Lck activation: puzzling the pieces together

Immune control in chronic myeloid leukemia

SMX makes the cut in genome stability

Avelumab demonstrates promise in advanced NSCLC

Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

Prognostic effect of adjuvant chemoradiotherapy for patients with gastric cancer: an updated evidence of randomized controlled trials

Mutational profile of primary breast diffuse large B-cell lymphoma

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism

GUCY2C maintains intestinal LGR5⁺ stem cells by opposing ER stress

Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers

Delineating the distinct role of AKT in mediating cell survival and proliferation induced by CD154 and IL-4/IL-21 in chronic lymphocytic leukemia

Efficacy and toxicity of image-guided intensity-modulated radiation therapy combined with dose-escalated brachytherapy for stage IIB cervical cancer

Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway

Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α

LincRNA FEZF1-AS1 contributes to the proliferation of LAD cells by silencing p57 expression

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer

Identification of SPOP related metabolic pathways in prostate cancer

Treatment and survival outcomes of lobular carcinoma in situ of the breast: a SEER population based study

Optimization of EGFR mutation detection by the fully-automated qPCR-based Idylla system on tumor tissue from patients with non-small cell lung cancer

Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma

Neutrophil-to-lymphocyte ratio predicts survival in European patients with hepatocellular carcinoma administered sorafenib

Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6

A framework for exploring associations between biomedical terms in PubMed

Predictors of overall survival in metastatic castration-resistant prostate cancer patients receiving [¹⁷⁷Lu]Lu-PSMA-617 radioligand therapy

Predictive clinical parameters for the response of nivolumab in pretreated advanced non-small-cell lung cancer

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy

Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B

Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury

Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling

A niche that triggers aggressiveness within BRCA1-IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment

PIK3CA^H1047R-induced paradoxical ERK activation results in resistance to BRAF^V600E specific inhibitors in BRAF^V600E PIK3CA^H1047R double mutant thyroid tumors

Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome

Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury

MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells

Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis, splenomegaly and with a shorter median time to disease progression

Anti-NY-ESO-1 autoantibody may be a tumor marker for intrahepatic cholangiocarcinoma

Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics

Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy

Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma

A prognostic 4-gene expression signature for patients with HER2-negative breast cancer receiving taxane and anthracycline-based chemotherapy

Characterization of epithelial-mesenchymal transition intermediate/hybrid phenotypes associated to resistance to EGFR inhibitors in non-small cell lung cancer cell lines

HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway

Prioritizing chronic obstructive pulmonary disease (COPD) candidate genes in COPD-related networks

Evaluation of the association of UBASH3A and SYNGR1 with rheumatoid arthritis and disease activity and severity in Han Chinese

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma and its association with PD-L1 expression

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy

IGF-1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines

The association of triglycerides and total cholesterol concentrations with newly diagnosed diabetes in adults in China

Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis

Marital status and survival in patients with non-small cell lung cancer: an analysis of 70006 patients in the SEER database

A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/albumin ratio

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer

CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer

STAT3-mediated activation of miR-21 is involved in downregulation of TIMP3 and neovascularization in the ischemic retina

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

IL-22 promotes the progression of breast cancer through regulating HOXB-AS5

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia

Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer

The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation

Multi-omics analyses of red blood cell reveal antioxidation mechanisms associated with hemolytic toxicity of gossypol

Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer

Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model

Fusion of the genes ataxin 2 like, ATXN2L, and Janus kinase 2, JAK2, in cutaneous CD4 positive T-cell lymphoma

SAMMSON drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/β-catenin activation

Ruxolitinib combined with vorinostat suppresses tumor growth and alters metabolic phenotype in hematological diseases

Dihydroartemisinin inhibits EMT induced by platinum-based drugs via Akt–Snail pathway

LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells

Is there a difference in testosterone levels and its regulators in men carrying BRCA mutations?

Interaction and joint effect of ALT and chronic liver disease on liver cancer in type 2 diabetes patients

Elevated serum urate is a potential factor in reduction of total bilirubin: a Mendelian randomization study

Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

“Paradoxical” findings of tumor vascularity and oxygenation in recurrent glioblastomas refractory to bevacizumab

Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma

Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method

PARP inhibition causes premature loss of cohesion in cancer cells

Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma

LPI-NRLMF: lncRNA-protein interaction prediction by neighborhood regularized logistic matrix factorization

Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop

Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53

Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma

Kv4.3 expression reverses I_Ca remodeling in ventricular myocytes of heart failure

Combination therapy with capecitabine and temozolomide in patients with low and high grade neuroendocrine tumors, with an exploratory analysis of O⁶-methylguanine DNA methyltransferase as a biomarker for response

Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore

The WAVE3-YB1 interaction regulates cancer stem cells activity in breast cancer

Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo

Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway

Genomic variations in paired normal controls for lung adenocarcinomas

Pattern of p53 protein expression is predictive for survival in chemoradiotherapy-naive esophageal adenocarcinoma

Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis

Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab

Long non-coding RNA ZFAS1 sponges miR-486 to promote osteosarcoma cells progression and metastasis in vitro and vivo

Deletion of resistin-like molecule-beta attenuates angiotensin II-induced abdominal aortic aneurysm

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells

Overexpression of miR-216b sensitizes NSCLC cells to cisplatin-induced apoptosis by targeting c-Jun

Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade

Preoperative prediction of hepatocellular carcinoma with portal vein tumor thrombus based on conventional data

The significance of eosinophils in predicting the severity of acute ischemic stroke

Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

A PiggyBac mediated approach for lactoferricin gene transfer in bovine mammary epithelial stem cells for management of bovine mastitis

GEJ cancers: gastric or esophageal tumors? searching for the answer according to molecular identity

Dynamic changes in the cell membrane on three dimensional low coherent quantitative phase microscopy (3D LC-QPM) after treatment with the near infrared photoimmunotherapy

Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice

EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner

Therapeutic effects of the euglenoid ichthyotoxin, euglenophycin, in colon cancer

Inhibition of microRNA-218 reduces HIF-1α by targeting on Robo1 in mice aortic endothelial cells under intermittent hypoxia

Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells

Predicting survival time of lung cancer patients using radiomic analysis

ETS1, nucleolar and non-nucleolar TERT expression in nevus to melanoma progression

Human glioma stem-like cells induce malignant transformation of bone marrow mesenchymal stem cells by activating TERT expression

High frequency of radiological differential responses with poly(ADP-Ribose) polymerase (PARP) inhibitor therapy

Radiomic analysis in contrast-enhanced CT: predict treatment response to chemoradiotherapy in esophageal carcinoma

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)

Prognostic impact of multimorbidity in patients with type 2 diabetes and ST-elevation myocardial infarction

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)

Neuroprotective effects of allicin on ischemia-reperfusion brain injury

hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC

Human CRL4^DDB2 ubiquitin ligase preferentially regulates post-repair chromatin restoration of H3K56Ac through recruitment of histone chaperon CAF-1

Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment

Comparison of repeated surgical resection and radiofrequency ablation for small recurrent hepatocellular carcinoma after primary resection

Sex differences in outcomes and risk factors among elderly patients with ischemic stroke

Effect of postoperative analgesia technique on the prognosis of gastric cancer: a retrospective analysis

Improved glycemic control with proximal intestinal bypass and weight loss following gastrectomy in non-obese diabetic gastric cancer patients

Current diagnostics and treatment of fibrosarcoma –perspectives for future therapeutic targets and strategies

Testicular cancer from diagnosis to epigenetic factors

Advances in the understanding and management of T-cell prolymphocytic leukemia

Tumor-derived exosomes in ovarian cancer – liquid biopsies for early detection and real-time monitoring of cancer progression