-Hamprecht, Weili Xu, Ma Schwe Zin Nyunt, Anusha Vasudev, Bernett Teck Kwong Lee, Graham Pawelec, Kia Joo Puan, Olaf Rotzschke, Tze Pin Ng,  and Anis Larbi
44906-44918
Abstract PDF HTML
Baicalein is an available anti-atherosclerotic compound through modulation of nitric oxide-related mechanism under oxLDL exposure

DOI: 10.18632/oncotarget.10263

Shih-Hung Chan, Ching-Hsia Hung, Jhih-Yuan Shih, Pei-Ming Chu, Yung-Hsin Cheng, Yi-Ju Tsai, Huei-Chen Lin,  and Kun-Ling Tsai
42881-42891
Abstract PDF HTML
Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells

DOI: 10.18632/oncotarget.9772

Zhao Liu, Long Wang, Junhua Yang, Abhik Bandyopadhyay, Virginia Kaklamani, Shui Wang,  and Lu-Zhe Sun
39097-39107
Abstract PDF HTML
Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer’s disease

DOI: 10.18632/oncotarget.9773

Ellen Umlauf, Eduard Rappold, Bettina Schiller, Petra Fuchs, Michael Rainer, Brigitte Wolf,  and Maria Zellner
39108-39117
Abstract PDF HTML Supplementary Information
Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease

DOI: 10.18632/oncotarget.9776

Sylvie L. Lesuis, Herve Maurin, Peter Borghgraef, Paul J. Lucassen, Fred Van Leuven,  and Harm J. Krugers
39118-39135
Abstract PDF HTML
MEF2C rs190982 polymorphism with late-onset Alzheimer’s disease in Han Chinese: A replication study and meta-analyses

DOI: 10.18632/oncotarget.9819

Shan-Shan Tang, Hui-Fu Wang, Wei Zhang, Ling-Li Kong, Zhan-Jie Zheng, Meng-Shan Tan, Chen-Chen Tan, Zi-Xuan Wang, Lin Tan, Teng Jiang, Jin-Tai Yu,  and Lan Tan
39136-39142
Abstract PDF HTML
Age-related increase of thromboxane B2 and risk of cardiovascular disease in atrial fibrillation

DOI: 10.18632/oncotarget.9826

Pastori Daniele, Pignatelli Pasquale, Farcomeni Alessio, Nocella Cristina, Bartimoccia Simona, Carnevale Roberto,  and Violi Francesco
39143-39147
Abstract PDF HTML
Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice

DOI: 10.18632/oncotarget.9834

Donghua Zou, Yijing Zhou, Long Liu, Fengping Dong, Tianzhi Shu, Ying Zhou, Li-Huei Tsai,  and Yingwei Mao
39148-39161
Abstract PDF HTML Supplementary Information
Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes

DOI: 10.18632/oncotarget.10043

Yng-Tay Chen, Jiunn-Wang Liao, Ya-Ching Tsai,  and Fuu-Jen Tsai
39162-39170
Abstract PDF HTML Supplementary Information
IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

DOI: 10.18632/oncotarget.10047

Xin Zhou, Jacob W. Hopkins, Chongkai Wang, Vinayak Brahmakshatriya, Susan L. Swain, George A. Kuchel, Laura Haynes,  and Janet E. McElhaney
39171-39183
Abstract PDF HTML Supplementary Information
The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons

DOI: 10.18632/oncotarget.9545

Riccardo Vezzali, Stefan Christopher Weise, Nicole Hellbach, Venissa Machado, Stefanie Heidrich,  and Tanja Vogel
37436-37455
Abstract PDF HTML Supplementary Information
Age, serum 25-hydroxyvitamin D and vitamin D receptor (VDR) expression and function in peripheral blood mononuclear cells

DOI: 10.18632/oncotarget.9398

Laura A. Coleman, Margarita Mishina, Mark Thompson, Sarah M. Spencer, Adrian J. Reber, William G. Davis, Po-Yung Cheng, Edward A. Belongia, H. Keipp Talbot, Maria E. Sundaram, Marie R. Griffin, David K. Shay,  and Suryaprakash Sambhara
35512-35521
Abstract PDF HTML Supplementary Information
Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis

DOI: 10.18632/oncotarget.9550

William R. Swindell, Xianying Xing, Yi Fritz, Doina Diaconu, Daniel I. Simon, Nicole L. Ward,  and Johann E. Gudjonsson
35535-35551
Abstract PDF HTML Supplementary Information
Thigh muscle size and vascular function after blood flow-restricted elastic band training in older women

DOI: 10.18632/oncotarget.9564

Tomohiro Yasuda, Kazuya Fukumura, Takanobu Tomaru,  and Toshiaki Nakajima
33595-33607
Abstract PDF HTML
Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans
Yan-Hui Li,  and Gai-Gai Zhang
19185-19192
Abstract PDF HTML Supplementary Information
The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse
Sharon E. Mitchell, Camille Delville, Penelope Konstantopedos, Davina Derous, Cara L. Green, Yingchun Wang, Jing-Dong J. Han, Daniel E.L. Promislow, Alex Douglas, Luonan Chen, David Lusseau,  and John R. Speakman
19147-19170
Abstract PDF HTML Supplementary Information
Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior
Panayotis K. Thanos, John Hamilton, Joseph R. O'Rourke, Anthony Napoli, Marcelo Febo, Nora D. Volkow, Kenneth Blum,  and Mark Gold
19111-19123
Abstract PDF HTML Supplementary Information
RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
Xiaoyu Cai, Yuanyuan Hu, Hao Tang, Han Hu, Lijun Pang, Junyue Xing, Zhenyun Liu, Yuhong Luo, Bin Jiang, Te Liu, Myriam Gorospe, Chuan Chen,  and Wengong Wang
19099-19110
Abstract PDF HTML Supplementary Information
Common DNA methylation alterations of Alzheimer's disease and aging in peripheral whole blood
Hongdong Li, Zheng Guo, You Guo, Mengyao Li, Haidan Yan, Jun Cheng, Chenguang Wang,  and Guini Hong
19089-19098
Abstract PDF HTML Supplementary Information
Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients
Ana-Maria Buga, Ovidiu Ciobanu, George Mihai Bădescu, Catalin Bogdan, Ria Weston, Mark Slevin, Mario Di Napoli,  and Aurel Popa-Wagner
17415-17430
Abstract PDF HTML
Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis
Hong-Fang Ji, Qi-Shuai Zhuang,  and Liang Shen
17410-17414
Abstract PDF HTML
Improved muscle function and quality after diet intervention with leucine-enriched whey and antioxidants in antioxidant deficient aged mice
Miriam van Dijk, Francina J. Dijk, Annelies Bunschoten, Dorien A.M. van Dartel, Klaske van Norren, Stephane Walrand, Marion Jourdan, Sjors Verlaan,  and Yvette Luiking
17338-17355
Abstract PDF HTML Supplementary Information
Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer's disease
Feng Bai, Yonggui Yuan, Yongmei Shi,  and Zhijun Zhang
15315-15328
Abstract PDF HTML Supplementary Information
Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy
Mònica Bosch-Morató, Cinta Iriondo, Biuse Guivernau, Victòria Valls-Comamala, Noemí Vidal, Montse Olivé, Henry Querfurth,  and Francisco J. Muñoz
13354-13371
Abstract PDF HTML Supplementary Information
Age-related changes in the transcriptome of antibody-secreting cells
Senthil Kannan, Noor Dawany, Raj Kurupati, Louise C. Showe,  and Hildegund C. J. Ertl
13340-13353
Abstract PDF HTML Supplementary Information
Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway
Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu,  and Zhi-Jun Zhang
13328-13339
Abstract PDF HTML
Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts
Lei Cao, Hui-Fu Wang, Lin Tan, Fu-Rong Sun, Meng-Shan Tan, Chen-Chen Tan, Teng Jiang, Jin-Tai Yu, Lan Tan,  and Alzheimer's Disease Neuroimaging Initiative
13319-13327
Abstract PDF HTML Supplementary Information
Aging is a weak but relentless determinant of dementia severity
Donald R. Royall,  and Raymond F. Palmer
13307-13318
Abstract PDF HTML
A multimodal assessment of balance in elderly and young adults
Gregory W. King, Eduardo L. Abreu, An-Lin Cheng, Keyna K. Chertoff, Leticia Brotto, Patricia J. Kelly,  and Marco Brotto
13297-13306
Abstract PDF HTML
Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis
Kelsey O'Hagan-Wong, Stéphanie Nadeau, Audrey Carrier-Leclerc, Felipe Apablaza, Reggie Hamdy, Dominique Shum-Tim, Francis Rodier,  and Inés Colmegna
13285-13296
Abstract PDF HTML Supplementary Information
Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging
Michael A. Paltsev, Victoria O. Polyakova, Igor M. Kvetnoy, George Anderson, Tatiana V. Kvetnaia, Natalia S. Linkova, Ekaterina M. Paltseva, Rosa Rubino, Salvatore De Cosmo, Angelo De Cata,  and Gianluigi Mazzoccoli
11972-11983
Abstract PDF HTML
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
Javier A. Menendez, Núria Folguera-Blasco, Elisabet Cuyàs, Salvador Fernàndez-Arroyo, Jorge Joven,  and Tomàs Alarcón
11959-11971
Abstract PDF HTML
Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
Francesco Prattichizzo, Angelica Giuliani, Rina Recchioni, Massimiliano Bonafè, Fiorella Marcheselli, Sabrina De Carolis, Anna Campanati, Katia Giuliodori, Maria Rita Rippo, Francesca Brugè, Luca Tiano, Carla Micucci, Antonio Ceriello, Annamaria Offidani, Antonio Domenico Procopio,  and Fabiola Olivieri
11945-11958
Abstract PDF HTML Supplementary Information
Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia
Fabrizio Biundo, Keita Ishiwari, Dolores Del Prete,  and Luciano D'Adamio
11923-11944
Abstract PDF HTML
Age-related alterations in blood and colonic dendritic cell properties
Rakesh Vora, David Bernardo, Lydia Durant, Durga Reddi, Ailsa L. Hart, John M. E. Fell, Hafid O. Al-Hassi,  and Stella C. Knight
11913-11922
Abstract PDF HTML Supplementary Information
Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty
Samuel Golpanian, Darcy L. DiFede, Marietsy V. Pujol, Maureen H. Lowery, Silvina Levis-Dusseau, Bradley J. Goldstein, Ivonne H. Schulman, Bangon Longsomboon, Ariel Wolf, Aisha Khan, Alan W. Heldman, Pascal J. Goldschmidt-Clermont,  and Joshua M. Hare
11899-11912
Abstract PDF HTML
Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1
Verónica D'Annunzio, Virginia Perez, Tamara Mazo, Marina C. Muñoz, Fernando P. Dominici, María C. Carreras, Juan José Poderoso, Junichi Sadoshima,  and Ricardo J. Gelpi
11889-11898
Abstract PDF HTML
The effect of D-serine administration on cognition and mood in older adults
Marcos Avellar, Linda Scoriels, Caroline Madeira, Charles Vargas-Lopes, Priscila Marques, Camila Dantas, Alex C. Manhães, Homero Leite,  and Rogerio Panizzutti
11881-11888
Abstract PDF HTML Supplementary Information
Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice
Maude Bordeleau, Ayman ElAli,  and Serge Rivest
11864-11880
Abstract PDF HTML Supplementary Information
In normal aging ventricular system never attains pathological values of Evans' index
Paolo Missori, Aurelia Rughetti, Simone Peschillo, Gianfranco Gualdi, Claudio Di Biasi, Italo Nofroni, Lucio Marinelli, Francesco Fattapposta,  and Antonio Currà
11860-11863
Abstract PDF HTML
The role of fine-needle aspiration in the thyroid nodules of elderly patients
Esther Diana Rossi, Tommaso Bizzarro, Maurizio Martini, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca,  and Guido Fadda
11850-11859
Abstract PDF HTML
Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion
Ying Cai,  and Yue-Hua Wei
10812-10826
Abstract PDF HTML Supplementary Information
Identification of long non-coding RNAs as novel biomarker and potential therapeutic target for atrial fibrillation in old adults
Yingjia Xu, Ritai Huang, Jianing Gu,  and Weifeng Jiang
10803-10811
Abstract PDF HTML Supplementary Information
Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow
Gabrielis Kundrotas, Evelina Gasperskaja, Grazina Slapsyte, Zivile Gudleviciene, Jan Krasko, Ausra Stumbryte,  and Regina Liudkeviciene
10788-10802
Abstract PDF HTML
Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
Ching-Hsia Hung, Shih-Hung Chan, Pei-Ming Chu, Huei-Chen Lin,  and Kun-Ling Tsai
10773-10787
Abstract PDF HTML
DNA methylation in PRDM8 is indicative for dyskeratosis congenita
Carola I. Weidner, Qiong Lin, Carina Birkhofer, Uwe Gerstenmaier, Andrea Kaifie, Martin Kirschner, Heiko Bruns, Stefan Balabanov, Arne Trummer, Clemens Stockklausner, Britta Höchsmann, Hubert Schrezenmeier, Marcin Wlodarski, Jens Panse, Tim H. Brümmendorf, Fabian Beier,  and Wolfgang Wagner
10765-10772
Abstract PDF HTML Supplementary Information
NFE2L2 variations reduce antioxidant response in patients with Parkinson disease
YaXing Gui, LiShan Zhang, Wen Lv, WenMing Zhang, JinJia Zhao,  and XingYue Hu
10756-10764
Abstract PDF HTML
GDF15 contributes to radiation-induced senescence through the ros-mediated p16 pathway in human endothelial cells
Hyejin Park, Chun-Ho Kim, Jae-Hoon Jeong, Myungjin Park,  and Kwang Seok Kim
9634-9644
Abstract PDF HTML
Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy
Marina Zieger,  and Claudio Punzo
9620-9633
Abstract PDF HTML Supplementary Information
Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells
Cheng-Wei Li, Wen-Hsin Wang,  and Bor-Sen Chen
8556-8579
Abstract PDF HTML Supplementary Information
Highlighting the impact of aging on type I collagen: label-free investigation using confocal reflectance microscopy and diffuse reflectance spectroscopy in 3D matrix model
Marie Guilbert, Blandine Roig, Christine Terryn, Roselyne Garnotel, Pierre Jeannesson, Ganesh D. Sockalingum, Michel Manfait, François Perraut, Jean-Marc Dinten, Anne Koenig,  and Olivier Piot
8546-8555
Abstract PDF HTML
Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration
Ahmed S. Ibrahim, Suchreet Mander, Khaled A. Hussein, Nehal M. Elsherbiny, Sylvia B. Smith, Mohamed Al-Shabrawey,  and Amany Tawfik
8532-8545
Abstract PDF HTML
Epigenetic clock analyses of cellular senescence and ageing
Donna Lowe, Steve Horvath,  and Kenneth Raj
8524-8531
Abstract PDF HTML
Molecular signatures of age-associated chronic degeneration of shoulder muscles
Yotam Raz, Jan Ferdinand Henseler, Arjen Kolk, Zuotian Tatum, Niels Kuipers Groosjohan, Nisha E. Verwey, Wibowo Arindrarto, Szymon M. Kielbasa, Jochem Nagels, Peter A. C. 't Hoen, Rob G. H. H. Nelissen,  and Vered Raz
8513-8523
Abstract PDF HTML Supplementary Information
Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats
Jianying Zhang, Ting Yuan,  and James H-C. Wang
8498-8512
Abstract PDF HTML
Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology
Dale Chaput, Lisa Kirouac, Stanley M. Stevens, Jr.,  and Jaya Padmanabhan
8481-8497
Abstract PDF HTML
Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains
Min Chen, Weiwei Yang, Xin Li, Xuran Li, Peng Wang, Feng Yue, Hui Yang, Piu Chan,  and Shun Yu
8466-8480
Abstract PDF HTML
Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease
Jun Wang, Weina Bi, Wei Zhao, Merina Varghese, Rick J. Koch, Ruth H. Walker, Roshantha A. Chandraratna, Martin E. Sanders, Amanda Janesick, Bruce Blumberg, Libby Ward, Lap Ho,  and  Giulio M. Pasinetti
7469-7479
Abstract PDF HTML
Identification of novel plasma glycosylation-associated markers of aging
Mariangela Catera, Vincenzo Borelli, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Celso A. Reis, Hugo Osorio, Provvidenza M. Abruzzo, Miriam Capri, Daniela Monti, Rita Ostan, Claudio Franceschi,  and  Fabio Dall'Olio
7455-7468
Abstract PDF HTML Supplementary Information
Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains
Weiwei Yang, Xuran Li, Xin Li, Xuying Li,  and  Shun Yu
7441-7454
Abstract PDF HTML
Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes
Gloria Castellano-González, Nicolas Pichaud, J. William O. Ballard, Alban Bessede, Helder Marcal,  and  Gilles J. Guillemin
7426-7440
Abstract PDF HTML Supplementary Information
The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice
Chantal A. A. Heppolette, Jian-Hua Chen, Sarah K. Carr, Donald B. Palmer,  and  Susan E. Ozanne
6398-6409
Abstract PDF HTML
XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence
Jong-Ik Heo, Wonwoo Kim, Kyu Jin Choi, Sangwoo Bae, Jae-Hoon Jeong,  and  Kwang Seok Kim
5118-5130
Abstract PDF HTML
Core level regulatory network of osteoblast as molecular mechanism for osteoporosis and treatment
Ruoshi Yuan, Shengfei Ma, Xiaomei Zhu, Jun Li, Yuhong Liang, Tao Liu, Yanxia Zhu, Bingbing Zhang, Shuang Tan, Huajie Guo, Shuguang Guan, Ping Ao,  and  Guangqian Zhou
3692-3701
Abstract PDF HTML Supplementary Information
Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
Bing Wu, Lu Yu, Yishi Wang, Hongtao Wang, Chen Li, Yue Yin, Jingrun Yang, Zhifa Wang, Qiangsun Zheng,  and  Heng Ma
2175-2188
Abstract PDF HTML Supplementary Information
Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice
Xue Yang, Lei Liang, Chen Zong, Fobao Lai, Pengxi Zhu, Yu Liu, Jinghua Jiang, Yang Yang, Lu Gao, Fei Ye, Qiudong Zhao, Rong Li, Zhipeng Han,  and  Lixin Wei
1084-1095
Abstract PDF HTML
Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway
Fengtao Su, Souparno Bhattacharya, Salim Abdisalaam, Shibani Mukherjee, Hirohiko Yajima, Yanyong Yang, Ritu Mishra, Kalayarasan Srinivasan, Subroto Ghose, David J. Chen, Steven M. Yannone,  and  Aroumougame Asaithamby
46-65
Abstract PDF HTML Supplementary Information
Identification of cardiac-related circulating microRNA profile in human chronic heart failure
Huaping Li, Jiahui Fan, Zhongwei Yin, Feng Wang, Chen Chen,  and  Dao Wen Wang
33-45
Abstract PDF HTML Supplementary Information
Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population
Ning Li, Huaichao Luo, Xiaoqi Liu, Shi Ma, He Lin, Rong Chen, Fang Hao,  and  Dingding Zhang
23-32
Abstract PDF HTML
miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis
Maria Ines Almeida, Andreia Machado Silva, Daniel Marques Vasconcelos, Catarina Rodrigues Almeida, Hugo Caires, Marta Teixeira Pinto, George Adrian Calin, Susana Gomes Santos,  and  Mário Adolfo Barbosa
7-22
Abstract PDF HTML Supplementary Information

Reviews: Gerotarget (Focus on Aging)

Characterization and redox mechanism of asthma in the elderly
Li Zuo, Benjamin K. Pannell,  and Zewen Liu
25010-25021
Abstract PDF HTML
Reprogramming of energy metabolism as a driver of aging
Zhaoyang Feng, Richard W. Hanson, Nathan A. Berger,  and Alexander Trubitsyn
15410-15420
Abstract PDF HTML

2015

Editorial: Gerotarget (Focus on Aging)

Measuring refractive index distribution in the human eye lens
James M. Pope,  and  David A. Atchison
39395-39395
PDF
Rapid and simple detection of gero-suppressive agents
Zbigniew Darzynkiewicz
23050-23051
PDF
Aging interventions get human
Brian K. Kennedy,  and  Juniper K. Pennypacker
590-591
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Research Papers: Gerotarget (Focus on Aging)

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
Neeraj Kumar, Vaibhav Jain, Anupama Singh, Urmila Jagtap, Sonia Verma,  and  Arnab Mukhopadhyay
41418-41433
Abstract PDF HTML Supplementary Information
Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
Umberto Galderisi, Servet Özcan, Nicola Alessio, Mustafa Burak Acar, Guler Toprak, Zeynep Burcin Onal,  and  Gianfranco Peluso
39482-39492
Abstract PDF HTML Supplementary Information
Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats
Sabzali Javadov, Sehwan Jang, Natividad Rodriguez-Reyes, Ana E. Rodriguez-Zayas, Jessica Soto Hernandez, Tanja Krainz, Peter Wipf,  and  Walter Frontera
39469-39481
Abstract PDF HTML
Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells
Stefania Capasso, Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Mariarosa A. Melone, Marilena Cipollaro, Gianfranco Peluso,  and  Umberto Galderisi
39457-39468
Abstract PDF HTML
Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer's disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies
María Victoria Zelaya, Estela Pérez-Valderrama, Xabier Martínez de Morentin, Teresa Tuñon, Isidro Ferrer, María Rosario Luquin, Joaquín Fernandez-Irigoyen,  and  Enrique Santamaría
39437-39456
Abstract PDF HTML Supplementary Information
Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population
Qianyi Xiao, Zhi-Jun Liu, Sha Tao, Yi-Min Sun, Deke Jiang, Hong-Lei Li, Haitao Chen, Xu Liu, Brittany Lapin, Chi-Hsiung Wang, S. Lilly Zheng, Jianfeng Xu,  and  Zhi-Ying Wu
36955-36964
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Prolonged ovarian hormone deprivation alters the effects of 17β-estradiol on microRNA expression in the aged female rat hypothalamus
Yathindar S. Rao, Cody L. Shults, Elena Pinceti,  and  Toni R. Pak
36965-36983
Abstract PDF HTML Supplementary Information
Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development
Afshin Beheshti, Justin Wage, J. Tyson McDonald, Clare Lamont, Michael Peluso, Philip Hahnfeldt,  and  Lynn Hlatky
35419-35432
Abstract PDF HTML Supplementary Information
c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells
Pei-Min Chen, Chia-Hua Lin, Nan-Ting Li, Yao-Ming Wu, Ming-Tsan Lin, Shih-Chieh Hung,  and  Men-Luh Yen
35404-35418
Abstract PDF HTML Supplementary Information
Association between serum uric acid and bone health in general population: a large and multicentre study
Xianfeng Lin, Chenchen Zhao, An Qin, Dun Hong, Wenyue Liu, Kangmao Huang, Jian Mo, Hejun Yu, Shengjie Wu,  and  Shunwu Fan
35395-35403
Abstract PDF HTML Supplementary Information
Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts
Po-Hsiang Liao, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Chao-Hung Lai, Ray-Jade Chen, V. Vijaya Padma, Wei- Wen Kuo,  and  Chih-Yang Huang
35383-35394
Abstract PDF HTML
MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications
Fabiola Olivieri, Liana Spazzafumo, Massimiliano Bonafè, Rina Recchioni, Francesco Prattichizzo, Fiorella Marcheselli, Luigina Micolucci, Emanuela Mensà, Angelica Giuliani, Gabriele Santini, Mirko Gobbi, Raffaella Lazzarini, Massimo Boemi, Roberto Testa, Roberto Antonicelli, Antonio Domenico Procopio,  and  Anna Rita Bonfigli
35372-35382
Abstract PDF HTML
Age-dependent uncoupling of mitochondria from Ca2+ release units in skeletal muscle
Laura Pietrangelo, Alessandra D'Incecco, Alina Ainbinder, Antonio Michelucci, Helmut Kern, Robert T. Dirksen, Simona Boncompagni,  and  Feliciano Protasi
35358-35371
Abstract PDF HTML Supplementary Information
Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
Stefania Rigacci, Caterina Miceli, Chiara Nediani, Andrea Berti, Roberta Cascella, Daniela Pantano, Pamela Nardiello, Ilaria Luccarini, Fiorella Casamenti,  and  Massimo Stefani
35344-35357
Abstract PDF HTML
Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model
Ji-Ae Kim, Seul-Ki Park, Mukesh Kumar, Chan-Hee Lee,  and  Ok Sarah Shin
35324-35343
Abstract PDF HTML
IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity
John Papaconstantinou,  and  Ching-Chyuan Hsieh
35315-35323
Abstract PDF HTML
Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis
Cong Lin, Farhad Rezaee, Maaike Waasdorp, Kun Shi, Tom van der Poll, Keren Borensztajn,  and  C. Arnold Spek
35304-35314
Abstract PDF HTML
Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)
Janette Bester, Prashilla Soma, Douglas B. Kell,  and  Etheresia Pretorius
35284-35303
Abstract PDF HTML
Rapamycin preserves gut homeostasis during Drosophila aging
Xiaolan Fan, Qing Liang, Ting Lian, Qi Wu, Uma Gaur, Diyan Li, Deying Yang, Xueping Mao, Zhihua Jin, Ying Li,  and  Mingyao Yang
35274-35283
Abstract PDF HTML
RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium
Sung Wook Park, Jin Hyoung Kim, Sang Min Park, Minho Moon, Kihwang Lee, Kyu Hyung Park, Woo Jin Park,  and  Jeong Hun Kim
35263-35273
Abstract PDF HTML
Suppression of FoxO6 by lipopolysaccharide in aged rat liver
Dae Hyun Kim, Min Hi Park, Ki Wung Chung, Min Jo Kim, Daeui Park, Bonggi Lee, Eun Kyeong Lee, Yeon Ja Choi, Nam Deuk Kim, Byung Pal Yu,  and  Hae Young Chung
34143-34157
Abstract PDF HTML Supplementary Information
Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice
Beibei Wu, Yan Wei, Yujing Wang, Tao Su, Lei Zhou, Ying Liu,  and  Rongqiao He
34128-34142
Abstract PDF HTML Supplementary Information
Aging with ING: a comparative study of different forms of stress induced premature senescence
Uma Karthika Rajarajacholan,  and  Karl Riabowol
34118-34127
Abstract PDF HTML Supplementary Information
Identification of ageing-associated naturally occurring peptides in human urine
Esther Nkuipou-Kenfack, Akshay Bhat, Julie Klein, Vera Jankowski, William Mullen, Antonia Vlahou, Mohammed Dakna, Thomas Koeck, Joost P. Schanstra, Petra Zürbig, Karl L. Rudolph, Björn Schumacher, Andreas Pich,  and  Harald Mischak
34106-34117
Abstract PDF HTML Supplementary Information
The eye lens: age-related trends and individual variations in refractive index and shape parameters
Barbara Pierscionek, Mehdi Bahrami, Masato Hoshino, Kentaro Uesugi, Justyn Regini,  and  Naoto Yagi
30532-30544
Abstract PDF HTML
New insights into the impact of Lactobacillus population on host-bacteria metabolic interplay
Caroline I. Le Roy, Jelena Štšepetova, Epp Sepp, Epp Songisepp, Sandrine P. Claus,  and  Marika Mikelsaar
30545-30556
Abstract PDF HTML
Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny
Saara Marttila, Laura Kananen, Juulia J ylhävä, Tapio Nevalainen, Antti Hervonen, Marja Jylhä,  and  Mikko Hurme
30557-30567
Abstract PDF HTML Supplementary Information
Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster
Anika E. Wagner, Stefanie Piegholdt, Doerte Rabe, Nieves Baenas, Anke Schloesser, Manfred Eggersdorfer, Achim Stocker,  and  Gerald Rimbach
30568-30578
Abstract PDF HTML
Serotonin 6 receptor controls alzheimer's disease and depression
Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim, Sanghyeon Kim,  and  Jin Tae Hong
26716-26728
Abstract PDF HTML Supplementary Information
Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice
Michael B. Stout, William R. Swindell, Xu Zhi, Kyle Rohde, Edward O. List, Darlene E. Berryman, John J. Kopchick, Adam Gesing, Yimin Fang,  and  Michal M. Masternak
26702-26715
Abstract PDF HTML Supplementary Information
To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss
Jaimie Hoh Kam,  and  Glen Jeffery
26690-26701
Abstract PDF HTML
Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration
Carmen Diaz-Ruiz, Ana I. Rodriguez-Perez, Daniel Beiroa, Jannette Rodriguez-Pallares,  and  Jose L. Labandeira-Garcia
26675-26689
Abstract PDF HTML
APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
Frederic Sampedro, Eduard Vilaplana, Mony J. de Leon, Daniel Alcolea, Jordi Pegueroles, Victor Montal, María Carmona-Iragui, Isabel Sala, María-Belén Sánchez-Saudinos, Sofía Antón-Aguirre, Estrella Morenas-Rodríguez, Valle Camacho, Carles Falcón, Javier Pavía, Jordi Clarimón, Rafael Blesa, Alberto Lleó,  and  Juan Fortea
26663-26674
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Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways
Cong Fu, Bing Li, Yuning Sun, Genshan Ma,  and  Yuyu Yao
24675-24689
Abstract PDF HTML Supplementary Information
Neuroprotective effect of cellular prion protein (PrPC) is related with activation of alpha7 nicotinic acetylcholine receptor (α7nAchR)-mediated autophagy flux
Jae-Kyo Jeong,  and  Sang-Youel Park
24660-24674
Abstract PDF HTML
The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice
Sharon E. Mitchell, Camille Delville, Penelope Konstantopedos, Jane Hurst, Davina Derous, Cara Green, Luonan Chen, Jackie J.D. Han, Yingchun Wang, Daniel E.L. Promislow, David Lusseau, Alex Douglas,  and  John R. Speakman
23213-23237
Abstract PDF HTML
Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells
Eugene Makarev, Kristen Fortney, Maria Litovchenko, Karl H. Braunewell, Alex Zhavoronkov,  and  Anthony Atala
23204-23212
Abstract PDF HTML Supplementary Information
Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline
Scott H. Deibel, Erin L. Zelinski, Robin J. Keeley, Olga Kovalchuk,  and  Robert J. McDonald
23181-23203
Abstract PDF HTML
Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice
Fei Wang, Xueyan Shen, Shuping Li, Long Chen, Yanru Wang, Jie Qin, Guomin Zhou, Yuwen Peng, Xiaoyuan Feng, Ruixi Li,  and  Chunmin Liang
20851-20862
Abstract PDF HTML
BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine
Senthil Kannan, Raj K. Kurupati, Susan A. Doyle, Gordon J. Freeman, Kenneth E. Schmader,  and  Hildegund C.J. Ertl
19445-19455
Abstract PDF HTML
Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity
Anton Danilov, Mikhail Shaposhnikov, Oksana Shevchenko, Nadezhda Zemskaya, Alex Zhavoronkov,  and  Alexey Moskalev
19428-19444
Abstract PDF HTML Supplementary Information
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
Speranza Rubattu, Franca Bianchi, Carla Letizia Busceti, Maria Cotugno, Rosita Stanzione, Simona Marchitti, Sara Di Castro, Michele Madonna, Ferdinando Nicoletti,  and  Massimo Volpe
18800-18818
Abstract PDF HTML
Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16
Hong Qian, Xiangru Xu,  and  Laura E. Niklason
18790-18799
Abstract PDF HTML Supplementary Information
The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse
Sharon E. Mitchell, Camille Delville, Penelope Konstantopedos, Davina Derous, Cara L. Green, Luonan Chen, Jing-Dong J. Han, Yingchun Wang, Daniel E.L. Promislow, Alex Douglas, David Lusseau,  and  John R. Speakman
18314-18337
Abstract PDF HTML Supplementary Information
Exercise-mimetic AICAR transiently benefits brain function
Davide Guerrieri,  and  Henriette van Praag
18293-18313
Abstract PDF HTML Supplementary Information
Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence
Ping Niu, Aibek Smagul, Lu Wang, Aiman Sadvakas, Ying Sha, Laura M. Pérez, Aliya Nussupbekova, Aday Amirbekov, Akan A. Akanov, Beatriz G. Gálvez, I. King Jordan,  and  Victoria V. Lunyak
17938-17957
Abstract PDF HTML Supplementary Information
Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice
Jean-Philippe Leduc-Gaudet, Martin Picard, Félix St-Jean Pelletier, Nicolas Sgarioto, Marie-Joëlle Auger, Joanne Vallée, Richard Robitaille, David H. St-Pierre,  and  Gilles Gouspillou
17923-17937
Abstract PDF HTML
Effects of eight weeks of aerobic interval training and of isoinertial resistance training on risk factors of cardiometabolic diseases and exercise capacity in healthy elderly subjects
Paolo Bruseghini, Elisa Calabria, Enrico Tam, Chiara Milanese, Eugenio Oliboni, Andrea Pezzato, Silvia Pogliaghi, Gian Luca Salvagno, Federico Schena, Roberto Pozzi Mucelli,  and  Carlo Capelli
16998-17015
Abstract PDF HTML
The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse
Sharon E. Mitchell, Zhanhui Tang, Celine Kerbois, Camille Delville, Penelope Konstantopedos, Aurélie Bruel, Davina Derous, Cara Green, Richard M. Aspden, Simon R. Goodyear, Luonan Chen, Jackie J.D. Han, Yingchun Wang, Daniel E.L. Promislow, David Lusseau, Alex Douglas,  and  John R. Speakman
15902-15930
Abstract PDF HTML Supplementary Information
Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression
Ianina C. Ferder,  and  Ning Wang
15891-15901
Abstract PDF HTML Supplementary Information
Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain
Huan Gong, Hong Qian, Robin Ertl, Clinton M. Astle, Gang G. Wang, David E. Harrison,  and  Xiangru Xu
15882-15890
Abstract PDF HTML
Zinc finger factor 521 enhances adipogenic differentiation of mouse multipotent cells and human bone marrow mesenchymal stem cells
Kuo-Yun Tseng,  and  Shankung Lin
14874-14884
Abstract PDF HTML Supplementary Information
Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study
Mathilde Marot, Antoine Valéry, Eric Esteve, Guido Bens, Adelheid Müller, Stéphanie Rist, Hechmi Toumi,  and  Eric Lespessailles
14865-14873
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Genomic instability and cellular stress in organ biopsies and peripheral blood lymphocytes from patients with colorectal cancer and predisposing pathologies
Sara Lombardi, Ilenia Fuoco, Giorgia di Fluri, Francesco Costa, Angelo Ricchiuti, Graziano Biondi, Vincenzo Nardini,  and  Roberto Scarpato
14852-14864
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VGF expression by T lymphocytes in patients with Alzheimer’s disease
Stefan Busse, Johann Steiner, Sarah Glorius, Henrik Dobrowolny, Sabrina Greiner-Bohl, Christian Mawrin, Ursula Bommhardt, Roland Hartig, Bernhard Bogerts,  and  Mandy Busse
14843-14851
Abstract PDF HTML Supplementary Information
Dynamic self-guiding analysis of Alzheimer’s disease
Alexei Kurakin,  and  Dale E. Bredesen
14092-14122
Abstract PDF HTML Supplementary Information
APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study
Diego Iacono, Peter Zandi, Myron Gross, William R. Markesbery, Olga Pletnikova, Gay Rudow,  and  Juan C. Troncoso
14082-14091
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Involvement of cellular metabolism in age-related LTP modifications in rat hippocampal slices
Dominika Drulis-Fajdasz, Tomasz Wójtowicz, Marcin Wawrzyniak, Jakub Wlodarczyk, Jerzy W. Mozrzymas,  and  Dariusz Rakus
14065-14081
Abstract PDF HTML
PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes
Yng-Tay Chen, Wei-De Lin, Wen-Lin Liao, Ying-Ju Lin, Jan-Gowth Chang,  and  Fuu-Jen Tsai
12997-13005
Abstract PDF HTML Supplementary Information
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
Hanadie Yousef, Michael J. Conboy, Adam Morgenthaler, Christina Schlesinger, Lukasz Bugaj, Preeti Paliwal, Christopher Greer, Irina M. Conboy,  and  David Schaffer
11959-11978
Abstract PDF HTML Supplementary Information
New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor
Rosemeire M. Kanashiro-Takeuchi, Luca Szalontay, Andrew V. Schally, Lauro M. Takeuchi, Petra Popovics, Miklos Jaszberenyi, Irving Vidaurre, Marta Zarandi, Ren-Zhi Cai, Norman L. Block, Joshua M. Hare,  and  Ferenc G. Rick
9728-9739
Abstract PDF HTML
Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats
Ekaterina A. Lesovaya, Kirill I. Kirsanov, Elena E. Antoshina, Lubov S. Trukhanova, Tatiana G. Gorkova, Elena V. Shipaeva, Ramiz M. Salimov, Gennady A. Belitsky, Mikhail V. Blagosklonny, Marianna G. Yakubovskaya,  and  Olga B. Chernova
9718-9727
Abstract PDF HTML
EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells
Ju-Hee Lee, Ji-Hong Moon, Sung-Wook Kim, Jae-Kyo Jeong, Uddin MD. Nazim, You-Jin Lee, Jae-Won Seol,  and  Sang-Youel Park
9701-9717
Abstract PDF HTML
A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging
Marianne Schauer, Tina Kottek, Madeleine Schönherr, Animesh Bhattacharya, Saleh M. Ibrahim, Misa Hirose, Rüdiger Köhling, Georg Fuellen, Ulf Schmitz,  and  Manfred Kunz
8552-8566
Abstract PDF HTML Supplementary Information
Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins
Camilla Evangelisti, Pia Bernasconi, Paola Cavalcante, Cristina Cappelletti, Maria Rosaria D’Apice, Paolo Sbraccia, Giuseppe Novelli, Sabino Prencipe, Silvia Lemma, Nicola Baldini, Sofia Avnet, Stefano Squarzoni, Alberto M. Martelli,  and  Giovanna Lattanzi
7424-7437
Abstract PDF HTML
Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors
Emanuela Corsini, Valentina Galbiati, Antonella Pinto, Annalisa Davin, Letizia Polito, Antonio Guaita,  and  Marco Racchi
6524-6534
Abstract PDF HTML
Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium
Júlia Santos, Fernanda Leitão-Correia, Maria João Sousa,  and  Cecília Leão
6511-6523
Abstract PDF HTML Supplementary Information
Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
Nana Akagi Tsuchihashi, Ken Hayashi, Katsuaki Dan, Fumiyuki Goto, Yasuyuki Nomura, Masato Fujioka, Sho Kanzaki, Shizuo Komune,  and  Kaoru Ogawa
3644-3655
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DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3’-end GC density
Bo Yu MD, Valya R. Russanova, Silvia Gravina, Stephen Hartley, James C. Mullikin, Alice Ignezweski, James Graham, James H. Segars, Alan H. DeCherney,  and  Bruce H. Howard
3627-3643
Abstract PDF HTML Supplementary Information
The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
Zubaidah M. Ramdzan, Ranjana Pal, Simran Kaur, Lam Leduy, Ginette Bérubé, Sayeh Davoudi, Charles Vadnais,  and  Alain Nepveu
3613-3626
Abstract PDF HTML Supplementary Information
Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival
Sangkyu Kim, David A. Welsh, Leann Myers, Katie E. Cherry, Jennifer Wyckoff,  and  S. Michal Jazwinski
3600-3612
Abstract PDF HTML Supplementary Information
Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent
Maria Giovanna Sabbieti, Dimitrios Agas, Melania Capitani, Luigi Marchetti, Antonio Concetti, Cecilia Vullo, Giuseppe Catone, Vladimir Gabai, Victor Shifrin, Michael Y. Sherman, Alexander Shneider,  and  Franco M. Venanzi
3590-3599
Abstract PDF HTML Supplementary Information
Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
Jean-Yun Chang, Ming-Hui Lee, Sing-Ru Lin, Li-Yi Yang, Sunny H. Sun, Chun-I Sze, Qunying Hong, Yee-Shin Lin, Ying-Tsen Chou, Li-Jin Hsu, Ming-Shiou Jan, Cheng-Xin Gong,  and  Nan-Shan Chang
3578-3589
Abstract PDF HTML Supplementary Information
Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells
Mille Løhr, Annie Jensen, Louise Eriksen, Morten Grønbæk, Steffen Loft,  and  Peter Møller
2641-2653
Abstract PDF HTML Supplementary Information
Methyl-β-cyclodextrin up-regulates collagen I expression in chronologically-aged skin via its anti-caveolin-1 activity
Jung-Ae Lee, Da-In Choi, Jee-Young Choi, Sun-Ok Kim, Kyung-A Cho, Jee-Bum Lee, Sook-Jung Yun,  and  Seung-Chul Lee
1942-1953
Abstract PDF HTML
Age-Independent Rise of Inflammatory Scores May Contribute to Accelerated Aging in Multi-Morbidity
Maria Stepanova, Edgar Rodriguez, Aybike Birerdinc,  and  Ancha Baranova
1414-1421
Abstract PDF HTML
Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats
Natalia A. Stefanova, Natalia A. Muraleva, Elena E. Korbolina, Elena Kiseleva, Kseniya Yi. Maksimova,  and  Nataliya G. Kolosova
1396-1413
Abstract PDF HTML
Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies
Tyesha N. Burks, Ruth Marx, Laura Powell, Jasma Rucker, Djahida Bedja, Elisa Heacock, Barbara J. Smith, D. Brian Foster, David Kass, Brian O’Rourke, Jeremy D. Walston,  and  Peter M. Abadir
11979-11993
Abstract PDF HTML Supplementary Information
Synthetic Aβ peptides acquire prion-like properties in the brain
Xiangzhu Xiao, Ignazio Cali, Jue Yuan, Laura Cracco, Paul Curtiss, Liang Zeng, Mai Abouelsaad, Dimitris Gazgalis, Gong-Xian Wang, Qingzhong Kong, Hisashi Fujioka, Gianfranco Puoti,  and  Wen-Quan Zou
642-650
Abstract PDF HTML
Impact of age on the survival of patients with liver cancer: an analysis of 27,255 patients in the SEER database
Wenjie Zhang,  and  Beicheng Sun
633-641
Abstract PDF HTML Supplementary Information

Reviews: Gerotarget (Focus on Aging)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
Fabiola Olivieri, Maria Cristina Albertini, Monia Orciani, Artan Ceka, Monica Cricca, Antonio Domenico Procopio,  and  Massimiliano Bonafè
35509-35521
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Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
Didier. Rémond, Danit R. Shahar, Doreen Gille, Paula Pinto, Josefa Kachal, Marie-Agnès Peyron, Claudia Nunes Dos Santos, Barbara Walther, Alessandra Bordoni, Didier Dupont, Lidia Tomás-Cobos,  and  Guy Vergères
13858-13898
Abstract PDF HTML

2014

Editorial: Gerotarget (Focus on Aging)

mTORC2 takes the longevity stAGE
Dudley W. Lamming
7214-7215
PDF
Contact inhibition against senescence
Peiqing Sun
7212-7213
PDF

Research Papers: Gerotarget (Focus on Aging)

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions
Sandra Schütze, Sandra Ribes, Annika Kaufmann, Anja Manig, Jörg Scheffel, Sandra Redlich, Stephanie Bunkowski, Uwe-Karsten Hanisch, Wolfgang Brück,  and  Roland Nau
12573-12592
Abstract PDF HTML
A microRNA signature profile in EBV+ diffuse large B-cell lymphoma of the elderly
Tathiana Azevedo de Andrade, Adriane Feijo Evangelista, Antonio Hugo Froes Campos, Wagner Augusto Poles, Natalia Morais Borges, Claudia Malheiros Coutinho Camillo, Fernando Augusto Soares, Jose Vassallo, Roberto Pinto Paes, Maria Claudia Zerbini, Cristovam Scapulatempo, Antonio Correa Alves, Ken H. Young,  and  Gisele Wally Braga Colleoni
11813-11826
Abstract PDF HTML
ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age
Elena I. Kovalenko, Anna A. Boyko, Victor F. Semenkov, Gennady V. Lutsenko, Maria V. Grechikhina, Leonid M. Kanevskiy, Tatyana L. Azhikina, William G. Telford,  and  Alexander M. Sapozhnikov
11800-11812
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A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells
Peixin Huang, Sean M. Riordan, Daniel P. Heruth, Dmitry N. Grigoryev, Li Qin Zhang,  and  Shui Qing Ye
10812-10824
Abstract PDF HTML Supplementary Information
Ovariectomy shortens the life span of female mice
Valeria Benedusi, Elisa Martini, Marinos Kallikourdis, Alessandro Villa, Clara Meda,  and  Adriana Maggi
10801-10811
Abstract PDF HTML Supplementary Information

Reviews: Gerotarget (Focus on Aging)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
Hsin-Tzu Chang, Chan-Chuan Liu, Shur-Tzu Chen, Ye Vone Yap, Nan-Shang Chang,  and  Chun-I Sze
11792-11799
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