Oncotarget

Research Papers: Pathology:

The associations between serum biomarkers and stenosis of the coronary arteries

Lei Feng _, Shiyan Nian, Shu Zhang, Wenbo Xu, Xingfeng Zhang, Dan Ye and Lei Zheng

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Oncotarget. 2016; 7:39231-39240. https://doi.org/10.18632/oncotarget.9645

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Abstract

Lei Feng1,2,4,*, Shiyan Nian3,*, Shu Zhang4, Wenbo Xu1, Xingfeng Zhang1, Dan Ye1 and Lei Zheng2

1 Department of Laboratory, People’s Hospital of Yuxi City, Yuxi City, Yunnan, P.R. China

2 Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Baiyun District, Guangzhou, Guangdong, P.R. China

3 Intensive Care Unit, People’s Hospital of Yuxi City, Yuxi City, Yunnan, P.R. China

4 Department of Laboratory, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan, P.R. China

* These authors have contributed equally to this study

Correspondence to:

Lei Feng, email:

Lei Zheng, email:

Keywords: coronary heart disease; serum biochemical indices; risk factors; binary multiple logistic regression analysis; ordinal multiple logistic regression analysis; Pathology Section

Received: March 29, 2016 Accepted: May 16, 2016 Published: May 26, 2016

Abstract

Serum biochemical indices reflect dynamic physiological and pathophysiological processes within the body, the associations between these markers and the number of stenotic coronary arteries have been rarely studied. 627 healthy controls and 1,049 coronary heart disease (CHD) patients were sequentially recruited in our hospital. The association patterns between serum biochemical markers and the numbers of stenotic coronary arteries were evaluated in a cross-sectional manner. Upon binary multiple logistic regression analysis, the risk factor patterns differed by gender. Age, high-density lipoprotein cholesterol (HDL) and homocysteine (HCY) were common risk factors for CHD in both males and females. Upon ordinal multiple logistic regression analysis, age, low-density lipoprotein cholesterol (LDL) and lipoprotein (Lp) (a) increased, and HDL decreased, as the number of stenotic coronary arteries increased in male patients. Age and Lp(a) were positively associated with the number of stenotic coronary arteries and total bilirubin (TBil) was negatively associated with the number of stenotic coronary arteries in female patients. Age and Lp(a) were common risk factors positively associated with the number of stenotic coronary arteries in both male and female patients. HDL and LDL were male-specific risk factors and TBil was a female-specific risk factor for an increasing number of stenotic coronary arteries. In conclusion, serum biomarker levels correlated with the number of stenotic coronary arteries and showed gender different patterns.


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