Oncotarget

Clinical Research Papers:

Clinicopathological features and prognosis of colonic gastrointestinal stromal tumors: evaluation of a pooled case series

Fan Feng, Yangzi Tian, Zhen Liu, Guanghui Xu, Shushang Liu, Man Guo, Xiao Lian, Daiming Fan and Hongwei Zhang _

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Oncotarget. 2016; 7:40735-40745. https://doi.org/10.18632/oncotarget.9196

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Abstract

Fan Feng1,*, Yangzi Tian2,*, Zhen Liu1,*, Guanghui Xu1, Shushang Liu1, Man Guo1, Xiao Lian1, Daiming Fan1 and Hongwei Zhang1

1 Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

2 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

* These authors have contributed equally to this work

Correspondence to:

Hongwei Zhang, email:

Keywords: gastrointestinal stromal tumor, colon, feature, prognosis

Received: November 30, 2015 Accepted: April 16, 2016 Published: May 05, 2016

Abstract

Background: Due to the extremely rare incidence, data about colonic GISTs are limited. Therefore, aim of the present study was to explore clinicopathological characteristics and prognosis of colonic GISTs.

Patients and Methods: Colonic GISTs cases were obtained from our center and from case report and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analyzed.

Results: There were 79 colonic GISTs patients with a female predominance. The median age was 66 years (range 0.17-84). The median tumor size was 5.8 cm (range 0.5-29). The most common location was sigmoid colon (45.8%), followed by transverse colon (19.5%). The majority of colonic GISTs were high risk (70.8%). Mitotic index was correlated with gender (P = 0.002) and tumor size (P = 0.005), and tumor location was correlated with age (P = 0.017). The five year DFS and DSS were 57.4% and 61.6%, respectively. Mitotic index and NIH risk classification were associated with prognosis of colonic GISTs. However, mitotic index was the only independent risk factor. The distribution of tumor size and NIH risk classification were significantly different between colonic and gastric GISTs (both P = 0.000). The DFS and DSS of colonic GISTs were significantly lower than that of gastric GISTs (P = 0.012 and P = 0.002, respectively).

Conclusions: The most common location for colonic GISTs was sigmoid colon. Most tumors were high risk. Mitotic index was the only independent risk factor for prognosis of colonic GISTs. Colonic GISTs differ significantly from gastric GISTs in respect to clinicopathological features. The prognosis of colonic GISTs was worse than that of gastric GISTs.


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