microRNA involvement in the onset and progression of Barrett’s esophagus: a systematic review

Reilly J. Clark; Michael P. Craig; Sangeeta Agrawal; Madhavi Kadakia

doi:10.18632/oncotarget.24145

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

microRNA involvement in the onset and progression of Barrett’s esophagus: a systematic review

Reilly J. Clark, Michael P. Craig, Sangeeta Agrawal and Madhavi Kadakia _

PDF | HTML | How to cite

Oncotarget. 2018; 9:8179-8196. https://doi.org/10.18632/oncotarget.24145

Metrics: PDF 2343 views | HTML 3620 views | ?

Abstract

Reilly J. Clark1,*, Michael P. Craig1,*, Sangeeta Agrawal2 and Madhavi Kadakia1

1Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA

2Dayton VA Medical Center, Dayton, OH, USA

*These authors have contributed equally to this work

Correspondence to:

Madhavi Kadakia, email: [email protected]

Keywords: Barrett’s esophagus; microRNA; EAC; biomarker

Received: October 27, 2016 Accepted: December 22, 2017 Published: January 11, 2018

ABSTRACT

Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that develops from Barrett’s esophagus (BE), an intestinal metaplasia of the distal esophagus. microRNAs (miRNAs), short non-coding regulatory RNAs, are frequently dysregulated in BE and are thought to play key roles in the onset of BE and its progression to EAC. miRNAs thus have potential diagnostic and prognostic value and are increasingly being used as cancer biomarkers. This review summarizes the current literature related to miRNAs that are dysregulated in BE within the context of Hedgehog, Notch, MAPK, NF kappa-B, Wnt and epithelial-mesenchymal transition (EMT) signaling which are thought to drive BE onset and progression. This comprehensive analysis of miRNAs and their associated signaling in the regulation of BE provides an overview of vital discoveries in this field and highlights gaps in our understanding of BE pathophysiology that warrant further investigation.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24145

Publication Alerts

Reviews:

microRNA involvement in the onset and progression of Barrett’s esophagus: a systematic review

Abstract