The molecular mechanism of G 2 /M cell cycle arrest induced by AFB 1  in the jejunum

Heng Yin; Min Jiang; Xi Peng; Hengmin Cui; Yi Zhou; Min He; Zhicai Zuo; Ping Ouyang; Junde Fan; Jing Fang

doi:10.18632/oncotarget.9594

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Research Papers: Pathology:

The molecular mechanism of G₂/M cell cycle arrest induced by AFB₁ in the jejunum

Heng Yin, Min Jiang, Xi Peng, Hengmin Cui, Yi Zhou, Min He, Zhicai Zuo, Ping Ouyang, Junde Fan and Jing Fang _

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Oncotarget. 2016; 7:35592-35606. https://doi.org/10.18632/oncotarget.9594

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Abstract

Heng Yin1, Min Jiang1, Xi Peng1,2, Hengmin Cui1,2, Yi Zhou2, Min He2, Zhicai Zuo1,2, Ping Ouyang2, Junde Fan3 and Jing Fang1,2

1 Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Chengdu, Sichuan, PR China

2 College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, PR China

3 College of Biological and Agro-Forestry Engineering, Tongren University, Tongren, Guizhou, PR China

Correspondence to:

Jing Fang, email:

Keywords: AFB₁; G₂/M phase; cell cycle arrest; mechanism; jejunum; Pathology Section

Received: March 11, 2016 Accepted: May 12, 2016 Published: May 25, 2016

Abstract

Aflatoxin B1 (AFB1) has potent hepatotoxic, carcinogenic, genotoxic, immunotoxic and other adverse effects in human and animals. The aim of this study was to investigate the molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum of broilers. Broilers, as experimental animals, were fed 0.6 mg/kg AFB1 diet for 3 weeks. Our results showed that AFB1 reduced the jejunal villus height, villus height/crypt ratio and caused G2/M cell cycle arrest. The G2/M cell cycle was accompanied by the increase of ataxia telangiectasia mutated (ATM), p53, Chk2, p21 protein and mRNA expression, and the decrease of Mdm2, cdc25C, cdc2, cyclin B and proliferating cell nuclear antigen protein and mRNA expression. In conclusion, AFB1 blocked G2/M cell cycle by ATM pathway in the jejunum of broilers.

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Research Papers: Pathology:

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

Abstract

The molecular mechanism of G₂/M cell cycle arrest induced by AFB₁ in the jejunum