Research Papers: Pathology:
Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis
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Luqian Zhao1, Zhigang Zhu1, Huiling Lou1, Guodong Zhu1, Weimin Huang1, Shaogang Zhang1 and Feng Liu1
1 Department of Geriatrics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Feng Liu, email:
Keywords: PCOS; cardiovascular disease; association; meta-analysis; Pathology Section
Received: April 03, 2016 Accepted: May 13, 2016 Published: May 22, 2016
Some studies reported a significant association between polycystic ovary syndrome (PCOS) and risk of cardiovascular disease (CVD). However, the results are controversial. A systematic search was conducted in the PubMed, Science Direct, EMBASE, and Cochrane Library databases. Five case-control studies and 5 cohort studies were selected, involving a total of 104392 subjects in this meta-analysis. PCOS was significantly associated with the increased risk of CVD (OR = 1.30; 95% CI 1.09 – 1.56; P = 0.004). In the subgroup analysis of study design, both case-control studies and prospective cohort studies showed significant results (OR = 1.79; 95% CI 1.16 – 2.77; P = 0.009; OR = 1.20; 95% CI 1.06 – 1.37; P = 0.005), while retrospective cohort studies did not show positive result (OR = 0.91; 95% CI 0.60 – 1.40; P = 0.68). In a further stratified analysis by type of CVD, a significant association was found between PCOS and coronary heart disease (CHD) (OR = 1.44; 95% CI 1.13 – 1.84; P = 0.004). However, no significant association was observed between PCOS and myocardial infarction (MI) (OR = 1.01; 95% CI 0.68 – 1.51; P = 0.95). In conclusion, this meta-analysis suggested that PCOS is significantly associated with increased CHD risk.
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