Oncotarget

Research Papers:

Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats

Jin Hyun Kim, Kyung Mi Kim, Myeong Hee Jung, Jung Hwa Jung, Ki Mun Kang, Bae Kwon Jeong, Jin Pyeong Kim, Jung Je Park and Seung Hoon Woo _

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Oncotarget. 2016; 7:29143-29153. https://doi.org/10.18632/oncotarget.8661

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Abstract

Jin Hyun Kim1,2, Kyung Mi Kim3, Myeong Hee Jung1, Jung Hwa Jung2,4, Ki Mun Kang2,5, Bae Kwon Jeong2,5, Jin Pyeong Kim2,3, Jung Je Park2,3, Seung Hoon Woo2,3

1Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Gyeongnam, Republic of Korea

2Institute of Health Science, Jinju, Gyeongnam, Republic of Korea

3Department of Otolaryngology, Jinju, Gyeongnam, Republic of Korea

4Department of Internal Medicine, Jinju, Gyeongnam, Republic of Korea

5Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Gyeongnam, Republic of Korea

Correspondence to:

Seung Hoon Woo, email: lesaby@hanmail.net

Keywords: alpha lipoic acid, salivary gland, radiation, Nox-2, complication

Received: December 27, 2015     Accepted: March 16, 2016     Published: April 09, 2016

ABSTRACT

Purpose: Radiation therapy is a treatment for patients with head and neck (HN) cancer. However, radiation exposure to the HN often induces salivary gland (SG) dysfunction. We investigated the effect of α-lipoic acid (ALA) on radiation-induced SG injury in rats.

Results: ALA preserved acinoductal integrity and acinar cell secretary function following irradiation. These results are related to the mechanisms by which ALA inhibits oxidative stress by inhibiting gp91 mRNA and 8-OHdG expression and apoptosis of acinar cells and ductal cells by inactivating MAPKs in the early period and expression of inflammation-related factors including NF-κB, IκB-α, and TGF-β1 and fibrosis in late irradiated SG. ALA effects began in the acute phase and persisted for at least 56 days after irradiation.

Materials and Methods: Rats were assigned to followings: control, ALA only (100 mg/kg, i.p.), irradiated, and ALA administered 24 h and 30 min prior to irradiation. The neck area including the SG was evenly irradiated with 2 Gy per minute (total dose, 18 Gy) using a photon 6-MV linear accelerator. Rats were killed at 4, 7, 28, and 56 days after radiation.

Conclusions: Our results show that ALA could be used to ameliorate radiation-induced SG injury in patients with HN cancer.


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