Non-mutational (epigenomic) structural variation in the transcriptome of cancer cells

Prelamin A and Oct-1: a puzzle of aging

D-ß-hydroxybutyrate: an anti-aging ketone body

The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3

Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets

Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?

Graphene oxide selectively targets cancer stem cells, across multiple tumor types: Implications for non-toxic cancer treatment, via “differentiation-based nano-therapy”

p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia

Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent

Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival

The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts

DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3’-end GC density

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma

PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation

Interleukin-27 re-educates intratumoral myeloid cells and down-regulates stemness genes in non-small cell lung cancer

Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells

Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells

Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo

CtBP2 is an independent prognostic marker that promotes GLI1 induced epithelial-mesenchymal transition in hepatocellular carcinoma

MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma

Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein

Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer

NF-kB signaling mediates acquired resistance after PARP inhibition

MicroRNA-153 promotes Wnt/β-catenin activation in hepatocellular carcinoma through suppression of WWOX

NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells

Shed syndecan-2 enhances tumorigenic activities of colon cancer cells

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Downregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway

Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines

Identification of NDUFAF1 in mediating K-Ras induced mitochondrial dysfunction by a proteomic screening approach

Morphine promotes cancer stem cell properties, contributing to chemoresistance in breast cancer

Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy

miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway

C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis

Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model

Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer

Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells

miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma

Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer

Multilevel-analysis identify a cis-expression quantitative trait locus associated with risk of renal cell carcinoma

p22phox confers resistance to cisplatin, by blocking its entry into the nucleus

A novel orally active water-soluble Inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ

Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice

Stage-specific prognostic biomarkers in melanoma

Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma

RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel

Glycolytic metabolism influences global chromatin structure

Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma

WISP-1, a novel angiogenic regulator of the CCN family, promotes oral squamous cell carcinoma angiogenesis through VEGF-A expression

Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21^WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells

Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth

Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: A promising biomarker and therapeutic target for pancreatic cancer

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2

PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling

Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas

GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling

Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells

CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4

Progression of naive intraepithelial neoplasia genome to aggressive squamous cell carcinoma genome of uterine cervix

IL-32θ inhibits monocytic differentiation of leukemia cells by attenuating expression of transcription factor PU.1

HIF-2α mediates hypoxia-induced LIF expression in human colorectal cancer cells

Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α

Hepatocellular carcinoma in a large medical center of China over a 10-year period: evolving therapeutic option and improving survival

RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer

Immunological data from cancer patients treated with Ad5/3 E2F Δ24 GMCSF suggests utility for tumor immunotherapy

Poor survival is associated with the methylated degree of Zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer

Safety and biodistribution of ¹¹¹In-amatuximab in patients with mesothelin expressing cancers using single photon emission computed tomography-computed tomography (SPECT-CT) imaging

Circulation long non-coding RNAs act as biomarkers for predicting tumorigenesis and metastasis in hepatocellular carcinoma

GOT1/AST1 expression status as a prognostic biomarker in pancreatic ductal adenocarcinoma

A Phase I trial of high dose gefitinib for patients with leptomeningeal metastases from non-small cell lung cancer

Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma