mTOR: Alzheimer’s disease prevention for APOE4 carriers

Arenaviral vaccine vectors to combat infectious diseases

Vδ2+ and α/β T cells show divergent trajectories during human aging

Platelets as an indicator of vascular repair in elderly Japanese men

EPCs enhance angiogenesis in renal regeneration

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway

Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours

Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma

Neuregulin expression in solid tumors: Prognostic value and predictive role to anti-HER3 therapies

LTBP2 is a prognostic marker in head and neck squamous cell carcinoma

C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms

Targeting cancer stem cells with p53 modulators

Quantitative ultrasound assessment of breast tumor response to chemotherapy using a multi-parameter approach

Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance

Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests

EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling

DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers

A novel anticancer agent SNG1153 inhibits growth of lung cancer stem/progenitor cells

GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells

HER2 reduces breast cancer radiosensitivity by activating focal adhesion kinase in vitro and in vivo

MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4

Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells

Recurrence pattern and TP53 mutation in upper urinary tract urothelial carcinoma

Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder

MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma

A novel approach to inoperable or recurrent rectal cancer by chemoembolization. A new arrow in our quiver?

Neutrophil-to-lymphocyte ratio for the prognostic assessment of hepatocellular carcinoma: A systematic review and meta-analysis of observational studies

EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway

Proliferation and ovarian hormone signaling are impaired in normal breast tissues from women with BRCA1 mutations: benefit of a progesterone receptor modulator treatment as a breast cancer preventive strategy in women with inherited BRCA1 mutations

Role of FOXO1 in aldosterone-induced autophagy: A compensatory protective mechanism related to podocyte injury

PRAME expression and promoter hypomethylation in epithelial ovarian cancer

The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer

Role of microRNA-4516 involved autophagy associated with exposure to fine particulate matter

Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit

The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells

Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27^kip1

Single, immediate postoperative instillation of chemotherapy in non-muscle invasive bladder cancer: a systematic review and network meta-analysis of randomized clinical trials using different drugs

Quercetin induces cell apoptosis of myeloma and displays a synergistic effect with dexamethasone in vitro and in vivo xenograft models

The HIV-derived protein Vpr_52-96 has anti-glioma activity in vitro and in vivo

Fluorouracil-based neoadjuvant chemoradiotherapy with or without oxaliplatin for treatment of locally advanced rectal cancer: An updated systematic review and meta-analysis

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses

MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis

Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)

Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells

Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs

The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein

KLF4α stimulates breast cancer cell proliferation by acting as a KLF4 antagonist

MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer

Serum microRNA profiles as prognostic biomarkers for HBV-positive hepatocellular carcinoma

Heterogeneity of metastatic pancreatic adenocarcinoma: Lung metastasis show better prognosis than liver metastasis—a case control study

Extremely stringent activation of p16^INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression

Prognostic role of sentinel lymph node biopsy for patients with cutaneous melanoma: A retrospective study of surveillance, epidemiology, and end-result population-based data

IL-35 expression in hepatocellular carcinoma cells is associated with tumor progression

miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13

Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling

Calcineurin complex isolated from T-cell acute lymphoblastic leukemia (T-ALL) cells identifies new signaling pathways including mTOR/AKT/S6K whose inhibition synergize with calcineurin inhibition to promote T-ALL cell death

STAT5 induces miR-21 expression in cutaneous T cell lymphoma

The relevance of using 3D cell cultures, in addition to 2D monolayer cultures, when evaluating breast cancer drug sensitivity and resistance

Systematic analyses and comprehensive field synopsis of genetic association studies in hepatocellular carcinoma

A 4-miRNA signature predicts the therapeutic outcome of glioblastoma

Identification of CHEK1, SLC26A4, c-KIT, TPO and TG as new biomarkers for human follicular thyroid carcinoma

Impaired lymphatic function accelerates cancer growth

Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression

TES inhibits colorectal cancer progression through activation of p38

Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway

Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer

Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression

Downregulation of vimentin expression increased drug resistance in ovarian cancer cells

Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings

NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription

Pharmacological inhibitors of c-KIT block mutant c-KIT mediated migration of melanocytes and melanoma cells in vitro and in vivo

Assessing the clinical utility of genomic expression data across human cancers

Construction of a lncRNA-mediated feed-forward loop network reveals global topological features and prognostic motifs in human cancers

FMLNCSIM: fuzzy measure-based lncRNA functional similarity calculation model

Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics

miR146a-mediated targeting of FANCM during inflammation compromises genome integrity

Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer

PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma

Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction

Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo

High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Overexpression of TELO2 decreases survival in human high-grade gliomas

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

SRF promotes gastric cancer metastasis through stromal fibroblasts in an SDF1-CXCR4-dependent manner

Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1α and PERK pathways

Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines

Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1

The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer

Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism

Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy

Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation

Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer

Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP

Elevated plasma fibrinogen level shows superior prognostic value than Epstein–Barr virus DNA load for stage IVA/B nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era

Elevated expression of FABP3 and FABP4 cooperatively correlates with poor prognosis in non-small cell lung cancer (NSCLC)

Alveolar rhabdomyosarcoma: morphoproteomics and personalized tumor graft testing further define the biology of PAX3-FKHR(FOXO1) subtype and provide targeted therapeutic options

National incidence of autoimmune liver diseases and its relationship with the human development index

RING1B contributes to Ewing sarcoma development by repressing the Na_V1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein

Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia

Disintegrin targeting of an α_vβ₃ integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro

Caveolin-1 regulates hormone resistance through lipid synthesis, creating novel therapeutic opportunities for castration-resistant prostate cancer

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

Epac1 links prostaglandin E₂ to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells

Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis

RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells

Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation

A mechanism for 1,4-Benzoquinone-induced genotoxicity

Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells

Maintenance therapy with histamine plus IL-2 induces a striking expansion of two CD56^bright NK cell subpopulations in patients with acute myeloid leukemia and supports their activation

Prognostic value of androgen receptor in triple negative breast cancer: A meta-analysis

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer

Evaluating prognosis by CK7 differentiating renal cell carcinomas from oncocytomas can be used as a promising tool for optimizing diagnosis strategies

Possible contribution of IMRT in postoperative radiochemotherapy for rectal cancer: analysis on 1798 patients by prediction model

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter

Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells

Measuring PC activity in endocervical swab may provide a simple and non-invasive method to detect endometrial cancer in post-menopausal women

Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells’ survival and growth revealing a new strategy for Hodgkin lymphoma treatment

ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways

Delta-9-tetrahydrocannabinol protects against MPP⁺ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis

ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2

Effect of nodal status on clinical outcomes of triple-negative breast cancer: a population-based study using the SEER 18 database

Survival benefits from postoperative radiation therapy on lymph node positive patients with pancreatic adenocarcinoma

A prognostic model combining CD4/CD8 ratio and N stage predicts the risk of distant metastasis for patients with nasopharyngeal carcinoma treated by intensity modulated radiotherapy

Setup uncertainties for inter-fractional head and neck cancer in radiotherapy

Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents

Atlas on substrate recognition subunits of CRL2 E3 ligases

Kirsten Ras* oncogene: Significance of its discovery in human cancer research

The challenge of developmental therapeutics for adrenocortical carcinoma

The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets

Melatonin as a potential anticarcinogen for non-small-cell lung cancer

Myosins as fundamental components during tumorigenesis: diverse and indispensable

Future paradigms for precision oncology