This study analyzed the expression levels of and correlation between PLCE1 and PRKCA in human esophagitis, carcinogen NMBA-induced rat esophagus, PLCE1 genetic deficient mouse esophageal epithelial tissues and human esophageal cancer cell line, integrated with Online oncology data sets.
The research team found that the expression levels of both PLCE1 and PRKCA were significantly elevated in human esophagitis, esophageal squamous cell carcinoma, Barretts esophagus, esophageal adenocarcinoma and in NMBA-treated rat esophageal epithelia.
Dr. Wancai Yang from the Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, China & the Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA said, "Esophageal cancer is one of the most common cancer types worldwide and is frequently fatal; 5-year survival is approximately 13%"
The studies from the authors, and others, have revealed the risk susceptibility of the single nucleotide polymorphism of PLCE1 in esophageal carcinoma, they have further shown that the 5780G allele in PLCE participates in the inflammatory process in esophageal epithelium and is associated with esophagitis and esophageal cancer.
Figure 1: mRNA levels of PLCE1 and PRKCA were significantly increased in esophagitis and esophageal squamous cell carcinoma (ESCC). (A) PLCE1 and PRKCA mRNA levels were increased in esophagitis, in comparison with their matched normal mucosa. (N, the number of patients.) (B) PLCE1 and PRKCA mRNA was significantly elevated in severe esophagitis tissues than those in the mild or moderate esophagitis. (N, the number of patients in each group.) (C) PLCE1 and PRKCA mRNA levels were increased in ESCC, compared to the adjacent normal esophageal mucosa (17 patients in each group).
The Research Team concluded, "this study has demonstrated that PRKCA is involved in initiation and progression of esophageal epithelium inflammation, Barretts esophagus, and carcinogenesis, in terms of significantly increased expression along with PLCE1 and cytokines in esophagitis, Barretts esophagus, esophageal squamous cell carcinoma and adenocarcinoma, and in NMBA-treated rat esophageal epithelia, and it was decreased in mouse esophageal epithelia of PLCE1-deficient mouse model.
Based on the model of esophagitis initiation and progression, we hypothesized that PRKCA might form a partnership and close correlation with PLCE1 along with the whole process of esophageal inflammation initiation, progression and tumorigenesis.
Moreover, the expression levels, partnership or correlation of PLCE1 and PRKCA are also associated with ESCC patient outcome, for instance, low expression of both PLCE1 and PRKCA exhibited better survival of ESCC patients, but high expression of both PLCE1 and PRKCA showed the worst outcomes."
Full text - https://doi.org/10.18632/oncotarget.16635
Correspondence to - Wancai Yang - [email protected]
Keywords - esophagitis, Barrett's esophagus, squamous cell carcinoma, adenocarcinoma, PLCE1
