Oncotarget

Clinical Research Papers:

Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China

Kun Yang, Yoon Young Choi, Wei-Han Zhang, Xin-Zu Chen, Mi Kyung Song, Jinae Lee, Bo Zhang, Zhi-Xin Chen, Hyoung-Il Kim, Jia-Ping Chen, Jae-Ho Cheong, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu and Sung Hoon Noh _

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Oncotarget. 2016; 7:44660-44675. https://doi.org/10.18632/oncotarget.9378

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Abstract

Kun Yang1,2,3,4,*, Yoon Young Choi3,*, Wei-Han Zhang1,2, Xin-Zu Chen1,2, Mi Kyung Song5, Jinae Lee5, Bo Zhang1, Zhi-Xin Chen1, Hyoung-Il Kim3,4, Jia-Ping Chen1, Jae-Ho Cheong3, Zong-Guang Zhou1, Woo Jin Hyung3,4, Jian-Kun Hu1,2, Sung Hoon Noh3

1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China

2Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

3Department of Surgery, Severance Hospital, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Republic of Korea

4Robot and Minimal Invasive Surgery Center, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea

5Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea

*Co-first authors

Correspondence to:

Sung Hoon Noh, email: sunghoonn@yuhs.ac

Jian-Kun Hu, email: hujkwch@126.com

Keywords: gastric cancer, gastrectomy, tumour characteristics, D2 lymphadenectomy, chemotherapy

Received: December 03, 2015     Accepted: April 23, 2016     Published: May 15, 2016

ABSTRACT

China has high incidence of gastric cancer (GC). However, the treatment outcomes of China were unsatisfactory compared to those of Korea. We performed this study to compare tumour characteristics, treatment parameters, and survival outcomes of GC patients between Korea and China based on the databases of two high-volume hospitals, with the aim of identifying indicators of GC prognosis. Data of patients undergoing gastrectomy for GC from 2006 to 2010 were analysed retrospectively. Subgroup survival analyses, stratified by clinicopathologic factors and multivariable analyses, were performed. The interactive roles of chemotherapy and D2 lymphadenectomy for overall survival were also investigated. Among 1365 Chinese and 4981 Korean patients, the proportion of early cancer detection in Chinese patients was much lower relative to that of Korean patients. There were no significant differences between countries in terms of surgical morbidity and mortality. The overall 5-year survival rates were 54.3% and 81.4%; when stratified by clinicopathologic factors, the survival were generally statistically higher in Korean patients. Gender, age, T stage, N stage, extent of lymphadenectomy, radicality of surgery, resection type, and chemotherapy were independently associated with survival in patients without metastasis. Survival rates for stage II and III GC differed significantly between the two countries, but this difference was eliminated among patients who underwent D2 lymphadenectomy or received chemotherapy. These treatments were given to patients with advanced-stage diagnoses (approximately 20% and 80% of patients, respectively). Treatment type was selected as independent prognostic factors in stage I–III and D2/D2+, with chemotherapy resulting in the best prognosis. Many differences in GC tumour characteristics exist between two countries. Early cancer detection and standardized treatment in Korea contribute to superior survival rates. Promotion of an early screening program, training and dissemination of standard D2 lymphadenectomy, and appropriate applications of chemotherapy would improve survival outcomes.


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