Prostate cancer and the unfolded protein response

Margrethe Storm; Xia Sheng; Yke Jildouw Arnoldussen; Fahri Saatcioglu

doi:10.18632/oncotarget.9912

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Prostate cancer and the unfolded protein response

Margrethe Storm, Xia Sheng, Yke Jildouw Arnoldussen and Fahri Saatcioglu _

PDF | HTML | How to cite

Oncotarget. 2016; 7:54051-54066. https://doi.org/10.18632/oncotarget.9912

Metrics: PDF 2675 views | HTML 5481 views | ?

Abstract

Margrethe Storm1,*, Xia Sheng1,*, Yke Jildouw Arnoldussen3 and Fahri Saatcioglu1,2

1 Department of Biosciences, University of Oslo, Oslo, Norway

2 Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway

3 Department of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway

* These authors have contributed equally to this work

Correspondence to:

Fahri Saatcioglu, email:

Keywords: endoplasmic reticulum stress, prostate cancer, unfolded protein response, therapeutic targeting

Received: February 04, 2016 Accepted: May 23, 2016 Published: June 09, 2016

Abstract

The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 9912

Publication Alerts

Reviews:

Prostate cancer and the unfolded protein response

Abstract