Prevention of pancreatic cancer in a hamster model by cAMP decrease

Jheelam Banerjee; Arokya M.S. Papu John; Mohammed H. Al-Wadei; Hildegard M. Schuller

doi:10.18632/oncotarget.9790

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Prevention of pancreatic cancer in a hamster model by cAMP decrease

Jheelam Banerjee, Arokya M.S. Papu John, Mohammed H. Al-Wadei and Hildegard M. Schuller _

PDF | HTML | How to cite

Oncotarget. 2016; 7:44430-44441. https://doi.org/10.18632/oncotarget.9790

Metrics: PDF 1940 views | HTML 1820 views | ?

Abstract

Jheelam Banerjee1, Arokya M.S. Papu John1, Mohammed H. Al-Wadei1, Hildegard M. Schuller1

1Experimental Oncology Laboratory, Department of Biomedical & Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA

Correspondence to:

Hildegard M. Schuller, email: [email protected]

Keywords: pancreatic cancer, prevention, γ-aminobutyric acid, cyclic adenosine monophosphate, cancer stem cell signaling

Received: December 2, 2015 Accepted: May 22, 2016 Published: June 02, 2016

ABSTRACT

Smoking and alcoholism are risk factors for the development of pancreatitis-associated pancreatic ductal adenocarcinoma (PDAC). We have previously shown that these cancers overexpressed stress neurotransmitters and cyclic adenosine monophosphate (cAMP) while the inhibitory neurotransmitter γ-aminobutyric acid (GABA) was suppressed. Using a hamster model, the current study has tested the hypothesis that cAMP decrease by GABA supplementation in the drinking water prevents the development of pancreatitis-associated PDAC. Our data reveal strong preventive effects of GABA supplementation on the development of PDAC and pancreatic intraductal neoplasia (PanIN). ELISA assays and immunohistochemistry revealed significant decreases in the levels of cAMP and interleukin 6 accompanied by reductions in the expression of several cancer stem cell markers and phosphorylated signaling proteins, which stimulate cell proliferation, and migration in pancreatic exocrine cells of GABA treated animals. We conclude that cAMP decrease by GABA supplementation inhibits multiple cancer stimulating pathways in cancer stem cells, differentiated cancer cells and the immune system, identifying this approach as promising novel tool for the prevention of PDAC in individuals with a history of smoking and alcoholism.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 9790

Publication Alerts

Research Papers:

Prevention of pancreatic cancer in a hamster model by cAMP decrease

Abstract