A propensity score matching analysis of survival following segmentectomy or wedge resection in early-stage lung invasive adenocarcinoma or squamous cell carcinoma

Yang Zhang; Yihua Sun; Haiquan Chen

doi:10.18632/oncotarget.7284

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Research Papers:

A propensity score matching analysis of survival following segmentectomy or wedge resection in early-stage lung invasive adenocarcinoma or squamous cell carcinoma

Yang Zhang _, Yihua Sun and Haiquan Chen

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Oncotarget. 2016; 7:13880-13885. https://doi.org/10.18632/oncotarget.7284

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Abstract

Yang Zhang1,2, Yihua Sun1,2, Haiquan Chen1,2,3,4

1Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

3Shanghai Chest Hospital, Shanghai Jiao Tong University, China

4Institutes of Biomedical Sciences, Fudan University, Shanghai, China

Correspondence to:

Haiquan Chen, e-mail: [email protected]

Yihua Sun, e-mail: [email protected]

Keywords: non-small cell lung cancer, wedge resection, segmentectomy, survival outcomes

Received: October 17, 2015 Accepted: January 28, 2016 Published: February 9, 2016

ABSTRACT

Purpose: To compare the survival outcomes following segmentectomy or wedge resection in early-stage lung cancer.

Methods: A total of 5880 patients with invasive lung adenocarcinoma or squamous cell carcinoma from the Surveillance, Epidemiology, and End Results (SEER) database were included in this study, of which 1156 received segmentectomy. Baseline characteristics were balanced using propensity score methods. Cox regression analysis was used to compare overall survival (OS) and lung cancer-specific survival (LCSS) following segmentectomy or wedge resection after matching patients based on propensity scores.

Results: Overall, patients undergoing segmentectomy and wedge resection had no significant different OS and LCSS both in the invasive adenocarcinoma group and the squamous cell carcinoma group. Segmentectomy was associated with improved OS (hazard ratio = 0.626, 95% confidence interval: 0.457-0.858, P = 0.004) and LCSS (hazard ratio = 0.643, 95% CI: 0.440-0.939, P = 0.022) in invasive adenocarcinoma patients ≤ 65 years old. In patients with ≤ 2 cm invasive adenocarcinoma, segmentectomy was associated with significantly better OS (hazard ratio = 0.811, 95% confidence interval: 0.666-0.988, P = 0.038).

Conclusion: Survival following segmentectomy or wedge resection was generally equivalent in lung invasive adenocarcinoma and squamous cell carcinoma. However, invasive adenocarcinoma patients who were ≤ 65 years or had tumors ≤ 2 cm in size may have improved survival outcomes after segmentectomy.

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Research Papers:

A propensity score matching analysis of survival following segmentectomy or wedge resection in early-stage lung invasive adenocarcinoma or squamous cell carcinoma

Abstract