TORC2 inhibition may boost DNA-damaging chemotherapy

Predicting response to HER2 kinase inhibition

Aging interventions get human

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

Synthetic Aβ peptides acquire prion-like properties in the brain

Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers

IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

SWI/SNF complexes are required for full activation of the DNA-damage response

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor

The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis

The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy

Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer

c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia

The inverse relationship between bladder and liver in 4-aminobiphenyl-induced DNA damage

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape

An HSV-2 based oncolytic virus can function as an attractant to guide migration of adoptively transferred T cells to tumor sites

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

FGF8 promotes colorectal cancer growth and metastasis by activating YAP1

EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity

Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors

Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer

Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin

Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells

ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA

Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer

Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models

The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction

Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells

Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

A switch from CD44⁺ cell to EMT cell drives the metastasis of prostate cancer

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment

Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype

Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia

The Na⁺/H⁺ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation

A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors

PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients