Research Papers: Immunology:
Association of FCGR2A rs1801274 polymorphism with susceptibility to autoimmune diseases: A meta-analysis
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Chang’e Zhang1,*, Wenju Wang2,*, Hong’e Zhang3,*, Lulu Wei4 and Shuping Guo4
1 Department of Dermatology, Zhengzhou Children’s Hospital, Henan, China
2 Department of Dermatology, The Second People’s Hospital in Chengdu, Sichuan, China
3 Department of Medicine, Xiangfu District Hospital of Traditional Chinese Medicine, Kaifeng, Henan, China
4 Department of Dermatology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
* These authors have contributed equally to this work
Chang’e Zhang, email:
Keywords: autoimmune diseases, FCGR2A, polymorphism, susceptibility, meta-analysis, Immunology and Microbiology Section, Immune response, Immunity
Received: February 23, 2016 Accepted: May 28, 2016 Published: June 05, 2016
Objectives: The aim of this meta-analysis was to estimate the association between the FCGR2A rs1801274 polymorphism and the susceptibility to autoimmune diseases more precisely. Methods: A meta-analysis was conducted on the association between the FCGR2A gene variants and ADs by allelic contrast, homozygote contrast, the recessive model, and the dominant model. Results: A total of 17 studies with 30 comparisons in different populations and genotype-methods were available for this meta-analysis, including 10 Kawasaki disease (KD), 7 Ulcerative colitis (UC), 6 Crohn’s disease (CD), 3 Rheumatoid arthritis (RA), 2 Systemic lupus erythematosus (SLE), 1 Autoimmune thyroid disease (ATD) and 1 diabetes mellitus type 1 (T1D). A significant association between FCGR2A rs1801274 polymorphism were found in KD (OR = 1.409, P < 0.001) and UC (OR = 1.237, P < 0.001). A overall meta-analysis increased risk of AD significant association between FCGR2A rs1801274 gene polymorphism and ADs under allelic (OR = 1.378, P=0.000), homozygous (OR: 1.866, P=0.001), dominant (OR = 1.667, P = 0.000) and recessive (OR = 1.434, P=0.000) in Asian population. Meanwhile, a decreased risk of AD was detected in the allelic (OR= 0.882, P = 0.011), homozygous (OR = 0.777, P = 0.013), dominant (OR = 0.850, P = 0.032) and recessive (OR = 0.840, P = 0.048) in African-American population. Conclusions: This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC. Data also suggests that the FCGR2A rs1801274 polymorphism may be associated with the susceptibility of multiple ADs in Asian and African-American populations.
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