Oncotarget

Vol 8, No 47

October 10, 2017

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About The Cover

The cover for issue 47 of Oncotarget features Figure 3, "Combined PI3Kα and PI3Kδ inhibition cooperates to decrease viability and NF-κB activity in ABC DLBCL," from Pongas, et al.

Table of Contents

Editorial

LIR and APEAR, two distinct Atg8-binding features within Atg4

LIR and APEAR, two distinct Atg8-binding features within Atg4

https://doi.org/10.18632/oncotarget.17697

Franziska Kriegenburg,  and Fulvio Reggiori
81717-81718
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Intentional weight loss and cancer risk

Intentional weight loss and cancer risk

https://doi.org/10.18632/oncotarget.20671

Juhua Luo, Michael Hendryx,  and Rowan T. Chlebowski
81719-81720
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Community mining of open clinical trial data

Community mining of open clinical trial data

https://doi.org/10.18632/oncotarget.20853

Teemu D. Laajala, Justin Guinney,  and James C. Costello
81721-81722
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Novel function of the tumor suppressor PML at ER-mitochondria sites in the control of autophagy

Novel function of the tumor suppressor PML at ER-mitochondria sites in the control of autophagy

https://doi.org/10.18632/oncotarget.18974

Sonia Missiroli, Massimo Bonora, Simone Patergnani,  and Carlotta Giorgi
81723-81724
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Taking it up a NOTCH: anovel subgroup of ACC is identified

Taking it up a NOTCH: anovel subgroup of ACC is identified

https://doi.org/10.18632/oncotarget.20879

Renata Ferrarotto,  and John V. Heymach
81725-81726
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Eph receptors as oncotargets

Eph receptors as oncotargets

https://doi.org/10.18632/oncotarget.21045

Sara Charmsaz,  and Andrew W. Boyd
81727-81728
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‘ILC-poiesis’: generating tissue ILCs from naïve precursors

‘ILC-poiesis’: generating tissue ILCs from naïve precursors

https://doi.org/10.18632/oncotarget.21046

James P. Di Santo, Ai Ing Lim,  and Hans Yssel
81729-81730
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Immune-DDR crosstalk in pre-leukemia stem cells

Immune-DDR crosstalk in pre-leukemia stem cells

https://doi.org/10.18632/oncotarget.21047

Limei Wu, Allison Cole,  and Wei Du
81731-81732
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UCB HCT in FLT3+ AML

UCB HCT in FLT3+ AML

https://doi.org/10.18632/oncotarget.21048

Celalettin Ustun, Annalisa Ruggeri,  and Daniel J. Weisdorf
81733-81734
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Importance of FISH genetics in light chain amyloidosis

Importance of FISH genetics in light chain amyloidosis

https://doi.org/10.18632/oncotarget.21052

Morie A. Gertz, Angela Dispenzieri,  and Eli Muchtar
81735-81736
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Priority Research Papers

Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression

Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression

https://doi.org/10.18632/oncotarget.19387

Lin Chen, Shauna N. Vasilatos, Ye Qin, Tiffany A. Katz, Chunyu Cao, Hao Wu, Nilgun Tasdemir, Kevin M. Levine, Steffi Oesterreich, Nancy E. Davidson,  and Yi Huang
81737-81753
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Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

https://doi.org/10.18632/oncotarget.19953

Timothy G. Pestell, Xuanmao Jiao, Mukesh Kumar, Amy R. Peck, Marco Prisco, Shengqiong Deng, Zhiping Li, Adam Ertel, Mathew C. Casimiro, Xiaoming Ju, Agnese Di Rocco, Gabriele Di Sante, Sanjay Katiyar, Alison Shupp, Michael P. Lisanti, Pooja Jain, Kongming Wu, Hallgeir Rui, Douglas C. Hooper, Zuoren Yu, Aaron R. Goldman, David W. Speicher, Lisa Laury-Kleintop,  and Richard G. Pestell
81754-81775
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP

Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP

https://doi.org/10.18632/oncotarget.20819

Avital Lev, Amriti R. Lulla, Jessica Wagner, Marie D. Ralff, Joshua B. Kiehl, Yan Zhou, Cyril H. Benes, Varun V. Prabhu, Wolfgang Oster, Igor Astsaturov, David T. Dicker,  and Wafik S. El-Deiry
81776-81793
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphoma

PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.20864

Georgios N. Pongas, Christina M. Annunziata,  and Louis M. Staudt
81794-81802
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Priority Reviews

Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer

Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer

https://doi.org/10.18632/oncotarget.19413

Gabriele Di Sante, Agnese Di Rocco, Claudia Pupo, Mathew C. Casimiro,  and Richard G. Pestell
81803-81812
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Research Papers: Pathology

Role of the inflammasome in chronic obstructive pulmonary disease (COPD)

Role of the inflammasome in chronic obstructive pulmonary disease (COPD)

https://doi.org/10.18632/oncotarget.17850

Chiara Colarusso, Michela Terlizzi, Antonio Molino, Aldo Pinto,  and Rosalinda Sorrentino
81813-81824
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Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection

Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection

https://doi.org/10.18632/oncotarget.18998

Meisheng Zou, Chixiong Huang, Xinzhong Li, Xiang He, Yanmei Chen, Wangjun Liao, Yulin Liao, Jie Sun, Ze Liu, Lintao Zhong,  and Jianping Bin
81825-81837
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The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology

The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology

https://doi.org/10.18632/oncotarget.19003

Xumin Ou, Sai Mao, Jingyu Cao, Yunchao Ma, Guangpeng Ma, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu,  and Xiaoyue Chen
81838-81851
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

Re-balance of memory T cell subsets in peripheral blood from patients with CML after TKI treatment

Re-balance of memory T cell subsets in peripheral blood from patients with CML after TKI treatment

https://doi.org/10.18632/oncotarget.20965

Danlin Yao, Ling Xu, Jiaxiong Tan, Yikai Zhang, Shuai Lu, Mingde Li, Sichun Lu, Lijian Yang, Shaohua Chen, Jie Chen, Jing Lai, Yuhong Lu, Xiuli Wu, Xianfeng Zha,  and Yangqiu Li
81852-81859
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A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A

A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A

https://doi.org/10.18632/oncotarget.19899

Tianshu Xu, Tianlei Ying, Lili Wang, Xiaohua Douglas Zhang, Ying Wang, Lishan Kang, Tao Huang, Liang Cheng, Liping Wang,  and Qi Zhao
81860-81872
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Activation of VIP signaling enhances immunosuppressive effect of MDSCs on CMV-induced adaptive immunity

Activation of VIP signaling enhances immunosuppressive effect of MDSCs on CMV-induced adaptive immunity

https://doi.org/10.18632/oncotarget.20704

Parvin Forghani, Christopher T. Petersen,  and Edmund K. Waller
81873-81879
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells

Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells

https://doi.org/10.18632/oncotarget.18737

Jiaoli Wang, Yilei Wu, Jufeng Guo, Xuefeng Fei, Lei Yu,  and Shenglin Ma
81880-81891
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An oral keratinocyte life cycle model identifies novel host genome regulation by human papillomavirus 16 relevant to HPV positive head and neck cancer

An oral keratinocyte life cycle model identifies novel host genome regulation by human papillomavirus 16 relevant to HPV positive head and neck cancer

https://doi.org/10.18632/oncotarget.18328

Michael R. Evans, Claire D. James, Oonagh Loughran, Tara J. Nulton, Xu Wang, Molly L. Bristol, Brad Windle,  and Iain M. Morgan
81892-81909
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia

Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia

https://doi.org/10.18632/oncotarget.18434

Louise Y. Fong, Ruiyan Jing, Karl J. Smalley, Cristian Taccioli, Johannes Fahrmann, Dinesh K. Barupal, Hansjuerg Alder, John L. Farber, Oliver Fiehn,  and Carlo M. Croce
81910-81925
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Outcome of patients treated for myelodysplastic syndromes with 5q deletion after failure of lenalidomide therapy

Outcome of patients treated for myelodysplastic syndromes with 5q deletion after failure of lenalidomide therapy

https://doi.org/10.18632/oncotarget.18477

Thomas Prebet, Thomas Cluzeau, Sophie Park, Mikkael A. Sekeres, Ulrich Germing, Lionel Ades, Uwe Platzbecker, Katharina Gotze, Norbert Vey, Esther Oliva, Mary M. Sugrue, Cecile Bally, Charikleia Kelaidi, Najla Al Ali, Pierre Fenaux, Steven D. Gore,  and Rami Komrokji
81926-81935
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34+ cells

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34+ cells

https://doi.org/10.18632/oncotarget.19567

Cristina Prieto, Rolf Marschalek, Alessa Kühn, Adelheid Bursen, Clara Bueno,  and Pablo Menéndez
81936-81941
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The significance of post-translational removal of α-DG-N in early stage endometrial cancer development

The significance of post-translational removal of α-DG-N in early stage endometrial cancer development

https://doi.org/10.18632/oncotarget.17286

Sophea Heng, Jemma Evans, Lois A. Salamonsen, Tom W. Jobling,  and Guiying Nie
81942-81952
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The nucleocytoplasmic translocation and up-regulation of ING5 protein in breast cancer: a potential target for gene therapy

The nucleocytoplasmic translocation and up-regulation of ING5 protein in breast cancer: a potential target for gene therapy

https://doi.org/10.18632/oncotarget.17918

Xiao-Qing Ding, Shuang Zhao, Lei Yang, Xin Zhao, Gui-Feng Zhao, Shu-Peng Zhao, Zhi-Jie Li,  and Hua-Chuan Zheng
81953-81966
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cryoablation combined with allogenic natural killer cell immunotherapy improves the curative effect in patients with advanced hepatocellular cancer

Cryoablation combined with allogenic natural killer cell immunotherapy improves the curative effect in patients with advanced hepatocellular cancer

https://doi.org/10.18632/oncotarget.17804

Mao Lin, Shuzhen Liang, Xiaohua Wang, Yinqing Liang, Mingjie Zhang, Jibing Chen, Lizhi Niu,  and Kecheng Xu
81967-81977
Abstract  |  PDF  |  HTML  |  Order a Reprint

Significance of NLDA, the commixed index of inflammation, immune responses, hemostasis, and nutrition, for predicting metastatic non-small cell lung cancer prognosis and metastases

Significance of NLDA, the commixed index of inflammation, immune responses, hemostasis, and nutrition, for predicting metastatic non-small cell lung cancer prognosis and metastases

https://doi.org/10.18632/oncotarget.18184

Wen-Wen Sun, Jia-An Hu, Wen-Quan Niu, Bei-Li Gao,  and Zhi-Hong Xu
81978-81993
Abstract  |  PDF  |  HTML  |  Order a Reprint

Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets

Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets

https://doi.org/10.18632/oncotarget.17813

Naomi Li, Steven Hébert, Jingwen Song, Claudia L. Kleinman,  and Stéphane Richard
81994-82005
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer’s disease

Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer’s disease

https://doi.org/10.18632/oncotarget.18299

Anastasia P. Grigorenko, Youri K. Moliaka, Olga V. Plotnikova, Alexander Smirnov, Vera A. Nikishina, Andrey Y. Goltsov, Fedor Gusev, Tatiana V. Andreeva, Omar Nelson, Ilya Bezprozvanny,  and Evgeny I. Rogaev
82006-82026
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activity in vitro and in vivo

ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activity in vitro and in vivo

https://doi.org/10.18632/oncotarget.18303

Gang Yin, Jin Fan, Wei Zhou, Qingfeng Ding, Jun Zhang, Xuan Wu, Pengyu Tang, Hao Zhou, Bowen Wan,  and Guoyong Yin
82027-82036
Abstract  |  PDF  |  HTML  |  Order a Reprint

Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: Implications for immunotherapy

Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: Implications for immunotherapy

https://doi.org/10.18632/oncotarget.18301

Kellie B. Haworth, Michael A. Arnold, Christopher R. Pierson, Kwangmin Choi, Nicholas D. Yeager, Nancy Ratner, Ryan D. Roberts, Jonathan L. Finlay,  and Timothy P. Cripe
82037-82048
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE-cadherin

Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE-cadherin

https://doi.org/10.18632/oncotarget.18282

Sylwia Kabacik,  and Ken Raj
82049-82063
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress

MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress

https://doi.org/10.18632/oncotarget.18289

Xiao-Peng Yuan, Long-Shan Liu, Chuan-Bao Chen, Jian Zhou, Yi-Tao Zheng, Xiao-Ping Wang, Ming Han,  and Chang-Xi Wang
82064-82077
Abstract  |  PDF  |  HTML  |  Order a Reprint

Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

https://doi.org/10.18632/oncotarget.18427

Hao Rong, Xue He, Li Wang, Yongjun He, Longli Kang,  and Tianbo Jin
82078-82084
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

https://doi.org/10.18632/oncotarget.18294

Ai-Mei Gao, Xiao-Yu Zhang,  and Zun-Ping Ke
82085-82091
Abstract  |  PDF  |  HTML  |  Order a Reprint

The influence of marital status on survival in patients with oral tongue squamous cell carcinoma

The influence of marital status on survival in patients with oral tongue squamous cell carcinoma

https://doi.org/10.18632/oncotarget.18538

Wei Sun, Zeting Qiu, Wulin Tan, Zhongqi Liu, Zhongxing Wang, Wenqi Huang,  and Minghui Cao
82092-82102
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of striking life events with primary breast cancer in 265 Chinese women: a case-control study

Association of striking life events with primary breast cancer in 265 Chinese women: a case-control study

https://doi.org/10.18632/oncotarget.18744

Yan Lin, Shengsheng Wang, Xiaohui Zhang, Changjun Wang, Guangliang Shan, Yidong Zhou, Feng Mao, Jinghong Guan, Xin Huang, Ying Zhong,  and Qiang Sun
82103-82113
Abstract  |  PDF  |  HTML  |  Order a Reprint

Endoscopic retrograde cholangiopancreatography versus laparoscopic exploration for common bile duct stones in post-cholecystectomy patients: a retrospective study

Endoscopic retrograde cholangiopancreatography versus laparoscopic exploration for common bile duct stones in post-cholecystectomy patients: a retrospective study

https://doi.org/10.18632/oncotarget.18839

Xiaohong Wang, Chenguang Dai, Zhonghua Jiang, Lili Zhao, Min Wang, Limei Ma, Xueming Tan, Li Liu, Xiang Wang,  and Zhining Fan
82114-82122
Abstract  |  PDF  |  HTML  |  Order a Reprint

Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

https://doi.org/10.18632/oncotarget.18899

Zuzanna Tracz-Gaszewska, Marta Klimczak, Przemyslaw Biecek, Marcin Herok, Marcin Kosinski, Maciej B. Olszewski, Patrycja Czerwińska, Milena Wiech, Maciej Wiznerowicz, Alicja Zylicz, Maciej Zylicz,  and Bartosz Wawrzynow
82123-82143
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration

https://doi.org/10.18632/oncotarget.19285

Asfar S. Azmi, Yiwei Li, Irfana Muqbil, Amro Aboukameel, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael G. Kauffman, Philip A. Philip,  and Ramzi M. Mohammad
82144-82155
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel mutation R190H in the AT-hook 1 domain of MeCP2 identified in an atypical Rett syndrome

A novel mutation R190H in the AT-hook 1 domain of MeCP2 identified in an atypical Rett syndrome

https://doi.org/10.18632/oncotarget.18955

Xiao Zhou, Yuangao Liao, Miaojing Xu, Zhong Ji, Yunqi Xu, Liang Zhou, Xiaoming Wei, Peiqian Hu, Peng Han, Fanghan Yang, Suyue Pan,  and Yafang Hu
82156-82164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

https://doi.org/10.18632/oncotarget.19280

Shuo Pan, Gong-Chang Guan, Ying Lv, Zhong-Wei Liu, Fu-Qiang Liu, Yong Zhang, Shun-Ming Zhu, Rong-Huai Zhang, Na Zhao, Shuang Shi, Tomohiro Nakayama,  and Jun-Kui Wang
82165-82173
Abstract  |  PDF  |  HTML  |  Order a Reprint

Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting β-catenin signaling pathway

Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting β-catenin signaling pathway

https://doi.org/10.18632/oncotarget.19066

Xuexia Zhou, Xuebing Li, Cuiyun Sun, Cuijuan Shi, Dan Hua, Lin Yu, Yanjun Wen, Feng Hua, Qian Wang, Qinghua Zhou,  and Shizhu Yu
82174-82184
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Potential genotoxic and cytotoxicity of emamectin benzoate in human normal liver cells

Potential genotoxic and cytotoxicity of emamectin benzoate in human normal liver cells

https://doi.org/10.18632/oncotarget.18988

Zhijie Zhang, Xinyu Zhao,  and Xiaosong Qin
82185-82195
Abstract  |  PDF  |  HTML  |  Order a Reprint

QiShenYiQi pill attenuates atherosclerosis by promoting regulatory T cells, inhibiting T helper 17 cells and accelerating cholesterol excretion

QiShenYiQi pill attenuates atherosclerosis by promoting regulatory T cells, inhibiting T helper 17 cells and accelerating cholesterol excretion

https://doi.org/10.18632/oncotarget.19072

Li Peng, Chong-Shan Lv, Yun Zhao, Shao-Dong Chen, Yang Huang, Da-Wei Lu, Shu-Qiong Huang, Zong-Bao Yang, Lin-Chao Qian,  and Lei Wen
82196-82206
Abstract  |  PDF  |  HTML  |  Order a Reprint

Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway

Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway

https://doi.org/10.18632/oncotarget.19200

Haiqing Guo, Wei Lin, Xiangying Zhang, Xiaohui Zhang, Zhongjie Hu, Liying Li, Zhongping Duan, Jing Zhang,  and Feng Ren
82207-82216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma

Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma

https://doi.org/10.18632/oncotarget.19283

Megan Wu, Jennifer Guan, Chris Li, Simon Gunter, Labeeba Nusrat, Sheena Ng, Karan Dhand, Cindi Morshead, Albert Kim,  and Sunit Das
82217-82230
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth

Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth

https://doi.org/10.18632/oncotarget.19288

Zhiyong Deng, David H. Manz, Suzy V. Torti,  and Frank M. Torti
82231-82243
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pathologic subtype-defined prognosis is dependent on both tumor stage and status of oncogenic driver mutations in lung adenocarcinoma

Pathologic subtype-defined prognosis is dependent on both tumor stage and status of oncogenic driver mutations in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.19284

Yu Dong, Ying Li, Bo Jin, Jie Zhang, Jinchen Shao, Hong Peng, Shichun Tu,  and Baohui Han
82244-82255
Abstract  |  PDF  |  HTML  |  Order a Reprint

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation

https://doi.org/10.18632/oncotarget.19286

Naida Suleymanova, Caitrin Crudden, Claire Worrall, Anica Dricu, Ada Girnita,  and Leonard Girnita
82256-82267
Abstract  |  PDF  |  HTML  |  Order a Reprint

Disease spectrum of abnormal serum free light chain ratio and its diagnostic significance

Disease spectrum of abnormal serum free light chain ratio and its diagnostic significance

https://doi.org/10.18632/oncotarget.19391

Bin Xu, Yi Tang, Jianfeng Zhou, Peiling Zhang,  and Huijun Li
82268-82279
Abstract  |  PDF  |  HTML  |  Order a Reprint

Melatonin suppresses hepatocellular carcinoma progression via lncRNA-CPS1-IT-mediated HIF-1α inactivation

Melatonin suppresses hepatocellular carcinoma progression via lncRNA-CPS1-IT-mediated HIF-1α inactivation

https://doi.org/10.18632/oncotarget.19316

Tong-Hong Wang, Chi-Hao Wu, Chau-Ting Yeh, Shih-Chi Su, Shih-Min Hsia, Kung-Hao Liang, Chin-Chuan Chen, Chuen Hsueh,  and Chi-Yuan Chen
82280-82293
Abstract  |  PDF  |  HTML  |  Order a Reprint

Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc

Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc

https://doi.org/10.18632/oncotarget.19393

Raquel Conde-Muiño, Carlos Cano, Victoria Sánchez-Martín, Antonio Herrera, Ana Comino, Pedro P. Medina, Pablo Palma,  and Marta Cuadros
82294-82302
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer

c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer

https://doi.org/10.18632/oncotarget.19398

Song Wang, Xiao Wang, Jiangfeng Li, Shuai Meng, Zhen Liang, Xin Xu, Yi Zhu, Shiqi Li, Jian Wu, Mingjie Xu, Alin Ji, Yiwei Lin, Ben Liu, Xiangyi Zheng, Bo Xie,  and Liping Xie
82303-82313
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Correlation of placental microbiota with fetal macrosomia and clinical characteristics in mothers and newborns

Correlation of placental microbiota with fetal macrosomia and clinical characteristics in mothers and newborns

https://doi.org/10.18632/oncotarget.19319

Jia Zheng, Xin-Hua Xiao, Qian Zhang, Li-Li Mao, Miao Yu, Jian-Ping Xu,  and Tong Wang
82314-82325
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumacrophage: macrophages transformed into tumor stem-like cells by virulent genetic material from tumor cells

Tumacrophage: macrophages transformed into tumor stem-like cells by virulent genetic material from tumor cells

https://doi.org/10.18632/oncotarget.19320

Yizhuang Zhang, Na Zhou, Xiuyan Yu, Xuehui Zhang, Shanxin Li, Zhen Lei, Ruobi Hu, Hui Li, Yiqing Mao, Xi Wang, Jinshu Zhang, Yuan Li, Hongyan Guo, David M. Irwin, Gang Niu,  and Huanran Tan
82326-82343
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2

https://doi.org/10.18632/oncotarget.19323

Angelo Toto, Daniela Bonetti, Alfonso De Simone,  and Stefano Gianni
82344-82351
Abstract  |  PDF  |  HTML  |  Order a Reprint

Local blockage of self-sustainable erythropoietin signaling suppresses tumor progression in non-small cell lung cancer

Local blockage of self-sustainable erythropoietin signaling suppresses tumor progression in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.19354

Lei He, Shouzhen Wu, Qiang Hao, Elhadji M. Dioum, Kuo Zhang, Cun Zhang, Weina Li, Wei Zhang, Yingqi Zhang, Jiming Zhou, Zhijun Pang, Lijuan Zhao, Xiaowen Ma, Meng Li,  and Qiuyang Zhang
82352-82365
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human mesenchymal stem cells ameliorate experimental pulmonary hypertension induced by maternal inflammation and neonatal hyperoxia in rats

Human mesenchymal stem cells ameliorate experimental pulmonary hypertension induced by maternal inflammation and neonatal hyperoxia in rats

https://doi.org/10.18632/oncotarget.19388

Chung-Ming Chen, Willie Lin, Liang-Ti Huang,  and Hsiu-Chu Chou
82366-82375
Abstract  |  PDF  |  HTML  |  Order a Reprint

Environmental conditions differentially affect neurobehavioral outcomes in a mouse model of sepsis-associated encephalopathy

Environmental conditions differentially affect neurobehavioral outcomes in a mouse model of sepsis-associated encephalopathy

https://doi.org/10.18632/oncotarget.19595

Mu-Huo Ji, Hui Tang, Dan Luo, Li-Li Qiu, Min Jia, Hong-Mei Yuan, Shan-Wu Feng,  and Jian-Jun Yang
82376-82389
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Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children

Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children

https://doi.org/10.18632/oncotarget.19326

Jiang Xie, Li Huang, Xiaohong Li, Hua Li, Yongmei Zhou, Hua Zhu, Tianying Pan, Keith M. Kendrick,  and Wenming Xu
82390-82398
Abstract  |  PDF  |  HTML  |  Order a Reprint

Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection

Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection

https://doi.org/10.18632/oncotarget.19390

Mi Jung Kwon, Kab-Choong Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hye Kyung Lee, Ho Suk Kang,  and Kyueng-Whan Min
82399-82414
Abstract  |  PDF  |  HTML  |  Order a Reprint

Effective protection against acute respiratory distress syndrome/sepsis injury by combined adipose-derived mesenchymal stem cells and preactivated disaggregated platelets

Effective protection against acute respiratory distress syndrome/sepsis injury by combined adipose-derived mesenchymal stem cells and preactivated disaggregated platelets

https://doi.org/10.18632/oncotarget.19312

Chih-Hung Chen, Yung-Lung Chen, Pei-Hsun Sung, Cheuk-Kwan Sun, Kuan-Hung Chen, Yi-Ling Chen, Tien-Hung Huang, Hung-I Lu, Fan-Yen Lee, Jiunn-Jye Sheu, Sheng-Ying Chung, Mel S. Lee,  and Hon-Kan Yip
82415-82429
Abstract  |  PDF  |  HTML  |  Order a Reprint

Vinculin and filamin-C are two potential prognostic biomarkers and therapeutic targets for prostate cancer cell migration

Vinculin and filamin-C are two potential prognostic biomarkers and therapeutic targets for prostate cancer cell migration

https://doi.org/10.18632/oncotarget.19397

Jianzhong Ai, Tao Jin, Lu Yang, Qiang Wei, Yang Yang, Hong Li,  and Ye Zhu
82430-82436
Abstract  |  PDF  |  HTML  |  Order a Reprint

Potential clinical value of PET/CT in predicting occult nodal metastasis in T1-T2N0M0 lung cancer patients staged by PET/CT

Potential clinical value of PET/CT in predicting occult nodal metastasis in T1-T2N0M0 lung cancer patients staged by PET/CT

https://doi.org/10.18632/oncotarget.19535

Xiang Zhou, Ruohua Chen, Gang Huang,  and Jianjun Liu
82437-82445
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ningnanmycin inhibits tobacco mosaic virus virulence by binding directly to its coat protein discs

Ningnanmycin inhibits tobacco mosaic virus virulence by binding directly to its coat protein discs

https://doi.org/10.18632/oncotarget.19401

Xiangyang Li, Gefei Hao, Qingmin Wang, Zhuo Chen, Yan Ding, Lu Yu, Deyu Hu,  and Baoan Song
82446-82458
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers

Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers

https://doi.org/10.18632/oncotarget.19614

Scott Langevin, Damaris Kuhnell, Tess Parry, Jacek Biesiada, Shouxiong Huang, Trisha Wise-Draper, Keith Casper, Xiang Zhang, Mario Medvedovic,  and Susan Kasper
82459-82474
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Implications of mutational spectrum in myelodysplastic syndromes based on targeted next-generation sequencing

Implications of mutational spectrum in myelodysplastic syndromes based on targeted next-generation sequencing

https://doi.org/10.18632/oncotarget.19628

Yuanyuan Xu, Yan Li, Qingyu Xu, Yuelong Chen, Na Lv, Yu Jing, Liping Dou, Jian Bo, Guangyuan Hou, Jing Guo, Xiuli Wang, Lili Wang, Yonghui Li, Chongjian Chen,  and Li Yu
82475-82490
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PPARγ sumoylation-mediated lipid accumulation in lung cancer

PPARγ sumoylation-mediated lipid accumulation in lung cancer

https://doi.org/10.18632/oncotarget.19700

Ai N.H. Phan, Vu T.A. Vo, Tuyen N.M. Hua, Min-Kyu Kim, Se-Young Jo, Jong-Whan Choi, Hyun-Won Kim, Jaekyoung Son, Young-Ah Suh,  and Yangsik Jeong
82491-82505
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner

Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner

https://doi.org/10.18632/oncotarget.19714

Razan Sheta, Zhi-Qiang Wang, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Alexandra Sebastianelli, Stephane Gobeil, Chantale Morin, Elizabeth Macdonald, Barbara Vanderhyden,  and Dimcho Bachvarov
82506-82530
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional polymorphisms in the promoter region of miR-17-92 cluster are associated with a decreased risk of colorectal cancer

Functional polymorphisms in the promoter region of miR-17-92 cluster are associated with a decreased risk of colorectal cancer

https://doi.org/10.18632/oncotarget.19753

Ruifen Sun, Yundan Liang, Fang Yuan, Xinwen Nie, Hong Sun, Yanyun Wang, Tao Yu, Linbo Gao,  and Lin Zhang
82531-82540
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

C1q/Tumor necrosis factor-related protein-3 protects macrophages against LPS-induced lipid accumulation, inflammation and phenotype transition via PPARγ and TLR4-mediated pathways

C1q/Tumor necrosis factor-related protein-3 protects macrophages against LPS-induced lipid accumulation, inflammation and phenotype transition via PPARγ and TLR4-mediated pathways

https://doi.org/10.18632/oncotarget.19657

Jiale Lin, Qi Liu, Hui Zhang, Xingtao Huang, Ruoxi Zhang, Shuyuan Chen, Xuedong Wang, Bo Yu,  and Jingbo Hou
82541-82557
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Treatment strategy and prognostic factors for Krukenberg tumors of gastric origin: report of a 10-year single-center experience from China

Treatment strategy and prognostic factors for Krukenberg tumors of gastric origin: report of a 10-year single-center experience from China

https://doi.org/10.18632/oncotarget.19759

Pengfei Yu, Ling Huang, Guoping Cheng, Litao Yang, Gaiguo Dai, Jieer Ying,  and Yian Du
82558-82570
Abstract  |  PDF  |  HTML  |  Order a Reprint

Genetic and immune features of resectable malignant brainstem gliomas

Genetic and immune features of resectable malignant brainstem gliomas

https://doi.org/10.18632/oncotarget.19653

Yang Zhang, Changcun Pan, Junmei Wang, Jingli Cao, Yuhan Liu, Yajie Wang,  and Liwei Zhang
82571-82582
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fibroblast growth factor modulates mast cell recruitment in a murine model of prostate cancer

Fibroblast growth factor modulates mast cell recruitment in a murine model of prostate cancer

https://doi.org/10.18632/oncotarget.19773

Roberto Ronca, Roberto Tamma, Daniela Coltrini, Simona Ruggieri, Marco Presta,  and Domenico Ribatti
82583-82592
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

N-myc downstream-regulated gene 1 promotes apoptosis in colorectal cancer via up-regulating death receptor 4

N-myc downstream-regulated gene 1 promotes apoptosis in colorectal cancer via up-regulating death receptor 4

https://doi.org/10.18632/oncotarget.19658

Xian Zhang, Bo Feng, Fan Zhu, Chaoran Yu, Jiaoyang Lu, Meng Pan, Zirui He, Xiongzhi Wangpu, Jing Sun,  and Xiao Yang
82593-82608
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma

Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma

https://doi.org/10.18632/oncotarget.19664

Pritha Paul, Eric J. Rellinger, Jingbo Qiao, Sora Lee, Natasha Volny, Chandrasekhar Padmanabhan, Carmelle V. Romain, Bret Mobley, Hernan Correa,  and Dai H. Chung
82609-82620
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lingguizhugan decoction improves non-alcoholic fatty liver disease by altering insulin resistance and lipid metabolism related genes: a whole trancriptome study by RNA-Seq

Lingguizhugan decoction improves non-alcoholic fatty liver disease by altering insulin resistance and lipid metabolism related genes: a whole trancriptome study by RNA-Seq

https://doi.org/10.18632/oncotarget.19734

Mingzhe Zhu, Shijun Hao, Tao Liu, Lili Yang, Peiyong Zheng, Li Zhang,  and Guang Ji
82621-82631
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of protein kinase A and the kappa opioid receptor in selected brain regions and conditioned place aversion in morphine-dependent rats

Expression of protein kinase A and the kappa opioid receptor in selected brain regions and conditioned place aversion in morphine-dependent rats

https://doi.org/10.18632/oncotarget.19671

Xiuhua Song, Wenqiang Li, Yuzhong Shi, Jingdan Zhang,  and Yi Li
82632-82642
Abstract  |  PDF  |  HTML  |  Order a Reprint

The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies

The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies

https://doi.org/10.18632/oncotarget.19740

Hengwei Fan, Wanwan Yi, Chenxing Wang,  and Jisheng Wang
82643-82660
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The clinical significance of c-Kit mutations in metastatic oral mucosal melanoma in China

The clinical significance of c-Kit mutations in metastatic oral mucosal melanoma in China

https://doi.org/10.18632/oncotarget.19746

Xuhui Ma, Yunteng Wu, Tian Zhang, Hao Song, Houyu Jv, Wei Guo,  and Guoxin Ren
82661-82673
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of novel genetic regulations associated with airway epithelial homeostasis using next-generation sequencing data and bioinformatics approaches

Identification of novel genetic regulations associated with airway epithelial homeostasis using next-generation sequencing data and bioinformatics approaches

https://doi.org/10.18632/oncotarget.19752

Chau-Chyun Sheu, Ming-Ju Tsai, Feng-Wei Chen, Kuo-Feng Chang, Wei-An Chang, Inn-Wen Chong, Po-Lin Kuo,  and Ya-Ling Hsu
82674-82688
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine

Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine

https://doi.org/10.18632/oncotarget.19831

Jing Pan, Qi Zhang, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Yian Wang,  and Ming You
82689-82699
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical outcome of dynamic hip locking plates and proximal femoral nails anti-rotation-Asia for treating intertrochanteric femur fracture with lateral wall fractures in the elder patients

Clinical outcome of dynamic hip locking plates and proximal femoral nails anti-rotation-Asia for treating intertrochanteric femur fracture with lateral wall fractures in the elder patients

https://doi.org/10.18632/oncotarget.19754

Hui Xie, Zhan Wang, Junji Zhang, Langhai Xu,  and Bao Chen
82700-82704
Abstract  |  PDF  |  HTML  |  Order a Reprint

Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging

Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging

https://doi.org/10.18632/oncotarget.19751

Xiao Chen, Yizeng Yang,  and Sharyn Katz
82705-82713
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Probably less than one-tenth of the genes produce only the wild type protein without at least one additional protein isoform in some human cancer cell lines

Probably less than one-tenth of the genes produce only the wild type protein without at least one additional protein isoform in some human cancer cell lines

https://doi.org/10.18632/oncotarget.20015

Rui Yan, Ju Zhang, Lucas Zellmer, Lichan Chen, Di Wu, Siqi Liu, Ningzhi Xu,  and Joshua D. Liao
82714-82727
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ING4 expressing oncolytic vaccinia virus promotes anti-tumor efficiency and synergizes with gemcitabine in pancreatic cancer

ING4 expressing oncolytic vaccinia virus promotes anti-tumor efficiency and synergizes with gemcitabine in pancreatic cancer

https://doi.org/10.18632/oncotarget.21095

Yinfang Wu, Xiaozhou Mou, Shibing Wang, Xing-E Liu,  and Xiaodong Sun
82728-82739
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

https://doi.org/10.18632/oncotarget.21098

Kim C. Ohaegbulam, Weifeng Liu, Hyungjun Jeon, Steven C. Almo,  and Xingxing Zang
82740-82753
Abstract  |  PDF  |  HTML  |  Order a Reprint

PATZ1 knockdown enhances malignant phenotype in thyroid epithelial follicular cells and thyroid cancer cells

PATZ1 knockdown enhances malignant phenotype in thyroid epithelial follicular cells and thyroid cancer cells

https://doi.org/10.18632/oncotarget.19787

Asumi Iesato, Teruo Nakamura, Hiroto Izumi, Takeshi Uehara,  and Ken-Ichi Ito
82754-82772
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Antitumor efficacy of triple monoclonal antibody inhibition of epidermal growth factor receptor (EGFR) with MM151 in EGFR-dependent and in cetuximab-resistant human colorectal cancer cells

Antitumor efficacy of triple monoclonal antibody inhibition of epidermal growth factor receptor (EGFR) with MM151 in EGFR-dependent and in cetuximab-resistant human colorectal cancer cells

https://doi.org/10.18632/oncotarget.19797

Stefania Napolitano, Giulia Martini, Erika Martinelli, Carminia Maria Della Corte, Floriana Morgillo, Valentina Belli, Claudia Cardone, Nunzia Matrone, Fortunato Ciardiello,  and Teresa Troiani
82773-82783
Abstract  |  PDF  |  HTML  |  Order a Reprint

Functional and non-functional pancreatic neuroendocrine tumours: ENETS or AJCC TNM staging system?

Functional and non-functional pancreatic neuroendocrine tumours: ENETS or AJCC TNM staging system?

https://doi.org/10.18632/oncotarget.20007

Min Yang, Neng-Wen Ke, Yi Zhang, Chun-Lu Tan, Bo-Le Tian, Xu-Bao Liu, Wei Huang, Quentin Nunes,  and Robert Sutton
82784-82795
Abstract  |  PDF  |  HTML  |  Order a Reprint

The association between CCR5 Δ32 polymorphism and susceptibility to breast cancer

The association between CCR5 Δ32 polymorphism and susceptibility to breast cancer

https://doi.org/10.18632/oncotarget.19959

Junlong Li, Yuan Peng, Hui Liu,  and Qiang Wu
82796-82802
Abstract  |  PDF  |  HTML  |  Order a Reprint

Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells

Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells

https://doi.org/10.18632/oncotarget.20294

Filipa Lopes-Coelho, Carolina Nunes, Sofia Gouveia-Fernandes, Rita Rosas, Fernanda Silva, Paula Gameiro, Tânia Carvalho, Maria Gomes da Silva, José Cabeçadas, Sérgio Dias, Luís G. Gonçalves,  and Jacinta Serpa
82803-82823
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-93-3p inhibition suppresses clear cell renal cell carcinoma proliferation, metastasis and invasion

miR-93-3p inhibition suppresses clear cell renal cell carcinoma proliferation, metastasis and invasion

https://doi.org/10.18632/oncotarget.20458

Lu Wang, Guang Yang, Xiangwei Zhu, Ziqi Wang, Hongzhi Wang, Yang Bai, Pengcheng Sun, Li Peng, Wei Wei, Guang Chen, Guangbin Li, Andrey A. Zamyatnin Jr, Peter V. Glybochko,  and Wanhai Xu
82824-82834
Abstract  |  PDF  |  HTML  |  Order a Reprint

MMP9 polymorphism is associated with susceptibility to non-traumatic osteonecrosis of femoral head in a Chinese Han population

MMP9 polymorphism is associated with susceptibility to non-traumatic osteonecrosis of femoral head in a Chinese Han population

https://doi.org/10.18632/oncotarget.20463

Yuan Liu, Yanfei Jia, Yuju Cao, Yan Zhao, Jieli Du, Feimeng An, Yuxin Qi, Xue Feng, Tianbo Jin, Jianping Shi,  and Jianzhong Wang
82835-82841
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer

Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer

https://doi.org/10.18632/oncotarget.20666

Hongsheng Tang, Lisi Zeng, Jiahong Wang, Xiangliang Zhang, Qiang Ruan, Jin Wang, Shuzhong Cui,  and Dinghua Yang
82842-82853
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-23a promotes pancreatic cancer metastasis by targeting epithelial splicing regulator protein 1

MicroRNA-23a promotes pancreatic cancer metastasis by targeting epithelial splicing regulator protein 1

https://doi.org/10.18632/oncotarget.20692

Guo Wu, Zhonghu Li, Peng Jiang, Xi Zhang, Yingqiang Xu, Kai Chen,  and Xiaowu Li
82854-82871
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-proliferative and pro-apoptotic effects induced by simultaneous inactivation of HER1 and HER2 through endogenous polyclonal antibodies

Anti-proliferative and pro-apoptotic effects induced by simultaneous inactivation of HER1 and HER2 through endogenous polyclonal antibodies

https://doi.org/10.18632/oncotarget.19958

Narjara González Suárez, Gretchen Bergado Báez, Mabel Cruz Rodríguez, Amelia Gutiérrez Pérez, Lisset Chao García, Diana Rosa Hernández Fernández, Judith Raymond Pous,  and Belinda Sánchez Ramírez
82872-82884
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ex vivo evaluation of tumor cell specific drug responses in malignant pleural effusions

Ex vivo evaluation of tumor cell specific drug responses in malignant pleural effusions

https://doi.org/10.18632/oncotarget.20889

Carl-Olof Hillerdal, Rita Ötvös, Tünde Szatmári, Sulaf Abd Own, Gunnar Hillerdal, Åsa-Lena Dackland, Katalin Dobra,  and Anders Hjerpe
82885-82896
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia

Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia

https://doi.org/10.18632/oncotarget.19970

Kerstin Maria Kampa-Schittenhelm, Julia Frey, Lara A. Haeusser, Barbara Illing, Ashly A. Pavlovsky, Gunnar Blumenstock,  and Marcus Matthias Schittenhelm
82897-82909
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neurofibromatosis type-1 is a prognostic indicator in human gastric carcinoma

Neurofibromatosis type-1 is a prognostic indicator in human gastric carcinoma

https://doi.org/10.18632/oncotarget.19876

Debao Liu, Yueying Zhang, Yan Li,  and Kaixi Fan
82910-82919
Abstract  |  PDF  |  HTML  |  Order a Reprint

RNA-seq reveals distinctive RNA profiles of small extracellular vesicles from different human liver cancer cell lines

RNA-seq reveals distinctive RNA profiles of small extracellular vesicles from different human liver cancer cell lines

https://doi.org/10.18632/oncotarget.20503

Martina Berardocco, Annalisa Radeghieri, Sara Busatto, Marialucia Gallorini, Chiara Raggi, Clarissa Gissi, Igea D’Agnano, Paolo Bergese, Armando Felsani,  and Anna C. Berardi
82920-82939
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lack of both androgen receptor and forkhead box A1 (FOXA1) expression is a poor prognostic factor in estrogen receptor-positive breast cancers

Lack of both androgen receptor and forkhead box A1 (FOXA1) expression is a poor prognostic factor in estrogen receptor-positive breast cancers

https://doi.org/10.18632/oncotarget.20937

Seho Park, Eunjin Koh, Ja Seung Koo, Seung Il Kim, Byeong-Woo Park,  and Kyung-Sup Kim
82940-82955
Abstract  |  PDF  |  HTML  |  Order a Reprint

Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway

Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway

https://doi.org/10.18632/oncotarget.19981

Zhiqiang Qin, Jingyuan Tang, Peng Han, Xuping Jiang, Chengdi Yang, Ran Li, Min Tang, Baixin Shen, Wei Wang, Chao Qin,  and Wei Zhang
82956-82967
Abstract  |  PDF  |  HTML  |  Order a Reprint

RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis

RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis

https://doi.org/10.18632/oncotarget.20897

Xin-Lin Wu, Zhi-Wen Yang, Li He, Pei-De Dong, Ming-Xing Hou, Xing-Kai Meng, Hai-Ping Zhao, Zhao-Yang Wang, Feng Wang, Baoluri, Wurenqimuge, Agudamu, Yong-Feng Jia,  and Lin Shi
82968-82980
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Mcl-1 stabilization confers resistance to taxol in human gastric cancer

Mcl-1 stabilization confers resistance to taxol in human gastric cancer

https://doi.org/10.18632/oncotarget.20222

Wu Shuang, Lili Hou, Yan Zhu, Qun Li,  and Wanglai Hu
82981-82990
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miR-27a-3p targeting RXRα promotes colorectal cancer progression by activating Wnt/β-catenin pathway

miR-27a-3p targeting RXRα promotes colorectal cancer progression by activating Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.19635

Jiangtao Liang, Jianming Tang, Huijuan Shi, Hui Li, Tiantian Zhen, Jing Duan, Lili Kang, Fenfen Zhang, Yu Dong,  and Anjia Han
82991-83008
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Effects of growth hormone on cardiac remodeling and soleus muscle in rats with aortic stenosis-induced heart failure

Effects of growth hormone on cardiac remodeling and soleus muscle in rats with aortic stenosis-induced heart failure

https://doi.org/10.18632/oncotarget.20583

Aline R.R. Lima, Luana U. Pagan, Ricardo L. Damatto, Marcelo D.M. Cezar, Camila Bonomo, Mariana J. Gomes, Paula F. Martinez, Daniele M. Guizoni, Dijon H.S. Campos, Felipe C. Damatto, Katashi Okoshi,  and Marina P. Okoshi
83009-83021
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A phase II study of S-1 with concurrent radiotherapy in elderly patients with esophageal cancer

A phase II study of S-1 with concurrent radiotherapy in elderly patients with esophageal cancer

https://doi.org/10.18632/oncotarget.20938

Yongling Ji, Xianghui Du, Ye Tian, Liming Sheng, Lei Cheng, Ying Chen, Guoqing Qiu, Xia Zhou, Wuan Bao, Danhong Zhang,  and Ming Chen
83022-83029
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The role of indoxyl sulfate in renal anemia in patients with chronic kidney disease

The role of indoxyl sulfate in renal anemia in patients with chronic kidney disease

https://doi.org/10.18632/oncotarget.18789

Chih-Jen Wu, Cheng-Yi Chen, Thung-S. Lai, Pei-Chen Wu, Chih-Kuang Chuang, Fang-Ju Sun, Hsuan-Liang Liu, Han-Hsiang Chen, Hung-I. Yeh, Chih-Sheng Lin,  and Cheng-Jui Lin
83030-83037
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The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies

The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies

https://doi.org/10.18632/oncotarget.19886

Lucia Buccarello, Alessandra Sclip, Matteo Sacchi, Anna Maria Castaldo, Ilaria Bertani, Andrea ReCecconi, Silvia Maestroni, Gianpaolo Zerbini, Paolo Nucci,  and Tiziana Borsello
83038-83051
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NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction

NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction

https://doi.org/10.18632/oncotarget.20943

Shida Yang, Xin Li, Wenchang Guan, Mingqin Qian, Zhicheng Yao, Xiaoxue Yin,  and Hongmei Zhao
83052-83062
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Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer

Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer

https://doi.org/10.18632/oncotarget.20945

Katharina Prieske, Stefan Prieske, Simon A. Joosse, Fabian Trillsch, Donata Grimm, Eike Burandt, Sven Mahner, Barbara Schmalfeldt, Karin Milde-Langosch, Leticia Oliveira-Ferrer,  and Linn Woelber
83063-83074
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RLIM suppresses hepatocellular carcinogenesis by up-regulating p15 and p21

RLIM suppresses hepatocellular carcinogenesis by up-regulating p15 and p21

https://doi.org/10.18632/oncotarget.20904

Yongsheng Huang, Meng Nie, Chuang Li, Yingjie Zhao, Jiahui Li, Lan Zhou,  and Lin Wang
83075-83087
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Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells

https://doi.org/10.18632/oncotarget.20236

Jia-Sin Yang, Chiao-Wen Lin, Yi-Hsien Hsieh, Ming-Hsien Chien, Chun-Yi Chuang,  and Shun-Fa Yang
83088-83099
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Regulation of FBXO4-mediated ICAM-1 protein stability in metastatic breast cancer

Regulation of FBXO4-mediated ICAM-1 protein stability in metastatic breast cancer

https://doi.org/10.18632/oncotarget.20912

Jae-Hyeok Kang, Mi-Young Choi, Yan-Hong Cui, Neha Kaushik, Nizam Uddin, Ki-Chun Yoo, Min-Jung Kim,  and Su-Jae Lee
83100-83113
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Trends of long noncoding RNA research from 2007 to 2016: a bibliometric analysis

Trends of long noncoding RNA research from 2007 to 2016: a bibliometric analysis

https://doi.org/10.18632/oncotarget.20851

Yan Miao, Si-Yi Xu, Lu-Si Chen, Ge-Yu Liang, Yue-Pu Pu,  and Li-Hong Yin
83114-83127
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Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials

Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials

https://doi.org/10.18632/oncotarget.20914

Judit Fazekas-Singer, Neydher Berroterán-Infante, Christina Rami-Mark, Monika Dumanic, Miroslawa Matz, Michael Willmann, Fritz Andreae, Josef Singer, Wolfgang Wadsak, Markus Mitterhauser,  and Erika Jensen-Jarolim
83128-83141
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Virtual screening approach to identifying influenza virus neuraminidase inhibitors using molecular docking combined with machine-learning-based scoring function

Virtual screening approach to identifying influenza virus neuraminidase inhibitors using molecular docking combined with machine-learning-based scoring function

https://doi.org/10.18632/oncotarget.20915

Li Zhang, Hai-Xin Ai, Shi-Meng Li, Meng-Yuan Qi, Jian Zhao, Qi Zhao,  and Hong-Sheng Liu
83142-83154
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HDAC inhibitors enhance the immunotherapy response of melanoma cells

HDAC inhibitors enhance the immunotherapy response of melanoma cells

https://doi.org/10.18632/oncotarget.17950

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, John Kirkwood,  and Paul Dent
83155-83170
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Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression

Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression

https://doi.org/10.18632/oncotarget.20487

Yang Xiao, Usenko Alexander Yurievich,  and Smorzhevskyi Valentyn Yosypovych
83171-83182
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Preoperative chronic kidney disease predicts poor oncological outcomes after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma

Preoperative chronic kidney disease predicts poor oncological outcomes after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma

https://doi.org/10.18632/oncotarget.20554

Hirotake Kodama, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Go Anan, Ken Fukushi, Takuma Narita, Toshikazu Tanaka, Yuka Kubota, Hirotaka Horiguchi, Masaki Momota, Koichi Kido, Teppei Matsumoto, Osamu Soma, Itsuto Hamano, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Atsushi Sasaki, Toshiaki Kawaguchi, Makoto Sato,  and Chikara Ohyama
83183-83194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression

The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression

https://doi.org/10.18632/oncotarget.20541

Kyoung-Jin Min, Hee Jung Um, Jee In Kim,  and Taeg Kyu Kwon
83195-83206
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Inhibition of cell cycle progression by the hydroxytyrosol–cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells

Inhibition of cell cycle progression by the hydroxytyrosol–cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells

https://doi.org/10.18632/oncotarget.20544

Erika Terzuoli, Ginevra Nannelli, Maria Frosini, Antonio Giachetti, Marina Ziche,  and Sandra Donnini
83207-83224
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Meta-Analysis

Percutaneous laser ablation for benign thyroid nodules: a meta-analysis

Percutaneous laser ablation for benign thyroid nodules: a meta-analysis

https://doi.org/10.18632/oncotarget.17928

Wei Fan Sui, Jian Yun Li,  and Jian Hua Fu
83225-83236
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Alcohol consumption and gastric cancer risk: a meta-analysis of prospective cohort studies

Alcohol consumption and gastric cancer risk: a meta-analysis of prospective cohort studies

https://doi.org/10.18632/oncotarget.19177

Xue Han, Li Xiao, Yao Yu, Yu Chen,  and Hai-Hua Shu
83237-83245
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: A meta-analysis

Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: A meta-analysis

https://doi.org/10.18632/oncotarget.18452

Yong Li, Yi-Hong Liu, Xian Chen, Yan-Juan Zhu, Hai-Bo Zhang, Yan Li, Jian-Ping Bai, Li-Rong Liu, Yan-Chun Qu,  and Xin Qu
83246-83250
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Meta-analysis of differences in Constant-Murley scores for three mid-shaft clavicular fracture treatments

Meta-analysis of differences in Constant-Murley scores for three mid-shaft clavicular fracture treatments

https://doi.org/10.18632/oncotarget.18456

Wei Jiang, Hua Wang, Yu-Sheng Li, Tian-Jian Zhou,  and Xin-Jia Hu
83251-83260
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Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: a systematic review and meta-analysis

Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.18743

Jian Cao, Jun Liu, Ran Xu, Xuan Zhu, Xiaokun Zhao,  and Bin-Zhi Qian
83261-83269
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinicopathological significance of the p16 hypermethylation in multiple myeloma, a systematic review and meta-analysis

Clinicopathological significance of the p16 hypermethylation in multiple myeloma, a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.18742

Huiqing Yu, Liejun Yang, Yunfeng Fu, Meng Gao,  and Ling Tian
83270-83279
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Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis

Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis

https://doi.org/10.18632/oncotarget.21059

Ling Peng, Yina Wang, Yun Hong, Xianghua Ye, Peng Shi, Junyan Zhang,  and Qiong Zhao
83280-83291
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Prognostic value of lncRNAs in lung carcinoma: a meta-analysis

Prognostic value of lncRNAs in lung carcinoma: a meta-analysis

https://doi.org/10.18632/oncotarget.21096

Fan Fan, Zhengqiu Zhu, Chao Gao, Yun Liu, Baoqing Wang, Ziquan Wang,  and Jifeng Feng
83292-83305
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Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.20667

Zhanwei Zhao, Quanxin Feng, Zifang Yin, Jianbo Shuang, Bin Bai, Pengfei Yu, Min Guo,  and Qingchuan Zhao
83306-83314
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

The efficacy and safety of adjunctive corticosteroids in the treatment of tuberculous pleurisy: a systematic review and meta-analysis

The efficacy and safety of adjunctive corticosteroids in the treatment of tuberculous pleurisy: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.18160

Shuanshuan Xie, Lin Lu, Ming Li, Mengting Xiong, Shunping Zhou, Guoliang Zhang, Aimei Peng,  and Changhui Wang
83315-83322
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Safety of the neprilysin/renin-angiotensin system inhibitor LCZ696

Safety of the neprilysin/renin-angiotensin system inhibitor LCZ696

https://doi.org/10.18632/oncotarget.18312

Bo Li, Yunhe Zhao, Bo Yin, Mengfei Helian, Xinmei Wang, Feng Chen, Hongxia Zhang, Hui Sun, Bin Meng,  and Fengshuang An
83323-83333
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Antiandrogenic and antimineralocorticoid health benefits of COC containing newer progestogens: dienogest and drospirenone

Antiandrogenic and antimineralocorticoid health benefits of COC containing newer progestogens: dienogest and drospirenone

https://doi.org/10.18632/oncotarget.19833

Pedro-Antonio Regidor,  and Adolf E. Schindler
83334-83342
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Case Reports

Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non- small cell lung cancer (NSCLC): a pilot study

Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non- small cell lung cancer (NSCLC): a pilot study

https://doi.org/10.18632/oncotarget.18480

Vienna Ludovini, Rita Chiari, Lorenzo Tomassoni, Chiara Antonini, Elisa Baldelli, Sara Baglivo, Annamaria Siggillino, Francesca Romana Tofanetti, Guido Bellezza, K. Alex Hodge, Emanuel Petricoin, Mariaelena Pierobon, Lucio Crinò,  and Fortunato Bianconi
83343-83353
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