The PI3K-AKT-mTOR pathway activates recovery from general anesthesia

Biochemical and structural characterization of a DNA N⁶-adenine methyltransferase from Helicobacter pylori

4,4’-diaponeurosporene, a C₃₀ carotenoid, effectively activates dendritic cells via CD36 and NF-κB signaling in a ROS independent manner

Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma

NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand

Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia

Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women

Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses

The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer

Interferon regulatory factor 4 attenuates Notch signaling to suppress the development of chronic lymphocytic leukemia

Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5

SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth

Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis

Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated

Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside

Identifying and targeting determinants of melanoma cellular invasion

Autophagy gene expression profiling identifies a defective microtubule-associated protein light chain 3A mutant in cancer

The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer

The impact of ¹⁷⁷Lu-octreotide therapy on ^99mTc-MAG3 clearance is not predictive for late nephropathy

A comparison of R-EPOCH and R-CHOP as a first-line regimen in de novo DLBCL patients with high Ki-67 expression in a single institution

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Absorbable polymeric surgical clips for appendicular stump closure: A randomized control trial of laparoscopic appendectomy with lapro-clips

Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint

Androgen receptor expression predicts different clinical outcomes for breast cancer patients stratified by hormone receptor status

Mesenchymal stem cells promote pancreatic adenocarcinoma cells invasion by transforming growth factor-β1 induced epithelial-mesenchymal transition

microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway

Distinct mechanisms contribute to acquired cisplatin resistance of urothelial carcinoma cells

rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer

Isolation, identification, and characterization of novel nanovesicles

COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo

The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases

Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib

Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer

Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma

Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment

RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma

The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas

Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases

Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy

MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway

Moderate and strong static magnetic fields directly affect EGFR kinase domain orientation to inhibit cancer cell proliferation

EZH2 promotes colorectal cancer stem-like cell expansion by activating p21^cip1-Wnt/β-catenin signaling

Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer

Plasma microRNA panels to diagnose pancreatic cancer: Results from a multicenter study

Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts

Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia

Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: Pathogenesis and therapeutic options

Reactive oxygen species formation and bystander effects in gradient irradiation on human breast cancer cells

Altered glutamine metabolism in platinum resistant ovarian cancer

Lnc-CC3 increases metastasis in cervical cancer by increasing Slug expression

Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

Establishment of a multimarker qPCR panel for the molecular characterization of circulating tumor cells in blood samples of metastatic breast cancer patients during the course of palliative treatment

MET exon 14 skipping defines a unique molecular class of non-small cell lung cancer

Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples

Associations between genetic variants located in mature microRNAs and risk of lung cancer

Inhibition of chronic lymphocytic leukemia progression by full-length chromogranin A and its N-terminal fragment in mouse models

Identification of prognostic biomarkers in glioblastoma using a long non-coding RNA-mediated, competitive endogenous RNA network

GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer

High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma

Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells

Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma

Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination

Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia

A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway

Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma

Viral oncomiR spreading between B and T cells is employed by Kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation

TACC3 promotes colorectal cancer tumourigenesis and correlates with poor prognosis

Altered splicing leads to reduced activation of CPEB3 in high-grade gliomas

Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma

Candidate genes and pathways downstream of PAX8 involved in ovarian high-grade serous carcinoma

Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer

Comparative evaluation of three proliferation markers, Ki-67, TOP2A, and RacGAP1, in bronchopulmonary neuroendocrine neoplasms: Issues and prospects

The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts

High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma

Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer

Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma

Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy

IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib

A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms

The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux

Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer

Opposite prognostic roles of HIF1α and HIF2α expressions in bone metastatic clear cell renal cell cancer

Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo

Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling

Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203

Expression of oncofetal antigen glypican-3 associates significantly with poor prognosis in HBV-related hepatocellular carcinoma

Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205 - PROX1 mechanism

TLR4/ROS/miRNA-21 pathway underlies lipopolysaccharide instructed primary tumor outgrowth in lung cancer patients

Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO

Virus-stimulated neutrophils in the tumor microenvironment enhance T cell-mediated anti-tumor immunity

Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death

Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (CIN3) identifies a new susceptibility locus

Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC)

miR-145 promotes osteosarcoma growth by reducing expression of the transcription factor friend leukemia virus integration 1

Mutation spectrum of TP53 gene predicts clinicopathological features and survival of gastric cancer

miRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer

MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis

Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein

CHES-1-like, the ortholog of a non-obstructive azoospermia-associated gene, blocks germline stem cell differentiation by upregulating Dpp expression in Drosophila testis

Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells

Increased serum levels of betatrophin in pancreatic cancer-associated diabetes

Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D

Glaucarubinone sensitizes KB cells to paclitaxel by inhibiting ABC transporters via ROS-dependent and p53-mediated activation of apoptotic signaling pathways

PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma

Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of Kras mutation-positive, non-small cell lung cancer

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis

Comprehensive analysis of long non-coding RNA expression profiles in hepatitis B virus-related hepatocellular carcinoma

LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway

Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells

MicroRNA-33a-3p suppresses cell migration and invasion by directly targeting PBX3 in human hepatocellular carcinoma

MR molecular imaging of tumors based on an optimal hTERT promoter tyrosinase expression system

Musashi-1 regulates AKT-derived IL-6 autocrinal/paracrinal malignancy and chemoresistance in glioblastoma

Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma

Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling

WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck

Emerging role of LOXL2 in the promotion of pancreas cancer metastasis

Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas

Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factor-β1

Automatic segmentation software in locally advanced rectal cancer: READY (REsearch program in Auto Delineation sYstem)-RECTAL 02: prospective study

Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer

Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence

NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative atrial fibrillation: a prospective study among Chinese population

Phase I study of pemetrexed with sorafenib in advanced solid tumors

Percutaneous computed tomography-guided cryoablation for recurrent retroperitoneal soft tissue sarcoma: a study of safety and efficacy

The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China

MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia

Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy

The biology of DHX9 and its potential as a therapeutic target

Cancer drug resistance: redox resetting renders a way

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma

Osteoprotegerin rich tumor microenvironment: implications in breast cancer

FOXM1 in sarcoma: role in cell cycle, pluripotency genes and stem cell pathways

Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing