Oncotarget

Case Reports:

Nasal NK/T cell lymphoma presents with long-term nasal blockage and fever: a rare case report and literature review

Hai Zou, Ke-Hua Pan, Liang Wu, Hong-Ying Pan, Ya-Hui Ding and Ming-Hua Zheng _

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Oncotarget. 2016; 7:9613-9617. https://doi.org/10.18632/oncotarget.7386

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Abstract

Hai Zou1, Ke-Hua Pan2, Liang Wu3, Hong-Ying Pan1, Ya-Hui Ding4 and Ming-Hua Zheng5,6

1 Department of Infection Diseases, Zhejiang Provincial People’s Hospital, Hangzhou, China

2 Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

4 Department of Cardiovascular Medicine, Zhejiang Provincial People’s Hospital, Hangzhou, China

5 Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

6 Institute of Hepatology, Wenzhou Medical University, Wenzhou, China

Correspondence to:

Ming-Hua Zheng, email:

Ya-Hui Ding, email:

Keywords: NK/T cell lymphoma, fever of unknown origin, clinical manifestation

Received: December 10, 2015 Accepted: January 30, 2016 Published: February 14, 2016

Abstract

NK/T cell lymphoma (NKTCL) is a common disease which is a threat to human health. Nasal NKTCL is a rare but serious type of systemic lymphoma because of its high mortality rate and serious complications. In this case report, we describe a male who presented with nasal blockage in the right side, a fever of one month duration and a soy-like, painless and gradually increasing mass in the right submandibular region due to nasal NKTCL. The patient had no significant medical history and the initial clinical symptoms were nasal blockage. Contrast computed tomography showed that the nasopharyngeal mucosa was thickened and that the celiac and retroperitoneal lymphaden was intumescent. Finally a biopsy, guided by nasal endoscopy and examined using flow cytometry confirmed a diagnosis of NKTCL. Nasal NKTCL is rare and has no unique characteristics at first presentation, such as epidemiology and obvious clinical manifestation. As no effective therapy is currently available for this disease, early diagnosis and therapy of nasal NKTCL remains challenging.


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