Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis

Hong-Fang Ji _, Qi-Shuai Zhuang and Liang Shen

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Oncotarget. 2016; 7:17410-17414. https://doi.org/10.18632/oncotarget.8202

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Abstract

Hong-Fang Ji1, Qi-Shuai Zhuang1 and Liang Shen1

1 Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, P. R. China

Correspondence to:

Hong-Fang Ji, email:

Liang Shen, email:

Keywords: type 2 diabetes; major depressive disorder; single nucleotide polymorphisms; bioinformatics; Gerotarget

Received: December 20, 2015 Accepted: February 15, 2016 Published: March 19, 2016

Abstract

Our study investigated the shared genetic etiology underlying type 2 diabetes (T2D) and major depressive disorder (MDD) by analyzing large-scale genome wide association studies statistics. A total of 496 shared SNPs associated with both T2D and MDD were identified at p-value ≤ 1.0E-07. Functional enrichment analysis showed that the enriched pathways pertained to immune responses (Fc gamma R-mediated phagocytosis, T cell and B cell receptors signaling), cell signaling (MAPK, Wnt signaling), lipid metabolism, and cancer associated pathways. The findings will have potential implications for future interventional studies of the two diseases.


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