Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy

Kazuhide Sato; Rira Watanabe; Hirofumi Hanaoka; Takahito Nakajima; Peter L. Choyke; Hisataka Kobayashi

doi:10.18632/oncotarget.7365

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy

Kazuhide Sato, Rira Watanabe, Hirofumi Hanaoka, Takahito Nakajima, Peter L. Choyke and Hisataka Kobayashi _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:14324-14335. https://doi.org/10.18632/oncotarget.7365

Metrics: PDF 2337 views | HTML 2546 views | ?

Abstract

Kazuhide Sato1, Rira Watanabe1, Hirofumi Hanaoka1, Takahito Nakajima1, Peter L. Choyke1, Hisataka Kobayashi1

1Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

Correspondence to:

Hisataka Kobayashi, e-mail: [email protected]

Keywords: near infrared photoimmunotherapy, light emitting diode (LED), light amplification by stimulated emission of radiation (Laser), epidermal growth factor receptor, super-enhanced permeability and retention (SUPR) effect

Received: December 03, 2015 Accepted: January 29, 2016 Published: February 13, 2016

ABSTRACT

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light. Herein we compare two NIR-light sources; light emitting diodes (LEDs) and Lasers, for their effectiveness in NIR-PIT.

A photosensitizer, IRDye-700DX, conjugated to panitumumab (pan-IR700), was incubated with EGFR-expressing A431 and MDA-MB-468-luc cells. NIR-light was provided by LEDs or Lasers at the same light dose. Laser-light produced more cytotoxicity and greater reductions in IR700-fluorescence intensity than LED-light. Laser-light also produced more cytotoxicity in vivo in both cell lines. Assessment of super-enhanced permeability and retention (SUPR) effects were stronger with Laser than LED.

These results suggest that Laser-light produced significantly more cytotoxic effects compared to LEDs. Although LED is less expensive, Laser-light produces superior results in NIR-PIT.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 7365

Publication Alerts

Research Papers:

Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy

Abstract