Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice

Junjun Sun, Hong Zhou, Feng Bai, Qingguo Ren _ and Zhijun Zhang

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Oncotarget. 2016; 7:30003-30017. https://doi.org/10.18632/oncotarget.8981

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Abstract

Junjun Sun1, Hong Zhou1, Feng Bai1, Qingguo Ren1 and Zhijun Zhang1

1 Department of Neuropsychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China

Correspondence to:

Qingguo Ren, email:

Keywords: demyelination, axonal transport, tau, beta amyloid, remyelination, Gerotarget

Received: December 28, 2015 Accepted: April 16, 2016 Published: April 25, 2016

Abstract

Both multiple sclerosis (MS) and Alzheimer’s disease (AD) are progressive neurological disorders with myelin injury and memory impairment. However, whether myelin impairment could cause AD-like neurological pathology remains unclear. To explore neurological pathology following myelin injury, we assessed cognitive function, the expression of myelin proteins, axonal transport-associated proteins, axonal structural proteins, synapse-associated proteins, tau and beta amyloid and the status of neurons, using the cuprizone mouse model of demyelination. We found the mild impairment of learning ability in cuprizone-fed mice and the decreased expression of myelin basic protein (MBP) in the hippocampus. And anti-LINGO-1 improved learning ability and partly restored MBP level. Furthermore, we also found kinesin light chain (KLC), neurofilament light chain (NFL) and neurofilament heavy chain (NF200) were declined in demyelinated hippocampus, which could be partly improved by treatment with anti-LINGO-1. However, we did not observe the increased expression of beta amyloid, hyperphosphorylation of tau and loss of neurons in demyelinated hippocampus. Our results suggest that demyelination might lead to the impairment of neuronal transport, but not cause increased level of hyperphosphorylated tau and beta amyloid. Our research demonstrates remyelination might be an effective pathway to recover the function of neuronal axons and cognition in MS.


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