Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer
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Meixian Xiang1,2,*, Hanwen Su3,*, Guangwen Shu1, Dingrong Wan1, Feng He1, Morgann Loaec2, Yali Ding2, Jun Li1, Sinisa Dovat2, Gaungzhong Yang1, Chunhua Song2
1College of Pharmacy, South-Central University for Nationalities, Wuhan, PR China
2Pennsylvania State University College of Medicine, Department of Pediatrics, Hershey, PA, USA
3Renmin Hospital of Wuhan University, Wuhan, PR China
*These authors contributed equally to this work
Guangzhong Yang, e-mail: firstname.lastname@example.org
Chunhua Song, e-mail: email@example.com
Keywords: amplexicaule A, apoptosis, Akt/mTOR, MCL-1, breast cancer
Received: September 02, 2015 Accepted: January 18, 2016 Published: March 02, 2016
Chemotherapy is the main treatment for patients with breast cancer metastases, but natural alternatives have been receiving attention for their potential as novel anti-tumor reagents. Amplexicaule A (APA) is a flavonoid glucoside isolated from rhizomes of Polygonum amplexicaule D. Don var. sinense Forb (PADF). We found that APA has anti-tumor effects in a breast cancer xenograft mouse model and induces apoptosis in breast cancer cell lines. APA increased levels of cleaved caspase-3,-8,-9 and PARP, which resulted from suppression of MCL-1 and BCL-2 expression in the cells. APA also inactivated the Akt/mTOR pathway in breast cancer cells. Thus, APA exerts a strong anti-tumor effect on breast cancer cells, most likely through induction of apoptosis. Our study is the first to identify this novel anti-tumor compound and provides a new strategy for isolation and separation of single compounds from herbs.
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