Oncotarget

Vol 8, No 61

November 28, 2017

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About The Cover

The cover for issue 61 of Oncotarget features Figure 2, "Pedigrees of the families 6006 and 6043 showing the haplotypes of selected family members (the families’ risk haplotype is indicated in grey shade)," from Jiao, et al.

Table of Contents

Editorial

Therapy of polycythemia vera: is it time to change?

Therapy of polycythemia vera: is it time to change?

https://doi.org/10.18632/oncotarget.22282

Francesco Passamonti, Margherita Maffioli,  and Barbara Mora
102759-102760
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Lck activation: puzzling the pieces together

Lck activation: puzzling the pieces together

https://doi.org/10.18632/oncotarget.22309

Luca Simeoni
102761-102762
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Immune control in chronic myeloid leukemia

Immune control in chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.22279

Mette Ilander,  and Satu Mustjoki
102763-102764
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SMX makes the cut in genome stability

SMX makes the cut in genome stability

https://doi.org/10.18632/oncotarget.22420

Haley D.M. Wyatt,  and Stephen C. West
102765-102766
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Avelumab demonstrates promise in advanced NSCLC

Avelumab demonstrates promise in advanced NSCLC

https://doi.org/10.18632/oncotarget.22418

Ariel E. Marciscano,  and James L. Gulley
102767-102768
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Priority Research Papers

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

https://doi.org/10.18632/oncotarget.21800

Xiang Jiao, Christos Aravidis, Rajeshwari Marikkannu, Johanna Rantala, Simone Picelli, Tatjana Adamovic, Tao Liu, Paula Maguire, Barbara Kremeyer, Liping Luo, Susanna von Holst, Vinaykumar Kontham, Jessada Thutkawkorapin, Sara Margolin, Quan Du, Johanna Lundin, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Matthias W. Beckmann, Carl Blomqvist, William Blot, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Jenny Chang-Claude, NBCS Collaborators, Fergus J. Couch, Angela Cox, Simon S. Cross, Sandra L. Deming-Halverson, Peter Devilee, Isabel dos-Santos-Silva, Thilo Dörk, Mikael Eriksson, Peter A. Fasching, Jonine Figueroa, Dieter Flesch-Janys, Henrik Flyger, Marike Gabrielson, Montserrat García-Closas, Graham G. Giles, Anna González-Neira, Pascal Guénel, Qi Guo, Melanie Gündert, Christopher A. Haiman, Emily Hallberg, Ute Hamann, Patricia Harrington, Maartje J. Hooning, John L. Hopper, Guanmengqian Huang, Anna Jakubowska, Michael E. Jones, Michael J. Kerin, Veli-Matti Kosma, Vessela N. Kristensen, Diether Lambrechts, Loic Le Marchand, Jan Lubinski, Arto Mannermaa, John W.M. Martens, Alfons Meindl, Roger L. Milne, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Julian Peto, Katri Pylkas, Paolo Radice, Valerie Rhenius, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Caroline Seynaeve, Mitul Shah, Jacques Simard, Melissa C. Southey, Anthony J. Swerdlow, Therese Truong, Camilla Wendt, Robert Winqvist, Wei Zheng, kConFab/AOCS Investigators, Javier Benitez, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton, Kamila Czene, Per Hall,  and Annika Lindblom
102769-102782
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Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity

Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity

https://doi.org/10.18632/oncotarget.22245

Markus Kaller, Ursula Götz,  and Heiko Hermeking
102783-102800
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Research Papers: Gerotarget (Focus on Aging)

Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor α in a β-amyloid protein -dependent mechanism

Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor α in a β-amyloid protein -dependent mechanism

https://doi.org/10.18632/oncotarget.18462

Shao-Qin Zheng, Zi-Yi Gong, Chen-Di Lu,  and Pu Wang
102801-102819
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Research Papers: Pathology

Chronic inflammation and apoptosis propagate in ischemic cerebellum and heart of non-human primates

Chronic inflammation and apoptosis propagate in ischemic cerebellum and heart of non-human primates

https://doi.org/10.18632/oncotarget.18330

Sandra A. Acosta, Sherwin Mashkouri, Diana Nwokoye, Jea Y. Lee,  and Cesar V. Borlongan
102820-102834
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Research Papers: Immunology

Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection

Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection

https://doi.org/10.18632/oncotarget.22159

Katharina S. Rauch, Miriam Hils, Alexandra J. Menner, Mikael Sigvardsson, Susana Minguet, Peter Aichele, Christian Schachtrup,  and Kristina Schachtrup
102835-102851
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Research Papers

Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells

Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells

https://doi.org/10.18632/oncotarget.9913

Barbara Pascucci, Mariarosaria D’Errico, Alessandra Romagnoli, Chiara De Nuccio, Miriam Savino, Donatella Pietraforte, Manuela Lanzafame, Angelo Salvatore Calcagnile, Paola Fortini, Sara Baccarini, Donata Orioli, Paolo Degan, Sergio Visentin, Miria Stefanini, Ciro Isidoro, Gian Maria Fimia,  and Eugenia Dogliotti
102852-102867
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APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

https://doi.org/10.18632/oncotarget.22263

Monica K. VanKlompenberg, Emily Leyden, Anne H. Arnason, Jian-Ting Zhang, Casey D. Stefanski,  and Jenifer R. Prosperi
102868-102879
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Prognostic effect of adjuvant chemoradiotherapy for patients with gastric cancer: an updated evidence of randomized controlled trials

Prognostic effect of adjuvant chemoradiotherapy for patients with gastric cancer: an updated evidence of randomized controlled trials

https://doi.org/10.18632/oncotarget.21983

Mei-Juan Wang, Chao Li, Yue Sun, Fu-Jun Shen,  and Chun-Bin Wang
102880-102887
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Mutational profile of primary breast diffuse large B-cell lymphoma

Mutational profile of primary breast diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.21986

Fernando Franco, Julia González-Rincón, Javier Lavernia, Juan F. García, Paloma Martín, Carmen Bellas, Miguel A. Piris, Lucia Pedrosa, José Miramón, José Gómez-Codina, Delvys Rodríguez-Abreu, Isidro Machado, Carmen Illueca, Jesús Alfaro, Mariano Provencio,  and Margarita Sánchez-Beato
102888-102897
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Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis

https://doi.org/10.18632/oncotarget.22048

Benedetta Lombardi, Paul Ashford, Aurelio A. Moya-Garcia, Aleksander Rust, Mark Crawford, Sarah V. Williams, Margaret A. Knowles, Matilda Katan, Christine Orengo,  and Jasminka Godovac-Zimmermann
102898-102911
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High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism

https://doi.org/10.18632/oncotarget.22076

Elena Ioana Braicu, Silvia Darb-Esfahani, Wolfgang D. Schmitt, Kaisa M. Koistinen, Laura Heiskanen, Päivi Pöhö, Jan Budczies, Marc Kuhberg, Manfred Dietel, Christian Frezza, Carsten Denkert, Jalid Sehouli,  and Mika Hilvo
102912-102922
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GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress

https://doi.org/10.18632/oncotarget.22084

Crystal L. Kraft, Jeffrey A. Rappaport, Adam E. Snook, Amanda M. Pattison, John P. Lynch,  and Scott A. Waldman
102923-102933
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Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers

Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers

https://doi.org/10.18632/oncotarget.22173

Angelina A. Akishina, Julia E. Vorontsova, Roman O. Cherezov, Il’ya B. Mertsalov, Olga G. Zatsepina, Mikhail S. Slezinger, Vladislav M. Panin, Svetlana Petruk, Grigori N. Enikolopov, Alexander Mazo, Olga B. Simonova,  and Boris A. Kuzin
102934-102947
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Delineating the distinct role of AKT in mediating cell survival and proliferation induced by CD154 and IL-4/IL-21 in chronic lymphocytic leukemia

Delineating the distinct role of AKT in mediating cell survival and proliferation induced by CD154 and IL-4/IL-21 in chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.22292

Elinor A. Chapman, Melanie Oates, Ishaque S. Mohammad, Barry R. Davies, Paul K. Stockman, Jianguo Zhuang,  and Andrew R. Pettitt
102948-102964
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy and toxicity of image-guided intensity-modulated radiation therapy combined with dose-escalated brachytherapy for stage IIB cervical cancer

Efficacy and toxicity of image-guided intensity-modulated radiation therapy combined with dose-escalated brachytherapy for stage IIB cervical cancer

https://doi.org/10.18632/oncotarget.22434

Weiping Wang, Qingyu Meng, Xiaorong Hou, Xin Lian, Junfang Yan, Shuai Sun, Zhikai Liu, Zheng Miao, Dunhuang Wang, Xiaoliang Liu, Ke Hu,  and Fuquan Zhang
102965-102973
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Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway

Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway

https://doi.org/10.18632/oncotarget.16875

Liuqin He, Huan Li, Niu Huang, Xihong Zhou, Junquan Tian, Tiejun Li, Jing Wu, Yanan Tian, Yulong Yin,  and Kang Yao
102974-102988
Abstract  |  PDF  |  HTML  |  Order a Reprint

Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α

Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α

https://doi.org/10.18632/oncotarget.19900

Xueyan Liang, Yufang Yang, Zhenguang Huang, Jinling Zhou, Yue’e Li,  and Xiaobin Zhong
102989-103003
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LincRNA FEZF1-AS1 contributes to the proliferation of LAD cells by silencing p57 expression

LincRNA FEZF1-AS1 contributes to the proliferation of LAD cells by silencing p57 expression

https://doi.org/10.18632/oncotarget.21265

Shuai Jin, Siyu Chen, Yongfu Ma, Bo Yang,  and Yang Liu
103004-103013
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer

https://doi.org/10.18632/oncotarget.20488

Katie M. Mishall, Thomas C. Beadnell, Brent M. Kuenzi, Dorothy M. Klimczak, Giulio Superti-Furga, Uwe Rix,  and Rebecca E. Schweppe
103014-103031
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of SPOP related metabolic pathways in prostate cancer

Identification of SPOP related metabolic pathways in prostate cancer

https://doi.org/10.18632/oncotarget.21460

Min Yan, Huan Qi, Jia Li, Guozhu Ye, Yaping Shao, Tongming Li, Jing Liu, Hai-Long Piao,  and Guowang Xu
103032-103046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Treatment and survival outcomes of lobular carcinoma in situ of the breast: a SEER population based study

Treatment and survival outcomes of lobular carcinoma in situ of the breast: a SEER population based study

https://doi.org/10.18632/oncotarget.21461

Pu Cheng, Qi Huang, Jiafeng Shou, Guoming Hu, Mengjiao Han,  and Jian Huang
103047-103054
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Optimization of EGFR mutation detection by the fully-automated qPCR-based Idylla system on tumor tissue from patients with non-small cell lung cancer

Optimization of EGFR mutation detection by the fully-automated qPCR-based Idylla system on tumor tissue from patients with non-small cell lung cancer

https://doi.org/10.18632/oncotarget.21476

Marius Ilie, Catherine Butori, Sandra Lassalle, Simon Heeke, Nicolas Piton, Jean-Christophe Sabourin, Virginie Tanga, Kevin Washetine, Elodie Long-Mira, Priscilla Maitre, Nathalie Yazbeck, Olivier Bordone, Virginie Lespinet, Sylvie Leroy, Charlotte Cohen, Jérôme Mouroux, Charles Hugo Marquette, Véronique Hofman,  and Paul Hofman
103055-103062
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma

Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.21523

Etsuko Yokota, Tomoki Yamatsuji, Munenori Takaoka, Minoru Haisa, Nagio Takigawa, Noriko Miyake, Tomoko Ikeda, Tomoaki Mori, Serika Ohno, Takashi Sera, Takuya Fukazawa,  and Yoshio Naomoto
103063-103076
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neutrophil-to-lymphocyte ratio predicts survival in European patients with hepatocellular carcinoma administered sorafenib

Neutrophil-to-lymphocyte ratio predicts survival in European patients with hepatocellular carcinoma administered sorafenib

https://doi.org/10.18632/oncotarget.21528

Alberto Lué, Maria Trinidad Serrano, Francisco Javier Bustamante, Mercedes Iñarrairaegui, Juan Ignacio Arenas, Milagros Testillano, Sara Lorente, Cristina Gil, Manuel de la Torre, Alexandra Gomez,  and Bruno Sangro
103077-103086
Abstract  |  PDF  |  HTML  |  Order a Reprint

Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6

Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6

https://doi.org/10.18632/oncotarget.20710

Yu-Zhi Li, Si Yu, Pei-Ao Yan, Dao-Yin Gong, Fang-Li Wu, Zhi He, Yu-Yao Yuan, An-Yan Zhao, Xue Tang, Ruo-Qi Zhang, Cheng Peng,  and Zhi-Xing Cao
103087-103099
Abstract  |  PDF  |  HTML  |  Order a Reprint

A framework for exploring associations between biomedical terms in PubMed

A framework for exploring associations between biomedical terms in PubMed

https://doi.org/10.18632/oncotarget.21532

Haixiu Yang, Lingling Zhao, Ying Zhang, Hong Ju, Dong Wang, Yang Hu, Jun Zhang,  and Liang Cheng
103100-103107
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictors of overall survival in metastatic castration-resistant prostate cancer patients receiving [177Lu]Lu-PSMA-617 radioligand therapy

Predictors of overall survival in metastatic castration-resistant prostate cancer patients receiving [177Lu]Lu-PSMA-617 radioligand therapy

https://doi.org/10.18632/oncotarget.21600

Hojjat Ahmadzadehfar, Stephan Schlolaut, Rolf Fimmers, Anna Yordanova, Stefan Hirzebruch, Carl Schlenkhoff, Florian C. Gaertner, Zool Hilmi Awang, Stefan Hauser,  and Markus Essler
103108-103116
Abstract  |  PDF  |  HTML  |  Order a Reprint

Predictive clinical parameters for the response of nivolumab in pretreated advanced non-small-cell lung cancer

Predictive clinical parameters for the response of nivolumab in pretreated advanced non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.21602

Yuko Oya, Tatsuya Yoshida, Hiroaki Kuroda, Masashi Mikubo, Chiaki Kondo, Junichi Shimizu, Yoshitsugu Horio, Yukinori Sakao, Toyoaki Hida,  and Yasushi Yatabe
103117-103128
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy

https://doi.org/10.18632/oncotarget.20789

Kentaro Miyake, Takashi Murakami, Tasuku Kiyuna, Kentaro Igarashi, Kei Kawaguchi, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Michael Bouvet, Irmina A. Elliott, Tara A. Russell, Arun S. Singh, Mark A. Eckardt, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chishima, Itaru Endo, Fritz C. Eilber,  and Robert M. Hoffman
103129-103136
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B

Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B

https://doi.org/10.18632/oncotarget.21663

Karel Vališ, Valéria Grobárová, Lucie Hernychová, Martina Bugáňová, Daniel Kavan, Martin Kalous, Jiří Černý, Eva Stodůlková, Marek Kuzma, Miroslav Flieger, Jan Černý,  and Petr Novák
103137-103153
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury

Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury

https://doi.org/10.18632/oncotarget.20790

Jun Zhou, Youling Fan, Simin Tang, Huiping Wu, Jiying Zhong, Zhengxing Huang, Chengxiang Yang,  and Hongtao Chen
103154-103166
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling

Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling

https://doi.org/10.18632/oncotarget.21704

Jingkai Zhou, Tiangang Zhao, Linfeng Ma, Min Liang, Ying-Jie Guo,  and Li-Mei Zhao
103167-103181
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A niche that triggers aggressiveness within BRCA1-IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment

A niche that triggers aggressiveness within BRCA1-IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment

https://doi.org/10.18632/oncotarget.20892

Daniel Ryan, Abhilasha Sinha, Danielle Bogan, Joanna Davies, Jim Koziol,  and Wael M. ElShamy
103182-103206
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

https://doi.org/10.18632/oncotarget.21732

Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer,  and Roch-Philippe Charles
103207-103222
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Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome

Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome

https://doi.org/10.18632/oncotarget.21735

Qing Ji, Wenhai Wang, Yunquan Luo, Feifei Cai, Yiyu Lu, Wanli Deng, Qi Li,  and Shibing Su
103223-103235
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Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury

Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury

https://doi.org/10.18632/oncotarget.21139

Tai-Ho Hung, Song-Kun Shyue, Chun-Hu Wu, Chien-Cheng Chen, Chao-Chang Lin, Che-Feng Chang,  and Szu-Fu Chen
103236-103260
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MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells

MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells

https://doi.org/10.18632/oncotarget.21143

Guodong Xiao, Xiang Li, Gang Li, Boxiang Zhang, Chongwen Xu, Sida Qin, Ning Du, Jichang Wang, Shou-Ching Tang, Jing Zhang, Hong Ren, Ke Chen,  and Xin Sun
103261-103273
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Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis, splenomegaly and with a shorter median time to disease progression

Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis, splenomegaly and with a shorter median time to disease progression

https://doi.org/10.18632/oncotarget.21870

Kseniya Petrova-Drus, April Chiu, Elizabeth Margolskee, Sharon Barouk-Fox, Julia Geyer, Ahmet Dogan,  and Attilio Orazi
103274-103282
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Anti-NY-ESO-1 autoantibody may be a tumor marker for intrahepatic cholangiocarcinoma

Anti-NY-ESO-1 autoantibody may be a tumor marker for intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.22464

Zhen Zhang, Fan-Fan Li, Ming-Dian Lu, Shang-Xin Zhang,  and Yong-Xiang Li
103283-103289
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Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics

Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics

https://doi.org/10.18632/oncotarget.21179

Jieqiong Li, Lin Sun, Fang Xu, Jing Xiao, Weiwei Jiao, Hui Qi, Chen Shen,  and Adong Shen
103290-103301
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Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy

Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy

https://doi.org/10.18632/oncotarget.21871

Shana D. Hardy, Aparna Shinde, Wen-Horng Wang, Michael K. Wendt,  and Robert L. Geahlen
103302-103314
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Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma

Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma

https://doi.org/10.18632/oncotarget.21733

Francisca Dias, Ana Luísa Teixeira, Marta Ferreira, Bárbara Adem, Nuno Bastos, Joana Vieira, Mara Fernandes, Maria Inês Sequeira, Joaquina Maurício, Francisco Lobo, António Morais, Jorge Oliveira, Klaas Kok,  and Rui Medeiros
103315-103326
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A prognostic 4-gene expression signature for patients with HER2-negative breast cancer receiving taxane and anthracycline-based chemotherapy

A prognostic 4-gene expression signature for patients with HER2-negative breast cancer receiving taxane and anthracycline-based chemotherapy

https://doi.org/10.18632/oncotarget.21872

Pu Cheng, Zhen Wang, Guoming Hu, Qi Huang, Mengjiao Han,  and Jian Huang
103327-103339
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of epithelial-mesenchymal transition intermediate/hybrid phenotypes associated to resistance to EGFR inhibitors in non-small cell lung cancer cell lines

Characterization of epithelial-mesenchymal transition intermediate/hybrid phenotypes associated to resistance to EGFR inhibitors in non-small cell lung cancer cell lines

https://doi.org/10.18632/oncotarget.21132

Valentina Fustaino, Dario Presutti, Teresa Colombo, Beatrice Cardinali, Giuliana Papoff, Rossella Brandi, Paola Bertolazzi, Giovanni Felici,  and Giovina Ruberti
103340-103363
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HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway

HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway

https://doi.org/10.18632/oncotarget.21873

Hao Huang, Yong Han, Xingjiu Yang, Mengyuan Li, Ruimin Zhu, Juanjuan Hu, Xiaowei Zhang, Rongfei Wei, Kejuan Li,  and Ran Gao
103364-103374
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Prioritizing chronic obstructive pulmonary disease (COPD) candidate genes in COPD-related networks

Prioritizing chronic obstructive pulmonary disease (COPD) candidate genes in COPD-related networks

https://doi.org/10.18632/oncotarget.21874

Yihua Zhang, Wan Li, Yuyan Feng, Shanshan Guo, Xilei Zhao, Yahui Wang, Yuehan He, Weiming He,  and Lina Chen
103375-103384
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Evaluation of the association of UBASH3A and SYNGR1 with rheumatoid arthritis and disease activity and severity in Han Chinese

Evaluation of the association of UBASH3A and SYNGR1 with rheumatoid arthritis and disease activity and severity in Han Chinese

https://doi.org/10.18632/oncotarget.21875

Dan Liu, Jiayu Liu, Guofeng Cui, Haojie Yang, Tuanping Cao,  and Li Wang
103385-103392
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DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

https://doi.org/10.18632/oncotarget.21900

Min-Yu Zhang, Fei-Fei Guo, Hong-Wei Wu, Yang-Yang Yu, Jun-Ying Wei, Shi-Feng Wang, Yu-Xin Zhang, Ming-Hua Xian, Qing-Hua Wu, Bu-Chang Zhao, Shi-You Li,  and Hong-Jun Yang
103393-103409
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression

Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression

https://doi.org/10.18632/oncotarget.21902

Liyuan Guo, Yan Peng, Lei Sun, Xia Han, Juan Xu,  and Dongwei Mao
103410-103414
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

https://doi.org/10.18632/oncotarget.21910

John P. Gustin, Jernelle Miller, Mina Farag, D. Marc Rosen, Matthew Thomas, Robert B. Scharpf,  and Josh Lauring
103415-103427
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Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma and its association with PD-L1 expression

Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma and its association with PD-L1 expression

https://doi.org/10.18632/oncotarget.21952

Aly-Khan A. Lalani, Kathryn P. Gray, Laurence Albiges, Marcella Callea, Jean-Christophe Pignon, Soumitro Pal, Mamta Gupta, Rupal S. Bhatt, David F. McDermott, Michael B. Atkins, G.F. Vande Woude, Lauren C. Harshman, Toni K. Choueiri,  and Sabina Signoretti
103428-103436
Abstract  |  PDF  |  HTML  |  Order a Reprint

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue

https://doi.org/10.18632/oncotarget.21402

Linda Boldrup, Giuseppe Troiano, Xiaolian Gu, Philip Coates, Robin Fåhraeus, Torben Wilms, Lena Norberg-Spaak, Lixiao Wang,  and Karin Nylander
103437-103448
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The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy

https://doi.org/10.18632/oncotarget.21968

Hua-Chuan Zheng, Shuang Zhao, Yang Song,  and Xiao-Qing Ding
103449-103464
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGF-1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines

IGF-1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines

https://doi.org/10.18632/oncotarget.21403

Maria Grazia Refolo, Rosalba D’Alessandro, Catia Lippolis, Nicola Carella, Aldo Cavallini, Caterina Messa,  and Brian Irving Carr
103465-103476
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The association of triglycerides and total cholesterol concentrations with newly diagnosed diabetes in adults in China

The association of triglycerides and total cholesterol concentrations with newly diagnosed diabetes in adults in China

https://doi.org/10.18632/oncotarget.21969

Jing Cui, Jianping Sun, Wei Wang, Hualei Xin, Qing Qiao, Zulqarnain Baloch,  and Aiguo Ma
103477-103485
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Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice

Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice

https://doi.org/10.18632/oncotarget.21975

Qiang Fu, Yi Zheng, Xin Dong, Li Wang,  and Chun Guo Jiang
103486-103498
Abstract  |  PDF  |  HTML  |  Order a Reprint

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

https://doi.org/10.18632/oncotarget.21498

Hua-Tuo Huang, Yu-Lan Lu, Rong Wang, Hai-Mei Qin, Chun-Fang Wang, Jun-Li Wang, Yang Xiang, Jing Guo, Yan Lan,  and Ye-Sheng Wei
103499-103508
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Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis

Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis

https://doi.org/10.18632/oncotarget.21508

Sebastian Yu, Hamm-Ming Sheu,  and Chih-Hung Lee
103509-103517
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Marital status and survival in patients with non-small cell lung cancer: an analysis of 70006 patients in the SEER database

Marital status and survival in patients with non-small cell lung cancer: an analysis of 70006 patients in the SEER database

https://doi.org/10.18632/oncotarget.21568

Ying Wu, Zisheng Ai,  and Guotong Xu
103518-103534
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A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/albumin ratio

A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/albumin ratio

https://doi.org/10.18632/oncotarget.21989

Qiang Zhao, Sheng Chen,  and Ji-Feng Feng
103535-103542
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Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer

https://doi.org/10.18632/oncotarget.21569

Soma Samanta, Shuzo Tamura, Louis Dubeau, Paulette Mhawech-Fauceglia, Yohei Miyagi, Hisamori Kato, Rich Lieberman, Ronald J. Buckanovich, Yvonne G. Lin,  and Nouri Neamati
103543-103556
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CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer

CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer

https://doi.org/10.18632/oncotarget.21581

Mengjiao Han, Dongjun Dai, Neelum Aziz Yousafzai, Faliang Wang, Hanying Wang, Qiying Zhou, Haiqi Lu, Wenxia Xu, Lifeng Feng, Hongchuan Jin,  and Xian Wang
103557-103567
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STAT3-mediated activation of miR-21 is involved in downregulation of TIMP3 and neovascularization in the ischemic retina

STAT3-mediated activation of miR-21 is involved in downregulation of TIMP3 and neovascularization in the ischemic retina

https://doi.org/10.18632/oncotarget.21592

Diana R. Gutsaeva, Menaka Thounaojam, Shubhra Rajpurohit, Folami L. Powell, Pamela M. Martin, Stephanie Goei, Michael Duncan,  and Manuela Bartoli
103568-103580
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Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

https://doi.org/10.18632/oncotarget.21658

Christopher W. Wasson, Ethan L. Morgan, Marietta Müller, Rebecca L. Ross, Margaret Hartley, Sally Roberts,  and Andrew Macdonald
103581-103600
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IL-22 promotes the progression of breast cancer through regulating HOXB-AS5

IL-22 promotes the progression of breast cancer through regulating HOXB-AS5

https://doi.org/10.18632/oncotarget.22063

Jiang Rui, Zhao Chunming, Gao Binbin, Shao Na, Wang Shengxi,  and Song Wei
103601-103612
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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

https://doi.org/10.18632/oncotarget.21665

Pei-Yi Chu, Shih Sheng Jiang, Yan-Shen Shan, Wen-Chun Hung, Ming-Huang Chen, Hui-You Lin, Yu-Lin Chen, Hui-Jen Tsai,  and Li-Tzong Chen
103613-103625
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ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia

ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.22093

Carolina Yaeko Namasu, Christiane Katzerke, Daniela Bräuer-Hartmann, Alexander Arthur Wurm, Dennis Gerloff, Jens-Uwe Hartmann, Sebastian Schwind, Carsten Müller-Tidow, Nadja Hilger, Stephan Fricke, Maximilian Christopeit, Dietger Niederwieser,  and Gerhard Behre
103626-103639
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Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice

Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice

https://doi.org/10.18632/oncotarget.21760

Hao Jia Wu, Wai Han Yiu, Dickson W.L. Wong, Rui Xi Li, Loretta Y.Y. Chan, Joseph C.K. Leung, Yuelin Zhang, Qizhou Lian, Kar Neng Lai, Hung Fat Tse,  and Sydney C.W. Tang
103640-103656
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

https://doi.org/10.18632/oncotarget.21761

Vera Miranda-Gonçalves, Diana Cardoso-Carneiro, Inês Valbom, Fernanda Paula Cury, Viviane Aline Silva, Sara Granja, Rui M. Reis, Fátima Baltazar,  and Olga Martinho
103657-103670
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Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer

Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer

https://doi.org/10.18632/oncotarget.22110

Rin Ogiya, Naoki Niikura, Nobue Kumaki, Hiroyuki Yasojima, Tsutomu Iwasa, Chizuko Kanbayashi, Risa Oshitanai, Michiko Tsuneizumi, Ken-ichi Watanabe, Akira Matsui, Tomomi Fujisawa, Shigehira Saji, Norikazu Masuda, Yutaka Tokuda,  and Hiroji Iwata
103671-103681
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation

The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation

https://doi.org/10.18632/oncotarget.21771

Claudia Dollt, Kathrin Becker, Julia Michel, Susanne Melchers, Cleo-Aron Weis, Kai Schledzewski, Andreas Krewer, Loreen Kloss, Christoffer Gebhardt, Jochen Utikal,  and Astrid Schmieder
103682-103692
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Multi-omics analyses of red blood cell reveal antioxidation mechanisms associated with hemolytic toxicity of gossypol

Multi-omics analyses of red blood cell reveal antioxidation mechanisms associated with hemolytic toxicity of gossypol

https://doi.org/10.18632/oncotarget.21779

Chaohua Tang, Qingshi Meng, Kai Zhang, Tengfei Zhan, Qingyu Zhao, Sheng Zhang,  and Junmin Zhang
103693-103709
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Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway

Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway

https://doi.org/10.18632/oncotarget.21780

Mathieu Chocry, Ludovic Leloup,  and Hervé Kovacic
103710-103730
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

https://doi.org/10.18632/oncotarget.21909

Mohammad Alzrigat, Alba Atienza Párraga, Muntasir Mamun Majumder, Anqi Ma, Jian Jin, Anders Österborg, Hareth Nahi, Kenneth Nilsson, Caroline A. Heckman, Fredrik Öberg, Antonia Kalushkova,  and Helena Jernberg-Wiklund
103731-103743
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Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer

Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer

https://doi.org/10.18632/oncotarget.21781

Etienne Giroux Leprieur, Bhairavi Tolani, Hui Li, Fleur Leguay, Ngoc T. Hoang, Luis A. Acevedo, Joy Q. Jin, Hsin-Hui Tseng, Dongsheng Yue, Il-Jin Kim, Marie Wislez, Changli Wang, David M. Jablons,  and Biao He
103744-103757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model

Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model

https://doi.org/10.18632/oncotarget.21911

Hayley C. Affronti, Mark D. Long, Spencer R. Rosario, Bryan M. Gillard, Ellen Karasik, Christoph S. Boerlin, Anthony J. Pellerite, Barbara A. Foster, Kristopher Attwood, Roberto Pili, John H. Wilton, Moray J. Campbell,  and Dominic J. Smiraglia
103758-103774
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fusion of the genes ataxin 2 like, ATXN2L, and Janus kinase 2, JAK2, in cutaneous CD4 positive T-cell lymphoma

Fusion of the genes ataxin 2 like, ATXN2L, and Janus kinase 2, JAK2, in cutaneous CD4 positive T-cell lymphoma

https://doi.org/10.18632/oncotarget.21790

Ioannis Panagopoulos, Ludmila Gorunova, Signe Spetalen, Assia Bassarova, Klaus Beiske, Francesca Micci,  and Sverre Heim
103775-103784
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SAMMSON drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/β-catenin activation

SAMMSON drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/β-catenin activation

https://doi.org/10.18632/oncotarget.21792

Xiaopeng Li, Ming Li, JiaLi Chen, Hua Dai, Liang Wang, Ying Xiong, Yuanbin Zhong,  and Lunli Zhang
103785-103796
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Ruxolitinib combined with vorinostat suppresses tumor growth and alters metabolic phenotype in hematological diseases

Ruxolitinib combined with vorinostat suppresses tumor growth and alters metabolic phenotype in hematological diseases

https://doi.org/10.18632/oncotarget.21951

Monica Civallero, Maria Cosenza, Samantha Pozzi,  and Stefano Sacchi
103797-103814
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dihydroartemisinin inhibits EMT induced by platinum-based drugs via Akt–Snail pathway

Dihydroartemisinin inhibits EMT induced by platinum-based drugs via Akt–Snail pathway

https://doi.org/10.18632/oncotarget.21793

Yuan Qin, Guang Yang, Meng Li, Hui-Juan Liu, Wei-Long Zhong, Xue-Qin Yan, Kai-Liang Qiao, Jia-Huan Yang, Deng-Hui Zhai, Wei Yang, Shuang Chen, Hong-Gang Zhou, Tao Sun,  and Cheng Yang
103815-103827
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LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells

LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells

https://doi.org/10.18632/oncotarget.21953

Elsa M. Reyes-Reyes, Ivan Aispuro, Marco A. Tavera-Garcia, Matthew Field, Sara Moore, Irma Ramos,  and Kenneth S. Ramos
103828-103842
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Is there a difference in testosterone levels and its regulators in men carrying BRCA mutations?

Is there a difference in testosterone levels and its regulators in men carrying BRCA mutations?

https://doi.org/10.18632/oncotarget.21802

Hanan Goldberg, Liat Shavit Grievink, Roy Mano, Yaara Ber, Rachely Ozalbo, Sivan Tuval, Jack Baniel,  and David Margel
103843-103850
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Interaction and joint effect of ALT and chronic liver disease on liver cancer in type 2 diabetes patients

Interaction and joint effect of ALT and chronic liver disease on liver cancer in type 2 diabetes patients

https://doi.org/10.18632/oncotarget.21804

Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Pao-Hsuan Lin, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Jen-Huai Chiang,  and Cheng-Chieh Lin
103851-103863
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Elevated serum urate is a potential factor in reduction of total bilirubin: a Mendelian randomization study

Elevated serum urate is a potential factor in reduction of total bilirubin: a Mendelian randomization study

https://doi.org/10.18632/oncotarget.21977

Hui Zhang, Jing Liu, Zheng Dong, Yue Ding, Qiaoxia Qian, Jingru Zhou, Yanyun Ma, Zhendong Mei, Xiangxiang Chen, Yuan Li, Ziyu Yuan, Juan Zhang, Yajun Yang, Xingdong Chen, Li Jin, Hejian Zou, Xiaofeng Wang,  and Jiucun Wang
103864-103873
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Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

https://doi.org/10.18632/oncotarget.21808

Changde Zhang, Shanchun Guo, Lin Yang, Jiawang Liu, Shilong Zheng, Qiu Zhong, Qiang Zhang,  and Guangdi Wang
103874-103889
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“Paradoxical” findings of tumor vascularity and oxygenation in recurrent glioblastomas refractory to bevacizumab

“Paradoxical” findings of tumor vascularity and oxygenation in recurrent glioblastomas refractory to bevacizumab

https://doi.org/10.18632/oncotarget.21978

Yohei Yamamoto, Ryota Tamura, Toshihide Tanaka, Kentaro Ohara, Yukina Tokuda, Keisuke Miyake, Jun Takei, Yasuharu Akasaki, Kazunari Yoshida, Yuichi Murayama,  and Hikaru Sasaki
103890-103899
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Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma

Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma

https://doi.org/10.18632/oncotarget.21812

Jing-Jing Wang, Qing-Yun Chong, Xin-Bao Sun, Ming-Liang You, Vijay Pandey, Yi-Jun Chen, Qiu-Shi Zhuang, Dong-Xu Liu, Lan Ma, Zheng-Sheng Wu, Tao Zhu,  and Peter E. Lobie
103900-103918
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Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method

Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method

https://doi.org/10.18632/oncotarget.21865

Bing He, Peng Lu, Lei Guan, Ting Li, Lei Zhang, Qing-Ge Zhu, Xiao-Xiao Ding, Shi-Ming Zhang, Xue-Mei Chen, Jing Zhao, Song Lin, Zhi-Zhen Liu, Fang-E Liu, Wang Ma,  and Hu-Qin Zhang
103919-103930
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PARP inhibition causes premature loss of cohesion in cancer cells

PARP inhibition causes premature loss of cohesion in cancer cells

https://doi.org/10.18632/oncotarget.21879

Eva Kukolj, Tanja Kaufmann, Amalie E. Dick, Robert Zeillinger, Daniel W. Gerlich,  and Dea Slade
103931-103951
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Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

https://doi.org/10.18632/oncotarget.21895

Muhammad Kashif, Claes Andersson, Sharmineh Mansoori, Rolf Larsson, Peter Nygren,  and Mats G. Gustafsson
103952-103967
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Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma

Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma

https://doi.org/10.18632/oncotarget.21916

Jian He, Mingju Sun, Enyou Li, Yingyong Hou, Matthew J. Shepard, Di Chen, Karel Pacak, Changsong Wang, Lei Guo, Zhengping Zhuang,  and Yang Liu
103968-103974
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LPI-NRLMF: lncRNA-protein interaction prediction by neighborhood regularized logistic matrix factorization

LPI-NRLMF: lncRNA-protein interaction prediction by neighborhood regularized logistic matrix factorization

https://doi.org/10.18632/oncotarget.21934

Hongsheng Liu, Guofei Ren, Huan Hu, Li Zhang, Haixin Ai, Wen Zhang,  and Qi Zhao
103975-103984
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop

Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop

https://doi.org/10.18632/oncotarget.21944

Xiang-Li Bai, Xiao-Yan Yang, Ju-Yi Li, Ye Li, Xiong Jia, Zhi-Fan Xiong, Yu-Mei Wang,  and Si Jin
103985-103995
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53

Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53

https://doi.org/10.18632/oncotarget.22087

Neeraj K. Aryal, Amanda R. Wasylishen, Vinod Pant, Maurisa Riley-Croce,  and Guillermina Lozano
103996-104006
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation

Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation

https://doi.org/10.18632/oncotarget.21945

Silvia Senese, Yu-Chen Lo, Ankur A. Gholkar, Chien-Ming Li, Yong Huang, Jack Mottahedeh, Harley I. Kornblum, Robert Damoiseaux,  and Jorge Z. Torres
104007-104021
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma

https://doi.org/10.18632/oncotarget.21955

Zheng Wang, Lijun Wen, Fei Zhu, Yanping Wang, Qing Xie, Zijun Chen,  and Yunsen Li
104022-104036
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Kv4.3 expression reverses ICa remodeling in ventricular myocytes of heart failure

Kv4.3 expression reverses ICa remodeling in ventricular myocytes of heart failure

https://doi.org/10.18632/oncotarget.21956

Jun Cheng, Jianlei Cao, Xingchen Jiang, Lin Xu,  and Yanggan Wang
104037-104045
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combination therapy with capecitabine and temozolomide in patients with low and high grade neuroendocrine tumors, with an exploratory analysis of O6-methylguanine DNA methyltransferase as a biomarker for response

Combination therapy with capecitabine and temozolomide in patients with low and high grade neuroendocrine tumors, with an exploratory analysis of O6-methylguanine DNA methyltransferase as a biomarker for response

https://doi.org/10.18632/oncotarget.22001

Dwight H. Owen, Andrew J. Alexander, Bhavana Konda, Lai Wei, Jessica A. Hemminger, Carl R. Schmidt, Sherif R.Z. Abdel-Misih, Mary E. Dillhoff, Jennifer A. Sipos, Lawrence S. Kirschner,  and Manisha H. Shah
104046-104056
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore

Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore

https://doi.org/10.18632/oncotarget.22004

Shan Kuang, Ge Liu, Ruobing Cao, Linlin Zhang, Qiang Yu,  and Chaomin Sun
104057-104071
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The WAVE3-YB1 interaction regulates cancer stem cells activity in breast cancer

The WAVE3-YB1 interaction regulates cancer stem cells activity in breast cancer

https://doi.org/10.18632/oncotarget.22009

Kamila Bledzka, Barbara Schiemann, William P. Schiemann, Paul Fox, Edward F. Plow,  and Khalid Sossey-Alaoui
104072-104089
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo

Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo

https://doi.org/10.18632/oncotarget.22011

Zhenghu Chen, Yanling Zhao, Yang Yu, Jonathan C. Pang, Sarah E. Woodfield, Ling Tao, Shan Guan, Huiyuan Zhang, Shayahati Bieerkehazhi, Yan Shi, Roma Patel, Sanjeev A.Vasudevan, Joanna S. Yi, Jodi A. Muscal, Guo-Tong Xu,  and Jianhua Yang
104090-104103
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Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway

Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway

https://doi.org/10.18632/oncotarget.22017

Ying Gu, Yaling Feng, Jinjin Yu, Hua Yuan, Yongxiang Yin, Jian Ding, Jun Zhao, Yaohui Xu, Jianjuan Xu,  and Haisha Che
104104-104112
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Genomic variations in paired normal controls for lung adenocarcinomas

Genomic variations in paired normal controls for lung adenocarcinomas

https://doi.org/10.18632/oncotarget.22020

Li-Wei Qu, Bo Zhou, Gui-Zhen Wang, Ying Chen,  and Guang-Biao Zhou
104113-104122
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pattern of p53 protein expression is predictive for survival in chemoradiotherapy-naive esophageal adenocarcinoma

Pattern of p53 protein expression is predictive for survival in chemoradiotherapy-naive esophageal adenocarcinoma

https://doi.org/10.18632/oncotarget.22021

Fiebo J.C. Ten, Lucia Suzuki, Lambert C.J. Dorssers, Winand N.M. Dinjens, David T.W. Jones, Daan Nieboer, Michael Doukas, J. Jan B. Van Lanschot, Bas P.L. Wijnhoven, Leendert H.J. Looijenga,  and Katharina Biermann
104123-104135
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis

Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis

https://doi.org/10.18632/oncotarget.22024

Cristina Enríquez-Cortina, Oscar Bello-Monroy, Patricia Rosales-Cruz, Verónica Souza, Roxana U. Miranda, Rafael Toledo-Pérez, Armando Luna-López, Arturo Simoni-Nieves, Rogelio Hernández-Pando, María Concepción Gutiérrez-Ruiz, Diego F. Calvisi, Jens U. Marquardt, Leticia Bucio,  and Luis Enrique Gomez-Quiroz
104136-104148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab

Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab

https://doi.org/10.18632/oncotarget.22027

Renata Duchnowska, Jeff Sperinde, Bogumiła Czartoryska-Arłukowicz, Paulina Myśliwiec, John Winslow, Barbara Radecka, Christos Petropoulos, Regina Demlova, Marlena Orlikowska, Anna Kowalczyk, Istvan Lang, Barbara Ziółkowska, Sylwia Dębska-Szmich, Monika Merdalska, Aleksandra Grela-Wojewoda, Anton Żawrocki, Wojciech Biernat, Weidong Huang,  and Jacek Jassem
104149-104159
Abstract  |  PDF  |  HTML  |  Order a Reprint

Long non-coding RNA ZFAS1 sponges miR-486 to promote osteosarcoma cells progression and metastasis in vitro and vivo

Long non-coding RNA ZFAS1 sponges miR-486 to promote osteosarcoma cells progression and metastasis in vitro and vivo

https://doi.org/10.18632/oncotarget.22032

Nan Li, Zhen-Hui Sun, Min Fang, Jing-Yi Xin,  and Chun-You Wan
104160-104170
Abstract  |  PDF  |  HTML  |  Order a Reprint

Deletion of resistin-like molecule-beta attenuates angiotensin II-induced abdominal aortic aneurysm

Deletion of resistin-like molecule-beta attenuates angiotensin II-induced abdominal aortic aneurysm

https://doi.org/10.18632/oncotarget.22042

Xiao Meng, Kai Zhang, Jing Kong, Long Xu, Guipeng An, Weidong Qin, Jifu Li,  and Yun Zhang
104171-104181
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

https://doi.org/10.18632/oncotarget.22115

Ashley E. Ross, Robert M. Hughes, Stephanie Glavaris, Kamyar Ghabili, Ping He, Nicole M. Anders, Rana Harb, Jeffrey J. Tosoian, Luigi Marchionni, Edward M. Schaeffer, Alan W. Partin, Mohamad E. Allaf, Trinity J. Bivalacqua, Carolyn Chapman, Tanya O’Neal, Angelo M. DeMarzo, Paula J. Hurley, Michelle A. Rudek,  and Emmanuel S. Antonarakis
104182-104192
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells

https://doi.org/10.18632/oncotarget.22119

Yujuan Chen, Xiaoyun Wang, Chuan Cao, Xiaodong Wang, Shufang Liang, Cheng Peng, Leilei Fu,  and Gu He
104193-104205
Abstract  |  PDF  |  HTML  |  Order a Reprint

Overexpression of miR-216b sensitizes NSCLC cells to cisplatin-induced apoptosis by targeting c-Jun

Overexpression of miR-216b sensitizes NSCLC cells to cisplatin-induced apoptosis by targeting c-Jun

https://doi.org/10.18632/oncotarget.22171

Gang Huang, Jiongwei Pan, Zaiting Ye, Bingmu Fang, Wei Cheng,  and Zhuo Cao
104206-104215
Abstract  |  PDF  |  HTML  |  Order a Reprint

Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade

Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade

https://doi.org/10.18632/oncotarget.22185

Ruyuan Deng, Fengbo Mo, Bowen Chang, Qi Zhang, Hui Ran, Shuhua Yang, Zhiqiang Zhu, Lei Hu,  and Qing Su
104216-104226
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preoperative prediction of hepatocellular carcinoma with portal vein tumor thrombus based on conventional data

Preoperative prediction of hepatocellular carcinoma with portal vein tumor thrombus based on conventional data

https://doi.org/10.18632/oncotarget.22198

Pengpeng Zhu, Yan Liao, Jiyuan Fan, Xin Li, Lili Su, Jun Li, Shengguang Yuan, Junxiong Yu,  and Weijia Liao
104227-104237
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The significance of eosinophils in predicting the severity of acute ischemic stroke

The significance of eosinophils in predicting the severity of acute ischemic stroke

https://doi.org/10.18632/oncotarget.22199

Jun Wang, Li Ma, Tao Lin, Shi-Jing Li, Lei-Lei Chen,  and De-Zhao Wang
104238-104246
Abstract  |  PDF  |  HTML  |  Order a Reprint

Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells

Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells

https://doi.org/10.18632/oncotarget.22200

Wang Chengye, Tian Yu, Shao Ping, Sun Deguang, Wang Keyun, Wang Yan, Zhang Rixin, Liang Rui, Gao Zhenming, Ye Mingliang,  and Wang Liming
104247-104257
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

https://doi.org/10.18632/oncotarget.22208

Huan Tuo, Feng Shu, Sha She, Min Yang, Xiao Qin Zou, Juan Huang, Huai Dong Hu, Peng Hu, Hong Ren, Shi Fang Peng,  and Yi Xuan Yang
104258-104271
Abstract  |  PDF  |  HTML  |  Order a Reprint

A PiggyBac mediated approach for lactoferricin gene transfer in bovine mammary epithelial stem cells for management of bovine mastitis

A PiggyBac mediated approach for lactoferricin gene transfer in bovine mammary epithelial stem cells for management of bovine mastitis

https://doi.org/10.18632/oncotarget.22210

Neelesh Sharma, Do Luong Huynh, Sung Woo Kim, Mrinmoy Ghosh, Simrinder Singh Sodhi, Amit Kumar Singh, Nam Eun Kim, Sung Jin Lee, Kafil Hussain, Sung Jong Oh,  and Dong Kee Jeong
104272-104285
Abstract  |  PDF  |  HTML  |  Order a Reprint

GEJ cancers: gastric or esophageal tumors? searching for the answer according to molecular identity

GEJ cancers: gastric or esophageal tumors? searching for the answer according to molecular identity

https://doi.org/10.18632/oncotarget.22216

Williams Fernandes Barra, Fabiano Cordeiro Moreira, Aline Maria Pereira Cruz, André Salim Khayat, Danielle Queiroz Calcagno, Ney Pereira Carneiro dos Santos, Rui Wanderley Mascarenhas Junior, Taíssa Maíra Thomaz Araújo, Geraldo Ishak, Samia Demachki, Rommel Mario Rodríguez Burbano, Ândrea Kely Campos Ribeiro dos Santos, Sidney Emanuel Batista dos Santos, Gregory Joseph Riggins,  and Paulo Pimentel de Assumpção
104286-104294
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dynamic changes in the cell membrane on three dimensional low coherent quantitative phase microscopy (3D LC-QPM) after treatment with the near infrared photoimmunotherapy

Dynamic changes in the cell membrane on three dimensional low coherent quantitative phase microscopy (3D LC-QPM) after treatment with the near infrared photoimmunotherapy

https://doi.org/10.18632/oncotarget.22223

Fusa Ogata, Tadanobu Nagaya, Shuhei Okuyama, Yasuhiro Maruoka, Peter L. Choyke, Toyohiko Yamauchi,  and Hisataka Kobayashi
104295-104302
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent

Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent

https://doi.org/10.18632/oncotarget.22228

Bernadette V. Marquez-Nostra, Supum Lee, Richard Laforest, Laura Vitale, Xingyu Nie, Krzysztof Hyrc, Tibor Keler, Thomas Hawthorne, Jeremy Hoog, Shunqiang Li, Farrokh Dehdashti, Cynthia X. Ma,  and Suzanne E. Lapi
104303-104314
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice

https://doi.org/10.18632/oncotarget.22234

Silvia Ribback, Jenny Sonke, Andrea Lohr, Josephine Frohme, Kristin Peters, Johannes Holm, Michele Peters, Antonio Cigliano, Diego F. Calvisi,  and Frank Dombrowski
104315-104329
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner

EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner

https://doi.org/10.18632/oncotarget.22236

Azadeh Arabzadeh, Kevin McGregor, Valérie Breton, Lauren Van Der Kraak, Uri David Akavia, Celia M.T. Greenwood,  and Nicole Beauchemin
104330-104346
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Therapeutic effects of the euglenoid ichthyotoxin, euglenophycin, in colon cancer

Therapeutic effects of the euglenoid ichthyotoxin, euglenophycin, in colon cancer

https://doi.org/10.18632/oncotarget.22238

April B. Cabang, Keya De Mukhopadhyay, Sarah Meyers, Jay Morris, Paul V. Zimba,  and Michael J. Wargovich
104347-104358
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of microRNA-218 reduces HIF-1α by targeting on Robo1 in mice aortic endothelial cells under intermittent hypoxia

Inhibition of microRNA-218 reduces HIF-1α by targeting on Robo1 in mice aortic endothelial cells under intermittent hypoxia

https://doi.org/10.18632/oncotarget.22239

Kai-Xiong Liu, Qin Chen, Gong-Ping Chen, Jian-Chai Huang, Jie-Feng Huang, Xin-Ru He, Ting Lin,  and Qi-Chang Lin
104359-104366
Abstract  |  PDF  |  HTML  |  Order a Reprint

Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells

Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells

https://doi.org/10.18632/oncotarget.22248

Cinara O. D’Sousa, João H. Araujo, Ingrid R.S. Baliza, Rosane B. Dias, F. Valverde, Manuela T.A. Vidal, Caroline B.S. Sales, Clarissa A.G. Rocha, Diogo R.M. Moreira, Milena B.P. Soares, Alzir A. Batista,  and Daniel P. Bezerra
104367-104392
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predicting survival time of lung cancer patients using radiomic analysis

Predicting survival time of lung cancer patients using radiomic analysis

https://doi.org/10.18632/oncotarget.22251

Ahmad Chaddad, Christian Desrosiers, Matthew Toews,  and Bassam Abdulkarim
104393-104407
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ETS1, nucleolar and non-nucleolar TERT expression in nevus to melanoma progression

ETS1, nucleolar and non-nucleolar TERT expression in nevus to melanoma progression

https://doi.org/10.18632/oncotarget.22254

Jaskaren S. Kohli, Hira Mir, Afsheen Wasif, Heung Chong, Victoria Akhras, Rajiv Kumar, Eduardo Nagore,  and Dorothy C. Bennett
104408-104417
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human glioma stem-like cells induce malignant transformation of bone marrow mesenchymal stem cells by activating TERT expression

Human glioma stem-like cells induce malignant transformation of bone marrow mesenchymal stem cells by activating TERT expression

https://doi.org/10.18632/oncotarget.22301

Yaodong Zhao, Jinsheng Chen, Xingliang Dai, Honghua Cai, Xiaoyan Ji, Yujing Sheng, Hairui Liu, Lin Yang, Yanming Chen, Dengguo Xi, Minfeng Sheng, Yanping Xue, Jia Shi, Jiachi Liu, Xiaonan Li,  and Jun Dong
104418-104429
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High frequency of radiological differential responses with poly(ADP-Ribose) polymerase (PARP) inhibitor therapy

High frequency of radiological differential responses with poly(ADP-Ribose) polymerase (PARP) inhibitor therapy

https://doi.org/10.18632/oncotarget.22303

Raquel Perez-Lopez, Desam Roda, Begona Jimenez, Jessica Brown, Joaquin Mateo, Suzanne Carreira, Juanita Lopez, Udai Banerji, L. Rhoda Molife, Dow-Mu Koh, Stan B. Kaye, Johann S. de Bono, Nina Tunariu,  and Timothy A. Yap
104430-104443
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiomic analysis in contrast-enhanced CT: predict treatment response to chemoradiotherapy in esophageal carcinoma

Radiomic analysis in contrast-enhanced CT: predict treatment response to chemoradiotherapy in esophageal carcinoma

https://doi.org/10.18632/oncotarget.22304

Zhen Hou, Wei Ren, Shuangshuang Li, Juan Liu, Yu Sun, Suiren Wan,  and Suiren Wan
104444-104454
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)

https://doi.org/10.18632/oncotarget.22320

Paula M. Hauck, Eric R. Wolf, David J. Olivos III, Ciaran P. McAtarsney,  and Lindsey D. Mayo
104455-104466
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic impact of multimorbidity in patients with type 2 diabetes and ST-elevation myocardial infarction

Prognostic impact of multimorbidity in patients with type 2 diabetes and ST-elevation myocardial infarction

https://doi.org/10.18632/oncotarget.22324

Bartosz Hudzik, Ilona Korzonek-Szlacheta, Janusz Szkodziński, Marek Gierlotka, Andrzej Lekston, Barbara Zubelewicz-Szkodzińska,  and Mariusz Gąsior
104467-104477
Abstract  |  PDF  |  HTML  |  Order a Reprint

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)

https://doi.org/10.18632/oncotarget.22327

Judith E. Unterlass, Robert J. Wood, Arnaud Baslé, Julie Tucker, Céline Cano, Martin M.E. Noble,  and Nicola J. Curtin
104478-104491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neuroprotective effects of allicin on ischemia-reperfusion brain injury

Neuroprotective effects of allicin on ischemia-reperfusion brain injury

https://doi.org/10.18632/oncotarget.22355

Xiangyi Kong, Shun Gong, Lijuan Su, Chen Li,  and Yanguo Kong
104492-104507
Abstract  |  PDF  |  HTML  |  Order a Reprint

hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC

hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC

https://doi.org/10.18632/oncotarget.22356

Shitong Zhang, Jianjun Jin, Xiaoxiao Tian,  and Lijuan Wu
104508-104524
Abstract  |  PDF  |  HTML  |  Order a Reprint

Human CRL4DDB2 ubiquitin ligase preferentially regulates post-repair chromatin restoration of H3K56Ac through recruitment of histone chaperon CAF-1

Human CRL4DDB2 ubiquitin ligase preferentially regulates post-repair chromatin restoration of H3K56Ac through recruitment of histone chaperon CAF-1

https://doi.org/10.18632/oncotarget.21869

Qianzheng Zhu, Shengcai Wei, Nidhi Sharma, Gulzar Wani, Jinshan He,  and Altaf A. Wani
104525-104542
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Meta-Analysis

The microRNA miR-10b as a potentially promising biomarker to predict the prognosis of cancer patients: a meta-analysis

The microRNA miR-10b as a potentially promising biomarker to predict the prognosis of cancer patients: a meta-analysis

https://doi.org/10.18632/oncotarget.21428

Yi Zhang, Rong-Bo Liao, Li-Lin Hu, Bi-Xia Tong, Teng-Fei Hao,  and Hua-Jun Wu
104543-104551
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Clinical Research Papers

Multicenter phase II study of apatinib treatment for metastatic gastric cancer after failure of second-line chemotherapy

Multicenter phase II study of apatinib treatment for metastatic gastric cancer after failure of second-line chemotherapy

https://doi.org/10.18632/oncotarget.21053

Hanguang Ruan, Junlin Dong, Xueliang Zhou, Juan Xiong, Hua Wang, Xiaoming Zhong,  and Xiaolong Cao
104552-104559
Abstract  |  PDF  |  HTML  |  Order a Reprint

Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment

Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment

https://doi.org/10.18632/oncotarget.21282

Guan-Qun Chen, Xin Zhang, Yue Xing, Dong Wen, Guang-Bin Cui,  and Ying Han
104560-104570
Abstract  |  PDF  |  HTML  |  Order a Reprint

Comparison of repeated surgical resection and radiofrequency ablation for small recurrent hepatocellular carcinoma after primary resection

Comparison of repeated surgical resection and radiofrequency ablation for small recurrent hepatocellular carcinoma after primary resection

https://doi.org/10.18632/oncotarget.21604

Wei-Chi Sun, I-Shu Chen, Huei-Lung Liang, Cheng-Chung Tsai, Yu-Chia Chen, Being-Whey Wang, Huey-Shyan Lin, Hoi-Hung Chan, Ping-I Hsu, Wei-Lun Tsai,  and Jin-Shiung Cheng
104571-104581
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sex differences in outcomes and risk factors among elderly patients with ischemic stroke

Sex differences in outcomes and risk factors among elderly patients with ischemic stroke

https://doi.org/10.18632/oncotarget.21967

Chunying Zou, Chunjie Wei, Zengmian Wang,  and Yuling Jin
104582-104593
Abstract  |  PDF  |  HTML  |  Order a Reprint

Effect of postoperative analgesia technique on the prognosis of gastric cancer: a retrospective analysis

Effect of postoperative analgesia technique on the prognosis of gastric cancer: a retrospective analysis

https://doi.org/10.18632/oncotarget.21979

Seokyung Shin, Hyoung-Il Kim, Na Young Kim, Ki-Young Lee, Dong Wook Kim,  and Young Chul Yoo
104594-104604
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Improved glycemic control with proximal intestinal bypass and weight loss following gastrectomy in non-obese diabetic gastric cancer patients

Improved glycemic control with proximal intestinal bypass and weight loss following gastrectomy in non-obese diabetic gastric cancer patients

https://doi.org/10.18632/oncotarget.22262

Ali Guner, Minah Cho, Taeil Son, Hyoung-Il Kim, Sung Hoon Noh,  and Woo Jin Hyung
104605-104614
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Reviews

Exploiting cancer's phenotypic guise against itself: targeting ectopically expressed peptide G-protein coupled receptors for lung cancer therapy

Exploiting cancer's phenotypic guise against itself: targeting ectopically expressed peptide G-protein coupled receptors for lung cancer therapy

https://doi.org/10.18632/oncotarget.18403

Mahjabin Khan, Tao Huang, Cheng-Yuan Lin, Jiang Wu, Bao-Min Fan,  and Zhao-Xiang Bian
104615-104637
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Current diagnostics and treatment of fibrosarcoma –perspectives for future therapeutic targets and strategies

Current diagnostics and treatment of fibrosarcoma –perspectives for future therapeutic targets and strategies

https://doi.org/10.18632/oncotarget.20136

Daniela Augsburger, Peter J. Nelson, Thomas Kalinski, Andrej Udelnow, Thomas Knösel, Monika Hofstetter, Ji Wei Qin, Yan Wang, Arvid Sen Gupta, Susanne Bonifatius, Minglun Li, Christiane J. Bruns,  and Yue Zhao
104638-104653
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Testicular cancer from diagnosis to epigenetic factors

Testicular cancer from diagnosis to epigenetic factors

https://doi.org/10.18632/oncotarget.20992

Mariarosaria Boccellino, Daniela Vanacore, Silvia Zappavigna, Carla Cavaliere, Sabrina Rossetti, Carmine D’Aniello, Paolo Chieffi, Evzen Amler, Carlo Buonerba, Giuseppe Di Lorenzo, Rossella Di Franco, Alessandro Izzo, Raffaele Piscitelli, Gelsomina Iovane, Paolo Muto, Gerardo Botti, Sisto Perdonà, Michele Caraglia,  and Gaetano Facchini
104654-104663
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Advances in the understanding and management of T-cell prolymphocytic leukemia

Advances in the understanding and management of T-cell prolymphocytic leukemia

https://doi.org/10.18632/oncotarget.22272

Kamel Laribi, Pierre Lemaire, Jeremy Sandrini,  and Alix Baugier de Materre
104664-104686
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Tumor-derived exosomes in ovarian cancer – liquid biopsies for early detection and real-time monitoring of cancer progression

Tumor-derived exosomes in ovarian cancer – liquid biopsies for early detection and real-time monitoring of cancer progression

https://doi.org/10.18632/oncotarget.22191

Shayna Sharma, Felipe Zuñiga, Gregory E. Rice, Lewis C. Perrin, John D. Hooper,  and Carlos Salomon
104687-104703
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