Oncotarget

Research Papers: Gerotarget (Focus on Aging):

FERMT2 rs17125944 polymorphism with Alzheimer’s disease risk: a replication and meta-analysis

Qiu-Yue Zhang, Hui-Fu Wang, Zhan-Jie Zheng, Ling-Li Kong, Meng-Shan Tan, Chen-Chen Tan, Wei Zhang, Zi-Xuan Wang, Lin Tan, Jin-Tai Yu and Lan Tan _

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Oncotarget. 2016; 7:39044-39050. https://doi.org/10.18632/oncotarget.9679

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Abstract

Qiu-Yue Zhang1,*, Hui-Fu Wang1,*, Zhan-Jie Zheng2, Ling-Li Kong2, Meng-Shan Tan1, Chen-Chen Tan1, Wei Zhang3, Zi-Xuan Wang1, Lin Tan4, Jin-Tai Yu1 and Lan Tan1

1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China

2 Department of Geriatrics, Qingdao Mental Health Center, Qingdao, China

3 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China

4 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China

* These authors should be regarded as co-first authors

Correspondence to:

Lan Tan, email:

Keywords: Alzheimer’s disease, FERMT2, polymorphism, association study, meta-analysis, Gerotarget

Received: March 01, 2016 Accepted: April 26, 2016 Published: May 27, 2016

Abstract

A recent meta-analysis of genome-wide association studies (GWAS) in population of Caucasian identified a single nucleotide polymorphism (SNP) rs17125944 in the FERMT2 gene as a new susceptibility locus for late-onset Alzheimer’s disease (LOAD). In order to validate the association of the rs17125944 polymorphism with LOAD risk in the northern Han Chinese, we recruited a case–control study of 2338 Han Chinese subjects (984 cases and 1354 age- and gender-matched controls). Our results demonstrated that there was no significant association between the rs17125944 polymorphism and LOAD (genotype: P = 0.953; allele: P = 0.975). Furthermore, no significant differences were observed in alleles and genotypes distribution after stratification by apolipoprotein E (APOE) ε4 and multivariate logistic regression analysis. We also performed a meta-analysis in 81908 individuals. The meta-analysis showed that the C allele is the risk factor for LOAD in Caucasian group (OR = 1.15, 95 % CI = 1.10–1.20) and combined population (OR = 1.13, 95 % CI = 1.08–1.19). While in Chinese population, the C allele is not associated with increased risk of LOAD (OR = 1.07, 95 % CI = 0.89–1.28). In conclusion, our study showed that the rs17125944 polymorphism in FERMT2 gene might not be association with LOAD in northern Han Chinese population.


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