Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives

Chao Yang; Di Wu; Lin Gao; Xi Liu; Yinji Jin; Dong Wang; Tianzhen Wang; Xiaobo Li

doi:10.18632/oncotarget.7266

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives

Chao Yang _, Di Wu, Lin Gao, Xi Liu, Yinji Jin, Dong Wang, Tianzhen Wang and Xiaobo Li

PDF | HTML | How to cite

Oncotarget. 2016; 7:13479-13490. https://doi.org/10.18632/oncotarget.7266

Metrics: PDF 3133 views | HTML 3395 views | ?

Abstract

Chao Yang1,*, Di Wu2,*, Lin Gao3,*, Xi Liu4,*, Yinji Jin1, Dong Wang5, Tianzhen Wang1 and Xiaobo Li1

1 Department of Pathology, Harbin Medical University, Harbin, China

2 Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, China

3 Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China

4 Department of Cardiovascular Disease, Inner Mongolia People’s Hospital, Hohhot, China

5 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

* These authors have contributed to this work equally

Correspondence to:

Xiaobo Li, email:

Tianzhen Wang, email:

Dong Wang, email:

Keywords: competing endogenous RNA, cancer, miRNAs, lncRNA, pseudogene

Received: November 19, 2015 Accepted: January 31, 2016 Published: February 08, 2016

Abstract

Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is proposed recently. This hypothesis describes potential communication networks among all transcript RNA species mediated by miRNAs and miRNA-recognizing elements (MREs) within RNA transcripts. Here we review the evolution of the ceRNA hypothesis, summarize the validation experiments and discusses the significance and perspectives of this hypothesis in human cancer.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 7266

Publication Alerts

Reviews:

Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives

Abstract