Oncotarget

Vol 9, No 19

March 13, 2018

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About The Cover

The cover for issue 19 of Oncotarget features Figure 1, "Patient clinical course throughout a four year period," from Wolff, et al.

Table of Contents

Priority Research Papers

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response

https://doi.org/10.18632/oncotarget.10819

Xiaobin Zheng, Neal Andruska, Michael J. Lambrecht, Sisi He, Amadeo Parissenti, Paul J. Hergenrother, Erik R. Nelson,  and David J. Shapiro
14741-14753
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Research Papers: Chromosome

Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients

Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients

https://doi.org/10.18632/oncotarget.24546

Masako Ishikawa, Kentaro Nakayama, Kohei Nakamura, Ruriko Ono, Kaori Sanuki, Hitomi Yamashita, Tomoka Ishibashi, Toshiko Minamoto, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa,  and Satoru Kyo
14754-14763
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Research Papers

Dynamic changes during the treatment of pancreatic cancer

Dynamic changes during the treatment of pancreatic cancer

https://doi.org/10.18632/oncotarget.24483

Robert A. Wolff, Andrea Wang-Gillam, Hector Alvarez, Hervé Tiriac, Dannielle Engle, Shurong Hou, Abigail F. Groff, Anthony San Lucas, Vincent Bernard, Kelvin Allenson, Jonathan Castillo, Dong Kim, Feven Mulu, Jonathan Huang, Bret Stephens, Ignacio I. Wistuba, Matthew Katz, Gauri Varadhachary, YoungKyu Park, James Hicks, Arul Chinnaiyan, Louis Scampavia, Timothy Spicer, Chiara Gerhardinger, Anirban Maitra, David Tuveson, John Rinn, Gregory Lizee, Cassian Yee,  and Arnold J. Levine
14764-14790
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Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells

Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells

https://doi.org/10.18632/oncotarget.9462

Marije J. Veenstra, Peter M. van Koetsveld, Fadime Dogan, William E. Farrell, Richard A. Feelders, Steven W.J. Lamberts, Wouter W. de Herder, Giovanni Vitale,  and Leo J. Hofland
14791-14802
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Regulatory B cells induced by pancreatic cancer cell-derived interleukin-18 promote immune tolerance via the PD-1/PD-L1 pathway

Regulatory B cells induced by pancreatic cancer cell-derived interleukin-18 promote immune tolerance via the PD-1/PD-L1 pathway

https://doi.org/10.18632/oncotarget.22976

Yan Zhao, Ming Shen, Yecheng Feng, Ruizhi He, Xiaodong Xu, Yu Xie, Xiuhui Shi, Min Zhou, Shutao Pan, Min Wang, Xingjun Guo,  and Renyi Qin
14803-14814
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RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma

RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.24079

Xia Wu, Yingzhuo Yang, Yike Huang, Yang Chen, Tianying Wang, Shuo Wu, Lei Tong, Yan Wang, Lexun Lin, Meili Hao, Zhao-Hua Zhong, Fengmin Zhang,  and Wenran Zhao
14815-14827
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Developing a genetic signature to predict drug response in ovarian cancer

Developing a genetic signature to predict drug response in ovarian cancer

https://doi.org/10.18632/oncotarget.23663

Stephen Hyter, Jeff Hirst, Harsh Pathak, Ziyan Y. Pessetto, Devin C. Koestler, Rama Raghavan, Dong Pei,  and Andrew K. Godwin
14828-14848
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Effects of carbon ion beam alone or in combination with cisplatin on malignant mesothelioma cells in vitro

Effects of carbon ion beam alone or in combination with cisplatin on malignant mesothelioma cells in vitro

https://doi.org/10.18632/oncotarget.23756

Sei Sai, Masao Suzuki, Eun Ho Kim, Mitsuhiro Hayashi, Guillaume Vares, Naoyoshi Yamamoto,  and Tadaaki Miyamoto
14849-14861
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Coagulation cascade and complement system in systemic lupus erythematosus

Coagulation cascade and complement system in systemic lupus erythematosus

https://doi.org/10.18632/oncotarget.23206

Yan Liang, Shang-Bo Xie, Chang-Hao Wu, Yuan Hu, Qin Zhang, Si Li, Yin-Guang Fan, Rui-Xue Leng, Hai-Feng Pan, Hua-Bao Xiong,  and Dong-Qing Ye
14862-14881
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Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri

Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri

https://doi.org/10.18632/oncotarget.23957

Xia Wang, Xiaoyuan Du, Yang Zhou, Su Wang, Feng Su,  and Shicui Zhang
14882-14894
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Serum microRNAs as predictors of risk for non-muscle invasive bladder cancer

Serum microRNAs as predictors of risk for non-muscle invasive bladder cancer

https://doi.org/10.18632/oncotarget.24473

Jie Lian, Shu-Hong Lin, Yuanqing Ye, David W. Chang, Maosheng Huang, Colin P. Dinney,  and Xifeng Wu
14895-14908
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Pertuzumab, trastuzumab and eribulin mesylate therapy for previously treated advanced HER2-positive breast cancer: a feasibility study with analysis of biomarkers

Pertuzumab, trastuzumab and eribulin mesylate therapy for previously treated advanced HER2-positive breast cancer: a feasibility study with analysis of biomarkers

https://doi.org/10.18632/oncotarget.24504

Yasutaka Tono, Mikiya Ishihara, Yoshihiro Miyahara, Satoshi Tamaru, Hiroyasu Oda, Yoshiki Yamashita, Isao Tawara, Hiroaki Ikeda, Hiroshi Shiku, Toshiro Mizuno,  and Naoyuki Katayama
14909-14921
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PD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours

PD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours

https://doi.org/10.18632/oncotarget.24464

Angela Lamarca, Daisuke Nonaka, Wolfgang Breitwieser, Garry Ashton, Jorge Barriuso, Mairéad G. McNamara, Sharzad Moghadam, Jane Rogan, Wasat Mansoor, Richard A. Hubner, Christopher Clark, Bipasha Chakrabarty,  and Juan W. Valle
14922-14938
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PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells

PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells

https://doi.org/10.18632/oncotarget.24499

Lorenzo Bazzani, Sandra Donnini, Antonio Giachetti, Gerhard Christofori,  and Marina Ziche
14939-14958
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FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis

FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis

https://doi.org/10.18632/oncotarget.24127

Yarong Zhao, Haiyan Zhu, Haining Wang, Liang Ding, Lizhi Xu, Dai Chen, Sunan Shen, Yayi Hou,  and Huan Dou
14959-14976
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Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

https://doi.org/10.18632/oncotarget.24525

Caitriona O'Connor, Krishna Yalla, Mara Salomé, Hothri Ananyambica Moka, Eduardo Gómez Castañeda, Patrick A. Eyers,  and Karen Keeshan
14977-14992
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Molecular dissection of engraftment in a xenograft model of myelodysplastic syndromes

Molecular dissection of engraftment in a xenograft model of myelodysplastic syndromes

https://doi.org/10.18632/oncotarget.24538

Mathieu Meunier, Charles Dussiau, Natacha Mauz, Anne Sophie Alary, Christine Lefebvre, Gautier Szymanski, Mylène Pezet, Françoise Blanquet, Olivier Kosmider,  and Sophie Park
14993-15000
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A multicenter round robin test of PD-L1 expression assessment in urothelial bladder cancer by immunohistochemistry and RT-qPCR with emphasis on prognosis prediction after radical cystectomy

A multicenter round robin test of PD-L1 expression assessment in urothelial bladder cancer by immunohistochemistry and RT-qPCR with emphasis on prognosis prediction after radical cystectomy

https://doi.org/10.18632/oncotarget.24531

Markus Eckstein, Ralph M. Wirtz, Carolin Pfannstil, Sven Wach, Robert Stoehr, Johannes Breyer, Franziska Erlmeier, Cagatay Günes, Katja Nitschke, Wilko Weichert, Wolfgang Otto, Bastian Keck, Sebastian Eidt, Maximilian Burger, Helge Taubert, Bernd Wullich, Christian Bolenz, Arndt Hartmann,  and Philipp Erben
15001-15014
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma

Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.24551

Fengdan Ye, Dongya Jia, Mingyang Lu, Herbert Levine,  and Michael W. Deem
15015-15026
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Umbilical cord blood mononuclear cell therapy induces clinical remission of steroid-dependent or -resistant ulcerative colitis patients

Umbilical cord blood mononuclear cell therapy induces clinical remission of steroid-dependent or -resistant ulcerative colitis patients

https://doi.org/10.18632/oncotarget.24541

Liang Chen, Yuan Gao, Zongmei Zhang, Mingming Sun, Wenjing Yang, Zhanju Liu,  and Xueliang Jiang
15027-15035
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Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway

Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway

https://doi.org/10.18632/oncotarget.24542

Xiong Yuyun, Cheng Xi, Yin Qing, Xia Lin, Rui Ke,  and Sun Bingwei
15036-15046
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A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

https://doi.org/10.18632/oncotarget.24587

Liang Xu, Naoto Nagata, Mayumi Nagashimada, Fen Zhuge, Yinhua Ni, Guanliang Chen, Junzo Kamei, Hiroki Ishikawa, Yasuhiko Komatsu, Shuichi Kaneko,  and Tsuguhito Ota
15047-15060
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Role of cooperative groups and funding source in clinical trials supporting guidelines for systemic therapy of breast cancer

Role of cooperative groups and funding source in clinical trials supporting guidelines for systemic therapy of breast cancer

https://doi.org/10.18632/oncotarget.24589

Ariadna Tibau, Geòrgia Anguera, Fernando Andrés-Petrel, Arnoud J. Templeton, Bostjan Seruga, Agustí Barnadas, Eitan Amir,  and Alberto Ocana
15061-15067
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Meta-Analysis

The prognostic value of CXC chemokine receptor 2 (CXCR2) in cancers: a meta-analysis

The prognostic value of CXC chemokine receptor 2 (CXCR2) in cancers: a meta-analysis

https://doi.org/10.18632/oncotarget.23492

Bingbing Qiao, Wenqin Luo, Yanna Liu, Jing Wang, Chuan Liu, Zhao Liu, Sizhe Chen, Jingjing Gu, Xiaolong Qi,  and Tongwei Wu
15068-15076
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The association of 5HT2A and 5HTTLPR polymorphisms with Alzheimer’s disease susceptibility: a meta-analysis with 6945 subjects

The association of 5HT2A and 5HTTLPR polymorphisms with Alzheimer’s disease susceptibility: a meta-analysis with 6945 subjects

https://doi.org/10.18632/oncotarget.23611

Liang Tang, Jianming Li, Huaiqing Luo, Meihua Bao, Ju Xiang, Yiwei Chen,  and Yan Wang
15077-15089
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tooth loss and cancer risk: a dose–response meta analysis of prospective cohort studies

Tooth loss and cancer risk: a dose–response meta analysis of prospective cohort studies

https://doi.org/10.18632/oncotarget.23850

Jun Shi, Weidong Leng, Lunhua Zhao, Cai Deng, Chenli Xu, Jue Wang, Yu Wang,  and Xingchun Peng
15090-15100
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Does antipsychotic drug use increase the risk of long term mortality? A systematic review and meta-analysis of observational studies

Does antipsychotic drug use increase the risk of long term mortality? A systematic review and meta-analysis of observational studies

https://doi.org/10.18632/oncotarget.24120

Chunsong Yang, Zilong Hao, Jinhui Tian, Wei Zhang, Wenting Li, Ling-Li Zhang,  and Fujian Song
15101-15110
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association between the Glutathione-S-transferase T1 null genotype and esophageal cancer susceptibility: a meta-analysis involving 11,163 subjects

Association between the Glutathione-S-transferase T1 null genotype and esophageal cancer susceptibility: a meta-analysis involving 11,163 subjects

https://doi.org/10.18632/oncotarget.24534

Feng He, Changyu Liu, Ruijie Zhang, Zhipeng Hao, Yangkai Li, Ni Zhang,  and Liang Zheng
15111-15121
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Clinical Research Papers

Radial EBUS versus CT-guided needle biopsy for evaluation of solitary pulmonary nodules

Radial EBUS versus CT-guided needle biopsy for evaluation of solitary pulmonary nodules

https://doi.org/10.18632/oncotarget.23952

Wei Wang, Like Yu, Yuchao Wang, Qian Zhang, Chuanzhen Chi, Ping Zhan,  and Chunhua Xu
15122-15131
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reviews

The genes associated with early-onset Alzheimer’s disease

The genes associated with early-onset Alzheimer’s disease

https://doi.org/10.18632/oncotarget.23738

Meng-Hui Dai, Hui Zheng, Ling-Dan Zeng,  and Yan Zhang
15132-15143
Abstract  |  PDF  |  HTML  |  Order a Reprint

Liquid biopsy provides new insights into gastric cancer

Liquid biopsy provides new insights into gastric cancer

https://doi.org/10.18632/oncotarget.24540

Camila Tavares Uchôa Guimarães, Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Caroline Martins Almeida, Thayanne Macedo Pinheiro, Carolina Oliveira Gigek, Sandro Roberto de Araújo Cavallero, Paulo Pimentel Assumpção, Marília Arruda Cardoso Smith, Rommel Rodríguez Burbano,  and Danielle Queiroz Calcagno
15144-15156
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Case Reports

BK virus-associated collecting duct carcinoma of the renal allograft in a kidney-pancreas allograft recipient

BK virus-associated collecting duct carcinoma of the renal allograft in a kidney-pancreas allograft recipient

https://doi.org/10.18632/oncotarget.24552

Myriam Dao, Adrien Pécriaux, Thomas Bessede, Antoine Dürrbach, Charlotte Mussini, Catherine Guettier,  and Sophie Ferlicot
15157-15163
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Corrections

Correction: Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy

Correction: Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy

https://doi.org/10.18632/oncotarget.24689

Philip Carter, Costi Alifrangis, Biancastella Cereser, Pramodh Chandrasinghe, Lisa Del Bel Belluz, Christina Fotopoulou, Andreja Frilling, Thomas Herzog, Nina Moderau, Neha Tabassum, Jonathan Krell,  and Justin Stebbing
15164-15164
Correction  |  PDF

Correction: The benefit of tumor molecular profiling on predicting treatments for colorectal adenocarcinomas

Correction: The benefit of tumor molecular profiling on predicting treatments for colorectal adenocarcinomas

https://doi.org/10.18632/oncotarget.24690

Philip Carter, Costi Alifrangis, Pramodh Chandrasinghe, Biancastella Cereser, Lisa Del Bel Belluz, Cosimo Alex Leo, Nina Moderau, Neha Tabassum, Janindra Warusavitarne, Jonathan Krell,  and Justin Stebbing
15165-15165
Correction  |  PDF

Correction: Does molecular profiling of tumors using the Caris molecular intelligence platform improve outcomes for cancer patients?

Correction: Does molecular profiling of tumors using the Caris molecular intelligence platform improve outcomes for cancer patients?

https://doi.org/10.18632/oncotarget.24691

Philip Carter, Costi Alifrangis, Biancastella Cereser, Pramodh Chandrasinghe, Lisa Del Bel Belluz, Thomas Herzog, Joel Levitan, Nina Moderau, Lee Schwartzberg, Neha Tabassum, Jinrui Wen, Jonathan Krell,  and Justin Stebbing
15166-15166
Correction  |  PDF

Correction: Librarians against scientists: Oncotarget’s lesson

Correction: Librarians against scientists: Oncotarget’s lesson

https://doi.org/10.18632/oncotarget.24692

Mikhail V. Blagosklonny
15167-15167
Correction  |  PDF


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