Oncotarget

Research Papers: Gerotarget (Focus on Aging):

The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain

Jianhui Wang, Xiaorui Cheng, Xiaorui Zhang, Junping Cheng, Yiran Xu, Ju Zeng, Wenxia Zhou and Yongxiang Zhang _

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Oncotarget. 2016; 7:26949-26965. https://doi.org/10.18632/oncotarget.8877

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Abstract

Jianhui Wang1,2,*, Xiaorui Cheng1,2,*, Xiaorui Zhang1,2, Junping Cheng1,2, Yiran Xu1,2, Ju Zeng1,2, Wenxia Zhou1,2 and Yongxiang Zhang1,2

1 Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China

2 State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China

* Co-first author, these two authors contributed equally to this work

Correspondence to:

Xiaorui Cheng, email:

Wenxia Zhou, email:

Yongxiang Zhang, email:

Keywords: LW-AFC; senescence accelerated mouse resistant 1 (SAMR1) strain; immunosenescence; immunodeficiency; chronic inflammation; Gerotarget

Received: March 23, 2016 Accepted: April 03, 2016 Published: April 20, 2016

Abstract

Although there were considerable advances in the anti-aging medical field, it is short of therapeutic drug for anti-aging. Mounting evidence indicates that the immunosenescence is the key physiopathological mechanism of aging. This study showed the treatment of LW-AFC, an herbal medicine, decreased the grading score of senescence, increased weight, prolonged average life span and ameliorated spatial memory impairment in 12- and 24-month-old senescence accelerated mouse resistant 1 (SAMR1) strain. And these anti-aging effects of LW-AFC were more excellent than melatonin. The administration of LW-AFC enhanced ConA- and LPS-induced splenocyte proliferation in aged SAMR1 mice. The treatment of LW-AFC not only reversed the decreased the proportions of helper T cells, suppressor T cells and B cells, the increased regulatory T cells in the peripheral blood of old SAMR1 mice, but also could modulate the abnormal secretion of IL-1β, IL-2, IL-6, IL-17, IL-23, GM-CSF, IFN-γ, TNF-α, TNF-β, RANTES, eotaxin, MCP-1, IL-4, IL-5, IL-10 and G-CSF. These data indicated that LW-AFC reversed the immunosenescence status by restoring immunodeficiency and decreasing chronic inflammation and suggested LW-AFC may be an effective anti-aging agent.


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