Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells

Jing-Jing Zhang; Yi Zhu; Chuang Yang; Xian Liu; Yun-Peng Peng; Kui-Rong Jiang; Yi Miao; Ze-Kuan Xu

doi:10.18632/oncotarget.8654

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells

Jing-Jing Zhang _, Yi Zhu, Chuang Yang, Xian Liu, Yun-Peng Peng, Kui-Rong Jiang, Yi Miao and Ze-Kuan Xu

PDF | HTML | How to cite

Oncotarget. 2016; 7:28498-28509. https://doi.org/10.18632/oncotarget.8654

Metrics: PDF 2065 views | HTML 2371 views | ?

Abstract

Jing-Jing Zhang1,2,3,*, Yi Zhu1,2,3,*, Chuang Yang1,2,3, Xian Liu1,2,3, Yun-Peng Peng1,2,3, Kui-Rong Jiang1,2,3, Yi Miao1,2,3, Ze-Kuan Xu3

1Pancreas Institute of Nanjing Medical University, Nanjing 210029, People’s Republic of China

2Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China

3Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China

*These authors contributed equally to this work

Correspondence to:

Yi Miao, email: [email protected]

Ze-kuan Xu, email: [email protected]

Keywords: Yin Yang-1, pancreatic cancer, apoptosis, Bax

Received: January 28, 2016 Accepted: March 28, 2016 Published: April 08, 2016

ABSTRACT

The transcriptional regulator Yin Yang-1 (YY1) is a tumor suppressor known to be overexpressed in pancreatic cancer. We found that overexpression of YY1 promoted apoptosis and increased the expression and mitochondrial localization of the pro-apoptotic Bax protein in pancreatic cancer cell lines. Luciferase reporter, electrophoretic mobility shift (EMSA), and chromatin immunoprecipitation (ChIP) assays revealed binding of YY1 to the BAX promoter. Moreover, YY1 promoted pancreatic cancer cell apoptosis through Bax transcriptional activation and subsequent translocation of Bax to the mitochondrial membrane, leading to cytochrome c release, and caspase activation.YY1 and BAX are co-expressed in pancreatic cancer tissues and higher BAX expression predicts better outcomes for patients. The ability of YY1 to promote apoptosis in pancreatic cancer cells suggests it may represent a valuable diagnostic and therapeutic target.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 8654

Publication Alerts

Research Papers:

Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells

Abstract