The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

Absence of ERK5/MAPK7 delays tumorigenesis in Atm^-/- mice

Kinetics, prognostic and predictive values of ESR1 circulating mutations in metastatic breast cancer patients progressing on aromatase inhibitor

7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells

Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease

Long-term exposure to air pollution is associated with biological aging

G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers

Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis

Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome

Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome

Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells

Hyperosmotic treatment synergistically boost efficiency of cell-permeable peptides

Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice

The prognostic significance of heparanase expression in metastatic melanoma

Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells

Specificity and biologic activities of novel anti-membrane IgM antibodies

Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells

Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

Copy number gain of chromosome 3q is a recurrent event in patients with intraductal papillary mucinous neoplasm (IPMN) associated with disease progression

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells

Akt isoform specific effects in ovarian cancer progression

Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems

Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression

Neutrophilia in locally advanced cervical cancer: A novel biomarker for image-guided adaptive brachytherapy?

A three ion channel genes-based signature predicts prognosis of primary glioblastoma patients and reveals a chemotherapy sensitive subtype

Prognostic value of tumor infiltrating NK cells and macrophages in stage II+III esophageal cancer patients

Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity

Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis

Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro

nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer

Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway

Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo

Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β

The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma

The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

MiR-139-5p reverses CD44⁺/CD133⁺-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

Efficacy of crizotinib and pemetrexed-based chemotherapy in Chinese NSCLC patients with ROS1 rearrangement

Apoptosis signal-regulating kinase 1 exhibits oncogenic activity in pancreatic cancer

Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway

Genomic characterization of high-risk non-muscle invasive bladder cancer

miR-424-5p promotes proliferation of gastric cancer by targeting Smad3 through TGF-β signaling pathway

Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway

Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells

Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature

MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas

IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population

High-throughput proteomics integrated with gene microarray for discovery of colorectal cancer potential biomarkers

Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab

Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors

Tumor-specific gene therapy for pancreatic cancer using human neural stem cells encoding carboxylesterase

MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

Concentration of circulating miRNA-containing particles in serum enhances miRNA detection and reflects CRC tissue-related deregulations

Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells

Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway

Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

Targeting SALL4 by entinostat in lung cancer

TACC3 overexpression in cholangiocarcinoma correlates with poor prognosis and is a potential anti-cancer molecular drug target for HDAC inhibitors

The precision relationships between eight GWAS-identified genetic variants and breast cancer in a Chinese population

Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study

Second-line ramucirumab therapy for advanced hepatocellular carcinoma (REACH): an East Asian and non-East Asian subgroup analysis

Should all breast cancer patients with four or more positive lymph nodes who underwent modified radical mastectomy be treated with postoperative radiotherapy? A population-based study

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer

Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration

An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway

PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

IL-1 drives breast cancer growth and bone metastasis in vivo

c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts

Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species

Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

Epithelial cells captured from ductal carcinoma in situ reveal a gene expression signature associated with progression to invasive breast cancer

Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy

SIRT1-mediated downregulation of p27^Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development

FOXC1 identifies basal-like breast cancer in a hereditary breast cancer cohort

Prognostic significance of AMPK in human malignancies: A meta-analysis

Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas

Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion

Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies

PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAF^V600E targeted inhibition in a novel syngeneic murine glioma model

Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells

Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling

Second-generation proteasome inhibitor carfilzomib sensitizes neuroblastoma cells to doxorubicin-induced apoptosis

Delayed reendothelialization with rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries

Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth

Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells

Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma

p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer

The prognostic value of DNA damage level in peripheral blood lymphocytes of chemotherapy-naïve patients with germ cell cancer

Autocrine interleukin-23 promotes self-renewal of CD133⁺ ovarian cancer stem-like cells

Common polymorphisms in CD44 gene and susceptibility to cancer: a systematic review and meta-analysis of 45 studies

SOX17 is a tumor suppressor in endometrial cancer

Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity

Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma

Genetic variants in PTPRD and risk of gestational diabetes mellitus

Overexpression of ZNF703 facilitates tumorigenesis and predicts unfavorable prognosis in patients with cholangiocarcinoma

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

Epithelial-to-mesenchymal transition leads to disease-stage differences in circulating tumor cell detection and metastasis in pre-clinical models of prostate cancer

Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy

Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue

Visualization of early prostatic adenocarcinoma as a stem cell disease

Microarray analysis on the lncRNA expression profile in male hepatocelluar carcinoma patients with chronic hepatitis B virus infection

Combination effect of therapies targeting the PI3K- and AR-signaling pathways in prostate cancer

Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection

Prognostic value of vascular mimicry in patients with urothelial carcinoma of the bladder after radical cystectomy

Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells

Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy

Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer

A new classification of lymph node metastases according to the lymph node stations for predicting prognosis in surgical patients with esophageal squamous cell carcinoma

Clinical characteristics and prognostic factors of brain central neurocytoma

Efficacy of preoperative chemotherapy regimens in patients with initially unresectable locally advanced gastric adenocarcinoma: capecitabine and oxaliplatin (XELOX) or with epirubicin (EOX)

Laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass for morbid obesity: a 1:1 matched cohort study in a Chinese population

Comparison of efficacy in adjuvant chemotherapy regimens in patients with radically resected gastric cancer: a propensity-matched analysis

Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis