Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma
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Junwen Luan1, Junfu Wang1, Qinghong Su1, Xuemei Chen2, Guosheng Jiang1, Xiaoqun Xu1
1Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China
2Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, Shandong 250033, China
Xiaoqun Xu, e-mail: firstname.lastname@example.org
Guosheng Jiang, e-mail: email@example.com
Keywords: nasopharyngeal carcinoma, miRNA, profiling, roubust rank aggregation method, meta-analysis
Received: July 02, 2015 Accepted: January 01, 2016 Published: January 25, 2016
MicroRNAs(miRNAs), as non-coding molecules, were proved to be correlated with gene expression in naspharyngeal carcinoma (NPC) development. In this research, a comprehensive meta-analysis of eight independent miRNA expression studies in NPC was preformed by using robust rank aggregation method (RRA), which contained a total of 775 tumor and 227 non-cancerous samples. There were 7 significant dysregulated miRNAs identified including three increased (miR-483–5p, miR-29c-3p and miR-205–5p) and four decreased (miR-29b-3p, let-7d-5p, miR-100– 5p and let-7g-5p) miRNAs. Subsequently, the miRNA target prediction and pathway enrichment analysis were carried out to find out the biological and functional relevant genes involved in the meta-signature miRNA regulation. Finally, several signaling and cancer pathogenesis pathways were suggested to be more frequently associated with the progression of NPC. In this research the meta-signature miRNA identified may be used to develop a series of diagnostic and prognostic biomarkers for NPC that serve specificity for use in clinics.
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