The impact of  177 Lu-octreotide therapy on  99m Tc-MAG3 clearance is not predictive for late nephropathy

Rudolf A. Werner; Seval Beykan; Takahiro Higuchi; Katharina Lückerath; Alexander Weich; Michael Scheurlen; Christina Bluemel; Ken Herrmann; Andreas K. Buck; Michael Lassmann; Constantin Lapa; Heribert Hänscheid

doi:10.18632/oncotarget.9775

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

The impact of ¹⁷⁷Lu-octreotide therapy on ^99mTc-MAG3 clearance is not predictive for late nephropathy

Rudolf A. Werner, Seval Beykan, Takahiro Higuchi, Katharina Lückerath, Alexander Weich, Michael Scheurlen, Christina Bluemel, Ken Herrmann, Andreas K. Buck, Michael Lassmann, Constantin Lapa and Heribert Hänscheid _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:41233-41241. https://doi.org/10.18632/oncotarget.9775

Metrics: PDF 1372 views | HTML 2256 views | ?

Abstract

Rudolf A. Werner1,2, Seval Beykan1, Takahiro Higuchi1,2, Katharina Lückerath1, Alexander Weich3, Michael Scheurlen3, Christina Bluemel1, Ken Herrmann1,4, Andreas K. Buck1,2, Michael Lassmann1, Constantin Lapa1,* and Heribert Hänscheid1,*

1 Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany

2 Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany

3 Department of Internal Medicine II, Gastroenterology, University Hospital Würzburg, Würzburg, Germany

4 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America

* These authors have contributed equally to this work

Correspondence to:

Heribert Hänscheid, email:

Keywords: renal scintigraphy, MAG3, PRRT, neuroendocrine tumor, ¹⁷⁷Lu

Received: April 04, 2016 Accepted: May 23, 2016 Published: June 01, 2016

Abstract

Peptide Receptor Radionuclide Therapy (PRRT) for the treatment of neuroendocrine tumors may lead to kidney deterioration. This study aimed to evaluate the suitability of 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) clearance for the early detection of PRRT-induced changes on tubular extraction (TE). TE rate (TER) was measured prior to 128 PRRT cycles (7.6±0.4 GBq 177Lu-octreotate/octreotide each) in 32 patients. TER reduction during PRRT was corrected for age-related decrease and analyzed for the potential to predict loss of glomerular filtration (GF). The GF rate (GFR) as measure for renal function was derived from serum creatinine. The mean TER was 234 ± 53 ml/min/1.73 m² before PRRT (baseline) and 221 ± 45 ml/min/1.73 m² after a median follow-up of 370 days. The age-corrected decrease (mean: -3%, range: -27% to +19%) did not reach significance (p=0.09) but significantly correlated with the baseline TER (Spearman p=-0.62, p<0.001). Patients with low baseline TER showed an improved TER after PRRT, high decreases were only observed in individuals with high baseline TER. Pre-therapeutic TER data were inferior to plasma creatinine-derived GFR estimates in predicting late nephropathy. TER assessed by 99mTc-MAG3clearance prior to and during PRRT is not suitable as early predictor of renal injury and an increased risk for late nephropathy.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 9775

Publication Alerts

Research Papers:

The impact of 177Lu-octreotide therapy on 99mTc-MAG3 clearance is not predictive for late nephropathy

Abstract

The impact of ¹⁷⁷Lu-octreotide therapy on ^99mTc-MAG3 clearance is not predictive for late nephropathy