Increased expression of SUMO1P3 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer

Yonghao Zhan; Yuchen Liu; Chaoliang Wang; Junhao Lin; Mingwei Chen; Xiaoying Chen; Chengle Zhuang; Li Liu; Wen Xu; Qing Zhou; Xiaojuan Sun; Qiaoxia Zhang; Guoping Zhao; Weiren Huang

doi:10.18632/oncotarget.6946

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Research Papers:

Increased expression of SUMO1P3 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer

Yonghao Zhan _, Yuchen Liu, Chaoliang Wang, Junhao Lin, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Qing Zhou, Xiaojuan Sun, Qiaoxia Zhang, Guoping Zhao and Weiren Huang

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Oncotarget. 2016; 7:16038-16048. https://doi.org/10.18632/oncotarget.6946

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Abstract

Yonghao Zhan1,2,3,*, Yuchen Liu1,2,*, Chaoliang Wang4,*, Junhao Lin1,3, Mingwei Chen1, Xiaoying Chen1,3, Chengle Zhuang1,3, Li Liu1,3, Wen Xu1, Qing Zhou1, Xiaojuan Sun1, Qiaoxia Zhang1, Guoping Zhao1,5, Weiren Huang1,2,3

1Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China

2Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, China

3Shantou University Medical College, Shantou, China

4Urology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

5Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Centerat Shanghai, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Weiren Huang, e-mail: [email protected]

Keywords: SUMO1P3, bladder cancer, tumor growth, tumor metastasis

Received: October 01, 2015 Accepted: January 02, 2016 Published: January 19, 2016

ABSTRACT

Bladder cancer is one of the most common malignancies worldwide. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play crucial roles in diverse biological processes. The pseudogene-expressed lncRNA is one major type of lncRNA family. Small ubiquitin-like modifier (SUMO) 1 pseudogene 3, (SUMO1P3) is a novel indentified lncRNA that was previously reported to be up-regulated in gastric cancer. However, we know nothing about the biological function and underlying mechanism of SUMO1P3 in tumor. Furthermore, the relationship between SUMO1P3 and bladder cancer is completely unknown. We hypothesized that SUMO1P3 also have roles in bladder cancer.

In this study, we found that SUMO1P3 was significantly up-regulated in bladder cancer tissues compared with paired-adjacent nontumorous tissues in a cohort of 55 bladder cancer patients. Moreover, up-regulated SUMO1P3 expression was positively correlated with greater histological grade (P<0.05) and advanced TNM stage (P<0.05). Furthermore, we found cell proliferation / migration inhibition and apoptosis induction were also observed in SUMO1P3 siRNA-transfected bladder cancer cells. Our data suggest that SUMO1P3 plays oncogenic roles in bladder cancer and can be used as a potential prognostic and therapeutic target.

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Research Papers:

Increased expression of SUMO1P3 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer

Abstract