Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma
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Zhao Liu1,2, Yuting Shi3, Yuyan Na4, Qi Zhang5, Sizhe Cao5, Xianglong Duan6, Xiyang Zhang7, Hua Yang7, Tianbo Jin7, Yiming Li1
1Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China
2Department of Surgery, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China
3Department of Medical Oncology, Graduate School of Inner Mongolia Medical University, Hohhot 010000, China
4Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
5Department of Medical, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China
6Second Department of General Surgery, Shaanxi Province People's Hospital, Xi’an 710001, China
7Department of Biochemistry, School of Life Sciences, Northwest University, Xi’an 710069, China
Yiming Li, email: email@example.com
Keywords: gastric carcinoma, single nucleotide polymorphisms (SNPs), TNF-α-induced protein 3-interacting protein 1 (TNIP1), case-control study
Received: March 30, 2016 Accepted: May 13, 2016 Published: May 26, 2016
The distribution and levels of TNIP1 in malignant and normal gastric mucosa are different, but it is not known whether TNIP1 polymorphisms are related to gastric carcinogenesis. To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population. These data were then compared using the Chi-square test/Fisher's exact test, genetic model analysis, and haplotype analysis. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the correlation. We observed that patients with the “G” allele of rs7708392 and the “C” allele of rs10036748 showed an increased risk of gastric carcinoma (OR= 1.335, 95%CI: 1.021-1.745, P= 0.035; OR= 1.358, 95%CI: 1.039-1.774, P= 0.025, respectively). Conversely, the haplotype “CT” of TNIP1 (rs7708392-rs10036748) may act as a genetic protective factor for gastric carcinoma (adjusted OR= 0.731, 95%CI: 0.552-0.970, P= 0.030). Our results are the first to suggest that genetic variation in TNIP1 gene is associated with gastric carcinoma, though, this finding must be confirmed in other populations with larger sample size.
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