Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-β1 signaling

Yun Luan; Luan Zhang; Sun Chao; Xiaoli Liu; Kaili Li; Yibiao Wang; Zhaohua Zhang

doi:10.18632/oncotarget.9314

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-β1 signaling

Yun Luan, Luan Zhang, Sun Chao, Xiaoli Liu, Kaili Li, Yibiao Wang _ and Zhaohua Zhang

PDF | HTML | How to cite

Oncotarget. 2016; 7:47082-47094. https://doi.org/10.18632/oncotarget.9314

Metrics: PDF 1247 views | HTML 1977 views | ?

Abstract

Yun Luan1, Luan Zhang2, Sun Chao1, Xiaoli Liu3, Kaili Li1, Yibiao Wang2, Zhaohua Zhang2

1Central Research Laboratory, The Second Hospital of Shandong University, Jinan, China

2Department of Pediatrics, The Second Hospital of Shandong University, Jinan, China

3Department of Hematology, The Second Hospital of Shandong University, Jinan, China

Correspondence to:

Yibiao Wang, e-mail: [email protected]

Zhaohua Zhang, e-mail: [email protected]

Keywords: BPD, MSCs, EPO, TGF-β1, ETM

Received: December 09, 2015 Accepted: April 11, 2016 Published: May 12, 2016

ABSTRACT

The aim of the present study is to investigate the protection effects of bone marrow mesenchymal stem cells (MSCs) in combination with EPO against hyperoxia-induced bronchopulmonary dysplasia (BPD) injury in neonatal mice. BPD model was prepared by continuous high oxygen exposure, 1×10⁶ bone marrow MSCs and 5000U/kg recombinant human erythropoietin (EPO) were injected respectively. Results showed that administration of MSCs, EPO especially MSCs+EPO significant attenuated hyperoxia-induced lung damage with a decrease of fibrosis, radical alveolar counts and inhibition of the occurrence of epithelial-mesenchymal transition (EMT). Furthermore, MSCs+EPO co-treatment more significantly suppressed the levels of transforming growth factor-β1(TGF-β1) than MSCs or EPO alone. Collectively, these results suggested that MSCs, EPO in particular MSCs+EPO co-treatment could promote lung repair in hyperoxia-induced alveoli dysplasia injury via inhibition of TGF-β1 signaling pathway to further suppress EMT process and may be a promising therapeutic strategy.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 9314

Publication Alerts

Research Papers:

Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-β1 signaling

Abstract