Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Li Ge; Ming Yang; Na-Na Yang; Xin-Xin Yin; Wen-Gang Song

doi:10.18632/oncotarget.21130

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Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Li Ge, Ming Yang, Na-Na Yang, Xin-Xin Yin and Wen-Gang Song _

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Oncotarget. 2017; 8:102653-102673. https://doi.org/10.18632/oncotarget.21130

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Abstract

Li Ge1, Ming Yang2, Na-Na Yang3, Xin-Xin Yin2 and Wen-Gang Song4

1Department of Histology and Embryology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

2Department of Clinical Medicine, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

3Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University, Institute of Atherosclerosis, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

4Department of medical immunology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

Correspondence to:

Wen-Gang Song, email: [email protected]

Keywords: molecular hydrogen, selective anti-oxidation, gaseous signal modulator, preventive and therapeutic applications

Received: April 27, 2017 Accepted: August 26, 2017 Published: September 21, 2017

ABSTRACT

Since the 2007 discovery that molecular hydrogen (H₂) has selective antioxidant properties, multiple studies have shown that H₂ has beneficial effects in diverse animal models and human disease. This review discusses H₂ biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H₂ delivery approaches; and summarizes recent progress toward H₂ applications in human medicine. We also discuss remaining questions in H₂ therapy, and conclude with an appeal for a greater role for H₂ in the prevention and treatment of human ailments that are currently major global health burdens. This review makes a case for supporting hydrogen medicine in human disease prevention and therapy.

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Reviews:

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Abstract