Oncotarget

Research Papers:

Survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the Epstein-Barr virus status

Hao Peng, Lei Chen, Yuan Zhang, Rui Guo, Wen-Fei Li, Yan-Ping Mao, Ling-Long Tan, Ying Sun, Fan Zhang, Li-Zhi Liu, Li Tian, Ai-Hua Lin and Jun Ma _

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Oncotarget. 2016; 7:24208-24216. https://doi.org/10.18632/oncotarget.8144

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Abstract

Hao Peng1, Lei Chen1, Yuan Zhang1, Rui Guo1, Wen-Fei Li1, Yan-Ping Mao1, Ling-Long Tan1, Ying Sun1, Fan Zhang1, Li-Zhi Liu2, Li Tian2, Ai-Hua Lin3, Jun Ma1

1Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of China

2Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of China

3Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510275, People’s Republic of China

Correspondence to:

Jun Ma, e-mail: majun2@mail.sysu.edu.cn

Keywords: nasopharyngeal carcinoma, Epstein-Barr virus, prognosis, advanced stage, intensity-modulated radiation therapy

Received: October 30, 2015    Accepted: March 04, 2016    Published: March 17, 2016

ABSTRACT

Purpose: The main aim of this study is to analyze the prognostic differences in nasopharyngeal carcinoma (NPC) patients who are positive and negative for Epstein-Barr virus (EBV).

 

Results: Of the 1106 patients, 248 (22.4%) had undetectable pre-treatment plasma EBV DNA levels. The total distant metastasis rate for EBV-negative group vs. EBV-positive group were 3.6% (9/248) vs. 15.0% (128/858) (P < 0.001). The estimated 4-year disease-free survival (DFS), overall survival (OS), distant metastasis-free survival (DMFS) and locoregional relapse-free survival (LRRFS) for EBV-negative group vs. EBV-positive group were 88.9% vs. 76.9% (P < 0.001), 93.6% vs. 85.9% (P = 0.001), 96.7% vs. 84.8% (P < 0.001) and 94.1% vs. 90.0% (P = 0.1), respectively. Multivariate analysis revealed that the EBV status was an independent prognostic factor for DFS (HR, 1.813; 95% CI, 1.219-2.695; P = 0.003), OS (HR, 1.828; 95% CI, 1.075-3.107; P = 0.026) and DMFS (HR, 3.678; 95% CI, 1.859-7.277; P <0.001), and overall stage still remained the most important prognostic factor in patients with stage III-IVB NPC.

Methods and Materials: Data on 1106 patients with non-metastatic, histologically proven advanced-stage (III-IVB) NPC who underwent intensity-modulated radiotherapy (IMRT) were retrospectively reviewed. Patient survival between different EBV status groups were compared.

Conclusions: EBV status was an independent prognostic factor for patients with stage III–IVB NPC. Neoadjuvant chemotherapy (NCT) plus concurrent chemoradiotherapy (CCRT) should be better treatment regimen for EBV-positive patients since distant metastasis was the main failure pattern, and CCRT may be enough for EBV-negative patients.


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