Oncotarget

Research Papers:

Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

Zi-Xian Wang, Lu-Ping Yang, Miao-Zhen Qiu, Zhi-Qiang Wang, Yi-Xin Zhou, Feng Wang, Dong-Sheng Zhang, Feng-Hua Wang, Yu-Hong Li and Rui-Hua Xu _

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Oncotarget. 2016; 7:39945-39956. https://doi.org/10.18632/oncotarget.9459

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Abstract

Zi-Xian Wang1,2,*, Lu-Ping Yang2,*, Miao-Zhen Qiu1,*, Zhi-Qiang Wang1,*, Yi-Xin Zhou3, Feng Wang1, Dong-Sheng Zhang1, Feng-Hua Wang1, Yu-Hong Li1, Rui-Hua Xu1

1Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

2Faculty of Medical Sciences, Sun Yat-sen University, Guangzhou, China

3Department of VIP Region, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

*These authors have contributed equally to this study

Correspondence to:

Rui-Hua Xu, email: xurh@sysucc.org.cn

Keywords: gastric cancer, lactate dehydrogenase, D2 lymphadenectomy, prognosis, nomogram

Received: October 13, 2015     Accepted: April 2, 2016     Published: May 19, 2016

ABSTRACT

The present study aimed to evaluate the prognostic significance of preoperative serum lactate dehydrogenase (SLDH) levels for resected gastric cancer and construct prognostic nomograms for risk prediction. The study cohort consisted of 619 patients with D2-resected gastric cancer. The relationship of SLDH levels with clinicopathological features and clinical outcomes was evaluated. Prognostic nomograms were created using identified prognosticators to predict 3-year overall survival (OS) and 3-year disease-free survival (DFS), and bootstrap validation was performed. High SLDH levels were correlated with old age but not depth of invasion or lymph node metastasis. When assessed as a continuous variable, high SLDH levels were independently associated with poor OS and DFS. Internal validation of the developed nomograms revealed good predictive accuracy (bootstrap-corrected concordance indices: 0.77 and 0.75, respectively for prediction of OS and DFS). The preoperative SLDH levels, an identified unfavorable prognosticator, were incorporated into nomograms along with other clinicopathological features to refine the prediction of clinical outcomes for patients with D2-resected gastric cancer.


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