Oncotarget

Research Papers:

Systematic analyses and comprehensive field synopsis of genetic association studies in hepatocellular carcinoma

Dong Dong _, Yang Zou, Pan Zhang and Zhihong Wu

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Oncotarget. 2016; 7:45757-45763. https://doi.org/10.18632/oncotarget.9937

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Abstract

Dong Dong1,2,*, Yang Zou1,*, Pan Zhang1, Zhihong Wu2,3

1Laboratory of Molecular Ecology and Evolution, Institute of Estuarine and Coastal Research, East China Normal University, Shanghai, 200062, P.R. China

2Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, Beijing, 100730, P.R. China

3Central laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China

*These authors contributed equally to this work

Correspondence to:

Dong Dong, email: ddong.ecnu@gmail.com

Zhihong Wu, email: wuzh3000@126.com

Keywords: hepatocellular carcinoma, meta-analyses

Received: March 04, 2016    Accepted: May 23, 2016    Published: June 10, 2016

ABSTRACT

Hepatocellular carcinoma (HCC) is one of the most common malignancy in the world. In order to comprehensively examine the association between genetic variants and risk of HCC, a systematic literature search and meta-analyses of the evidences have been performed. With the data from 301 articles, we conducted meta-analyses for 69 polymorphisms involving 46 distinct genes. The result showed that 31 polymorphisms in 25 genes are significantly associated with HCC risk. Cumulative epidemiological evidence for a significant association with HCC risk was graded strong for one polymorphism (NQO1 rs1800566). Furthermore, we provided a database to integrate and analyze the association of genetic variants and HCC risk. To the best of our knowledge, this is the first comprehensive field synopsis and systematic meta-analysis of genetic association with HCC risk. We have provided a useful resource and platform for investigators to explore the association of sequence polymorphisms and HCC risk.


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