Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb

Analytic validation and real-time clinical application of an amplicon-based targeted gene panel for advanced cancer

Identification of potential long non-coding RNA biomarkers associated with the progression of colon cancer

MiR-26a contributes to the PDGF-BB-induced phenotypic switch of vascular smooth muscle cells by suppressing Smad1

Nicotine induces EP4 receptor expression in lung carcinoma cells by acting on AP-2α: The intersection between cholinergic and prostanoid signaling

A nation-wide multicenter 10-year (1999–2008) retrospective study of chemotherapy in Chinese breast cancer patients

Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model

Thrombospondin-1 promotes cell migration, invasion and lung metastasis of osteosarcoma through FAK dependent pathway

Somatic mutations in salivary duct carcinoma and potential therapeutic targets

Radiotherapy prolongs the survival of advanced non-small-cell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev)

Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner

Up-regulation of IRF-3 expression through GATA-1 acetylation by histone deacetylase inhibitor in lung adenocarcinoma A549 cells

Circulating microparticles are prognostic biomarkers in advanced non-small cell lung cancer patients

Exosomes containing differential expression of microRNA and mRNA in osteosarcoma that can predict response to chemotherapy

Genetic risk score to predict biochemical recurrence after radical prostatectomy in prostate cancer: prospective cohort study

The pVHL₁₇₂ isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13

NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients

Long noncoding RNA XIST promotes malignancies of esophageal squamous cell carcinoma via regulation of miR-101/EZH2

Chemosensitivity-directed therapy compared to dacarbazine in chemo-naive advanced metastatic melanoma: a multicenter randomized phase-3 DeCOG trial

CD133-targeted oncolytic adenovirus demonstrates anti-tumor effect in colorectal cancer

Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells

Diagnosis of nonexophytic nasopharyngeal lesion with endoscopy-guided core needle biopsy after narrow band imaging

Gamma analysis with a gamma criterion of 2%/1 mm for stereotactic ablative radiotherapy delivered with volumetric modulated arc therapy technique: a single institution experience

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

The correlation of neutrophil-to-lymphocyte ratio with the presence and activity of myasthenia gravis

Metabolic pathway for the universal fluorescent recognition of tumor cells

Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway

Assessment of anti-MDA5 antibody as a diagnostic biomarker in patients with dermatomyositis-associated interstitial lung disease or rapidly progressive interstitial lung disease

Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate

Long non-coding RNA MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p

Inhibitory effect of caveolin-1 in vascular endothelial cells, pericytes and smooth muscle cells

A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells

KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population

Cerebral blood flow changes in remitted early- and late-onset depression patients

Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells

Elevated serum interleukin-10 level and M2 macrophage infiltration are associated with poor survival in angioimmunoblastic T-cell lymphoma

Integration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species

Evaluating oral epithelial dysplasia classification system by near-infrared Raman spectroscopy

Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway

Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway

Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases

G2/M checkpoint plays a vital role at the early stage of HCC by analysis of key pathways and genes

Genes encoding neuropeptide receptors are epigenetic markers in patients with head and neck cancer: a site-specific analysis

Low BUB1 expression is an adverse prognostic marker in gastric adenocarcinoma

Prohibitin, relocated to the front ends, can control the migration directionality of colorectal cancer cells

The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population

Flt-1-positive cells are cancer-stem like cells in colorectal carcinoma

Berberine and cinnamaldehyde together prevent lung carcinogenesis

Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells

Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis

Expression of EZH2 in uveal melanomas patients and associations with prognosis

Enhanced antitumor effect of biodegradable cationic heparin-polyethyleneimine nanogels delivering FILIP1L∆C103 gene combined with low-dose cisplatin on ovarian cancer

Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure

Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo

Fiber-modified hexon-chimeric oncolytic adenovirus targeting cancer associated fibroblasts inhibits tumor growth in gastric carcinoma

Phosphatidylinositol 3-kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer cells

The interaction effect of rs4077515 and rs17019602 increases the susceptibility to IgA nephropathy

Cancer cell line specific co-factors modulate the FOXM1 cistrome

Protective cellular immunity generated by cross-presenting recombinant overlapping peptide proteins

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells

The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss

Functional consequence of the p53 codon 72 polymorphism in colorectal cancer

Paradoxical effects of ¹³⁷Cs irradiation on pharmacological stimulation of reactive oxygen species in hippocampal slices from apoE2 and apoE4 mice

Breast cancer induced nociceptor aberrant growth and collateral sensory axonal branching

Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α

Investigation of Cytotoxic T-lymphocyte antigen-4 polymorphisms in non-small cell lung cancer: a case-control study

Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors

Long non-coding RNA HNF1A-AS1 promotes proliferation and suppresses apoptosis of bladder cancer cells through upregulating Bcl-2

Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis

Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells

Combination immunohistochemistry for SMAD4 and Runt-related transcription factor 3 may identify a favorable prognostic subgroup of pancreatic ductal adenocarcinomas

Establishment and characterization of patient-derived xenograft models of gastrointestinal stromal tumor resistant to standard tyrosine kinase inhibitors

Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer

Glasgow prognostic score is superior to other inflammation-based scores in predicting survival of diffuse large B-cell lymphoma

Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03

Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α

Changes of Foxo3a in PBMCs and its associations with stress hyperglycemia in acute obstructive suppurative cholangitis patients

Alu hypomethylation and MGMT hypermethylation in serum as biomarkers of glioma

Prognostic value of chemotherapy in addition to concurrent chemoradiotherapy in T3-4N0-1 nasopharyngeal carcinoma: a propensity score matching study

Prognostic value of integrin variants and expression in post-operative patients with HBV-related hepatocellular carcinoma

Genetic variations in TERC and TERT genes are associated with renal cell carcinoma risk in a Chinese Han population

Ascites-derived IL-6 and IL-10 synergistically expand CD14⁺HLA-DR^-/low myeloid-derived suppressor cells in ovarian cancer patients

Mechanism of genistein regulating the differentiation of vascular smooth muscle cells into osteoblasts via the OPG/RANKL pathway

Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring

PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt’s lymphoma

Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide

The conjugated antimetabolite 5-FdU-ECyd and its cellular and molecular effects on platinum-sensitive vs. -resistant ovarian cancer cells in vitro

The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells

Glyoxalase 1 copy number variation in patients with well differentiated gastro-entero-pancreatic neuroendocrine tumours (GEP-NET)

The prognostic significance of combined androgen receptor, E-Cadherin, Ki67 and CK5/6 expression in patients with triple negative breast cancer

Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia

TCF7L2 rs290481 T>C polymorphism is associated with an increased risk of type 2 diabetes mellitus and fasting plasma glucose level

The value of detecting immunoglobulin gene rearrangements in the diagnosis of B-cell lymphoma

VEGF stimulated the angiogenesis by promoting the mitochondrial functions

Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer

Glis family proteins are differentially implicated in the cellular reprogramming of human somatic cells

Initial FDG-PET/CT predicts survival in adults Ewing sarcoma family of tumors

Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization

Do patients with oxyphilic cell papillary thyroid carcinoma have a poor prognosis? Analysis of the surveillance, epidemiology, and end results database 2004-2013 with propensity score matching

Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients

Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish

Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer

MLACP: machine-learning-based prediction of anticancer peptides

SHARPIN stabilizes estrogen receptor α and promotes breast cancer cell proliferation

Secreted gelsolin desensitizes and induces apoptosis of infiltrated lymphocytes in prostate cancer

Sitagliptin attenuates high glucose-induced alterations in migration, proliferation, calcification and apoptosis of vascular smooth muscle cells through ERK1/2 signal pathway

Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer

Circulating tumor cells in the differential diagnosis of adnexal masses

DUSP4 is associated with increased resistance against anti-HER2 therapy in breast cancer

Salubrinal attenuated retinal neovascularization by inhibiting CHOP-HIF1α-VEGF pathways

Association between TNIP1, MPHOSPH6 and ZNF208 genetic polymorphisms and the coronary artery disease risk in Chinese Han population

CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/β-catenin signaling pathway

Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines

Hypomethylation associated enhanced transcription of trefoil factor-3 mediates tamoxifen-stimulated oncogenicity of ER+ endometrial carcinoma cells

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties

Sirtuin 7: a new marker of aggressiveness in prostate cancer

Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment

FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression

Gene expression information improves reliability of receptor status in breast cancer patients

MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract

Down-regulation of traditional oncomiRs in plasma of breast cancer patients

Effects of photodynamic therapy on dermal fibroblasts from xeroderma pigmentosum and Gorlin-Goltz syndrome patients

Long noncoding RNA MALAT-1 is a novel inflammatory regulator in human systemic lupus erythematosus

Combination therapy of human umbilical cord mesenchymal stem cells and FTY720 attenuates acute lung injury induced by lipopolysaccharide in a murine model

Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy

Tenomodulin highly expressing MSCs as a better cell source for tendon injury healing

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A

Circulating epithelial cell counts for monitoring the therapeutic outcome of patients with papillary thyroid carcinoma

The prognostic role of nutrition risk score (NRS) in patients with metastatic or recurrent esophageal squamous cell carcinoma (ESCC)

STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway

Lactobacillus reuteri ZJ617 maintains intestinal integrity via regulating tight junction, autophagy and apoptosis in mice challenged with lipopolysaccharide

Chemopreventive effects of atractylenolide II on mammary tumorigenesis via activating Nrf2-ARE pathway

Gene network inherent in genomic big data improves the accuracy of prognostic prediction for cancer patients

Over-expression of protein tyrosine phosphatase 4A2 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

TERT promoter status and gene copy number gains: effect on TERT expression and association with prognosis in breast cancer

A novel Fc-engineered human ICAM-1/CD54 antibody with potent anti-myeloma activity developed by cellular panning of phage display libraries

Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides

Chidamide and decitabine can synergistically induce apoptosis of Hodgkin lymphoma cells by up-regulating the expression of PU.1 and KLF4

Gene-body hypermethylation controlled cryptic promoter and miR26A1-dependent EZH2 regulation of TET1 gene activity in chronic lymphocytic leukemia

The therapeutic effect of bromocriptine in combination with spironolactone in patients with primary aldosteronism: a hypothesis generating pilot study

The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells

The ROS/NF-κB/NR4A2 pathway is involved in H₂O₂ induced apoptosis of resident cardiac stem cells via autophagy

The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1

Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity

Inhibition of endoplasmic reticulum stress alleviates cigarette smoke-induced airway inflammation and emphysema

Contribution of GABAa, GABAc and glycine receptors to rat dark-adapted oscillatory potentials in the time and frequency domain

Association of ADAM12 gene polymorphisms with knee osteoarthritis susceptibility

Protein-bound uremic toxins impaired mitochondrial dynamics and functions

Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis

Prognostic role of neutrophil lymphocyte ratio in patients with spontaneous intracerebral hemorrhage

Expression profiles analysis of long non-coding RNAs identified novel lncRNA biomarkers with predictive value in outcome of cutaneous melanoma

Long-term allograft and patient outcomes of kidney transplant recipients with and without incident cancer – a population cohort study

Promoter methylation of tumor-related genes as a potential biomarker using blood samples for gastric cancer detection

Phytosphingosine exhibits an anti-epithelial–mesenchymal transition function by the inhibition of EGFR signaling in human breast cancer cells

Aberrant rhythmic expression of cryptochrome2 regulates the radiosensitivity of rat gliomas

Lactate stimulates CA IX expression in normoxic cancer cells

Association study of IGFBP1 and IGFBP3 polymorphisms with hypertension and cardio-cerebral vascular diseases in a Chinese Han population

Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy

Impact of microRNA-34a and polymorphism of its target gene CA9 on susceptibility to uterine cervical cancer

Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1

Portal vein resection and reconstruction with artificial blood vessels is safe and feasible for pancreatic ductal adenocarcinoma patients with portal vein involvement: Chinese center experience

Oncogenic driver mutations, treatment, and EGFR-TKI resistance in a Caucasian population with non-small cell lung cancer: survival in clinical practice

Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells

Intake of red and processed meat and risk of renal cell carcinoma: a meta-analysis of observational studies

Carrot intake and incidence of urothelial cancer: a systematic review and meta-analysis

Genetic polymorphisms in pre-miRNAs predict the survival of non-small-cell lung cancer in Chinese population: a cohort study and a meta-analysis

Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis

An association between the endothelial nitric oxide synthase gene G894T polymorphism and premature coronary artery disease: a meta-analysis

Evaluating the prognostic value of miR-148/152 family in cancers: based on a systemic review of observational studies

Effects of alcohol consumption, cigarette smoking, and betel quid chewing on upper digestive diseases: a large cross-sectional study and meta-analysis

Relationship between mitochondrial DNA A10398G polymorphism and Parkinson’s disease: a meta-analysis

Efficacy and safety of bronchoscopic lung volume reduction therapy in patients with severe emphysema: a meta-analysis of randomized controlled trials

Chronic obstructive pulmonary disease and risk of lung cancer: a meta-analysis of prospective cohort studies

Can peripheral blood be used as surrogate in detecting epidermal growth factor receptor mutation status in advanced non-small cell lung cancer patients? A meta-analysis

Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: long term results from a single institution

Meglitinides increase the risk of hypoglycemia in diabetic patients with advanced chronic kidney disease: a nationwide, population-based study

Comparison of the efficacy between intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in stage II nasopharyngeal carcinoma

Clinical significance of MSKCC nomogram on guiding the application of touch imprint cytology and frozen section in intraoperative assessment of breast sentinel lymph nodes

Preoperative vitamin D deficiency and postoperative hypocalcemia in thyroid cancer patients undergoing total thyroidectomy plus central compartment neck dissection

Peritoneal recurrence in gastric cancer following curative resection can be predicted by postoperative but not preoperative biomarkers: a single-institution study of 320 cases

Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity

Elevated serum tartrate-resistant acid phosphatase isoform 5a levels in metabolic syndrome

Nanobubbles as ultrasound contrast agent for facilitating small cell lung cancer imaging

BRAF inhibitors: resistance and the promise of combination treatments for melanoma

Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

Nanoparticle as a novel tool in hyperthermic intraperitoneal and pressurized intraperitoneal aerosol chemotheprapy to treat patients with peritoneal carcinomatosis

The role of substance P in epilepsy and seizure disorders

Chromosomal instability and acquired drug resistance in multiple myeloma