CRISPR-mediated multiplexed genetic manipulation

Axl in ovarian cancer: a step forward for clinical breakthrough?

Redox and metabolic regulation of transcription

Double hit mouse model of Parkinson’s disease

Rapamycin enhances survival in a Drosophila model of mitochondrial disease

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

Specific micro-RNA expression patterns distinguish the basal and luminal subtypes of muscle-invasive bladder cancer

MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial-mesenchymal transition in breast cancer

Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing

Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A

Circulation autoantibody against Lamin A/C in patients with Sjögren’s syndrome

Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation

Smad4 in T cells plays a protective role in the development of autoimmune Sjögren’s syndrome in the nonobese diabetic mouse

Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model

Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated

miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype

Strategies for power calculations in predictive biomarker studies in survival data

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells

CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma

Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas

Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes group

SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis

Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells

Prevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry

S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite

KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients

A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts

TRPC1-STIM1 activation modulates transforming growth factor β-induced epithelial-to-mesenchymal transition

Metformin enhances the radiosensitivity of human liver cancer cells to γ–rays and carbon ion beams

Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression

Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma

Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma

The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression

MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival

ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast

Integrative analysis of DNA copy number, DNA methylation and gene expression in multiple myeloma reveals alterations related to relapse

IL-10 and PRKDC polymorphisms are associated with glioma patient survival

Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro

The CEA^-/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells

The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma

miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival

Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-κB

Prognostic nomograms for patients with resectable hepatocelluar carcinoma incorporating systemic inflammation and tumor characteristics

Association of oncogenic bacteria with colorectal cancer in South China

Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment

Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children

TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic “Achilles heel” for the TrkAIII oncoprotein in neuroblastoma

Late-stage inhibition of autophagy enhances calreticulin surface exposure

Pharmacological interventions for melanoma: Comparative analysis using bayesian meta-analysis

The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model

FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc

RNAi screens identify CHD4 as an essential gene in breast cancer growth

Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations

Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma

Genetic susceptibility of eight nonsynonymous polymorphisms in HLA-DRB1 gene to hepatocellular carcinoma in Han Chinese

Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1

Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome

Circular RNAs and their associations with breast cancer subtypes

Dietary fibre intake and risk of breast cancer: A systematic review and meta-analysis of epidemiological studies

SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression

Prognostic role of extracellular matrix metalloproteinase inducer/CD147 in gastrointestinal cancer: a meta-analysis of related studies

Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine

Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway

Genetic polymorphisms in leptin, adiponectin and their receptors affect risk and aggressiveness of prostate cancer: evidence from a meta-analysis and pooled-review

YAP1 enhances cell proliferation, migration, and invasion of gastric cancer in vitro and in vivo

Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro

Is there a benefit of first- or second-line crizotinib in locally advanced or metastatic anaplastic lymphoma kinase-positive non-small cell lung cancer? a meta-analysis

Is senescence-associated β-galactosidase a marker of neuronal senescence?

Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma

Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells

Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer

Gankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression

The combination of MLN2238 (ixazomib) with interferon-alpha results in enhanced cell death in melanoma

The genes slyA, STM3120 and htrA are required for the anticancer ability of VNP20009

Kinetic changes of intestinal microbiota in the course of intestinal sensitization

Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis

Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into β-arrestin-dependent ERK signaling

Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression

Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma

Neurokinin-1 receptor is a novel positive regulator of Wnt/β-catenin signaling in melanogenesis

Primary tumor microRNA signature predicts recurrence and survival in patients with locally advanced esophageal adenocarcinoma

The prognostic value of long non coding RNAs in non small cell lung cancer: A meta-analysis

Signal regulatory protein α associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages

p16 overexpression and 9p21 deletion are linked to unfavorable tumor phenotype in breast cancer

Twist1 promotes radioresistance in nasopharyngeal carcinoma

Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8⁺ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors

Performance of multiplicom's BRCA MASTR Dx kit on the detection of BRCA1 and BRCA2 mutations in fresh frozen ovarian and breast tumor samples

miR-26a induced the suppression of tumor growth of cholangiocarcinoma via KRT19 approach

PC-1 works in conjunction with E3 ligase CHIP to regulate androgen receptor stability and activity

Incorporation of alpha-fetoprotein(AFP) into subclassification of BCLC C stage hepatocellular carcinoma according to a 5-year survival analysis based on the SEER database

Anti-EGFR antibody sensitizes colorectal cancer stem-like cells to Fluorouracil-induced apoptosis by affecting autophagy

Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-β1/p38/HSP27 signaling in renal cell carcinoma

Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway

Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer

LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK

Ubiquitin-like protein FAT10 promotes bladder cancer progression by stabilizing survivin

TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion

The evaluation of immunotherapy and chemotherapy treatment on melanoma: a network meta-analysis

TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection

Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer

Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2

Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma

Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma

Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line

Prognostic nutritional index predicts short-term outcomes after liver resection for hepatocellular carcinoma within the Milan criteria

miRNA-200a/c as potential biomarker in epithelial ovarian cancer (EOC): evidence based on miRNA meta-signature and clinical investigations

AEG-1 knockdown in colon cancer cell lines inhibits radiation-enhanced migration and invasion in vitro and in a novel in vivo zebrafish model

Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells

The associations between mast cell infiltration, clinical features and molecular types of invasive breast cancer

Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma

Prediction of the risk of mortality using risk score in patients with coronary heart disease

A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population

Regulatory landscape and clinical implication of MBD3 in human malignant glioma

Integrated bioinformatics analysis of chromatin regulator EZH2 in regulating mRNA and lncRNA expression by ChIP sequencing and RNA sequencing

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models

Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer

Transcriptional repression of FOXO1 by KLF4 contributes to glioma progression

Non-invasive diagnosis of papillary thyroid microcarcinoma: a NMR-based metabolomics approach

Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer

Tuftsin prevents the negative immunoregulation of neuropilin-1^highCD4⁺CD25⁺Regulatory T cells and improves survival rate in septic mice

Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells

TTK is a favorable prognostic biomarker for triple-negative breast cancer survival

Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma

Comparative study of single-nucleotide polymorphism array and next generation sequencing based strategies on triploid identification in preimplantation genetic diagnosis and screen

Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis

Growth hormone replacement therapy reduces risk of cancer in adult with growth hormone deficiency: A meta-analysis

Impact of HLA-B*58:01 allele and allopurinol-induced cutaneous adverse drug reactions: evidence from 21 pharmacogenetic studies

Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features

Clinical outcome of intensity modulated radiotherapy for carcinoma showing thymus-like differentiation

Risk factors of brain metastasis during the course of EGFR-TKIs therapy for patients with EGFR-mutated advanced lung adenocarcinoma

T4/N2 classification nasopharyngeal carcinoma benefit from concurrent chemotherapy in the era of intensity-modulated radiotherapy