Oncotarget

Reviews:

Role of multifaceted regulators in cancer glucose metabolism and their clinical significance

Luqing Zhao, Yitao Mao, Yuelong Zhao, Ya Cao and Xiang Chen _

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Oncotarget. 2016; 7:31572-31585. https://doi.org/10.18632/oncotarget.7765

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Abstract

Luqing Zhao1,2,3,4, Yitao Mao5, Yuelong Zhao7, Ya Cao6 and Xiang Chen1,2

1 Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China

2 Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China

3 Department of Pathology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, China

4 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China

5 Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China

6 Cancer Research Institute, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, China

7 School of Information Sceince and Engineering, Central South University, Changsha, Hunan, China

Correspondence to:

Xiang Chen, email:

Luqing Zhao, email:

Keywords: glucose metabolism, multifaceted regulators, p53, HIF-1, TIGAR

Received: October 14, 2015 Accepted: February 16, 2016 Published: February 26, 2016

Abstract

Aberrant glucose metabolism, “aerobic glycolysis” or “Warburg effect”, is a hallmark of human cancers. There is a cluster of “multifaceted regulators”, which plays a pivotal role in the regulation of glucose metabolism. They can not only modulate the activities of specific enzymes, but also act as transcriptional activators to regulate the expression of metabolism related genes. Additionally, they can crosstalk with other key factors involved in glucose metabolism and work together to initiate multiple oncogenic processes. These “multifaceted regulators”, especially p53, HIF-1, TIGAR and microRNA, will be focused in this review. And we will comprehensively illustrate their regulatory effects on cancer glucose metabolism, and further elaborate on their clinical significance. In-depth elucidation the role of “multifaceted regulators” in cancer glucose metabolism will provide us novel insights in cancer research field and offer promising therapeutic targets for anti-cancer therapies.


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