Oncotarget

Vol 9, No 14

February 20, 2018

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About The Cover

The cover for issue 14 of Oncotarget features "Symmetry and symmetry breaking in cancer: a foundational approach to the cancer problem," from Frost, et al.

Table of Contents

Research Perspectives

Symmetry and symmetry breaking in cancer: a foundational approach to the cancer problem

Symmetry and symmetry breaking in cancer: a foundational approach to the cancer problem

https://doi.org/10.18632/oncotarget.22939

J. James Frost, Kenneth J. Pienta,  and Donald S. Coffey
11429-11440
Abstract  |  PDF  |  HTML  |  Video Interview  |  Order a Reprint  |  Link to Dr. Donald S. Coffey Remembrance

Research Papers: Pathology

CD10-positive mantle cell lymphoma: clinicopathologic and prognostic study of 30 cases

CD10-positive mantle cell lymphoma: clinicopathologic and prognostic study of 30 cases

https://doi.org/10.18632/oncotarget.23571

Jie Xu, L. Jeffrey Medeiros, Annapurna Saksena, Michael Wang, Jiehao Zhou, Jingyi Li, C. Cameron Yin, Guilin Tang, Lifu Wang, Pei Lin,  and Shaoying Li
11441-11450
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Research Papers: Immunology

Impact on early outcomes and immune reconstitution of high-dose post-transplant cyclophosphamide vs anti-thymocyte globulin after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation

Impact on early outcomes and immune reconstitution of high-dose post-transplant cyclophosphamide vs anti-thymocyte globulin after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation

https://doi.org/10.18632/oncotarget.24328

Christelle Retière, Catherine Willem, Thierry Guillaume, Henri Vié, Laetitia Gautreau-Rolland, Emmanuel Scotet, Xavier Saulquin, Katia Gagne, Marie C. Béné, Berthe-Marie Imbert, Beatrice Clemenceau, Pierre Peterlin, Alice Garnier,  and Patrice Chevallier
11451-11464
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Research Papers

More severe toxicity of genetic polymorphisms on MTHFR activity in osteosarcoma patients treated with high-dose methotrexate

More severe toxicity of genetic polymorphisms on MTHFR activity in osteosarcoma patients treated with high-dose methotrexate

https://doi.org/10.18632/oncotarget.23222

Lu Xie, Wei Guo, Yi Yang, Tao Ji,  and Jie Xu
11465-11476
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MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells

MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells

https://doi.org/10.18632/oncotarget.22484

Satoshi Suzuki, Moriya Iwaizumi, Hidetaka Yamada, Tomohiro Sugiyama, Yasushi Hamaya, Takahisa Furuta, Shigeru Kanaoka, Haruhiko Sugimura, Hiroaki Miyajima, Satoshi Osawa, John M. Carethers,  and Ken Sugimoto
11477-11488
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An integrated approach identifies new oncotargets in melanoma

An integrated approach identifies new oncotargets in melanoma

https://doi.org/10.18632/oncotarget.23727

Daniela Cecconi, Luca Dalle Carbonare, Antonio Mori, Samuele Cheri, Michela Deiana, Jessica Brandi, Vincenzo Degaetano, Valentina Masiero, Giulio Innamorati, Monica Mottes, Giovanni Malerba,  and Maria Teresa Valenti
11489-11502
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Characterization of primary human mammary epithelial cells isolated and propagated by conditional reprogrammed cell culture

Characterization of primary human mammary epithelial cells isolated and propagated by conditional reprogrammed cell culture

https://doi.org/10.18632/oncotarget.23817

Liting Jin, Ying Qu, Liliana J. Gomez, Stacey Chung, Bingchen Han, Bowen Gao, Yong Yue, Yiping Gong, Xuefeng Liu, Farin Amersi, Catherine Dang, Armando E. Giuliano,  and Xiaojiang Cui
11503-11514
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Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam

https://doi.org/10.18632/oncotarget.23923

Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Barry J. Hoffer, Yu-Ching Chou, Yung-Hsiao Chiang, Hsin-I Ma,  and Jonathan P. Miller
11515-11527
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Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways

Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways

https://doi.org/10.18632/oncotarget.23936

Shengye Liu, Long Zhou, Liyu Yang, Shuai Mu, Tao Fang,  and Qin Fu
11528-11540
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Recurrent copy number alterations in young women with breast cancer

Recurrent copy number alterations in young women with breast cancer

https://doi.org/10.18632/oncotarget.24336

Chen Chi, Leigh C. Murphy,  and Pingzhao Hu
11541-11558
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5-FU therapeutic drug monitoring as a valuable option to reduce toxicity in patients with gastrointestinal cancer

5-FU therapeutic drug monitoring as a valuable option to reduce toxicity in patients with gastrointestinal cancer

https://doi.org/10.18632/oncotarget.24338

Katarzyna Morawska, Françoise Goirand, Laurine Marceau, Madeline Devaux, Adèle Cueff, Aurélie Bertaut, Julie Vincent, Leila Bengrine-Lefevre, François Ghiringhelli,  and Antonin Schmitt
11559-11571
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Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells

Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells

https://doi.org/10.18632/oncotarget.24098

Xiang Song, Yan Zhang, Li Zhang, Wengang Song,  and Lixin Shi
11572-11580
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CSA and CSB play a role in the response to DNA breaks

CSA and CSB play a role in the response to DNA breaks

https://doi.org/10.18632/oncotarget.24342

Barbara Pascucci, Alessandra Fragale, Veronica Marabitti, Giuseppe Leuzzi, Angelo Salvatore Calcagnile, Eleonora Parlanti, Annapaola Franchitto, Eugenia Dogliotti,  and Mariarosaria D’Errico
11581-11591
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MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

https://doi.org/10.18632/oncotarget.24294

Francesca Vena, Ruochen Jia, Arman Esfandiari, Juan J. Garcia-Gomez, Manuel Rodriguez-Justo, Jianguo Ma, Sakeena Syed, Lindsey Crowley, Brian Elenbaas, Samantha Goodstal, John A. Hartley,  and Daniel Hochhauser
11592-11603
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Calcium electroporation for treatment of sarcoma in preclinical studies

Calcium electroporation for treatment of sarcoma in preclinical studies

https://doi.org/10.18632/oncotarget.24352

Anna Szewczyk, Julie Gehl, Malgorzata Daczewska, Jolanta Saczko, Stine Krog Frandsen,  and Julita Kulbacka
11604-11618
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Using computer assisted image analysis to determine the optimal Ki67 threshold for predicting outcome of invasive breast cancer

Using computer assisted image analysis to determine the optimal Ki67 threshold for predicting outcome of invasive breast cancer

https://doi.org/10.18632/oncotarget.24398

Timothy Kwang Yong Tay, Aye Aye Thike, Nirmala Pathmanathan, Ana Richelia Jara-Lazaro, Jabed Iqbal, Adeline Shi Hui Sng, Heng Seow Ye, Jeffrey Chun Tatt Lim, Valerie Cui Yun Koh, Jane Sie Yong Tan, Joe Poh Sheng Yeong, Zi Long Chow, Hui Hua Li, Chee Leong Cheng,  and Puay Hoon Tan
11619-11630
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Interferon-free treatment for patients with chronic hepatitis C and autoimmune liver disease: higher SVR rates with special precautions for deterioration of autoimmune hepatitis

Interferon-free treatment for patients with chronic hepatitis C and autoimmune liver disease: higher SVR rates with special precautions for deterioration of autoimmune hepatitis

https://doi.org/10.18632/oncotarget.24391

Tatsuo Kanda, Shin Yasui, Masato Nakamura, Shingo Nakamoto, Koji Takahashi, Shuang Wu, Reina Sasaki, Yuki Haga, Sadahisa Ogasawara, Tomoko Saito, Kazufumi Kobayashi, Soichiro Kiyono, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Hitoshi Maruyama, Fumio Imazeki, Mitsuhiko Moriyama,  and Naoya Kato
11631-11637
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Long-term follow up of Hodgkin lymphoma

Long-term follow up of Hodgkin lymphoma

https://doi.org/10.18632/oncotarget.24392

David Perez-Callejo, Lorea Zurutuza, Ana Royuela, Maria Torrente, Beatriz Núñez, Virginia Calvo, Miriam Méndez, Fernando Franco, María Auxiliadora Brenes, Juan Cristobal Sánchez,  and Mariano Provencio
11638-11645
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CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein

https://doi.org/10.18632/oncotarget.24126

Ali Ben Djoudi Ouadda, Yi He, Viviane Calabrese, Hidetaka Ishii, Rony Chidiac, Jean-Philippe Gratton, Philippe P. Roux,  and Nathalie Lamarche-Vane
11646-11664
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Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells

Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells

https://doi.org/10.18632/oncotarget.24432

Min Huang, Li Zhu, Jacqueline S. Garcia, Michael X. Li, Andrew J. Gentles,  and Beverly S. Mitchell
11665-11676
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences

Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences

https://doi.org/10.18632/oncotarget.24433

Fariba Tayyari, G.A. Nagana Gowda, Olufunmilayo F. Olopade, Richard Berg, Howard H. Yang, Maxwell P. Lee, Wilfred F. Ngwa, Suresh K. Mittal, Daniel Raftery,  and Sulma I. Mohammed
11677-11690
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells

Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells

https://doi.org/10.18632/oncotarget.24450

Koji Yamamoto, Makiko Kawaguchi, Takeshi Shimomura, Aya Izumi, Kazuomi Konari, Arata Honda, Chen-Yong Lin, Michael D. Johnson, Yoshihiro Yamashita, Tsuyoshi Fukushima,  and Hiroaki Kataoka
11691-11706
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Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death

Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death

https://doi.org/10.18632/oncotarget.24451

Muhammad Mosaraf Hossain, David Barua, Vahid Arabkari, Nahidul Islam, Ananya Gupta,  and Sanjeev Gupta
11707-11721
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Percutaneous radiofrequency ablation in the treatment of pulmonary malignancies: efficacy, safety and predictive factors

Percutaneous radiofrequency ablation in the treatment of pulmonary malignancies: efficacy, safety and predictive factors

https://doi.org/10.18632/oncotarget.24270

Tina Streitparth, Denis Schumacher, Robert Damm, Bjoern Friebe, Konrad Mohnike, Ortrud Kosiek, Maciej Pech, Jens Ricke,  and Florian Streitparth
11722-11733
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Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer

Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer

https://doi.org/10.18632/oncotarget.24312

Verena M. Throm, David Männle, Thomas Giese, Andrea S. Bauer, Matthias M. Gaida, Juergen Kopitz, Thomas Bruckner, Konstanze Plaschke, Svetlana P. Grekova, Klaus Felix, Thilo Hackert, Nathalia A. Giese,  and Oliver Strobel
11734-11751
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APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer

APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer

https://doi.org/10.18632/oncotarget.24357

Caroline K. Søgaard, Siver A. Moestue, Morten B. Rye, Jana Kim, Anala Nepal, Nina-Beate Liabakk, Siri Bachke, Tone F. Bathen, Marit Otterlei,  and Deborah K. Hill
11752-11766
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CoQ10-loaded liposomes combined with UTMD prevented early nephropathy of diabetic rats

CoQ10-loaded liposomes combined with UTMD prevented early nephropathy of diabetic rats

https://doi.org/10.18632/oncotarget.24363

Pian-Pian Chen, He-Lin Xu, Ting-Yue  , De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Li-Fen Wang, Cui-Tao Lu, Ying-Zheng Zhao,  and Xiao-Kun Li
11767-11782
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CFIm25 inhibits hepatocellular carcinoma metastasis by suppressing the p38 and JNK/c-Jun signaling pathways

CFIm25 inhibits hepatocellular carcinoma metastasis by suppressing the p38 and JNK/c-Jun signaling pathways

https://doi.org/10.18632/oncotarget.24364

Yunwu Wang, Yu Xu, Wei Yan, Ping Han, Jingmei Liu, Jin Gong, Dongxiao Li, Xiangming Ding, Han Wang, Zhuoying Lin, Dean Tian,  and Jiazhi Liao
11783-11793
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In silico analysis of expression data during the early priming stage of liver regeneration after partial hepatectomy in rat

In silico analysis of expression data during the early priming stage of liver regeneration after partial hepatectomy in rat

https://doi.org/10.18632/oncotarget.24370

Li Yin, Xueqiang Guo, Chunyan Zhang, Zhihui Cai,  and Cunshuan Xu
11794-11804
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Meta-Analysis

Comparative outcome assessment of epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of advanced non-small-cell lung cancer: a network meta-analysis

Comparative outcome assessment of epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of advanced non-small-cell lung cancer: a network meta-analysis

https://doi.org/10.18632/oncotarget.23668

Ramon Andrade De Mello, Carles Escriu, Pedro Castelo-Branco, Paloma Lucena Cabral, Giannis Mountzios, Gilberto de Lima Lopes,  and Pedro Madureira
11805-11815
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The impact of surgical excision of the primary tumor in stage IV breast cancer on survival: a meta-analysis

The impact of surgical excision of the primary tumor in stage IV breast cancer on survival: a meta-analysis

https://doi.org/10.18632/oncotarget.23189

Shuangshuang Lu, Jiayi Wu, Yan Fang, Wei Wang, Yu Zong, Xiaosong Chen, Ou Huang, Jian-Rong He, Weiguo Chen, Yafen Li,  and Kunwei Shen
11816-11823
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The expression of circRNAs as a promising biomarker in the diagnosis and prognosis of human cancers: a systematic review and meta-analysis

The expression of circRNAs as a promising biomarker in the diagnosis and prognosis of human cancers: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.23484

Han-Xi Ding, Zhi Lv, Yuan Yuan,  and Qian Xu
11824-11836
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Renoprotective effect of nicorandil in patients undergoing percutaneous coronary intervention: a meta-analysis of 4 randomized controlled trials

Renoprotective effect of nicorandil in patients undergoing percutaneous coronary intervention: a meta-analysis of 4 randomized controlled trials

https://doi.org/10.18632/oncotarget.23965

Xiaobing Wang, Jin Geng, Hong Zhu,  and Changying Xing
11837-11845
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Efficacy of PD-1/PD-L1 inhibitors against pretreated advanced cancer: a systematic review and meta-analysis

Efficacy of PD-1/PD-L1 inhibitors against pretreated advanced cancer: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.24163

Hao Hu, Qian Zhu, Xian Shi Luo, Xiong Wen Yang, Hai Dong Wang,  and Chang Ying Guo
11846-11857
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Reviews

Effects of the polyunsaturated fatty acids, EPA and DHA, on hematological malignancies: a systematic review

Effects of the polyunsaturated fatty acids, EPA and DHA, on hematological malignancies: a systematic review

https://doi.org/10.18632/oncotarget.24405

Milad Moloudizargari, Esmaeil Mortaz, Mohammad Hossein Asghari, Ian M. Adcock, Frank A. Redegeld,  and Johan Garssen
11858-11875
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Case Reports

Dasatinib overrides the differentiation blockage in a patient with mutant-KIT D816V positive CBFβ-MYH11 leukemia

Dasatinib overrides the differentiation blockage in a patient with mutant-KIT D816V positive CBFβ-MYH11 leukemia

https://doi.org/10.18632/oncotarget.24376

Kerstin M. Kampa-Schittenhelm, Wichard Vogel, Irina Bonzheim, Falko Fend, Marius Horger, Lothar Kanz, Martin Soekler,  and Marcus M. Schittenhelm
11876-11882
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