Oncotarget

Vol 9, No 33

May 1, 2018

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About The Cover

The cover for issue 33 of Oncotarget features Figure 7A, "Anti-STn ADCs impede OvCa xenograft growth in vivo and target STn+ cells," from Starbuck, et al.


Table of Contents

Research Papers

SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia

SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.25089

Jolanda Sarno, Angela M. Savino, Chiara Buracchi, Chiara Palmi, Stefania Pinto, Cristina Bugarin, Astraea Jager, Silvia Bresolin, Ruth C. Barber, Daniela Silvestri, Shai Israeli, Martin J.S. Dyer, Giovanni Cazzaniga, Garry P. Nolan, Andrea Biondi, Kara L. Davis,  and Giuseppe Gaipa
22872-22885
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of KIT gene mutations in patients with melanoma of the head and neck mucosa: a retrospective clinical report

Analysis of KIT gene mutations in patients with melanoma of the head and neck mucosa: a retrospective clinical report

https://doi.org/10.18632/oncotarget.25094

Ullyanov Bezerra Toscano de Mendonça, Claudio Roberto Cernea, Leandro Luongo Matos,  and Roberto Rego Monteiro de Araujo Lima
22886-22894
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Comprehensive molecular analysis based on somatic copy number alterations in intramucosal colorectal neoplasias and early invasive colorectal cancers

Comprehensive molecular analysis based on somatic copy number alterations in intramucosal colorectal neoplasias and early invasive colorectal cancers

https://doi.org/10.18632/oncotarget.25112

Tamotsu Sugai, Makoto Eizuka, Wataru Habano, Yasuko Fujita, Ayaka Sato, Ryo Sugimoto, Kouki Otsuka, Eiichiro Yamamoto, Takayuki Matsumoto,  and Hiromu Suzuki
22895-22906
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Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk

Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk

https://doi.org/10.18632/oncotarget.25144

Angela Gutierrez-Camino, Idoia Martin-Guerrero, Vita Dolza, Janez Jazbec, Ana Carbone-Bañeres, Nagore Garcia de Andoin, Ana Sastre, Itziar Astigarraga, Aurora Navajas,  and Africa Garcia-Orad
22907-22914
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

YdjC chitooligosaccharide deacetylase homolog induces keratin reorganization in lung cancer cells: involvement of interaction between YDJC and CDC16

YdjC chitooligosaccharide deacetylase homolog induces keratin reorganization in lung cancer cells: involvement of interaction between YDJC and CDC16

https://doi.org/10.18632/oncotarget.25145

Eun Ji Kim, Mi Kyung Park, Hyun Jung Byun, Gyeoung Jin Kang, Lu Yu, Hyun Ji Kim, Jae Gal Shim, Ho Lee,  and Chang Hoon Lee
22915-22928
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Disturbed alternative splicing of FIR (PUF60) directed cyclin E overexpression in esophageal cancers

Disturbed alternative splicing of FIR (PUF60) directed cyclin E overexpression in esophageal cancers

https://doi.org/10.18632/oncotarget.25149

Yukiko Ogura, Tyuji Hoshino, Nobuko Tanaka, Guzhanuer Ailiken, Sohei Kobayashi, Kouichi Kitamura, Bahityar Rahmutulla, Masayuki Kano, Kentarou Murakami, Yasunori Akutsu, Fumio Nomura, Sakae Itoga, Hisahiro Matsubara,  and Kazuyuki Matsushita
22929-22944
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression

Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression

https://doi.org/10.18632/oncotarget.25159

Hayley Pye, Mohammed Adil Butt, Laura Funnell, Halla W. Reinert, Ignazio Puccio, Saif U. Rehman Khan, Savvas Saouros, Jared S. Marklew, Ioanna Stamati, Maryam Qurashi, Rehan Haidry, Vinay Sehgal, Dahmane Oukrif, Michael Gandy, Hayley C. Whitaker, Manuel Rodriguez-Justo, Marco Novelli, Rifat Hamoudi, Gokhan Yahioglu, Mahendra P. Deonarain,  and Laurence B. Lovat
22945-22959
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer

Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer

https://doi.org/10.18632/oncotarget.25160

Emily E. Bosco, R. James Christie, Rosa Carrasco, Darrin Sabol, Jiping Zha, Karma DaCosta, Lee Brown, Maureen Kennedy, John Meekin, Sandrina Phipps, Joanne Ayriss, Qun Du, Binyam Bezabeh, Partha Chowdhury, Shannon Breen, Cui Chen, Molly Reed, MaryJane Hinrichs, Haihong Zhong, Zhan Xiao, Rakesh Dixit, Ronald Herbst,  and David A. Tice
22960-22975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Carbon ion radiotherapy for inoperable pediatric osteosarcoma

Carbon ion radiotherapy for inoperable pediatric osteosarcoma

https://doi.org/10.18632/oncotarget.25165

Osama Mohamad, Reiko Imai, Tadashi Kamada, Yuki Nitta, Nobuhito Araki,  and the Working Group for Bone and Soft Tissue Sarcoma
22976-22985
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Combination of two anti-tubulin agents, eribulin and paclitaxel, enhances anti-tumor effects on triple-negative breast cancer through mesenchymal-epithelial transition

Combination of two anti-tubulin agents, eribulin and paclitaxel, enhances anti-tumor effects on triple-negative breast cancer through mesenchymal-epithelial transition

https://doi.org/10.18632/oncotarget.25184

Takaaki Oba,  and Ken-Ichi Ito
22986-23002
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma

Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma

https://doi.org/10.18632/oncotarget.25190

Takashi Sakaguchi, Hirofumi Yoshino, Satoshi Sugita, Kazutaka Miyamoto, Masaya Yonemori, Yoichi Osako, Makiko Meguro-Horike, Shin-ichi Horike, Masayuki Nakagawa,  and Hideki Enokida
23003-23017
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST

Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST

https://doi.org/10.18632/oncotarget.25195

Hsiang-Chih Lu, Vanessa Eulo, Anthony J. Apicelli, Melike Pekmezci, Yu Tao, Jingqin Luo, Angela C. Hirbe,  and Sonika Dahiya
23018-23028
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

https://doi.org/10.18632/oncotarget.25196

Lydia A. Hepburn, Angela McHugh, Kenneth Fernandes, Garry Boag, Charlotte M. Proby, Irene M. Leigh,  and Mark K. Saville
23029-23046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Risk-stratified surveillance protocol improves cost-effectiveness after radical nephroureterectomy in patients with upper tract urothelial carcinoma

Risk-stratified surveillance protocol improves cost-effectiveness after radical nephroureterectomy in patients with upper tract urothelial carcinoma

https://doi.org/10.18632/oncotarget.25198

Masaki Momota, Shingo Hatakeyama, Hayato Yamamoto, Hiromichi Iwamura, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Ikuya Iwabuchi, Masaru Ogasawara, Toshiaki Kawaguchi,  and Chikara Ohyama
23047-23057
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncodriver inhibition and CD4+ Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies

Oncodriver inhibition and CD4+ Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies

https://doi.org/10.18632/oncotarget.25208

Cinthia Rosemblit, Jashodeep Datta, Lea Lowenfeld, Shuwen Xu, Amrita Basu, Krithika Kodumudi, Doris Wiener,  and Brian J. Czerniecki
23058-23077
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma

Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.25212

Keith Unger, Khyati Y. Mehta, Prabhjit Kaur, Yiwen Wang, Smrithi S. Menon, Shreyans K. Jain, Rose A. Moonjelly, Shubhankar Suman, Kamal Datta, Rajbir Singh, Paul Fogel,  and Amrita K. Cheema
23078-23090
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Abundance of TRAIL attenuated by HIF2α and c-FLIP affects malignancy in renal cell carcinomas

Abundance of TRAIL attenuated by HIF2α and c-FLIP affects malignancy in renal cell carcinomas

https://doi.org/10.18632/oncotarget.25214

Takahiro Isono, Tokuhiro Chano, Tetsuya Yoshida, Susumu Kageyama, Akihiro Kawauchi, Junji Yonese,  and Takeshi Yuasa
23091-23101
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A targeted transforming growth factor-beta (TGF-β) blocker, TTB, inhibits tumor growth and metastasis

A targeted transforming growth factor-beta (TGF-β) blocker, TTB, inhibits tumor growth and metastasis

https://doi.org/10.18632/oncotarget.24562

Changhua Zhou, Jing Li, Limin Lin, Rui Shu, Bin Dong, Donglin Cao, Qing Li,  and Zhong Wang
23102-23113
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of increased primary breast tumor AGR2 with decreased disease-specific survival

Association of increased primary breast tumor AGR2 with decreased disease-specific survival

https://doi.org/10.18632/oncotarget.25225

Phoebe Ann, Brandon-Luke L. Seagle, Arunima Shilpi, Manoj Kandpal,  and Shohreh Shahabi
23114-23125
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential prognostic impact of interleukin-34 mRNA expression and infiltrating immune cell composition in intrinsic breast cancer subtypes

Differential prognostic impact of interleukin-34 mRNA expression and infiltrating immune cell composition in intrinsic breast cancer subtypes

https://doi.org/10.18632/oncotarget.25226

Karin Zins, Gerwin Heller, Mathias Mayerhofer, Martin Schreiber,  and Dietmar Abraham
23126-23148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1

SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1

https://doi.org/10.18632/oncotarget.25234

Margit Schwartz, Sabine Böckmann, Philipp Borchert,  and Burkhard Hinz
23149-23163
Abstract  |  PDF  |  HTML  |  Order a Reprint

Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma

Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma

https://doi.org/10.18632/oncotarget.25248

Kohei Nakamura, Kentaro Nakayama, Noriyoshi Ishikawa, Toshiko Minamoto, Tomoka Ishibashi, Kaori Ohnishi, Hitomi Yamashita, Ruriko Ono, Hiroki Sasamori, Sultana Razia, Mohammad Mahmud Hossain, Shanta Kamrunnahar, Masako Ishikawa,  and Satoru Kyo
23164-23172
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gene expression profiling in prognosis of distant recurrence in HR-positive and HER2-negative breast cancer patients

Gene expression profiling in prognosis of distant recurrence in HR-positive and HER2-negative breast cancer patients

https://doi.org/10.18632/oncotarget.25258

Tzu-Ting Huang, Nicolas Pennarun, Yu-Hao Cheng, Cheng-Fang Horng, Jason Lei,  and Skye Hung-Chun Cheng
23173-23182
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RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

https://doi.org/10.18632/oncotarget.25259

Sarita Rani Patnaik, Xun Zhang, Lincoln Biswas, Saeed Akhtar, Xinzhi Zhou, Deva Krupakar Kusuluri, James Reilly, Helen May-Simera, Susan Chalmers, John McCarron,  and Xinhua Shu
23183-23197
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation

DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation

https://doi.org/10.18632/oncotarget.25269

Takashi Nishizawa, Kiyotaka Nakano, Aya Harada, Miwako Kakiuchi, Shin-Ichi Funahashi, Masami Suzuki, Shumpei Ishikawa,  and Hiroyuki Aburatani
23198-23207
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer

https://doi.org/10.18632/oncotarget.25292

Caroline Spasojevic, Elisabetta Marangoni, Sophie Vacher, Franck Assayag, Didier Meseure, Sophie Château-Joubert, Martine Humbert, Manale Karam, Jean Marc Ricort, Christian Auclair, Marie Regairaz,  and Ivan Bièche
23208-23219
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MAP4K4 controlled integrin β1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells

MAP4K4 controlled integrin β1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells

https://doi.org/10.18632/oncotarget.25294

Dimitra Tripolitsioti, Karthiga Santhana Kumar, Anuja Neve, Jessica Migliavacca, Charles Capdeville, Elisabeth J. Rushing, Min Ma, Noriyuki Kijima, Ashish Sharma, Martin Pruschy, Scott McComb, Michael D. Taylor, Michael A. Grotzer,  and Martin Baumgartner
23220-23236
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma

Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.25296

Toshiyuki Kobayashi, Atsushi Shiozaki, Yoshito Nako, Daisuke Ichikawa, Toshiyuki Kosuga, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Eiichi Konishi, Yoshinori Marunaka,  and Eigo Otsuji
23237-23252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-34a, miR-424 and miR-513 inhibit MMSET expression to repress endometrial cancer cell invasion and sphere formation

miR-34a, miR-424 and miR-513 inhibit MMSET expression to repress endometrial cancer cell invasion and sphere formation

https://doi.org/10.18632/oncotarget.25298

Peixin Dong, Ying Xiong, Junming Yue, Sharon J.B. Hanley,  and Hidemichi Watari
23253-23263
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Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis

Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis

https://doi.org/10.18632/oncotarget.25297

William P. Bozza, Yaqin Zhang,  and Baolin Zhang
23264-23273
Abstract  |  PDF  |  HTML  |  Order a Reprint

The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells

The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells

https://doi.org/10.18632/oncotarget.25299

Arindam Banerjee, Pardis Arvinrad, Matthew Darley, Stéphanie A. Laversin, Rachel Parker, Matthew J.J. Rose-Zerilli, Paul A. Townsend, Ramsey I. Cutress, Stephen A. Beers, Franchesca D. Houghton, Charles N. Birts,  and Jeremy P. Blaydes
23274-23288
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau

Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau

https://doi.org/10.18632/oncotarget.25289

Kristen Starbuck, Linah Al-Alem, David A. Eavarone, Silvia Fatima Hernandez, Chiara Bellio, Jillian M. Prendergast, Jenna Stein, Daniel T. Dransfield, Bianca Zarrella, Whitfield B. Growdon, Jeff Behrens, Rosemary Foster,  and Bo R. Rueda
23289-23305
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Reviews

Cancer stem cells of hepatocellular carcinoma

Cancer stem cells of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.24623

Kewei Wang,  and Dianjun Sun
23306-23314
Abstract  |  PDF  |  HTML  |  Order a Reprint

Case Reports

A case of ALK-rearranged non–small cell lung cancer that responded to ceritinib after development of resistance to alectinib

A case of ALK-rearranged non–small cell lung cancer that responded to ceritinib after development of resistance to alectinib

https://doi.org/10.18632/oncotarget.25143

Yosuke Makuuchi, Hidetoshi Hayashi, Koji Haratani, Junko Tanizaki, Kaoru Tanaka, Masayuki Takeda, Kazuko Sakai, Shigeki Shimizu, Akihiko Ito, Kazuto Nishio,  and Kazuhiko Nakagawa
23315-23319
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