Oncotarget

Vol 9, No 17

March 2, 2018

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About The Cover

The cover for issue 17 of Oncotarget features Figure 4B, "A comparison of the structural elements comprising human PHGDH, sPHGDH and PHGDH-93. Amino acids involved in hydrogen bond formation to the substrate (*) or cofactor NAD+ (*) are highlighted," from Unterlass, et al.

Table of Contents

Research Papers: Pathology

The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome

The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome

https://doi.org/10.18632/oncotarget.24424

Jean-François Bureau, Patricia Cassonnet, Laura Grange, Julien Dessapt, Louis Jones, Caroline Demeret, Anavaj Sakuntabhai,  and Yves Jacob
13102-13115
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Research Papers: Immunology

Correlation and agreement between eplet mismatches calculated using serological, low-intermediate and high resolution molecular human leukocyte antigen typing methods

Correlation and agreement between eplet mismatches calculated using serological, low-intermediate and high resolution molecular human leukocyte antigen typing methods

https://doi.org/10.18632/oncotarget.24349

Samantha Fidler, Lloyd D’Orsogna, Ashley B. Irish, Joshua R. Lewis, Germaine Wong,  and Wai H. Lim
13116-13124
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IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner

IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner

https://doi.org/10.18632/oncotarget.24442

Romy Loschinski, Martin Böttcher, Andrej Stoll, Heiko Bruns, Andreas Mackensen,  and Dimitrios Mougiakakos
13125-13138
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Research Papers

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer

https://doi.org/10.18632/oncotarget.11487

Judith E. Unterlass, Arnaud Baslé, Timothy J. Blackburn, Julie Tucker, Céline Cano, Martin E.M. Noble,  and Nicola J. Curtin
13139-13153
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Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells

Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells

https://doi.org/10.18632/oncotarget.22743

Hua Chen, Jacson Shen, Edwin Choy, Francis J. Hornicek, Aijun Shan,  and Zhenfeng Duan
13154-13166
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Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells

Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells

https://doi.org/10.18632/oncotarget.23481

Hsin-Pao Chen, Yung-Kuo Lee, Shih Yin Huang, Pei-Chun Shi, Ping-Chi Hsu,  and Chuan-Fa Chang
13167-13180
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Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for anti-epilepsy drug discovery

Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for anti-epilepsy drug discovery

https://doi.org/10.18632/oncotarget.23719

Ze-Jia Cui, Ye-Mao Liu, Qiang Zhu, Jingbo Xia,  and Hong-Yu Zhang
13181-13192
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EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma

EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.24149

Hsin-Yi Lee, Chi-Kuan Chen, Chun-Ming Ho, Szu-Shuo Lee, Chieh-Yu Chang, Kuan-Ju Chen,  and Yuh-Shan Jou
13193-13205
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Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448

Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448

https://doi.org/10.18632/oncotarget.24152

Simeon Cua, Heng Liang Tan, Wey Jia Fong, Angela Chin, Ally Lau, Vanessa Ding, Zhiwei Song, Yuansheng Yang,  and Andre Choo
13206-13221
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The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma

The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.23812

Xiao Zhu, Qingming Kong, Liwei Xie, Zhihong Chen, Hongmei Li, Zhu Zhu, Yongmei Huang, Feifei Lan, Haiqing Luo, Jingting Zhan, Hongrong Ding, Jinli Lei, Qin Xiao, Weiming Fu, Wenguo Fan, Jinfang Zhang,  and Hui Luo
13222-13230
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Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance

Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance

https://doi.org/10.18632/oncotarget.24229

Min Young Lee, Austin Yeon, Muhammad Shahid, Eunho Cho, Vikram Sairam, Robert Figlin, Khae-Hwan Kim,  and Jayoung Kim
13231-13243
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miR-128 inhibits telomerase activity by targeting TERT mRNA

miR-128 inhibits telomerase activity by targeting TERT mRNA

https://doi.org/10.18632/oncotarget.24284

Herlinda Guzman, Katie Sanders, Adam Idica, Aurore Bochnakian, Douglas Jury, Iben Daugaard, Dimitrios G Zisoulis,  and Irene Munk Pedersen
13244-13253
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Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

https://doi.org/10.18632/oncotarget.24285

Maria Peiris-Pagès, Gloria Bonuccelli, Federica Sotgia,  and Michael P. Lisanti
13254-13275
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Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice

Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice

https://doi.org/10.18632/oncotarget.24022

Yong Zou, Xi Chen, Jian Xiao, Dong Bo Zhou, Xiao Xiao Lu, Wei Li, Bin Xie, Xiao Kuang,  and Qiong Chen
13276-13286
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Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma

Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.24324

Masahiro Yamashita, Masahito Ogasawara, Yasushi Kawasaki, Miyuki Niisato, Heisuke Saito, Shuya Kasai, Chihaya Maesawa, Makoto Maemondo,  and Kohei Yamauchi
13287-13300
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Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy

Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy

https://doi.org/10.18632/oncotarget.24327

Naoto Nishii, Hidetake Tachinami, Yuta Kondo, Yulong Xia, Yoshihisa Kashima, Tatsukuni Ohno, Shigenori Nagai, Lixin Li, Walter Lau, Hiroyuki Harada,  and Miyuki Azuma
13301-13312
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CD151 promotes cell metastasis via activating TGF-β1/Smad signaling in renal cell carcinoma

CD151 promotes cell metastasis via activating TGF-β1/Smad signaling in renal cell carcinoma

https://doi.org/10.18632/oncotarget.24028

Yajie Yu, Chao Liang, Shangqian Wang, Jundong Zhu, Chenkui Miao, Yibo Hua, Meiling Bao, Qiang Cao, Chao Qin, Pengfei Shao,  and Zengjun Wang
13313-13323
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Methotrexate sensitizes drug-resistant metastatic melanoma cells to BRAF V600E inhibitors dabrafenib and encorafenib

Methotrexate sensitizes drug-resistant metastatic melanoma cells to BRAF V600E inhibitors dabrafenib and encorafenib

https://doi.org/10.18632/oncotarget.24341

Kayleigh C. Ross, Kevin F. Chin, Daehwan Kim, Christopher D. Marion, Timothy J. Yen,  and Vikram Bhattacharjee
13324-13336
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Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction

Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction

https://doi.org/10.18632/oncotarget.24344

Firli R.P. Dewi, Takahiro Domoto, Masaharu Hazawa, Akiko Kobayashi, Takayuki Douwaki, Toshinari Minamoto,  and Richard W. Wong
13337-13352
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The metal-nonoate Ni(SalPipNONO) inhibits in vitro tumor growth, invasiveness and angiogenesis

The metal-nonoate Ni(SalPipNONO) inhibits in vitro tumor growth, invasiveness and angiogenesis

https://doi.org/10.18632/oncotarget.24350

Valerio Ciccone, Martina Monti, Enrico Monzani, Luigi Casella,  and Lucia Morbidelli
13353-13365
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Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin® protein MP0250: a preclinical study

Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin® protein MP0250: a preclinical study

https://doi.org/10.18632/oncotarget.24351

Luigia Rao, Kim De Veirman, Donato Giannico, Ilaria Saltarella, Vanessa Desantis, Maria Antonia Frassanito, Antonio Giovanni Solimando, Domenico Ribatti, Marcella Prete, Andreas Harstrick, Ulrike Fiedler, Hendrik De Raeve, Vito Racanelli, Karin Vanderkerken,  and Angelo Vacca
13366-13381
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Efficacy of different spinal nerve roots for neuromodulation of micturition reflex in rats

Efficacy of different spinal nerve roots for neuromodulation of micturition reflex in rats

https://doi.org/10.18632/oncotarget.23950

Jianshu Ni, Xiaohu Wang, Nailong Cao, Jiemin Si,  and Baojun Gu
13382-13389
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Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224

Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224

https://doi.org/10.18632/oncotarget.24385

Yung-Lung Chang, Shu-Ting Liu, Yi-Wen Wang, Wei-Shiang Lin,  and Shih-Ming Huang
13390-13406
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Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis

Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis

https://doi.org/10.18632/oncotarget.24388

Michael P. Marciel, Vedbar S. Khadka, Youpeng Deng, Pascal Kilicaslan, Andrew Pham, Pietro Bertino, Katie Lee, Suzie Chen, Natalija Glibetic, FuKun W. Hoffmann, Michelle L. Matter,  and Peter R. Hoffmann
13407-13422
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The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro

https://doi.org/10.18632/oncotarget.24393

Laura N. Eadie, Verity A. Saunders, Susan Branford, Deborah L. White,  and Timothy P. Hughes
13423-13437
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Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression

Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression

https://doi.org/10.18632/oncotarget.24412

Kazuaki Matsuoka, Fumio Nakagawa, Takashi Kobunai,  and Teiji Takechi
13438-13450
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL

Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL

https://doi.org/10.18632/oncotarget.24413

Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Satoshi Baba, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Aki Yamashita, Satoko Eguchi, Kensuke Tomio, Mayuyo Mori-Uchino, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga,  and Tomoyuki Fujii
13451-13461
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gram-negative bacteria facilitate tumor progression through TLR4/IL-33 pathway in patients with non-small-cell lung cancer

Gram-negative bacteria facilitate tumor progression through TLR4/IL-33 pathway in patients with non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.24008

Mengyao Sun, Yang Bai, Song Zhao, Xiyu Liu, Yongsheng Gao, Lei Wang, Bin Liu, Dashi Ma,  and Chunye Ma
13462-13473
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CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells

CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells

https://doi.org/10.18632/oncotarget.24414

Akito Nakamura, Daisuke Nakata, Yuichi Kakoi, Mihoko Kunitomo, Saomi Murai, Shunsuke Ebara, Akito Hata,  and Takahito Hara
13474-13487
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma

Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.24416

Maria Fernanda Setúbal Destro Rodrigues, Luke Gammon, Muhammad M. Rahman, Adrian Biddle, Fabio Daumas Nunes,  and Ian C. Mackenzie
13488-13500
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Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer

https://doi.org/10.18632/oncotarget.24417

Celia Pinto-Díez, Eva M. García-Recio, M. Isabel Pérez-Morgado, Marta García-Hernández, Lara Sanz-Criado, Silvia Sacristán, M. Val Toledo-Lobo, Belén Pérez-Mies, Isabel Esteban-Rodríguez, Alejandro Pascual, Mercedes Garcia-Villanueva, Noelia Martínez-Jañez, Víctor M. González,  and M. Elena Martín
13501-13516
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas

An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas

https://doi.org/10.18632/oncotarget.24399

Jarrod D. Predina, Andrew D. Newton, Leilei Xia, Christopher Corbett, Courtney Connolly, Michael Shin, Lydia Frezel Sulyok, Leslie Litzky, Charuhas Deshpande, Shuming Nie, Sumith A. Kularatne, Phillip S. Low,  and Sunil Singhal
13517-13529
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas

Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas

https://doi.org/10.18632/oncotarget.24418

Apurva Atak, Samiksha Khurana, Kishore Gollapalli, Panga Jaipal Reddy, Roei Levy, Stav Ben-Salmon, Dror Hollander, Maya Donyo, Anke Heit, Agnes Hotz-Wagenblatt, Hadas Biran, Roded Sharan, Shailendra Rane, Ashutosh Shelar, Gil Ast,  and Sanjeeva Srivastava
13530-13544
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CHL1 gene polymorphisms increase lung cancer susceptibility

CHL1 gene polymorphisms increase lung cancer susceptibility

https://doi.org/10.18632/oncotarget.24057

Wen Tian, Xuelian Li, Yangwu Ren, Zhihua Yin, Xiaowei Quan, Chang Zheng,  and Baosen Zhou
13545-13550
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Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways

Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways

https://doi.org/10.18632/oncotarget.24420

Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Mohamed Fahad, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash,  and Nehad M. Alajez
13551-13564
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human tripartite motif protein 52 is required for cell context-dependent proliferation

Human tripartite motif protein 52 is required for cell context-dependent proliferation

https://doi.org/10.18632/oncotarget.24422

Stefan Benke, Benedikt Agerer, Lisa Haas, Martin Stöger, Alexander Lercher, Lisa Gabler, Izabella Kiss, Sara Scinicariello, Walter Berger, Andreas Bergthaler, Anna C. Obenauf,  and Gijs A. Versteeg
13565-13581
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Leukocyte telomere length throughout the continuum of colorectal carcinogenesis

Leukocyte telomere length throughout the continuum of colorectal carcinogenesis

https://doi.org/10.18632/oncotarget.24431

Cornelia Zöchmeister, Stefanie Brezina, Philipp Hofer, Andreas Baierl, Michael M. Bergmann, Thomas Bachleitner-Hofmann, Judith Karner-Hanusch, Anton Stift, Armin Gerger, Gernot Leeb, Karl Mach, Sivaramakrishna Rachakonda, Rajiv Kumar,  and Andrea Gsur
13582-13592
Abstract  |  PDF  |  HTML  |  Order a Reprint

Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors

Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors

https://doi.org/10.18632/oncotarget.24423

Sonja Hinz, Gemma Navarro, Dasiel Borroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, Azeem Danish, Svenja K. Lacher, Barbora Červinková, Muhammad Rafehi, Kjell Fuxe, Anke C. Schiedel, Rafael Franco,  and Christa E. Müller
13593-13611
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements

https://doi.org/10.18632/oncotarget.24434

Viktoria N. Evdokimova, Manoj Gandhi, Alyaksandr V. Nikitski, Christopher J. Bakkenist,  and Yuri E. Nikiforov
13612-13622
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Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies

Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies

https://doi.org/10.18632/oncotarget.24426

Kevin Hollevoet, Elien De Smidt, Nick Geukens,  and Paul Declerck
13623-13636
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Protective role of integrin-linked kinase against oxidative stress and in maintenance of genomic integrity

Protective role of integrin-linked kinase against oxidative stress and in maintenance of genomic integrity

https://doi.org/10.18632/oncotarget.24444

Michelle Im,  and Lina Dagnino
13637-13651
Abstract  |  PDF  |  HTML  |  Order a Reprint

Structural insights into drug development strategy targeting EGFR T790M/C797S

Structural insights into drug development strategy targeting EGFR T790M/C797S

https://doi.org/10.18632/oncotarget.24113

Su-Jie Zhu, Peng Zhao, Jiao Yang, Rui Ma, Xiao-E Yan, Sheng-Yong Yang, Jing-Wen Yang,  and Cai-Hong Yun
13652-13665
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Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts

Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts

https://doi.org/10.18632/oncotarget.24446

Arnaud J. Legrand, Mattia Poletto, Daniela Pankova, Elena Clementi, John Moore, Francesc Castro-Giner, Anderson J. Ryan, Eric O’Neill, Enni Markkanen,  and Grigory L. Dianov
13666-13681
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Correlation of MET gene amplification and TP53 mutation with PD-L1 expression in non-small cell lung cancer

Correlation of MET gene amplification and TP53 mutation with PD-L1 expression in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.24455

Maher Albitar, Sucha Sudarsanam, Wanlong Ma, Shiping Jiang, Wayne Chen, Vincent Funari, Forrest Blocker,  and Sally Agersborg
13682-13693
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Engineered T lymphocytes eliminate lung metastases in models of pancreatic cancer

Engineered T lymphocytes eliminate lung metastases in models of pancreatic cancer

https://doi.org/10.18632/oncotarget.24122

Qiang Sun, Shixin Zhou, Jingjing Zhao, Changwen Deng, Ruidi Teng, Yiding Zhao, Jiajia Chen, Jiebin Dong, Ming Yin, Yun Bai, Hongkui Deng,  and Jinhua Wen
13694-13705
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inter-assay precision of clonogenic assays for radiosensitivity in cancer cell line A549

Inter-assay precision of clonogenic assays for radiosensitivity in cancer cell line A549

https://doi.org/10.18632/oncotarget.24448

Endang Nuryadi, Tiara Bunga Mayang Permata, Shuichiro Komatsu, Takahiro Oike,  and Takashi Nakano
13706-13712
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Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation

Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation

https://doi.org/10.18632/oncotarget.24459

Saidulu Mattapally, Mrityunjay Singh, Kona Samba Murthy, Shailendra Asthana,  and Sanjay K. Banerjee
13713-13732
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Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors

Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors

https://doi.org/10.18632/oncotarget.24460

Sergey Malchenko, Simone T. Sredni, Jerusha Boyineni, Yingtao Bi, Naira V. Margaryan, Maheedhara R. Guda, Yulia Kostenko, Tadanori Tomita, Ramana V. Davuluri, Kiran Velpula, Mary J.C. Hendrix,  and Marcelo B. Soares
13733-13747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells

Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells

https://doi.org/10.18632/oncotarget.24466

Ilona Zareba, Katarzyna Celinska-Janowicz, Arkadiusz Surazynski, Wojciech Miltyk,  and Jerzy Palka
13748-13757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2

MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2

https://doi.org/10.18632/oncotarget.24474

Ming-Jenn Chen, De-Wei Wu, Gao-Chang Wang, Yao-Chen Wang, Chi-Yi Chen,  and Huei Lee
13758-13767
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Artificial neural network approach to predict surgical site infection after free-flap reconstruction in patients receiving surgery for head and neck cancer

Artificial neural network approach to predict surgical site infection after free-flap reconstruction in patients receiving surgery for head and neck cancer

https://doi.org/10.18632/oncotarget.24468

Pao-Jen Kuo, Shao-Chun Wu, Peng-Chen Chien, Shu-Shya Chang, Cheng-Shyuan Rau, Hsueh-Ling Tai, Shu-Hui Peng, Yi-Chun Lin, Yi-Chun Chen, Hsiao-Yun Hsieh,  and Ching-Hua Hsieh
13768-13782
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Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway

Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway

https://doi.org/10.18632/oncotarget.24475

Chuan-Ming Xie, Xiao-Tong Lin, Di Wu, Ye Tan, Christopher H.K. Cheng,  and Jun Zhang
13783-13795
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Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors

Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors

https://doi.org/10.18632/oncotarget.24488

Bruce W. Konicek, Andrew R. Capen, Kelly M. Credille, Philip J. Ebert, Beverly L. Falcon, Gary L. Heady, Bharvin K.R. Patel, Victoria L. Peek, Jennifer R. Stephens, Julie A. Stewart, Stephanie L. Stout, David E. Timm, Suzane L. Um, Melinda D. Willard, Isabella H. Wulur, Yi Zeng, Yong Wang, Richard A. Walgren,  and Sau-Chi Betty Yan
13796-13806
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Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas

Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas

https://doi.org/10.18632/oncotarget.24480

Manila Antonelli, Antonio Fadda, Eleonora Loi, Loredana Moi, Cesare Zavattari, Pia Sulas, Davide Gentilini, Cincia Cameli, Elena Bacchelli, Manuela Badiali, Antonella Arcella, Isabella Morra, Felice Giangaspero,  and Patrizia Zavattari
13807-13821
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Nucleolar stress enhances lytic reactivation of the Kaposi's sarcoma-associated herpesvirus

Nucleolar stress enhances lytic reactivation of the Kaposi's sarcoma-associated herpesvirus

https://doi.org/10.18632/oncotarget.24497

Anastasia Gelgor, Chen Gam ze Letova, Yana Yegorov, Inna Kalt,  and Ronit Sarid
13822-13833
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Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

https://doi.org/10.18632/oncotarget.24481

Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice, Ronan T. Gray, Stephen McQuaid, Victoria Bingham, Maurice B. Loughrey, Jacqueline A. James, Amy M.B. McCorry, Alan Gilmore, Caitriona Holohan, Dirk Klingbiel, Sabine Tejpar, Patrick G. Johnston, Darragh G. McArt, Federica Di Nicolantonio, Daniel B. Longley,  and Mark Lawler
13834-13847
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CTBP1 and metabolic syndrome induce an mRNA and miRNA expression profile critical for breast cancer progression and metastasis

CTBP1 and metabolic syndrome induce an mRNA and miRNA expression profile critical for breast cancer progression and metastasis

https://doi.org/10.18632/oncotarget.24486

Paula L. Farré, Georgina D. Scalise, Rocío B. Duca, Guillermo N. Dalton, Cintia Massillo, Juliana Porretti, Karen Graña, Kevin Gardner, Paola De Luca,  and Adriana De Siervi
13848-13858
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Chemopreventive effects of angiotensin II receptor type 2 agonist on prostate carcinogenesis by the down-regulation of the androgen receptor

Chemopreventive effects of angiotensin II receptor type 2 agonist on prostate carcinogenesis by the down-regulation of the androgen receptor

https://doi.org/10.18632/oncotarget.24492

Yusuke Ito, Aya Naiki-Ito, Hiroyuki Kato, Shugo Suzuki, Toshiya Kuno, Yukari Ishiguro, Satoru Takahashi,  and Hiroji Uemura
13859-13869
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A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors

A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors

https://doi.org/10.18632/oncotarget.24493

Pieter A. Boonstra, Arja ter Elst, Marco Tibbesma, Lisette J. Bosman, Ron Mathijssen, Florence Atrafi, Frits van Coevorden, Neeltje Steeghs, Sheima Farag, Hans Gelderblom, Winette T.A. van der Graaf, Ingrid M.E. Desar, Jacqueline Maier, Jelle Overbosch, Albert J.H. Suurmeijer, Jourik Gietema, Ed Schuuring,  and An K.L. Reyners
13870-13883
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Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

https://doi.org/10.18632/oncotarget.24490

Ryutaro Asano, Keisuke Nagai, Koki Makabe, Kento Takahashi, Takashi Kumagai, Hiroko Kawaguchi, Hiromi Ogata, Kyoko Arai, Mitsuo Umetsu,  and Izumi Kumagai
13884-13893
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Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer

Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer

https://doi.org/10.18632/oncotarget.24532

Gati K. Panigrahi, Anand Ramteke, Diane Birks, Hamdy E. Abouzeid Ali, Sujatha Venkataraman, Chapla Agarwal, Rajeev Vibhakar, Lance D. Miller, Rajesh Agarwal, Zakaria Y. Abd Elmageed,  and Gagan Deep
13894-13910
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Meta-Analysis

Long non-coding RNA XIST as a potential prognostic biomarker in human cancers: a meta-analysis

Long non-coding RNA XIST as a potential prognostic biomarker in human cancers: a meta-analysis

https://doi.org/10.18632/oncotarget.23744

Shaopu Hu, Junli Chang, Yimian Li, Wenyi Wang, Mengyao Guo, Edward C. Zou, Yongjun Wang,  and Yanping Yang
13911-13919
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Prognostic value of PD-L1 in esophageal squamous cell carcinoma: a meta-analysis

Prognostic value of PD-L1 in esophageal squamous cell carcinoma: a meta-analysis

https://doi.org/10.18632/oncotarget.23810

Wei Guo, Pan Wang, Ning Li, Fei Shao, Hao Zhang, Zhenlin Yang, Renda Li, Yibo Gao,  and Jie He
13920-13933
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Clinicopathologic and prognostic significance of C-reactive protein/albumin ratio in patients with solid tumors: an updated systemic review and meta-analysis

Clinicopathologic and prognostic significance of C-reactive protein/albumin ratio in patients with solid tumors: an updated systemic review and meta-analysis

https://doi.org/10.18632/oncotarget.24172

Jiayuan Wu, Wenkai Tan, Lin Chen, Zhe Huang,  and Shao Mai
13934-13947
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MiR-486 as an effective biomarker in cancer diagnosis and prognosis: a systematic review and meta-analysis

MiR-486 as an effective biomarker in cancer diagnosis and prognosis: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.24189

Min Jiang, Xuelian Li, Xiaowei Quan, Xianglin Yang, Chang Zheng, Xia Hao, Ruoyi Qu,  and Baosen Zhou
13948-13958
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Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis

Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis

https://doi.org/10.18632/oncotarget.24210

Jiao Zhang, Qiang Chen, Zhan-Ming Li, Xu-Dong Xu, Ai-Fang Song,  and Li- Shun Wang
13959-13970
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Clinical Research Papers

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting longterm major adverse cardiac events in STEMI patients undergoing primary PCI

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting longterm major adverse cardiac events in STEMI patients undergoing primary PCI

https://doi.org/10.18632/oncotarget.24128

Xue-Wei Chang, Shou-Yan Zhang, Hao Wang, Ming-Ming Zhang, Wei-Feng Zheng, Hui-Fang Ma, Yun-Fei Gu, Jing-Han Wei,  and Chun-Guang Qiu
13971-13980
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Prevalence of non-syndromic orofacial clefts: based on 15,094,978 Chinese perinatal infants

Prevalence of non-syndromic orofacial clefts: based on 15,094,978 Chinese perinatal infants

https://doi.org/10.18632/oncotarget.24238

Dazhi Fan, Shuzhen Wu, Li Liu, Qing Xia, Guo Tian, Wen Wang, Shaoxin Ye, Lijuan Wang, Jiaming Rao, Xiao Yang, Zhen Yu, Lihong Xin, Song Li, Zhenghua Duan, Tianchen Zhang, Song Wu, Xiaoling Guo,  and Zhengping Liu
13981-13990
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Reviews

The development of CAR design for tumor CAR-T cell therapy

The development of CAR design for tumor CAR-T cell therapy

https://doi.org/10.18632/oncotarget.24179

Dandan Xu, Guoliang Jin, Dafei Chai, Xiaowan Zhou, Weiyu Gu, Yanyun Chong, Jingyuan Song,  and Junnian Zheng
13991-14004
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Impact of physical exercise in cancer survivors during and after antineoplastic treatments

Impact of physical exercise in cancer survivors during and after antineoplastic treatments

https://doi.org/10.18632/oncotarget.24456

Martina Ferioli, Giorgio Zauli, Alberto M. Martelli, Marco Vitale, James A. McCubrey, Simona Ultimo, Silvano Capitani,  and Luca M. Neri
14005-14034
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Corrections

Correction: A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C

Correction: A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C

https://doi.org/10.18632/oncotarget.24600

Xiaomin Luo, Chunman Li, Ran Tan, Xiaohui Xu, William K.K. Wu, Ayano Satoh, Tuanlao Wang,  and Sidney Yu
14035-14035
Correction  |  PDF


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